Details for: CPM

Gene ID: 1368

Symbol: CPM

Ensembl ID: ENSG00000135678

Description: carboxypeptidase M

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 8.61
    Marker Score: 35914
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 4.11
    Marker Score: 1501
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 3.47
    Marker Score: 1880
  • Cell Name: fat cell (CL0000136)
    Fold Change: 3.13
    Marker Score: 1748
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 3.04
    Marker Score: 2895
  • Cell Name: basophil (CL0000767)
    Fold Change: 2.86
    Marker Score: 1358
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.8
    Marker Score: 18247.5
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.68
    Marker Score: 42996
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 2.65
    Marker Score: 3194
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.1
    Marker Score: 11018
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 2
    Marker Score: 1100
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 1.99
    Marker Score: 892
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.96
    Marker Score: 709
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 1.95
    Marker Score: 2236
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.89
    Marker Score: 4647
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.83
    Marker Score: 4912
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.82
    Marker Score: 4368
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.79
    Marker Score: 1884
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.72
    Marker Score: 626
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.71
    Marker Score: 3471.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.65
    Marker Score: 1755
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 1.65
    Marker Score: 1903
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.6
    Marker Score: 5665
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.56
    Marker Score: 2508
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.54
    Marker Score: 39565
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.54
    Marker Score: 646
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 1.53
    Marker Score: 1088
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.53
    Marker Score: 1550
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167935
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.46
    Marker Score: 25936
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.43
    Marker Score: 8690
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.36
    Marker Score: 1362
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.27
    Marker Score: 2309
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.26
    Marker Score: 4138.5
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.23
    Marker Score: 2896
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.23
    Marker Score: 388
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.23
    Marker Score: 1483
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.23
    Marker Score: 16464
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.16
    Marker Score: 674
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.15
    Marker Score: 557
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.14
    Marker Score: 368
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.13
    Marker Score: 423
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.13
    Marker Score: 299
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.12
    Marker Score: 1614
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.11
    Marker Score: 2087
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.09
    Marker Score: 1172.5
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 1.07
    Marker Score: 281
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.05
    Marker Score: 1051
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.02
    Marker Score: 278
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1
    Marker Score: 587
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71747
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47971
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.99
    Marker Score: 299.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.96
    Marker Score: 496
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.95
    Marker Score: 451
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.95
    Marker Score: 1062
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.95
    Marker Score: 524
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.93
    Marker Score: 32311
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.93
    Marker Score: 2398
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2721
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.9
    Marker Score: 997.5
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 0.89
    Marker Score: 2809
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.89
    Marker Score: 13970
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.88
    Marker Score: 318
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.88
    Marker Score: 403
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 501
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4922
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.86
    Marker Score: 3709
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.85
    Marker Score: 919
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.84
    Marker Score: 5394
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.83
    Marker Score: 568
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 324
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.8
    Marker Score: 786
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.8
    Marker Score: 204
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.79
    Marker Score: 651
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 604
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.79
    Marker Score: 1256
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.79
    Marker Score: 1439
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.78
    Marker Score: 16701
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.77
    Marker Score: 3045
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.77
    Marker Score: 2276.5
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.76
    Marker Score: 1480
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.76
    Marker Score: 178
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.75
    Marker Score: 314
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.75
    Marker Score: 671
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 386
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.73
    Marker Score: 496
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3051
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.72
    Marker Score: 473.5
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.71
    Marker Score: 1009
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.71
    Marker Score: 647
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.7
    Marker Score: 420
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.7
    Marker Score: 603
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.69
    Marker Score: 1105
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.69
    Marker Score: 201
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.68
    Marker Score: 188

