Egf | ENSMUSG00000028017 | NCBI 13645

Details for: Egf

Gene ID: 13645

Symbol: Egf

Ensembl ID: ENSMUSG00000028017

Description: epidermal growth factor

Associated with

Cargo recognition for clathrin-mediated endocytosis
(R-MMU-8856825)
Clathrin-mediated endocytosis
(R-MMU-8856828)
Downregulation of erbb2 signaling
(R-MMU-8863795)
Egfr downregulation
(R-MMU-182971)
Egfr interacts with phospholipase c-gamma
(R-MMU-212718)
Erbb2 activates ptk6 signaling
(R-MMU-8847993)
Erbb2 regulates cell motility
(R-MMU-6785631)
Esr-mediated signaling
(R-MMU-8939211)
Extra-nuclear estrogen signaling
(R-MMU-9009391)
Gab1 signalosome
(R-MMU-180292)
Grb2 events in egfr signaling
(R-MMU-179812)
Hemostasis
(R-MMU-109582)
Intracellular signaling by second messengers
(R-MMU-9006925)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Membrane trafficking
(R-MMU-199991)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Notch3 activation and transmission of signal to the nucleus
(R-MMU-9013507)
Pi3k events in erbb2 signaling
(R-MMU-1963642)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-MMU-6811558)
Pip3 activates akt signaling
(R-MMU-1257604)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Platelet degranulation
(R-MMU-114608)
Raf/map kinase cascade
(R-MMU-5673001)
Response to elevated platelet cytosolic ca2+
(R-MMU-76005)
Shc1 events in egfr signaling
(R-MMU-180336)
Shc1 events in erbb2 signaling
(R-MMU-1250196)
Signaling by egfr
(R-MMU-177929)
Signaling by erbb2
(R-MMU-1227986)
Signaling by erbb4
(R-MMU-1236394)
Signaling by non-receptor tyrosine kinases
(R-MMU-9006927)
Signaling by notch
(R-MMU-157118)
Signaling by notch3
(R-MMU-9012852)
Signaling by nuclear receptors
(R-MMU-9006931)
Signaling by ptk6
(R-MMU-8848021)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signal transduction
(R-MMU-162582)
Vesicle-mediated transport
(R-MMU-5653656)
Angiogenesis
(GO:0001525)
Branching morphogenesis of an epithelial tube
(GO:0048754)
Calcium ion binding
(GO:0005509)
Cell population proliferation
(GO:0008283)
Cerebellar granule cell precursor proliferation
(GO:0021930)
Epidermal growth factor receptor binding
(GO:0005154)
Epidermal growth factor receptor signaling pathway
(GO:0007173)
Epithelial cell proliferation
(GO:0050673)
Erbb2-egfr signaling pathway
(GO:0038134)
Erk1 and erk2 cascade
(GO:0070371)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Growth factor activity
(GO:0008083)
Guanyl-nucleotide exchange factor activity
(GO:0005085)
Mammary gland alveolus development
(GO:0060749)
Negative regulation of cholesterol efflux
(GO:0090370)
Negative regulation of secretion
(GO:0051048)
Peptidyl-tyrosine phosphorylation
(GO:0018108)
Positive regulation of canonical wnt signaling pathway
(GO:0090263)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cerebellar granule cell precursor proliferation
(GO:0021940)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of dna binding
(GO:0043388)
Positive regulation of dna biosynthetic process
(GO:2000573)
Positive regulation of endothelial cell migration
(GO:0010595)
Positive regulation of endothelial cell proliferation
(GO:0001938)
Positive regulation of epithelial cell proliferation
(GO:0050679)
Positive regulation of epithelial tube formation
(GO:1905278)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of hyaluronan biosynthetic process
(GO:1900127)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of map kinase activity
(GO:0043406)
Positive regulation of mitotic nuclear division
(GO:0045840)
Positive regulation of peptidyl-threonine phosphorylation
(GO:0010800)
Positive regulation of peptidyl-tyrosine phosphorylation
(GO:0050731)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of phosphorylation
(GO:0042327)
Positive regulation of protein localization to early endosome
(GO:1902966)
Positive regulation of protein tyrosine kinase activity
(GO:0061098)
Positive regulation of receptor internalization
(GO:0002092)
Positive regulation of ubiquitin-dependent protein catabolic process
(GO:2000060)
Protein binding
(GO:0005515)
Receptor ligand activity
(GO:0048018)
Regulation of calcium ion import
(GO:0090279)
Regulation of peptidyl-tyrosine phosphorylation
(GO:0050730)
Regulation of protein localization to cell surface
(GO:2000008)
Regulation of protein transport
(GO:0051223)
Regulation of receptor signaling pathway via jak-stat
(GO:0046425)
Transmembrane receptor protein tyrosine kinase activator activity
(GO:0030297)

