Details for: CLDN7

Gene ID: 1366

Symbol: CLDN7

Ensembl ID: ENSG00000181885

Description: claudin 7

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 221.9933
    Cell Significance Index: -34.5300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 137.0428
    Cell Significance Index: -34.7600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 75.1431
    Cell Significance Index: -30.9600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 69.1926
    Cell Significance Index: -28.1100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 53.3365
    Cell Significance Index: -35.7900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 29.3273
    Cell Significance Index: -28.0000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 28.1194
    Cell Significance Index: -34.6700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 12.9610
    Cell Significance Index: 323.2100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 12.1208
    Cell Significance Index: -32.4700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 7.8182
    Cell Significance Index: 48.1200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 6.3519
    Cell Significance Index: 287.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 5.7951
    Cell Significance Index: 301.0400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 5.5168
    Cell Significance Index: 75.2700
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: 4.9386
    Cell Significance Index: 18.9100
  • Cell Name: peg cell (CL4033014)
    Fold Change: 4.8878
    Cell Significance Index: 112.9300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 4.8862
    Cell Significance Index: 140.7800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 4.7605
    Cell Significance Index: 50.5800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 4.6386
    Cell Significance Index: 42.7200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.1617
    Cell Significance Index: 194.0400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.5852
    Cell Significance Index: 267.2000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 3.4050
    Cell Significance Index: 51.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.9589
    Cell Significance Index: 1615.9100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.8241
    Cell Significance Index: 364.8600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.6696
    Cell Significance Index: 184.6200
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.5982
    Cell Significance Index: 16.0800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.5864
    Cell Significance Index: 70.4000
  • Cell Name: salivary gland glandular cell (CL1001596)
    Fold Change: 2.4613
    Cell Significance Index: 13.7000
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.3923
    Cell Significance Index: 26.6100
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 2.1739
    Cell Significance Index: 21.9300
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.0421
    Cell Significance Index: 29.0700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.9452
    Cell Significance Index: 316.3600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.8276
    Cell Significance Index: 329.4700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.5073
    Cell Significance Index: 70.8400
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.4382
    Cell Significance Index: 13.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.3536
    Cell Significance Index: 166.4400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0849
    Cell Significance Index: 979.5800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.0220
    Cell Significance Index: 6.3500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.9343
    Cell Significance Index: 7.4600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8858
    Cell Significance Index: 31.1300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6339
    Cell Significance Index: 13.5000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.5478
    Cell Significance Index: 17.5500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5072
    Cell Significance Index: 50.1700
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.4385
    Cell Significance Index: 3.6300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3984
    Cell Significance Index: 68.0300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.3865
    Cell Significance Index: 292.5500
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.3301
    Cell Significance Index: 3.4100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3218
    Cell Significance Index: 61.2400
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.3091
    Cell Significance Index: 3.3500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.2709
    Cell Significance Index: 30.9300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2255
    Cell Significance Index: 6.0200
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: 0.1347
    Cell Significance Index: 2.8100
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.1308
    Cell Significance Index: 1.8800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0701
    Cell Significance Index: 51.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0033
    Cell Significance Index: -2.4800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0114
    Cell Significance Index: -7.1500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0186
    Cell Significance Index: -34.9900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0216
    Cell Significance Index: -2.4700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0264
    Cell Significance Index: -14.9200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0308
    Cell Significance Index: -3.1500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0375
    Cell Significance Index: -7.9100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0428
    Cell Significance Index: -2.1600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0452
    Cell Significance Index: -0.9800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0470
    Cell Significance Index: -29.8600
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0490
    Cell Significance Index: -21.6700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0673
    Cell Significance Index: -1.8800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0784
    Cell Significance Index: -1.9600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0793
    Cell Significance Index: -35.9900
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: -0.0850
    Cell Significance Index: -0.3200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0943
    Cell Significance Index: -3.8600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0975
    Cell Significance Index: -34.9600
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.1139
    Cell Significance Index: -0.7900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1270
    Cell Significance Index: -17.4400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1366
    Cell Significance Index: -39.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1466
    Cell Significance Index: -17.0900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1613
    Cell Significance Index: -32.0200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1754
    Cell Significance Index: -35.1900
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.1870
    Cell Significance Index: -1.1600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1891
    Cell Significance Index: -27.4900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2193
    Cell Significance Index: -2.2700
  • Cell Name: stem cell (CL0000034)
    Fold Change: -0.2256
    Cell Significance Index: -1.6400
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.2569
    Cell Significance Index: -2.7100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.3229
    Cell Significance Index: -38.0900
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.3277
    Cell Significance Index: -5.0700
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.3363
    Cell Significance Index: -3.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3379
    Cell Significance Index: -35.1800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3412
    Cell Significance Index: -27.0200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3433
    Cell Significance Index: -3.9000
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.3511
    Cell Significance Index: -3.3400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3894
    Cell Significance Index: -11.4700
  • Cell Name: eosinophil (CL0000771)
    Fold Change: -0.4359
    Cell Significance Index: -3.8600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4632
    Cell Significance Index: -24.1300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4731
    Cell Significance Index: -29.8200
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.4852
    Cell Significance Index: -5.6400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5395
    Cell Significance Index: -41.4000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5396
    Cell Significance Index: -34.8100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5731
    Cell Significance Index: -35.1400
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: -0.5841
    Cell Significance Index: -3.5000
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.6383
    Cell Significance Index: -8.2200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6592
    Cell Significance Index: -36.9900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.6644
    Cell Significance Index: -24.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** Claudin 7 is a transmembrane protein with four transmembrane domains and a cytoplasmic domain that interacts with other claudin family members and occludin to form tight junctions. It is highly expressed in epithelial tissues, including the colon, intestine, and kidney, where it plays a crucial role in maintaining the integrity of the epithelial barrier. Claudin 7 has been shown to be involved in various cellular processes, including cell adhesion, migration, and proliferation. **Pathways and Functions:** Claudin 7 is involved in several key pathways, including: 1. **Tight junction assembly and maintenance**: Claudin 7 interacts with occludin and other claudin family members to form tight junctions, which are essential for maintaining the integrity of the epithelial barrier. 2. **Cell adhesion**: Claudin 7 has been shown to interact with various cell adhesion molecules, including N-cadherin and E-cadherin, to regulate cell adhesion and migration. 3. **Epithelial-mesenchymal transition (EMT)**: Claudin 7 has been implicated in the regulation of EMT during gastrulation and other developmental processes. 4. **Cell motility**: Claudin 7 has been shown to regulate cell motility and migration by interacting with various signaling pathways. **Clinical Significance:** Claudin 7 has been implicated in various diseases, including: 1. **Inflammatory bowel disease (IBD)**: Claudin 7 has been shown to be downregulated in IBD, leading to impaired tight junction function and increased permeability. 2. **Cancer**: Claudin 7 has been implicated in the development and progression of various cancers, including colon, breast, and lung cancer. 3. **Neurological disorders**: Claudin 7 has been shown to be involved in the regulation of EMT during neurodevelopment and has been implicated in various neurological disorders, including autism and schizophrenia. 4. **Infectious diseases**: Claudin 7 has been shown to play a role in the regulation of immune responses and has been implicated in various infectious diseases, including HIV and tuberculosis. In conclusion, claudin 7 is a critical component of tight junctions and plays a key role in maintaining the integrity and function of epithelial barriers. Its dysregulation has been implicated in various diseases, highlighting the importance of claudin 7 in human health and disease. Further research is needed to fully elucidate the functions and clinical significance of claudin 7.