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Other Information

**Key characteristics** * Protein type: transmembrane protein * Ensembl ID: ENSG00000135678 * Pathway/ontology: Anatomical structure morphogenesis, Carboxypeptidase activity, Cell surface, Extracellular exosome, Extracellular region, Extracellular space, Metabolism of proteins, Metallocarboxypeptidase activity, Peptide metabolic process, Plasma membrane, Post-translational modification: synthesis of gpi-anchored proteins, Post-translational protein modification, Protein processing, Side of membrane, Zinc ion binding * Significantly expressed cells: epithelial cell of lower respiratory tract, subcutaneous fat cell, contractile cell, fat cell, renal interstitial pericyte, basophil, type II pneumocyte, lactocyte, type I pneumocyte, epithelial cell of lung **Pathways and functions** The CPM gene product is a carboxypeptidase M protein, which is involved in a variety of cellular processes. These processes include: * Cell surface function: The CPM protein is expressed on the surface of epithelial cells of the lower respiratory tract, fat cells, and other cell types. It is involved in cell adhesion, migration, and signaling. * Extracellular matrix remodeling: The CPM protein is also expressed in the extracellular matrix. It is involved in the remodeling of the extracellular matrix by catalyzing the cleavage of ECM proteins. * Protein processing: The CPM protein is also involved in the processing of other proteins. It is a key enzyme in the production of growth factors and cytokines. **Clinical significance** Mutations in the CPM gene have been linked to a number of human diseases, including cancer and cardiovascular disease. The CPM protein is a target for a number of drugs, which are used to treat these diseases.

Genular Protein ID: 2762865358

Symbol: CBPM_HUMAN

Name: Carboxypeptidase M

UniProtKB Accession Codes:

P14384 B2R800 Q9H2K9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 12 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 3 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SABIO-RK 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2753907

Title: Molecular cloning and sequencing of the cDNA for human membrane-bound carboxypeptidase M. Comparison with carboxypeptidases A, B, H, and N.

PubMed ID: 2753907

DOI: 10.1016/s0021-9258(18)51610-0

PubMed ID: 11147789

Title: Type 2 diabetes locus on 12q15: further mapping and mutation screening of two candidate genes.

PubMed ID: 11147789

DOI: 10.2337/diabetes.50.1.204

PubMed ID: 11934264

Title: Molecular structure and alternative splicing of the human carboxypeptidase M gene.

PubMed ID: 11934264

DOI: 10.1515/bc.2002.028

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12457462

Title: Effect of mutation of two critical glutamic acid residues on the activity and stability of human carboxypeptidase M and characterization of its signal for glycosylphosphatidylinositol anchoring.

PubMed ID: 12457462

DOI: 10.1042/bj20021495

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 15066430

Title: Crystal structure of human carboxypeptidase M, a membrane-bound enzyme that regulates peptide hormone activity.

PubMed ID: 15066430

DOI: 10.1016/j.jmb.2004.02.058

Sequence Information:

  • Length: 443
  • Mass: 50514
  • Checksum: 98EB0C94E201B901
  • Sequence:
    • MDFPCLWLGL LLPLVAALDF NYHRQEGMEA FLKTVAQNYS SVTHLHSIGK SVKGRNLWVL 
VVGRFPKEHR IGIPEFKYVA NMHGDETVGR ELLLHLIDYL VTSDGKDPEI TNLINSTRIH 
IMPSMNPDGF EAVKKPDCYY SIGRENYNQY DLNRNFPDAF EYNNVSRQPE TVAVMKWLKT 
ETFVLSANLH GGALVASYPF DNGVQATGAL YSRSLTPDDD VFQYLAHTYA SRNPNMKKGD 
ECKNKMNFPN GVTNGYSWYP LQGGMQDYNY IWAQCFEITL ELSCCKYPRE EKLPSFWNNN 
KASLIEYIKQ VHLGVKGQVF DQNGNPLPNV IVEVQDRKHI CPYRTNKYGE YYLLLLPGSY 
IINVTVPGHD PHITKVIIPE KSQNFSALKK DILLPFQGQL DSIPVSNPSC PMIPLYRNLP 
DHSAATKPSL FLFLVSLLHI FFK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.