Other Information

Proteins

Genular Protein ID: 4075667850

Symbol: EGF_MOUSE

Name: Pro-epidermal growth factor

UniProtKB Accession Codes:

P01132 E9QNX6 Q569W5 Q6P9J2

Database IDs:

Citations:

PubMed ID: 6602382

Title: Structure of a mouse submaxillary messenger RNA encoding epidermal growth factor and seven related proteins.

PubMed ID: 6602382

DOI: 10.1126/science.6602382

PubMed ID: 6304537

Title: Nucleotide sequence of epidermal growth factor cDNA predicts a 128,000-molecular weight protein precursor.

PubMed ID: 6304537

DOI: 10.1038/303722a0

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 4636327

Title: The primary structure of epidermal growth factor.

PubMed ID: 4636327

DOI: 10.1016/s0021-9258(19)44569-9

PubMed ID: 4750422

Title: Epidermal growth factor. Location of disulfide bonds.

PubMed ID: 4750422

DOI: 10.1016/s0021-9258(19)43242-0

PubMed ID: 21439629

Title: Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling.

PubMed ID: 21439629

DOI: 10.1016/j.cell.2011.02.047

PubMed ID: 1731873

Title: Solution structure of murine epidermal growth factor determined by NMR spectroscopy and refined by energy minimization with restraints.

PubMed ID: 1731873

DOI: 10.1021/bi00116a033

PubMed ID: 1445923

Title: Three-dimensional nuclear magnetic resonance structures of mouse epidermal growth factor in acidic and physiological pH solutions.

PubMed ID: 1445923

DOI: 10.1021/bi00162a036

PubMed ID: 10082370

Title: Role of the 6-20 disulfide bridge in the structure and activity of epidermal growth factor.

PubMed ID: 10082370

DOI: 10.1002/pro.5560070808

Sequence Information:

Length: 1217
Mass: 133072
Checksum: 28F35C928280D31B
Sequence:

MPWGRRPTWL LLAFLLVFLK ISILSVTAWQ TGNCQPGPLE RSERSGTCAG PAPFLVFSQG 
KSISRIDPDG TNHQQLVVDA GISADMDIHY KKERLYWVDV ERQVLLRVFL NGTGLEKVCN 
VERKVSGLAI DWIDDEVLWV DQQNGVITVT DMTGKNSRVL LSSLKHPSNI AVDPIERLMF 
WSSEVTGSLH RAHLKGVDVK TLLETGGISV LTLDVLDKRL FWVQDSGEGS HAYIHSCDYE 
GGSVRLIRHQ ARHSLSSMAF FGDRIFYSVL KSKAIWIANK HTGKDTVRIN LHPSFVTPGK 
LMVVHPRAQP RTEDAAKDPD PELLKQRGRP CRFGLCERDP KSHSSACAEG YTLSRDRKYC 
EDVNECATQN HGCTLGCENT PGSYHCTCPT GFVLLPDGKQ CHELVSCPGN VSKCSHGCVL 
TSDGPRCICP AGSVLGRDGK TCTGCSSPDN GGCSQICLPL RPGSWECDCF PGYDLQSDRK 
SCAASGPQPL LLFANSQDIR HMHFDGTDYK VLLSRQMGMV FALDYDPVES KIYFAQTALK 
WIERANMDGS QRERLITEGV DTLEGLALDW IGRRIYWTDS GKSVVGGSDL SGKHHRIIIQ 
ERISRPRGIA VHPRARRLFW TDVGMSPRIE SASLQGSDRV LIASSNLLEP SGITIDYLTD 
TLYWCDTKRS VIEMANLDGS KRRRLIQNDV GHPFSLAVFE DHLWVSDWAI PSVIRVNKRT 
GQNRVRLQGS MLKPSSLVVV HPLAKPGADP CLYRNGGCEH ICQESLGTAR CLCREGFVKA 
WDGKMCLPQD YPILSGENAD LSKEVTSLSN STQAEVPDDD GTESSTLVAE IMVSGMNYED 
DCGPGGCGSH ARCVSDGETA ECQCLKGFAR DGNLCSDIDE CVLARSDCPS TSSRCINTEG 
GYVCRCSEGY EGDGISCFDI DECQRGAHNC GENAACTNTE GGYNCTCAGR PSSPGLSCPD 
STAPSLLGED GHHLDRNSYP GCPSSYDGYC LNGGVCMHIE SLDSYTCNCV IGYSGDRCQT 
RDLRWWELRH AGYGQKHDIM VVAVCMVALV LLLVLGMWGT YYYRTRKQLS NPPKNPCDEP 
SGSVSSSGPN SSSGAAVASC PQPWFVVLEK HQDPKNGSLP ADGTNGAVVD AGLSPSLQLG 
SVHLTSWRQK PHIDGMGTGQ SCWIPPSSDR GPQEIEGNSH LPSYRPVGPE KLHSLQSANG 
SCHERAPDLP RQTEPVQ

