Details for: Egr1

Gene ID: 13653

Symbol: Egr1

Ensembl ID: ENSMUSG00000038418

Description: early growth response 1

Associated with

  • Bmp signaling pathway
    (GO:0030509)
  • Cellular response to gamma radiation
    (GO:0071480)
  • Cellular response to heparin
    (GO:0071504)
  • Cellular response to interleukin-8
    (GO:0098759)
  • Cellular response to mycophenolic acid
    (GO:0071506)
  • Cellular response to organic substance
    (GO:0071310)
  • Chromatin
    (GO:0000785)
  • Circadian regulation of gene expression
    (GO:0032922)
  • Circadian temperature homeostasis
    (GO:0060086)
  • Cytoplasm
    (GO:0005737)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Double-stranded dna binding
    (GO:0003690)
  • Double-stranded methylated dna binding
    (GO:0010385)
  • Estrous cycle
    (GO:0044849)
  • Glomerular mesangial cell proliferation
    (GO:0072110)
  • Hemi-methylated dna-binding
    (GO:0044729)
  • Histone acetyltransferase binding
    (GO:0035035)
  • Interleukin-1-mediated signaling pathway
    (GO:0070498)
  • Learning or memory
    (GO:0007611)
  • Locomotor rhythm
    (GO:0045475)
  • Long-term memory
    (GO:0007616)
  • Metal ion binding
    (GO:0046872)
  • Negative regulation of canonical wnt signaling pathway
    (GO:0090090)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of chemokine production
    (GO:0032722)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of glomerular metanephric mesangial cell proliferation
    (GO:0072303)
  • Positive regulation of hormone biosynthetic process
    (GO:0046886)
  • Positive regulation of interleukin-1 beta production
    (GO:0032731)
  • Positive regulation of mirna transcription
    (GO:1902895)
  • Positive regulation of neuron apoptotic process
    (GO:0043525)
  • Positive regulation of post-translational protein modification
    (GO:1901875)
  • Positive regulation of smooth muscle cell migration
    (GO:0014911)
  • Positive regulation of smooth muscle cell proliferation
    (GO:0048661)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Promoter-specific chromatin binding
    (GO:1990841)
  • Regulation of apoptotic process
    (GO:0042981)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of long-term neuronal synaptic plasticity
    (GO:0048169)
  • Regulation of neuron apoptotic process
    (GO:0043523)
  • Regulation of progesterone biosynthetic process
    (GO:2000182)
  • Regulation of protein sumoylation
    (GO:0033233)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Response to glucose
    (GO:0009749)
  • Response to hypoxia
    (GO:0001666)
  • Response to insulin
    (GO:0032868)
  • Response to ischemia
    (GO:0002931)
  • Rhythmic process
    (GO:0048511)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii core promoter sequence-specific dna binding
    (GO:0000979)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Skeletal muscle cell differentiation
    (GO:0035914)
  • T cell differentiation
    (GO:0030217)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Zinc ion binding
    (GO:0008270)

Other Information

Genular Protein ID: 931806925

Symbol: EGR1_MOUSE

Name: Early growth response protein 1

UniProtKB Accession Codes:

P08046 Q61777

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 5 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 62 Gene3D 1 GeneTree 1 Genevisible 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 21 PDBsum 16 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 3 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 3127059

Title: A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization.

PubMed ID: 3127059

DOI: 10.1016/0092-8674(88)90485-0

PubMed ID: 3141919

Title: A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with 'zinc finger' sequences.

PubMed ID: 3141919

DOI: 10.1073/pnas.85.21.7857

PubMed ID: 2511075

Title: Structure, chromosome mapping and regulation of the mouse zinc-finger gene Krox-24; evidence for a common regulatory pathway for immediate-early serum-response genes.

PubMed ID: 2511075

DOI: 10.1016/0378-1119(89)90296-5

PubMed ID: 3133658

Title: Two mouse genes encoding potential transcription factors with identical DNA-binding domains are activated by growth factors in cultured cells.

PubMed ID: 3133658

DOI: 10.1073/pnas.85.13.4691

PubMed ID: 1740423

Title: In vivo mutational analysis of the NGFI-A zinc fingers.

PubMed ID: 1740423

DOI: 10.1016/s0021-9258(19)50584-1

PubMed ID: 8336701

Title: A novel repression module, an extensive activation domain, and a bipartite nuclear localization signal defined in the immediate-early transcription factor Egr-1.

PubMed ID: 8336701

DOI: 10.1128/mcb.13.8.4556-4571.1993

PubMed ID: 8703054

Title: Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1).

