Details for: CPM

Gene ID: 1368

Symbol: CPM

Ensembl ID: ENSG00000135678

Description: carboxypeptidase M

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 173.2615
    Cell Significance Index: -26.9500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 106.9218
    Cell Significance Index: -27.1200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 64.2696
    Cell Significance Index: -26.1100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 21.9067
    Cell Significance Index: -27.0100
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 11.7442
    Cell Significance Index: 147.8900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.2357
    Cell Significance Index: -27.4200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 8.2676
    Cell Significance Index: 191.0100
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.2291
    Cell Significance Index: -18.0100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.8689
    Cell Significance Index: -27.1100
  • Cell Name: subcutaneous adipocyte (CL0002521)
    Fold Change: 4.3715
    Cell Significance Index: 19.0300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.9490
    Cell Significance Index: 52.0400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.6943
    Cell Significance Index: 28.5400
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.5920
    Cell Significance Index: 9.5400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.5710
    Cell Significance Index: 42.1000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.4204
    Cell Significance Index: 19.3800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.7862
    Cell Significance Index: 20.2100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7830
    Cell Significance Index: 427.6200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.7725
    Cell Significance Index: 4.8000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.7543
    Cell Significance Index: 11.6700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.6712
    Cell Significance Index: 133.2000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6670
    Cell Significance Index: 14.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5441
    Cell Significance Index: 24.6600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4670
    Cell Significance Index: 50.7900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4180
    Cell Significance Index: 49.2900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3947
    Cell Significance Index: 64.1900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3888
    Cell Significance Index: 38.4600
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.2283
    Cell Significance Index: 0.8600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2024
    Cell Significance Index: 14.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1677
    Cell Significance Index: 31.9100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1623
    Cell Significance Index: 118.9800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.1344
    Cell Significance Index: 83.9200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0932
    Cell Significance Index: 2.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0927
    Cell Significance Index: 83.6900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0886
    Cell Significance Index: 67.0500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0609
    Cell Significance Index: 1.3200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0267
    Cell Significance Index: 1.7300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0127
    Cell Significance Index: 23.8700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0061
    Cell Significance Index: 0.8400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0023
    Cell Significance Index: 0.0800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0017
    Cell Significance Index: -0.1800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0064
    Cell Significance Index: -0.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0067
    Cell Significance Index: -0.8700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0071
    Cell Significance Index: -0.8100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0076
    Cell Significance Index: -10.3900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0092
    Cell Significance Index: -6.7800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0102
    Cell Significance Index: -18.7400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0116
    Cell Significance Index: -2.1000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0116
    Cell Significance Index: -17.8700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0175
    Cell Significance Index: -3.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0196
    Cell Significance Index: -3.3400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0201
    Cell Significance Index: -0.5800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0210
    Cell Significance Index: -0.3100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0229
    Cell Significance Index: -15.8400
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0233
    Cell Significance Index: -0.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0258
    Cell Significance Index: -14.5300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0283
    Cell Significance Index: -10.1400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0328
    Cell Significance Index: -20.8000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0356
    Cell Significance Index: -15.7300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0521
    Cell Significance Index: -23.6500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0527
    Cell Significance Index: -0.7500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0694
    Cell Significance Index: -19.9800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0711
    Cell Significance Index: -7.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0744
    Cell Significance Index: -15.6700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0804
    Cell Significance Index: -0.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1009
    Cell Significance Index: -14.6700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1108
    Cell Significance Index: -12.6900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1564
    Cell Significance Index: -18.2300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1591
    Cell Significance Index: -2.9400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1802
    Cell Significance Index: -8.4700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1928
    Cell Significance Index: -11.8200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2021
    Cell Significance Index: -3.9500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2474
    Cell Significance Index: -18.9900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2482
    Cell Significance Index: -31.8200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2619
    Cell Significance Index: -20.7400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2665
    Cell Significance Index: -17.9200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2841
    Cell Significance Index: -14.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3240
    Cell Significance Index: -24.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3335
    Cell Significance Index: -10.6800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.3564
    Cell Significance Index: -6.0000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.3809
    Cell Significance Index: -4.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4008
    Cell Significance Index: -21.0500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.4076
    Cell Significance Index: -4.3700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.4181
    Cell Significance Index: -7.1700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4205
    Cell Significance Index: -26.5000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.4412
    Cell Significance Index: -31.2000
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    Fold Change: -0.4510
    Cell Significance Index: -3.7300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4513
    Cell Significance Index: -23.5100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4533
    Cell Significance Index: -8.0100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4536
    Cell Significance Index: -27.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4586
    Cell Significance Index: -20.2900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4658
    Cell Significance Index: -12.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4746
    Cell Significance Index: -22.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4853
    Cell Significance Index: -27.2300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5480
    Cell Significance Index: -16.1400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5621
    Cell Significance Index: -21.2900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.5762
    Cell Significance Index: -4.8400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.5980
    Cell Significance Index: -8.9600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6108
    Cell Significance Index: -17.0700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.6123
    Cell Significance Index: -8.8900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.6164
    Cell Significance Index: -31.1500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CPM is a member of the carboxypeptidase family, characterized by its ability to cleave amino acids from the carboxyl-terminal end of proteins. It is a zinc-dependent enzyme, requiring the presence of zinc ions to facilitate its enzymatic activity. CPM has a high specificity for cleaving peptides at the carboxyl-terminal end, resulting in the formation of C-terminal extensions of various proteins. This processing event is essential for the proper functioning of numerous cell surface proteins, including those involved in cell signaling, adhesion, and migration. **Pathways and Functions:** CPM's primary function is to process and regulate cell surface proteins, particularly those involved in cell signaling and adhesion. This processing event is critical for maintaining the integrity and function of the cell surface. CPM's activity is also involved in the regulation of protein metabolism, including the cleavage of peptides from the extracellular matrix. Furthermore, CPM plays a role in tissue morphogenesis, particularly in the development of the lower respiratory tract. The pathways and functions of CPM can be summarized as follows: * **Cell surface protein processing:** CPM cleaves the C-terminal extensions of cell surface proteins, regulating their function and signaling. * **Protein metabolism:** CPM participates in the cleavage of peptides from the extracellular matrix, influencing protein metabolism and cell signaling. * **Tissue morphogenesis:** CPM plays a role in the development of the lower respiratory tract, regulating the formation of epithelial cells and the extracellular matrix. **Clinical Significance:** CPM's dysregulation has been implicated in various diseases and disorders, including: * **Respiratory diseases:** CPM's role in tissue morphogenesis and cell surface protein processing makes it a potential target for the treatment of respiratory diseases, such as asthma and chronic obstructive pulmonary disease (COPD). * **Cancer:** CPM's involvement in cell signaling and adhesion has led to its investigation as a potential marker for cancer diagnosis and prognosis. * **Neurological disorders:** CPM's role in protein metabolism and cell surface protein processing has led to its investigation as a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, carboxypeptidase M is a critical enzyme involved in the processing and regulation of cell surface proteins, protein metabolism, and tissue morphogenesis. Its dysregulation has been implicated in various diseases and disorders, making it a promising target for the development of new therapeutic strategies.