Genular Protein ID: 2656558880

Symbol: CLD7_HUMAN

Name: Claudin-7

UniProtKB Accession Codes:

O95471 B2R9X7 D3DTP0 Q6IPN3 Q7Z4Y7 Q9BVN0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 4 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14502431

Title: Regulation of the expression of the prostate-specific antigen by claudin-7.

PubMed ID: 14502431

DOI: 10.1007/s00232-003-2038-4

PubMed ID: 12673207

Title: Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast.

PubMed ID: 12673207

DOI: 10.1038/sj.onc.1206199

PubMed ID: 16054130

Title: The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7.

PubMed ID: 16054130

DOI: 10.1016/j.yexcr.2005.06.013

PubMed ID: 20375010

Title: Claudin association with CD81 defines hepatitis C virus entry.

PubMed ID: 20375010

DOI: 10.1074/jbc.m110.104836

Sequence Information:

  • Length: 211
  • Mass: 22418
  • Checksum: 7F3CC1B963D9006A
  • Sequence:
    • MANSGLQLLG FSMALLGWVG LVACTAIPQW QMSSYAGDNI ITAQAMYKGL WMDCVTQSTG 
MMSCKMYDSV LALSAALQAT RALMVVSLVL GFLAMFVATM GMKCTRCGGD DKVKKARIAM 
GGGIIFIVAG LAALVACSWY GHQIVTDFYN PLIPTNIKYE FGPAIFIGWA GSALVILGGA 
LLSCSCPGNE SKAGYRVPRS YPKSNSSKEY V

Genular Protein ID: 2586158590

Symbol: F5H496_HUMAN

Name: N/A

UniProtKB Accession Codes:

F5H496

Database IDs:

ARBA 8 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 3 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 4 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 RuleBase 1 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 145
  • Mass: 15156
  • Checksum: A6ADFAD00862343C
  • Sequence:
    • MANSGLQLLG FSMALLGWVG LVACTAIPQW QMSSYAGDNI ITAQAMYKGL WMDCVTQSTG 
MMSCKMYDSV LALSAALQAT RALMVVSLVL GFLAMFVATM GMKCTRCGGD DKVKKARIAM 
GGGIIFIVAG MSLALPSLLA GQGLP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.