Genular: Defining Cellular Identity and Function

Details for: Ehd1

Gene ID: 13660

Symbol: Ehd1

Ensembl ID: ENSMUSG00000024772

Description: EH-domain containing 1

Associated with

Factors involved in megakaryocyte development and platelet production
(R-MMU-983231)
Hemostasis
(R-MMU-109582)
Atp binding
(GO:0005524)
Calcium ion binding
(GO:0005509)
Cell projection
(GO:0042995)
Cell projection organization
(GO:0030030)
Cellular response to nerve growth factor stimulus
(GO:1990090)
Cholesterol homeostasis
(GO:0042632)
Ciliary pocket membrane
(GO:0020018)
Cilium
(GO:0005929)
Cilium assembly
(GO:0060271)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Early endosome
(GO:0005769)
Early endosome membrane
(GO:0031901)
Endocytic recycling
(GO:0032456)
Endocytic vesicle
(GO:0030139)
Endocytosis
(GO:0006897)
Endosomal transport
(GO:0016197)
Endosome
(GO:0005768)
Endosome membrane
(GO:0010008)
Gtp binding
(GO:0005525)
Identical protein binding
(GO:0042802)
Intracellular protein transport
(GO:0006886)
Lipid droplet
(GO:0005811)
Low-density lipoprotein particle clearance
(GO:0034383)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Myelin sheath
(GO:0043209)
Neuron projection development
(GO:0031175)
Nucleotide binding
(GO:0000166)
Perinuclear region of cytoplasm
(GO:0048471)
Plasma membrane
(GO:0005886)
Platelet dense tubular network membrane
(GO:0031095)
Positive regulation of cholesterol storage
(GO:0010886)
Positive regulation of endocytic recycling
(GO:2001137)
Positive regulation of myoblast fusion
(GO:1901741)
Positive regulation of neuron projection development
(GO:0010976)
Protein binding
(GO:0005515)
Protein homooligomerization
(GO:0051260)
Protein localization to cilium
(GO:0061512)
Protein localization to plasma membrane
(GO:0072659)
Protein transport
(GO:0015031)
Recycling endosome membrane
(GO:0055038)
Small gtpase binding
(GO:0031267)

Other Information

Proteins

EHD1_MOUSE

Genular Protein ID: 4038957238

Symbol: EHD1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q9WVK4

Database IDs:

Citations:

PubMed ID: 10395801

Title: EHD1 -- an EH-domain-containing protein with a specific expression pattern.

PubMed ID: 10395801

DOI: 10.1006/geno.1999.5800

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15930129

Title: EHD proteins associate with syndapin I and II and such interactions play a crucial role in endosomal recycling.

PubMed ID: 15930129

DOI: 10.1091/mbc.e05-01-0076

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20159556

Title: The Connecdenn DENN domain: a GEF for Rab35 mediating cargo-specific exit from early endosomes.

PubMed ID: 20159556

DOI: 10.1016/j.molcel.2009.12.037

PubMed ID: 21177873

Title: Endocytic recycling proteins EHD1 and EHD2 interact with fer-1-like-5 (Fer1L5) and mediate myoblast fusion.

PubMed ID: 21177873

DOI: 10.1074/jbc.m110.157222

PubMed ID: 24373286

Title: A function for EHD family proteins in unidirectional retrograde dendritic transport of BACE1 and Alzheimer's disease Abeta production.

PubMed ID: 24373286

DOI: 10.1016/j.celrep.2013.12.006

PubMed ID: 23572513

Title: Rab35 establishes the EHD1-association site by coordinating two distinct effectors during neurite outgrowth.

PubMed ID: 23572513

DOI: 10.1242/jcs.117846

Sequence Information:

Length: 534
Mass: 60603
Checksum: 35502055BC6164F7
Sequence:

MFSWVSKDAR RKKEPELFQT VAEGLRQLYA QKLLPLEEHY RFHEFHSPAL EDADFDNKPM 
VLLVGQYSTG KTTFIRHLIE QDFPGMRIGP EPTTDSFIAV MHGPTEGVVP GNALVVDPRR 
PFRKLNAFGN AFLNRFMCAQ LPNPVLDSIS IIDTPGILSG EKQRISRGYD FAAVLEWFAE 
RVDRIILLFD AHKLDISDEF SEVIKALKNH EDKIRVVLNK ADQIETQQLM RVYGALMWSL 
GKIINTPEVV RVYIGSFWSH PLLIPDNRKL FEAEEQDLFK DIQSLPRNAA LRKLNDLIKR 
ARLAKVHAYI ISSLKKEMPN VFGKESKKKE LVNNLGEIYQ KIEREHQISS GDFPSLRKMQ 
ELLQTQDFSK FQALKPKLLD TVDDMLANDI ARLMVMVRQE ESLMPSQAVK GGAFDGTMNG 
PFGHGYGEGA GEGIDDVEWV VGKDKPTYDE IFYTLSPVNG KITGANAKKE MVKSKLPNTV 
LGKIWKLADV DKDGLLDDEE FALANHLIKV KLEGHELPAD LPPHLIPPSK RRHE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ehd1

Associated with

Other Information

EHD1 -- an EH-domain-containing protein with a specific expression pattern. PubMed ID: 10395801

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

EHD proteins associate with syndapin I and II and such interactions play a crucial role in endosomal recycling. PubMed ID: 15930129

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The Connecdenn DENN domain: a GEF for Rab35 mediating cargo-specific exit from early endosomes. PubMed ID: 20159556

Endocytic recycling proteins EHD1 and EHD2 interact with fer-1-like-5 (Fer1L5) and mediate myoblast fusion. PubMed ID: 21177873

A function for EHD family proteins in unidirectional retrograde dendritic transport of BACE1 and Alzheimer's disease Abeta production. PubMed ID: 24373286

Rab35 establishes the EHD1-association site by coordinating two distinct effectors during neurite outgrowth. PubMed ID: 23572513