Genular Protein ID: 2762865358

Symbol: CBPM_HUMAN

Name: Carboxypeptidase M

UniProtKB Accession Codes:

P14384 B2R800 Q9H2K9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 12 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2753907

Title: Molecular cloning and sequencing of the cDNA for human membrane-bound carboxypeptidase M. Comparison with carboxypeptidases A, B, H, and N.

PubMed ID: 2753907

DOI: 10.1016/s0021-9258(18)51610-0

PubMed ID: 11147789

Title: Type 2 diabetes locus on 12q15: further mapping and mutation screening of two candidate genes.

PubMed ID: 11147789

DOI: 10.2337/diabetes.50.1.204

PubMed ID: 11934264

Title: Molecular structure and alternative splicing of the human carboxypeptidase M gene.

PubMed ID: 11934264

DOI: 10.1515/bc.2002.028

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12457462

Title: Effect of mutation of two critical glutamic acid residues on the activity and stability of human carboxypeptidase M and characterization of its signal for glycosylphosphatidylinositol anchoring.

PubMed ID: 12457462

DOI: 10.1042/bj20021495

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 15066430

Title: Crystal structure of human carboxypeptidase M, a membrane-bound enzyme that regulates peptide hormone activity.

PubMed ID: 15066430

DOI: 10.1016/j.jmb.2004.02.058

Sequence Information:

  • Length: 443
  • Mass: 50514
  • Checksum: 98EB0C94E201B901
  • Sequence:
    • MDFPCLWLGL LLPLVAALDF NYHRQEGMEA FLKTVAQNYS SVTHLHSIGK SVKGRNLWVL 
VVGRFPKEHR IGIPEFKYVA NMHGDETVGR ELLLHLIDYL VTSDGKDPEI TNLINSTRIH 
IMPSMNPDGF EAVKKPDCYY SIGRENYNQY DLNRNFPDAF EYNNVSRQPE TVAVMKWLKT 
ETFVLSANLH GGALVASYPF DNGVQATGAL YSRSLTPDDD VFQYLAHTYA SRNPNMKKGD 
ECKNKMNFPN GVTNGYSWYP LQGGMQDYNY IWAQCFEITL ELSCCKYPRE EKLPSFWNNN 
KASLIEYIKQ VHLGVKGQVF DQNGNPLPNV IVEVQDRKHI CPYRTNKYGE YYLLLLPGSY 
IINVTVPGHD PHITKVIIPE KSQNFSALKK DILLPFQGQL DSIPVSNPSC PMIPLYRNLP 
DHSAATKPSL FLFLVSLLHI FFK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.