Details for: CLDN4

Gene ID: 1364

Symbol: CLDN4

Ensembl ID: ENSG00000189143

Description: claudin 4

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 6.9
    Marker Score: 6612
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 4.94
    Marker Score: 14660
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.79
    Marker Score: 11912
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.79
    Marker Score: 3383
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.72
    Marker Score: 2910
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 3.62
    Marker Score: 3466
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.46
    Marker Score: 2726
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 3.39
    Marker Score: 16287
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.29
    Marker Score: 12677
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 3.22
    Marker Score: 2192
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.19
    Marker Score: 16766
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.07
    Marker Score: 106319
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.86
    Marker Score: 6981.5
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.79
    Marker Score: 3365
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.77
    Marker Score: 1611
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.71
    Marker Score: 6431
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.7
    Marker Score: 3973
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.67
    Marker Score: 4122
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.65
    Marker Score: 942
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.61
    Marker Score: 22672.5
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.56
    Marker Score: 6465
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.56
    Marker Score: 1264
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.51
    Marker Score: 1676
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.46
    Marker Score: 5598
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.44
    Marker Score: 2567
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.41
    Marker Score: 18817
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.39
    Marker Score: 4236
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.35
    Marker Score: 15333
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 2.35
    Marker Score: 1291.5
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.33
    Marker Score: 9142
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.3
    Marker Score: 3658
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.3
    Marker Score: 2328
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.2
    Marker Score: 29525.5
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.18
    Marker Score: 690
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.18
    Marker Score: 3499
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.17
    Marker Score: 627
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.13
    Marker Score: 993
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 2.09
    Marker Score: 1115.5
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 2.09
    Marker Score: 3965
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.06
    Marker Score: 512
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.04
    Marker Score: 761
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.02
    Marker Score: 2011
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2
    Marker Score: 2076
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2
    Marker Score: 17205
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.99
    Marker Score: 14799
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 1.97
    Marker Score: 1019
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.96
    Marker Score: 474
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.96
    Marker Score: 384
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.95
    Marker Score: 2157
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.95
    Marker Score: 3227
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 1.93
    Marker Score: 559
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.93
    Marker Score: 666
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.91
    Marker Score: 2708
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.89
    Marker Score: 848
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 1.88
    Marker Score: 5396.5
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.84
    Marker Score: 692
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.76
    Marker Score: 904
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.75
    Marker Score: 354
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.74
    Marker Score: 408
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.54
    Marker Score: 4119
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.53
    Marker Score: 1791
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.41
    Marker Score: 1156
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.4
    Marker Score: 663
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.39
    Marker Score: 1474
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.36
    Marker Score: 1215.5
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.34
    Marker Score: 852
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.34
    Marker Score: 4765
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.34
    Marker Score: 2199
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.33
    Marker Score: 924
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.31
    Marker Score: 317
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.28
    Marker Score: 661
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 1.27
    Marker Score: 349
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.27
    Marker Score: 847
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.25
    Marker Score: 332
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 1.25
    Marker Score: 359
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 1.2
    Marker Score: 836
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.19
    Marker Score: 343
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.19
    Marker Score: 542
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.17
    Marker Score: 977
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.15
    Marker Score: 766
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.15
    Marker Score: 331
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.14
    Marker Score: 2374
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 1.12
    Marker Score: 631
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.12
    Marker Score: 7417
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.11
    Marker Score: 1199
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.11
    Marker Score: 1340
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 1.11
    Marker Score: 336
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.09
    Marker Score: 668.5
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 1.08
    Marker Score: 296
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 1.07
    Marker Score: 282
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.07
    Marker Score: 1951
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.06
    Marker Score: 11933
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251736.5
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.02
    Marker Score: 536
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.02
    Marker Score: 410
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1
    Marker Score: 218
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1
    Marker Score: 557
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 1
    Marker Score: 259.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71758
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 1
    Marker Score: 625

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Other Information

**Key characteristics:** - CLDN4 is a type of cadherin, a family of cell adhesion molecules that are expressed in various tissues. - It is a transmembrane protein with a molecular weight of approximately 140 kDa. - CLDN4 is found in both vertebrates and invertebrates. **Pathways and functions:** - CLDN4 is involved in cell-cell adhesion, cell junction organization, and cell migration. - It is crucial for the assembly of tight junctions between epithelial cells in tissues such as the skin, gut, and lungs. - It is also involved in cell signaling pathways, such as those involved in wound healing and pregnancy. - CLDN4 is also involved in regulating the permeability of cell membranes, which can affect the passage of ions and molecules. **Clinical significance:** - Mutations in CLDN4 have been linked to several human diseases, including skin diseases such as psoriasis and epidermolysis bullosa simplex, as well as cancer. - CLDN4 is a promising target for developing new therapeutic strategies for these diseases by blocking cell adhesion and preventing tissue damage. **Additional points:** - CLDN4 is a highly conserved protein, with similar sequences found in organisms ranging from humans to flies. - It is expressed in a wide range of cell types, including epithelial cells, endothelial cells, and immune cells. - CLDN4 is a highly dynamic protein, with its expression and function changing in response to various stimuli.

Genular Protein ID: 3292795725

Symbol: CLD4_HUMAN

Name: Claudin-4

UniProtKB Accession Codes:

O14493

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 3 EMDB 2 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 25 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 8 PDBsum 5 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9334247

Title: Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo.

PubMed ID: 9334247

DOI: 10.1074/jbc.272.42.26652

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16236711

Title: EphA2 phosphorylates the cytoplasmic tail of Claudin-4 and mediates paracellular permeability.

PubMed ID: 16236711

DOI: 10.1074/jbc.m503786200

PubMed ID: 20375010

Title: Claudin association with CD81 defines hepatitis C virus entry.

PubMed ID: 20375010

DOI: 10.1074/jbc.m110.104836

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24787463

Title: Claudin-18 deficiency results in alveolar barrier dysfunction and impaired alveologenesis in mice.

PubMed ID: 24787463

DOI: 10.1165/rcmb.2013-0456oc

PubMed ID: 27647526

Title: Structural basis for disruption of claudin assembly in tight junctions by an enterotoxin.

PubMed ID: 27647526

DOI: 10.1038/srep33632

Sequence Information:

  • Length: 209
  • Mass: 22077
  • Checksum: 0659A93AA5F0E4C5
  • Sequence:
    • MASMGLQVMG IALAVLGWLA VMLCCALPMW RVTAFIGSNI VTSQTIWEGL WMNCVVQSTG 
QMQCKVYDSL LALPQDLQAA RALVIISIIV AALGVLLSVV GGKCTNCLED ESAKAKTMIV 
AGVVFLLAGL MVIVPVSWTA HNIIQDFYNP LVASGQKREM GASLYVGWAA SGLLLLGGGL 
LCCNCPPRTD KPYSAKYSAA RSAAASNYV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.