Genular Protein ID: 966006306

Symbol: Q3UWD7_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UWD7

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 716
Mass: 77941
Checksum: CC1CA29F49966D98
Sequence:

MHFDGTDYKV LLSRQMGMVF ALDYDPVESK IYFAQTALKW IERANMDGSQ RERLITEGVD 
TLEGLALDWI GRRIYWTDSG KSVVGGSDLS GKHHRIIIQE RISRPRGIAV HPRARRLFWT 
DVGMSPRIES ASLQGSDRVL IASSSLLEPS GITIDYLTDT LYWCDTKRSV IEMANLDGSK 
RRRLIQNDVG HPFSLAVFED HLWVSDWAIP SVIRVNKRTG QNRVRLQGSM LKPSSLVVVH 
PLAKPGADPC LYRNGGCEHI CQESLGTARC LCREGFVKAW DGKMCLPQDY PILSGENADL 
SKEVTSLSNS TQAEVPDDDG TESSTLVAEI MVSGMNYEDD CGPGGCGSHA RCVSDGETAE 
CQCLKGFARD GNLCSDIDEC VLARSDCPST SSRCINTEGG YVCRCSEGYE GDGISCFDID 
ECQRGAHNCG ENAACTNTEG GYNCTCAGRP SSPGLSCPDS TAPSLLGEDG HHLDRNSYPG 
CPSSYDGYCL NGGVCMHIES LDSYTCNCVI GYSGDRCQTR DLRWWELRHA GYGQKHDIMV 
VAVCMVALVL LLVLGMWGTY YYRTRKQLSN PPKNPCDEPS GSVSSSGPNS SSGAAVASCP 
QPWFVVLEKH QDPKNGSLPA DGTNGAVVDA GLSPSLQLGS VHLTSWRQKP HIDGMGTGQS 
CWIPPSSDRG PQEIEGNSHL PSYRPVGPEK LHSLQSANGS CHERAPDLPR QTEPVQ

Genular Protein ID: 1976592511

Symbol: A0A0G2JDT8_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A0G2JDT8

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 675
Mass: 73826
Checksum: 4DDBD0FA14D3CB95
Sequence:

MHFDGTDYKV LLSRQMGMVF ALDYDPVESK IYFAQTALKW IERANMDGSQ RERLITEGVD 
TLEGLALDWI GRRIYWTDSG KSVVGGSDLS GKHHRIIIQE RISRPRGIAV HPRARRLFWT 
DVGMSPRIES ASLQGSDRVL IASSNLLEPS GITIDYLTDT LYWCDTKRSV IEMANLDGSK 
RRRLIQNDVG HPFSLAVFED HLWVSDWAIP SVIRVNKRTG QNRVRLQGSM LKPSSLVVVH 
PLAKPGADPC LYRNGGCEHI CQESLGTARC LCREGFVKAW DGKMCLPQDY PILSGENADL 
SKEVTSLSNS TQAEVPDDDG TESSTLVAEI MVSGMNYEDD CGPGGCGSHA RCVSDGETAE 
CQCLKGFARD GNLCSDIDEC VLARSDCPST SSRCINTEGG YVCRCSEGYE GDGISCFDST 
APSLLGEDGH HLDRNSYPGC PSSYDGYCLN GGVCMHIESL DSYTCNCVIG YSGDRCQTRD 
LRWWELRHAG YGQKHDIMVV AVCMVALVLL LVLGMWGTYY YRTRKQLSNP PKNPCDEPSG 
SVSSSGPNSS SGAAVASCPQ PWFVVLEKHQ DPKNGSLPAD GTNGAVVDAG LSPSLQLGSV 
HLTSWRQKPH IDGMGTGQSC WIPPSSDRGP QEIEGNSHLP SYRPVGPEKL HSLQSANGSC 
HERAPDLPRQ TEPVQ

