Details for: CLDN3

Gene ID: 1365

Symbol: CLDN3

Ensembl ID: ENSG00000165215

Description: claudin 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 196.7273
    Cell Significance Index: -30.6000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 64.8878
    Cell Significance Index: -30.6400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 44.5589
    Cell Significance Index: -29.9000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 29.9976
    Cell Significance Index: -28.6400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 24.8184
    Cell Significance Index: -30.6000
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 21.9003
    Cell Significance Index: 166.0700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 14.1504
    Cell Significance Index: 641.3900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.2295
    Cell Significance Index: -35.4400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 8.9965
    Cell Significance Index: 71.8300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 7.7749
    Cell Significance Index: -30.6800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 7.4020
    Cell Significance Index: 213.2700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 6.7648
    Cell Significance Index: 156.2900
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 5.4500
    Cell Significance Index: 30.3400
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 5.0827
    Cell Significance Index: 31.2800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 4.9890
    Cell Significance Index: 2724.6300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 4.8675
    Cell Significance Index: 72.9400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.3962
    Cell Significance Index: 204.9700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.7955
    Cell Significance Index: 490.3600
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 3.3176
    Cell Significance Index: 69.1900
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 3.1095
    Cell Significance Index: 33.7000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.1417
    Cell Significance Index: 159.6200
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.9408
    Cell Significance Index: 11.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.8583
    Cell Significance Index: 87.3400
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1.7491
    Cell Significance Index: 17.6500
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 1.6911
    Cell Significance Index: 1.2100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.6162
    Cell Significance Index: 188.3500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 1.4705
    Cell Significance Index: 51.6700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.4250
    Cell Significance Index: 45.6400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2013
    Cell Significance Index: 118.8400
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.1558
    Cell Significance Index: 19.4400
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.1053
    Cell Significance Index: 10.9500
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.1050
    Cell Significance Index: 14.2300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.0480
    Cell Significance Index: 22.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9544
    Cell Significance Index: 49.5800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.9490
    Cell Significance Index: 856.9200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.8390
    Cell Significance Index: 12.9800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7939
    Cell Significance Index: 151.0900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6987
    Cell Significance Index: 113.6400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6923
    Cell Significance Index: 95.0700
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.6108
    Cell Significance Index: 4.8600
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.5762
    Cell Significance Index: 2.1700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5093
    Cell Significance Index: 4.6900
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.3324
    Cell Significance Index: 3.4400
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.2899
    Cell Significance Index: 2.0400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2308
    Cell Significance Index: 8.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1123
    Cell Significance Index: 20.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1066
    Cell Significance Index: 18.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0977
    Cell Significance Index: 2.6600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0557
    Cell Significance Index: 6.8500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0252
    Cell Significance Index: 18.5100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0227
    Cell Significance Index: 17.1900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0007
    Cell Significance Index: 0.1300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0029
    Cell Significance Index: -0.0300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0058
    Cell Significance Index: -0.2900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0133
    Cell Significance Index: -0.3700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0150
    Cell Significance Index: -28.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0158
    Cell Significance Index: -1.8100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0200
    Cell Significance Index: -0.5000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0208
    Cell Significance Index: -38.2900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0246
    Cell Significance Index: -37.8600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0277
    Cell Significance Index: -0.6000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0282
    Cell Significance Index: -38.3600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0371
    Cell Significance Index: -27.4900
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.0435
    Cell Significance Index: -0.2700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0473
    Cell Significance Index: -26.6800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0479
    Cell Significance Index: -30.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0513
    Cell Significance Index: -1.3700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0569
    Cell Significance Index: -35.5600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0630
    Cell Significance Index: -6.4400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0665
    Cell Significance Index: -29.4200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0707
    Cell Significance Index: -0.8000
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0721
    Cell Significance Index: -1.0000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0815
    Cell Significance Index: -37.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0822
    Cell Significance Index: -29.4900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1236
    Cell Significance Index: -35.5600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1609
    Cell Significance Index: -33.8900
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: -0.1695
    Cell Significance Index: -0.3800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1732
    Cell Significance Index: -34.7400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1969
    Cell Significance Index: -5.8000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2169
    Cell Significance Index: -31.5300
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2318
    Cell Significance Index: -2.4500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2642
    Cell Significance Index: -33.8700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2760
    Cell Significance Index: -5.7300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3207
    Cell Significance Index: -37.8200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3421
    Cell Significance Index: -20.9800
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.3671
    Cell Significance Index: -3.1200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4117
    Cell Significance Index: -29.1200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4222
    Cell Significance Index: -33.4400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4346
    Cell Significance Index: -27.3900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.4526
    Cell Significance Index: -30.4300
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.4596
    Cell Significance Index: -3.3400
  • Cell Name: Merkel cell (CL0000242)
    Fold Change: -0.4648
    Cell Significance Index: -0.2800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.4656
    Cell Significance Index: -30.0400
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: -0.5385
    Cell Significance Index: -5.7200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.5550
    Cell Significance Index: -28.9100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.5585
    Cell Significance Index: -7.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6210
    Cell Significance Index: -34.8500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6404
    Cell Significance Index: -16.8400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6893
    Cell Significance Index: -42.3700
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: -0.7274
    Cell Significance Index: -4.2700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** CLDN3 is a transmembrane protein composed of four extracellular loops (ECLs) and three intracellular loops (ICLs). Its structure allows it to interact with other tight junction proteins, such as occludin and junctional adhesion molecule (JAM), to form a stable complex. 2. **Expression:** CLDN3 is widely expressed in various epithelial tissues, including colon, pancreas, intestine, and salivary gland. Its expression is also found in stem cells, ciliated columnar cells of the tracheobronchial tree, and enterocytes. 3. **Function:** CLDN3 regulates cell-cell adhesion by interacting with occludin and JAM, promoting the formation of tight junctions. It also modulates cell migration, proliferation, and differentiation by regulating the activity of various signaling pathways. 4. **Regulation:** CLDN3 is regulated by several mechanisms, including phosphorylation, ubiquitination, and interaction with other proteins. Its expression is also influenced by environmental factors, such as ethanol and hypoxia. **Pathways and Functions:** 1. **Apical Junction Complex:** CLDN3 forms a complex with occludin and JAM to regulate cell-cell adhesion and barrier function. 2. **Bicellular Tight Junction:** CLDN3 interacts with occludin and JAM to form a stable complex, promoting the formation of tight junctions. 3. **Cell Adhesion:** CLDN3 regulates cell-cell adhesion by interacting with occludin and JAM, promoting the formation of tight junctions. 4. **Cell Migration:** CLDN3 modulates cell migration by regulating the activity of signaling pathways, such as the PI3K/Akt and MAPK/ERK pathways. 5. **Gene Expression:** CLDN3 regulates gene expression by interacting with transcription factors, such as NF-κB and AP-1. 6. **Wound Healing:** CLDN3 regulates wound healing by modulating the activity of signaling pathways, such as the PI3K/Akt and MAPK/ERK pathways. **Clinical Significance:** 1. **Cancer:** CLDN3 is overexpressed in various types of cancer, including colon, pancreatic, and breast cancer. Its overexpression is associated with poor prognosis and increased tumor aggressiveness. 2. **Inflammatory Disorders:** CLDN3 is dysregulated in inflammatory disorders, such as inflammatory bowel disease (IBD) and rheumatoid arthritis. Its dysregulation contributes to the breakdown of epithelial barriers and the development of inflammation. 3. **Neurological Conditions:** CLDN3 is implicated in various neurological conditions, including multiple sclerosis and Alzheimer's disease. Its dysregulation contributes to the breakdown of blood-brain barriers and the development of neurological symptoms. 4. **Blood-Brain Barrier:** CLDN3 plays a critical role in maintaining the integrity of the blood-brain barrier, regulating the exchange of ions, metabolites, and signaling molecules between the bloodstream and the brain. In conclusion, CLDN3 is a critical component of tight junctions and epithelial barrier function, regulating cell-cell adhesion, cell migration, and gene expression. Its dysregulation has been implicated in various diseases, including cancer, inflammatory disorders, and neurological conditions. Further research is needed to fully understand the mechanisms of CLDN3 regulation and its role in maintaining epithelial barrier function.

