Details for: CLDN7

Gene ID: 1366

Symbol: CLDN7

Ensembl ID: ENSG00000181885

Description: claudin 7

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.85
    Marker Score: 12102
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 3.46
    Marker Score: 16602
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.37
    Marker Score: 2658
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 3.27
    Marker Score: 3136
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 3.26
    Marker Score: 5957
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.05
    Marker Score: 7687
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.04
    Marker Score: 4842
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.91
    Marker Score: 100799
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.74
    Marker Score: 10563
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.67
    Marker Score: 23037
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.67
    Marker Score: 4732.5
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.67
    Marker Score: 4111
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.66
    Marker Score: 6329
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.66
    Marker Score: 2218
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.65
    Marker Score: 4262
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.61
    Marker Score: 20357
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.59
    Marker Score: 3117
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.57
    Marker Score: 3779
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.55
    Marker Score: 1733.5
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.52
    Marker Score: 21919
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.52
    Marker Score: 1244
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.52
    Marker Score: 4174
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.47
    Marker Score: 877
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.42
    Marker Score: 1620
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.42
    Marker Score: 2550
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.3
    Marker Score: 17088
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.27
    Marker Score: 14825
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.25
    Marker Score: 3184
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.2
    Marker Score: 5009
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.19
    Marker Score: 1021
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 2.18
    Marker Score: 628
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.16
    Marker Score: 1357
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.14
    Marker Score: 679
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.1
    Marker Score: 8253
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.09
    Marker Score: 10976
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.07
    Marker Score: 2421
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.02
    Marker Score: 2011
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 2.01
    Marker Score: 6914
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.99
    Marker Score: 748
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.96
    Marker Score: 2035
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 1.96
    Marker Score: 537
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.95
    Marker Score: 3699
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 1.94
    Marker Score: 561
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.91
    Marker Score: 475
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.83
    Marker Score: 4915
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.77
    Marker Score: 8690
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.74
    Marker Score: 958
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.72
    Marker Score: 1537
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.72
    Marker Score: 772
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.64
    Marker Score: 4007
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.63
    Marker Score: 1733
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.61
    Marker Score: 409
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.58
    Marker Score: 309
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.56
    Marker Score: 1218
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.49
    Marker Score: 360
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.44
    Marker Score: 497
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.44
    Marker Score: 337
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.41
    Marker Score: 1489
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.35
    Marker Score: 697
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.32
    Marker Score: 1459
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.25
    Marker Score: 837
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.25
    Marker Score: 1270
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.25
    Marker Score: 2046
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 1.22
    Marker Score: 296
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.18
    Marker Score: 440
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 1.18
    Marker Score: 312
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 1.17
    Marker Score: 828
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.17
    Marker Score: 337
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.17
    Marker Score: 4138
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.11
    Marker Score: 28539
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.11
    Marker Score: 704
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.09
    Marker Score: 667
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.07
    Marker Score: 2253
  • Cell Name: epithelial fate stem cell (CL0000036)
    Fold Change: 1.06
    Marker Score: 304.5
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.04
    Marker Score: 897
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251776
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.03
    Marker Score: 551.5
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.03
    Marker Score: 297
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71793
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48019
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.99
    Marker Score: 514
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.99
    Marker Score: 469.5
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.98
    Marker Score: 685
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.98
    Marker Score: 213
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.97
    Marker Score: 219
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.97
    Marker Score: 390
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 454
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.95
    Marker Score: 1541
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.94
    Marker Score: 409
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.94
    Marker Score: 1177
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5333
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.92
    Marker Score: 672
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 320
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.88
    Marker Score: 230
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.88
    Marker Score: 1137
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5277

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Other Information

**Key characteristics:** * CLDN7 is a type of cell adhesion molecule (CAM). * It is expressed in a variety of epithelial cell types. * It is a key molecule for cell-cell adhesion in epithelial tissues. * It is involved in the regulation of epithelial cell migration and invasion. * It is a target for various signaling pathways, including those involved in cell adhesion, migration, and survival. **Pathways and functions:** * CLDN7 is involved in the assembly of tight junctions between epithelial cells. * It is a key regulator of epithelial cell migration and invasion. * It is involved in the regulation of cell adhesion and cell migration. * It is a target for various signaling pathways, including those involved in cell adhesion, migration, and survival. **Clinical significance:** * Mutations in CLDN7 have been linked to several human diseases, including cancer and cardiovascular disease. * Targeting CLDN7 has been investigated as a potential therapeutic strategy for these diseases. **Additional notes:** * CLDN7 is a highly conserved protein, with a similar gene found in other mammals. * It is a transmembrane protein that is expressed on both the extracellular and intracellular surfaces of epithelial cells. * It is a key molecule for cell-cell adhesion and is essential for the integrity of epithelial tissues.

Genular Protein ID: 2656558880

Symbol: CLD7_HUMAN

Name: Claudin-7

UniProtKB Accession Codes:

O95471 B2R9X7 D3DTP0 Q6IPN3 Q7Z4Y7 Q9BVN0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14502431

Title: Regulation of the expression of the prostate-specific antigen by claudin-7.

PubMed ID: 14502431

DOI: 10.1007/s00232-003-2038-4

PubMed ID: 12673207

Title: Loss of the tight junction protein claudin-7 correlates with histological grade in both ductal carcinoma in situ and invasive ductal carcinoma of the breast.

PubMed ID: 12673207

DOI: 10.1038/sj.onc.1206199

PubMed ID: 16054130

Title: The cell-cell adhesion molecule EpCAM interacts directly with the tight junction protein claudin-7.

PubMed ID: 16054130

DOI: 10.1016/j.yexcr.2005.06.013

PubMed ID: 20375010

Title: Claudin association with CD81 defines hepatitis C virus entry.

PubMed ID: 20375010

DOI: 10.1074/jbc.m110.104836

Sequence Information:

  • Length: 211
  • Mass: 22418
  • Checksum: 7F3CC1B963D9006A
  • Sequence:
    • MANSGLQLLG FSMALLGWVG LVACTAIPQW QMSSYAGDNI ITAQAMYKGL WMDCVTQSTG 
MMSCKMYDSV LALSAALQAT RALMVVSLVL GFLAMFVATM GMKCTRCGGD DKVKKARIAM 
GGGIIFIVAG LAALVACSWY GHQIVTDFYN PLIPTNIKYE FGPAIFIGWA GSALVILGGA 
LLSCSCPGNE SKAGYRVPRS YPKSNSSKEY V

Genular Protein ID: 2586158590

Symbol: F5H496_HUMAN

Name: N/A

UniProtKB Accession Codes:

F5H496

Database IDs:

ARBA 8 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 InterPro 4 MassIVE 1 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 RuleBase 1 SAM 1 SMR 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 145
  • Mass: 15156
  • Checksum: A6ADFAD00862343C
  • Sequence:
    • MANSGLQLLG FSMALLGWVG LVACTAIPQW QMSSYAGDNI ITAQAMYKGL WMDCVTQSTG 
MMSCKMYDSV LALSAALQAT RALMVVSLVL GFLAMFVATM GMKCTRCGGD DKVKKARIAM 
GGGIIFIVAG MSLALPSLLA GQGLP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.