Details for: CLDN4

Gene ID: 1364

Symbol: CLDN4

Ensembl ID: ENSG00000189143

Description: claudin 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 199.2668
    Cell Significance Index: -31.0000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 90.6426
    Cell Significance Index: -37.3400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 50.4007
    Cell Significance Index: -33.8200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 22.4205
    Cell Significance Index: 137.9800
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 12.9441
    Cell Significance Index: 98.1600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 12.8777
    Cell Significance Index: 350.5200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.4008
    Cell Significance Index: -33.2200
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 10.8932
    Cell Significance Index: 41.7100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 8.8211
    Cell Significance Index: 458.2300
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 8.6269
    Cell Significance Index: 53.3900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 8.0744
    Cell Significance Index: 74.3600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 7.5068
    Cell Significance Index: 559.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 7.1468
    Cell Significance Index: 923.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 6.9310
    Cell Significance Index: 314.1600
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 6.4013
    Cell Significance Index: 35.6300
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 5.7306
    Cell Significance Index: 34.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 4.5542
    Cell Significance Index: 131.2200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 4.0648
    Cell Significance Index: 93.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.7967
    Cell Significance Index: 178.4400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 3.7687
    Cell Significance Index: 56.4700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 3.6474
    Cell Significance Index: 79.0200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.5957
    Cell Significance Index: 167.6500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.5887
    Cell Significance Index: 1959.8500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.4462
    Cell Significance Index: 621.2400
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 3.3586
    Cell Significance Index: 47.8100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 3.2470
    Cell Significance Index: 321.2100
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 2.6089
    Cell Significance Index: 54.4100
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 2.5337
    Cell Significance Index: 8.7000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.4521
    Cell Significance Index: 301.5100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.8073
    Cell Significance Index: 14.4300
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.6722
    Cell Significance Index: 10.3900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.5852
    Cell Significance Index: 16.4100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.3388
    Cell Significance Index: -2.9300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 1.0684
    Cell Significance Index: 11.0600
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.0210
    Cell Significance Index: 10.3000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8565
    Cell Significance Index: 30.1000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.7175
    Cell Significance Index: 22.9800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5799
    Cell Significance Index: 40.1100
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.5457
    Cell Significance Index: 0.3900
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.5191
    Cell Significance Index: 4.1300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5079
    Cell Significance Index: 458.6000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4059
    Cell Significance Index: 69.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3715
    Cell Significance Index: 70.7000
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.3641
    Cell Significance Index: 3.0100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.3460
    Cell Significance Index: 9.6700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2688
    Cell Significance Index: 118.8400
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.2661
    Cell Significance Index: 0.6000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2170
    Cell Significance Index: 35.2900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1861
    Cell Significance Index: 140.9000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.1710
    Cell Significance Index: 19.5200
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.1252
    Cell Significance Index: 1.2400
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.1112
    Cell Significance Index: 1.2100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0484
    Cell Significance Index: 3.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0138
    Cell Significance Index: 10.1300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0127
    Cell Significance Index: 0.3400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0012
    Cell Significance Index: 2.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0004
    Cell Significance Index: 0.7500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0012
    Cell Significance Index: -0.8600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0065
    Cell Significance Index: -10.0000
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.0069
    Cell Significance Index: -0.0500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0137
    Cell Significance Index: -18.5700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0239
    Cell Significance Index: -14.9500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0248
    Cell Significance Index: -4.9300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0255
    Cell Significance Index: -3.5100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0295
    Cell Significance Index: -0.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0300
    Cell Significance Index: -16.9200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0304
    Cell Significance Index: -10.8900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0308
    Cell Significance Index: -0.4200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0360
    Cell Significance Index: -4.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0378
    Cell Significance Index: -23.9900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0413
    Cell Significance Index: -4.2200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0528
    Cell Significance Index: -6.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0596
    Cell Significance Index: -12.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0740
    Cell Significance Index: -33.5800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1099
    Cell Significance Index: -22.0500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1184
    Cell Significance Index: -2.9600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1354
    Cell Significance Index: -6.8400
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.1593
    Cell Significance Index: -1.1100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1700
    Cell Significance Index: -24.7200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1773
    Cell Significance Index: -20.6600
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.2000
    Cell Significance Index: -1.9000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.2143
    Cell Significance Index: -2.7600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2150
    Cell Significance Index: -3.8000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2315
    Cell Significance Index: -9.4900
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2436
    Cell Significance Index: -2.5700
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.2638
    Cell Significance Index: -1.6500
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2848
    Cell Significance Index: -6.0700
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: -0.2943
    Cell Significance Index: -1.3600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3014
    Cell Significance Index: -31.3800
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.3030
    Cell Significance Index: -1.8800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3126
    Cell Significance Index: -36.8700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3249
    Cell Significance Index: -11.2900
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.3366
    Cell Significance Index: -4.6700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3732
    Cell Significance Index: -4.2400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3944
    Cell Significance Index: -24.1800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4089
    Cell Significance Index: -25.7700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.4153
    Cell Significance Index: -10.6800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4176
    Cell Significance Index: -33.0700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4411
    Cell Significance Index: -29.6600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4810
    Cell Significance Index: -36.9200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane structure:** CLDN4 is a type II transmembrane protein, with four extracellular loops and two intracellular domains. 2. **Tight junction assembly:** CLDN4 forms homophilic interactions with other claudins, such as CLDN3 and CLDN5, to regulate the assembly and function of tight junctions. 3. **Cell-cell adhesion:** CLDN4 facilitates cell-cell adhesion by forming heterophilic interactions with other claudins, such as CLDN1 and CLDN2, and with occludin, a key component of tight junctions. 4. **Regulation of cell migration:** CLDN4 is involved in regulating cell migration by modulating the activity of metallopeptidases, such as matrix metalloproteinases (MMPs). 5. **Expression in various tissues:** CLDN4 is expressed in multiple epithelial tissues, including the retina, colon, thyroid, and mammary gland. **Pathways and Functions:** 1. **Apical plasma membrane:** CLDN4 is localized to the apical plasma membrane of epithelial cells, where it plays a crucial role in maintaining the integrity of the epithelial barrier. 2. **Bicellular tight junction:** CLDN4 forms heterophilic interactions with occludin and CLDN1 to regulate the assembly and function of bicellular tight junctions. 3. **Cell-cell communication:** CLDN4 facilitates cell-cell communication by modulating the activity of chloride channels and pumps, which are essential for maintaining the proper balance of ions across the epithelial barrier. 4. **Wound healing:** CLDN4 is involved in regulating wound healing by modulating the activity of metallopeptidases and promoting the migration of epithelial cells. 5. **Establishment of skin barrier:** CLDN4 plays a crucial role in establishing the skin barrier by regulating the assembly and function of tight junctions and maintaining the integrity of the epithelial barrier. **Clinical Significance:** Dysregulation of CLDN4 has been implicated in various diseases, including: 1. **Inflammatory bowel disease (IBD):** CLDN4 has been shown to be downregulated in patients with IBD, leading to impaired tight junction function and increased permeability of the epithelial barrier. 2. **Cancer:** CLDN4 has been shown to be downregulated in certain types of cancer, including colon cancer, leading to impaired cell-cell adhesion and increased metastasis. 3. **Neurological disorders:** CLDN4 has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease, where it plays a role in maintaining the integrity of the blood-brain barrier. In conclusion, CLDN4 is a critical component of tight junctions and cell-cell adhesion, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the functions of CLDN4 and its role in maintaining epithelial integrity.