PubMed ID: 8703054

DOI: 10.1126/science.273.5279.1219

PubMed ID: 11100120

Title: Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress.

PubMed ID: 11100120

DOI: 10.1038/82168

PubMed ID: 15265859

Title: Delayed hepatocellular mitotic progression and impaired liver regeneration in early growth response-1-deficient mice.

PubMed ID: 15265859

DOI: 10.1074/jbc.m407969200

PubMed ID: 15958557

Title: Early growth response 1 acts as a tumor suppressor in vivo and in vitro via regulation of p53.

PubMed ID: 15958557

DOI: 10.1158/0008-5472.can-04-3742

PubMed ID: 26471974

Title: EGR1 regulates hepatic clock gene amplitude by activating Per1 transcription.

PubMed ID: 26471974

DOI: 10.1038/srep15212

PubMed ID: 29138967

Title: Mice lacking EGR1 have impaired clock gene (BMAL1) oscillation, locomotor activity, and body temperature.

PubMed ID: 29138967

DOI: 10.1007/s12031-017-0996-8

PubMed ID: 2028256

Title: Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 A.

PubMed ID: 2028256

DOI: 10.1126/science.2028256

PubMed ID: 8939742

Title: Zif268 protein-DNA complex refined at 1.6 A: a model system for understanding zinc finger-DNA interactions.

PubMed ID: 8939742

DOI: 10.1016/s0969-2126(96)00125-6

Sequence Information:

  • Length: 533
  • Mass: 56590
  • Checksum: 36E3935767CEAA0F
  • Sequence:
    • MAAAKAEMQL MSPLQISDPF GSFPHSPTMD NYPKLEEMML LSNGAPQFLG AAGTPEGSGG 
NSSSSTSSGG GGGGGSNSGS SAFNPQGEPS EQPYEHLTTE SFSDIALNNE KAMVETSYPS 
QTTRLPPITY TGRFSLEPAP NSGNTLWPEP LFSLVSGLVS MTNPPTSSSS APSPAASSSS 
SASQSPPLSC AVPSNDSSPI YSAAPTFPTP NTDIFPEPQS QAFPGSAGTA LQYPPPAYPA 
TKGGFQVPMI PDYLFPQQQG DLSLGTPDQK PFQGLENRTQ QPSLTPLSTI KAFATQSGSQ 
DLKALNTTYQ SQLIKPSRMR KYPNRPSKTP PHERPYACPV ESCDRRFSRS DELTRHIRIH 
TGQKPFQCRI CMRNFSRSDH LTTHIRTHTG EKPFACDICG RKFARSDERK RHTKIHLRQK 
DKKADKSVVA SPAASSLSSY PSPVATSYPS PATTSFPSPV PTSYSSPGSS TYPSPAHSGF 
PSPSVATTFA SVPPAFPTQV SSFPSAGVSS SFSTSTGLSD MTATFSPRTI EIC

Genular Protein ID: 456778699

Symbol: Q8CAT6_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8CAT6

Database IDs:

AGR 1 ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 EPD 1 GO 4 Gene3D 1 Genevisible 1 InterPro 4 KEGG 1 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 Pfam 3 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 533
  • Mass: 56571
  • Checksum: A10386B89DC15FE0
  • Sequence:
    • MAAAKAEMQL MSPLQISDPF GSFPHSPTMD NYPKLEEMML LSNGAPQFLG AAGTPEGSGG 
NSSSSTSSGG GGGGGSNSGS SAFNPQGEPS EQPYEHLTTE SFSDIALNNE KAMVETSYPS 
QTTRLPPITY TGRFSLEPAP NSGNTLWPEP LFSLVSGLVS MTNPPTSSSS APSPAASSSS 
SASQSPPLSC AVPSNDSSPI YSAAPTFPTP NTDIFPEPQS QAFPGSAGTA LQYPPPAYPA 
TKGGFQVPMI PDYLFPQQQG DLSLGTPDQK PFQGLENRTQ QPSLTPLSTI KAFATQSGSQ 
DLKALNTTYQ SQLIKPSRMR KYPNRPSKTP PHERPYACPV ESCDRHFSRS DELTRHIRIH 
TGQKPFQCRI CMRNFSRSDH LTTHIRTHTG EKPFACDICG RKFARSDERK RHTKIHLRQK 
DKKADKSVVA SPAASSLSSY PSPVATSYPS PATTSFPSPV PTSYSSPGSS TYPSPAHSGF 
PSPSVATTFA SVPPAFPTQV SSFPSAGVSS SFSTSTGLSD MTATFSPRTI EIC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.