Genular Protein ID: 313265972

Symbol: CLD3_HUMAN

Name: Claudin-3

UniProtKB Accession Codes:

O15551

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 DIP 1 DNASU 1 DisGeNET 1 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 37 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9441748

Title: Analysis of a human gene homologous to rat ventral prostate.1 protein.

PubMed ID: 9441748

DOI: 10.1006/geno.1997.5033

PubMed ID: 9334247

Title: Clostridium perfringens enterotoxin utilizes two structurally related membrane proteins as functional receptors in vivo.

PubMed ID: 9334247

DOI: 10.1074/jbc.272.42.26652

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28028216

Title: Mosaic expression of claudins in thick ascending limbs of Henle results in spatial separation of paracellular Na+ and Mg2+ transport.

PubMed ID: 28028216

DOI: 10.1073/pnas.1611684114

PubMed ID: 36008380

Title: Nanoscale segregation of channel and barrier claudins enables paracellular ion flux.

PubMed ID: 36008380

DOI: 10.1038/s41467-022-32533-4

Sequence Information:

  • Length: 220
  • Mass: 23319
  • Checksum: 1C826EFFF1563C56
  • Sequence:
    • MSMGLEITGT ALAVLGWLGT IVCCALPMWR VSAFIGSNII TSQNIWEGLW MNCVVQSTGQ 
MQCKVYDSLL ALPQDLQAAR ALIVVAILLA AFGLLVALVG AQCTNCVQDD TAKAKITIVA 
GVLFLLAALL TLVPVSWSAN TIIRDFYNPV VPEAQKREMG AGLYVGWAAA ALQLLGGALL 
CCSCPPREKK YTATKVVYSA PRSTGPGASL GTGYDRKDYV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.