Genular Protein ID: 3292795725

Symbol: CLD4_HUMAN

Name: Williams-Beuren syndrome chromosomal region 8 protein

UniProtKB Accession Codes:

O14493

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 EMDB 5 Ensembl 3 ExpressionAtlas 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 4 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9334247

Title: Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo.

PubMed ID: 9334247

DOI: 10.1074/jbc.272.42.26652

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16236711

Title: EphA2 phosphorylates the cytoplasmic tail of Claudin-4 and mediates paracellular permeability.

PubMed ID: 16236711

DOI: 10.1074/jbc.m503786200

PubMed ID: 20375010

Title: Claudin association with CD81 defines hepatitis C virus entry.

PubMed ID: 20375010

DOI: 10.1074/jbc.m110.104836

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24787463

Title: Claudin-18 deficiency results in alveolar barrier dysfunction and impaired alveologenesis in mice.

PubMed ID: 24787463

DOI: 10.1165/rcmb.2013-0456oc

PubMed ID: 35773259

Title: Tight junction channel regulation by interclaudin interference.

PubMed ID: 35773259

DOI: 10.1038/s41467-022-31587-8

PubMed ID: 36008380

Title: Nanoscale segregation of channel and barrier claudins enables paracellular ion flux.

PubMed ID: 36008380

DOI: 10.1038/s41467-022-32533-4

PubMed ID: 27647526

Title: Structural basis for disruption of claudin assembly in tight junctions by an enterotoxin.

PubMed ID: 27647526

DOI: 10.1038/srep33632

Sequence Information:

  • Length: 209
  • Mass: 22077
  • Checksum: 0659A93AA5F0E4C5
  • Sequence:
    • MASMGLQVMG IALAVLGWLA VMLCCALPMW RVTAFIGSNI VTSQTIWEGL WMNCVVQSTG 
QMQCKVYDSL LALPQDLQAA RALVIISIIV AALGVLLSVV GGKCTNCLED ESAKAKTMIV 
AGVVFLLAGL MVIVPVSWTA HNIIQDFYNP LVASGQKREM GASLYVGWAA SGLLLLGGGL 
LCCNCPPRTD KPYSAKYSAA RSAAASNYV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.