Genular Protein ID: 2285581137

Symbol: A0A0G2JF92_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A0G2JF92

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 716
Mass: 77968
Checksum: C92F529AB7909566
Sequence:

MHFDGTDYKV LLSRQMGMVF ALDYDPVESK IYFAQTALKW IERANMDGSQ RERLITEGVD 
TLEGLALDWI GRRIYWTDSG KSVVGGSDLS GKHHRIIIQE RISRPRGIAV HPRARRLFWT 
DVGMSPRIES ASLQGSDRVL IASSNLLEPS GITIDYLTDT LYWCDTKRSV IEMANLDGSK 
RRRLIQNDVG HPFSLAVFED HLWVSDWAIP SVIRVNKRTG QNRVRLQGSM LKPSSLVVVH 
PLAKPGADPC LYRNGGCEHI CQESLGTARC LCREGFVKAW DGKMCLPQDY PILSGENADL 
SKEVTSLSNS TQAEVPDDDG TESSTLVAEI MVSGMNYEDD CGPGGCGSHA RCVSDGETAE 
CQCLKGFARD GNLCSDIDEC VLARSDCPST SSRCINTEGG YVCRCSEGYE GDGISCFDID 
ECQRGAHNCG ENAACTNTEG GYNCTCAGRP SSPGLSCPDS TAPSLLGEDG HHLDRNSYPG 
CPSSYDGYCL NGGVCMHIES LDSYTCNCVI GYSGDRCQTR DLRWWELRHA GYGQKHDIMV 
VAVCMVALVL LLVLGMWGTY YYRTRKQLSN PPKNPCDEPS GSVSSSGPNS SSGAAVASCP 
QPWFVVLEKH QDPKNGSLPA DGTNGAVVDA GLSPSLQLGS VHLTSWRQKP HIDGMGTGQS 
CWIPPSSDRG PQEIEGNSHL PSYRPVGPEK LHSLQSANGS CHERAPDLPR QTEPVQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Egf

Associated with

Other Information

Structure of a mouse submaxillary messenger RNA encoding epidermal growth factor and seven related proteins. PubMed ID: 6602382

Nucleotide sequence of epidermal growth factor cDNA predicts a 128,000-molecular weight protein precursor. PubMed ID: 6304537

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The primary structure of epidermal growth factor. PubMed ID: 4636327

Epidermal growth factor. Location of disulfide bonds. PubMed ID: 4750422

Rhomboid family pseudoproteases use the ER quality control machinery to regulate intercellular signaling. PubMed ID: 21439629

Solution structure of murine epidermal growth factor determined by NMR spectroscopy and refined by energy minimization with restraints. PubMed ID: 1731873

Three-dimensional nuclear magnetic resonance structures of mouse epidermal growth factor in acidic and physiological pH solutions. PubMed ID: 1445923

Role of the 6-20 disulfide bridge in the structure and activity of epidermal growth factor. PubMed ID: 10082370

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Database document:

PubMed ID: 6602382

PubMed ID: 6304537

PubMed ID: 19468303

PubMed ID: 15489334

PubMed ID: 4636327

PubMed ID: 4750422

PubMed ID: 21439629

PubMed ID: 1731873

PubMed ID: 1445923

PubMed ID: 10082370

PubMed ID: 10349636

PubMed ID: 11042159

PubMed ID: 11076861

PubMed ID: 11217851

PubMed ID: 12466851

PubMed ID: 16141073

PubMed ID: 19468303

PubMed ID: 19468303