Genular: Defining Cellular Identity and Function

Details for: Eif2s1

Gene ID: 13665

Symbol: Eif2s1

Ensembl ID: ENSMUSG00000021116

Description: eukaryotic translation initiation factor 2, subunit 1 alpha

Associated with

Abc-family proteins mediated transport
(R-MMU-382556)
Activation of the mrna upon binding of the cap-binding complex and eifs, and subsequent binding to 43s
(R-MMU-72662)
Cap-dependent translation initiation
(R-MMU-72737)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to mitochondrial stress
(R-MMU-9840373)
Eukaryotic translation initiation
(R-MMU-72613)
Formation of the ternary complex, and subsequently, the 43s complex
(R-MMU-72695)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-MMU-72706)
L13a-mediated translational silencing of ceruloplasmin expression
(R-MMU-156827)
Metabolism of proteins
(R-MMU-392499)
Perk regulates gene expression
(R-MMU-381042)
Recycling of eif2:gdp
(R-MMU-72731)
Ribosomal scanning and start codon recognition
(R-MMU-72702)
Translation initiation complex formation
(R-MMU-72649)
Transport of small molecules
(R-MMU-382551)
Unfolded protein response (upr)
(R-MMU-381119)
Cellular response to amino acid starvation
(GO:0034198)
Cellular response to heat
(GO:0034605)
Cellular response to oxidative stress
(GO:0034599)
Cellular response to uv
(GO:0034644)
Cytoplasm
(GO:0005737)
Cytoplasmic stress granule
(GO:0010494)
Cytosol
(GO:0005829)
Eukaryotic 48s preinitiation complex
(GO:0033290)
Eukaryotic translation initiation factor 2 complex
(GO:0005850)
Glial limiting end-foot
(GO:0097451)
Negative regulation of translational initiation in response to stress
(GO:0032057)
Nucleic acid binding
(GO:0003676)
Nucleus
(GO:0005634)
Perk-mediated unfolded protein response
(GO:0036499)
Positive regulation of type b pancreatic cell apoptotic process
(GO:2000676)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Regulation of translation
(GO:0006417)
Regulation of translational initiation in response to stress
(GO:0043558)
Regulation of translation in response to endoplasmic reticulum stress
(GO:0036490)
Response to endoplasmic reticulum stress
(GO:0034976)
Ribosome binding
(GO:0043022)
Rna binding
(GO:0003723)
Stress granule assembly
(GO:0034063)
Synapse
(GO:0045202)
Translation
(GO:0006412)
Translational initiation
(GO:0006413)
Translation initiation factor activity
(GO:0003743)
Translation initiation ternary complex
(GO:0044207)

Other Information

Proteins

Eukaryotic translation initiation factor 2 subunit 1

Genular Protein ID: 747598703

Symbol: IF2A_MOUSE

Name: Eukaryotic translation initiation factor 2 subunit 1

UniProtKB Accession Codes:

Q6ZWX6 Q3TIQ0

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10504407

Title: Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase.

PubMed ID: 10504407

DOI: 10.1046/j.1432-1327.1999.00780.x

PubMed ID: 11106749

Title: Regulated translation initiation controls stress-induced gene expression in mammalian cells.

PubMed ID: 11106749

DOI: 10.1016/s1097-2765(00)00108-8

PubMed ID: 12176355

Title: Activation of GCN2 in UV-irradiated cells inhibits translation.

PubMed ID: 12176355

DOI: 10.1016/s0960-9822(02)01037-0

PubMed ID: 15213227

Title: Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2.

PubMed ID: 15213227

DOI: 10.1074/jbc.m404559200

PubMed ID: 15277680

Title: Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells.

PubMed ID: 15277680

DOI: 10.1073/pnas.0400541101

PubMed ID: 16054071

Title: The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores.

PubMed ID: 16054071

DOI: 10.1016/j.cmet.2005.03.004

PubMed ID: 16931514

Title: Age-specific CUGBP1-eIF2 complex increases translation of CCAAT/enhancer-binding protein beta in old liver.

PubMed ID: 16931514

DOI: 10.1074/jbc.m605701200

PubMed ID: 19131336

Title: An upstream open reading frame regulates translation of GADD34 during cellular stresses that induce eIF2alpha phosphorylation.

PubMed ID: 19131336

DOI: 10.1074/jbc.m806735200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 19861488

Title: Functional reconstruction of NANOS3 expression in the germ cell lineage by a novel transgenic reporter reveals distinct subcellular localizations of NANOS3.

PubMed ID: 19861488

DOI: 10.1530/rep-09-0373

PubMed ID: 21285359

Title: Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation.

PubMed ID: 21285359

DOI: 10.1074/jbc.m110.216093

Sequence Information:

Length: 315
Mass: 36108
Checksum: 018480B89175D118
Sequence:

MPGLSCRFYQ HKFPEVEDVV MVNVRSIAEM GAYVSLLEYN NIEGMILLSE LSRRRIRSIN 
KLIRIGRNEC VVVIRVDKEK GYIDLSKRRV SPEEAIKCED KFTKSKTVYS ILRHVAEVLE 
YTKDEQLESL FQRTAWVFDD KYKRPGYGAY DAFKHAVSDP SILDSLDLNE DEREVLINNI 
NRRLTPQAVK IRADIEVACY GYEGIDAVKE ALRAGLNCST ETMPIKINLI APPRYVMTTT 
TLERTEGLSV LNQAMAVIKE KIEEKRGVFN VQMEPKVVTD TDETELARQL ERLERENAEV 
DGDDDAEEME AKAED

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Eif2s1

Associated with

Other Information

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase. PubMed ID: 10504407

Regulated translation initiation controls stress-induced gene expression in mammalian cells. PubMed ID: 11106749

Activation of GCN2 in UV-irradiated cells inhibits translation. PubMed ID: 12176355

Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2. PubMed ID: 15213227

Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cells. PubMed ID: 15277680

The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores. PubMed ID: 16054071

Age-specific CUGBP1-eIF2 complex increases translation of CCAAT/enhancer-binding protein beta in old liver. PubMed ID: 16931514

An upstream open reading frame regulates translation of GADD34 during cellular stresses that induce eIF2alpha phosphorylation. PubMed ID: 19131336

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Functional reconstruction of NANOS3 expression in the germ cell lineage by a novel transgenic reporter reveals distinct subcellular localizations of NANOS3. PubMed ID: 19861488

Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation. PubMed ID: 21285359