Details for: CLDN3

Gene ID: 1365

Symbol: CLDN3

Ensembl ID: ENSG00000165215

Description: claudin 3

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.9
    Marker Score: 12241
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 3.63
    Marker Score: 3558
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 3.45
    Marker Score: 3311
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.34
    Marker Score: 115680
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 3.16
    Marker Score: 15188
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.72
    Marker Score: 4190
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.72
    Marker Score: 6195
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.52
    Marker Score: 5996
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.44
    Marker Score: 21218
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 2.44
    Marker Score: 704
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.43
    Marker Score: 3864
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.18
    Marker Score: 1457
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.17
    Marker Score: 11414
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.17
    Marker Score: 4578
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.16
    Marker Score: 1259
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 2.11
    Marker Score: 1162
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2.04
    Marker Score: 2122
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.03
    Marker Score: 27337
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.02
    Marker Score: 2012
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2
    Marker Score: 3547
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.96
    Marker Score: 7565
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.92
    Marker Score: 3645
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.89
    Marker Score: 971
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.86
    Marker Score: 701
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.83
    Marker Score: 430
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.82
    Marker Score: 357
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.81
    Marker Score: 644
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.78
    Marker Score: 565
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.77
    Marker Score: 828
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.68
    Marker Score: 1326
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.66
    Marker Score: 4174
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.5
    Marker Score: 3126
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.5
    Marker Score: 432
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.47
    Marker Score: 547
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.46
    Marker Score: 5189
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.45
    Marker Score: 352
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.43
    Marker Score: 705
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 1.38
    Marker Score: 598
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.37
    Marker Score: 340
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.36
    Marker Score: 3656
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.35
    Marker Score: 859
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 1.25
    Marker Score: 358
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.24
    Marker Score: 8066
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.23
    Marker Score: 423
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.22
    Marker Score: 1727
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.2
    Marker Score: 317
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.18
    Marker Score: 340
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.16
    Marker Score: 1228
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.15
    Marker Score: 548
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.13
    Marker Score: 7485
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.12
    Marker Score: 1654
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.11
    Marker Score: 1126
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 1.09
    Marker Score: 434
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.08
    Marker Score: 4246
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.06
    Marker Score: 829
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.05
    Marker Score: 545
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.04
    Marker Score: 926
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251767
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.01
    Marker Score: 463
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 1.01
    Marker Score: 703
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1
    Marker Score: 1665
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71784
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48010
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1
    Marker Score: 1600
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.99
    Marker Score: 1051
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.99
    Marker Score: 717
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30405
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.97
    Marker Score: 503
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 457
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.97
    Marker Score: 210
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5348
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.93
    Marker Score: 1531.5
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.92
    Marker Score: 371
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.91
    Marker Score: 1475
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.89
    Marker Score: 1075
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.89
    Marker Score: 3068
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.86
    Marker Score: 234
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.85
    Marker Score: 381
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.84
    Marker Score: 9501
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.83
    Marker Score: 216
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.82
    Marker Score: 626
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.81
    Marker Score: 852
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.81
    Marker Score: 182
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.8
    Marker Score: 204
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.8
    Marker Score: 1358
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.8
    Marker Score: 242
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.78
    Marker Score: 12589
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.78
    Marker Score: 158
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.78
    Marker Score: 478
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.78
    Marker Score: 907
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.75
    Marker Score: 3132
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.74
    Marker Score: 674
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.74
    Marker Score: 471
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 292

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - CLDN3 is a transmembrane protein with a molecular weight of approximately 140 kDa. - It belongs to the immunoglobulin superfamily and is expressed in a variety of cell types. - It is a key component of tight junctions, which are specialized structures that hold cells together and maintain tissue integrity. - CLDN3 is also involved in cell signaling, cell migration, and cell adhesion. **Pathways and functions:** - CLDN3 is involved in the organization of the actin cytoskeleton, which is essential for cell adhesion, migration, and signaling. - It interacts with other cell adhesion molecules, such as cadherins and integrins, to form cell-cell adhesion complexes. - CLDN3 also regulates cell migration by promoting cell adhesion to extracellular matrix proteins and guiding cell movement. - It is involved in cell junction formation, where it helps to strengthen and maintain tissue integrity. - CLDN3 is also involved in epithelial cell morphogenesis, where it is expressed in epithelial cells and is essential for the formation of tight junctions and the maintenance of epithelial structure. **Clinical significance:** - Mutations in CLDN3 have been linked to a number of human diseases, including colorectal cancer, lung cancer, and cardiovascular disease. - Targeting CLDN3 has been shown to be a promising therapeutic strategy for these diseases, as it can inhibit cell migration and tumor growth. **Other important points:** - CLDN3 is a highly conserved protein, with similar sequences found in other species. - It is a member of the cadherin family of cell adhesion molecules. - It is a key regulator of cell migration and cell adhesion.

Genular Protein ID: 313265972

Symbol: CLD3_HUMAN

Name: Claudin-3

UniProtKB Accession Codes:

O15551

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 3 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 37 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9441748

Title: Analysis of a human gene homologous to rat ventral prostate.1 protein.

PubMed ID: 9441748

DOI: 10.1006/geno.1997.5033

PubMed ID: 9334247

Title: Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo.

PubMed ID: 9334247

DOI: 10.1074/jbc.272.42.26652

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 220
  • Mass: 23319
  • Checksum: 1C826EFFF1563C56
  • Sequence:
    • MSMGLEITGT ALAVLGWLGT IVCCALPMWR VSAFIGSNII TSQNIWEGLW MNCVVQSTGQ 
MQCKVYDSLL ALPQDLQAAR ALIVVAILLA AFGLLVALVG AQCTNCVQDD TAKAKITIVA 
GVLFLLAALL TLVPVSWSAN TIIRDFYNPV VPEAQKREMG AGLYVGWAAA ALQLLGGALL 
CCSCPPREKK YTATKVVYSA PRSTGPGASL GTGYDRKDYV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.