Genular: Defining Cellular Identity and Function

Details for: Eif4a1

Gene ID: 13681

Symbol: Eif4a1

Ensembl ID: ENSMUSG00000059796

Description: eukaryotic translation initiation factor 4A1

Associated with

Activation of the mrna upon binding of the cap-binding complex and eifs, and subsequent binding to 43s
(R-MMU-72662)
Antiviral mechanism by ifn-stimulated genes
(R-MMU-1169410)
Cap-dependent translation initiation
(R-MMU-72737)
Cytokine signaling in immune system
(R-MMU-1280215)
Deadenylation-dependent mrna decay
(R-MMU-429914)
Deadenylation of mrna
(R-MMU-429947)
Eukaryotic translation initiation
(R-MMU-72613)
Gtp hydrolysis and joining of the 60s ribosomal subunit
(R-MMU-72706)
Immune system
(R-MMU-168256)
Interferon signaling
(R-MMU-913531)
Isg15 antiviral mechanism
(R-MMU-1169408)
L13a-mediated translational silencing of ceruloplasmin expression
(R-MMU-156827)
Metabolism of proteins
(R-MMU-392499)
Metabolism of rna
(R-MMU-8953854)
Ribosomal scanning and start codon recognition
(R-MMU-72702)
Translation initiation complex formation
(R-MMU-72649)
Atp binding
(GO:0005524)
Cytoplasm
(GO:0005737)
Cytoplasmic translational initiation
(GO:0002183)
Cytosol
(GO:0005829)
Double-stranded rna binding
(GO:0003725)
Eukaryotic translation initiation factor 4f complex
(GO:0016281)
Helicase activity
(GO:0004386)
Hydrolase activity
(GO:0016787)
Nucleic acid binding
(GO:0003676)
Nucleotide binding
(GO:0000166)
Protein binding
(GO:0005515)
Rna binding
(GO:0003723)
Rna helicase activity
(GO:0003724)
Translation
(GO:0006412)
Translational initiation
(GO:0006413)
Translation initiation factor activity
(GO:0003743)

Other Information

Proteins

Eukaryotic initiation factor 4A-I
Q3TLL6_MOUSE

Genular Protein ID: 2077827561

Symbol: IF4A1_MOUSE

Name: Eukaryotic initiation factor 4A-I

UniProtKB Accession Codes:

P60843 P04765 Q61516

Database IDs:

Citations:

PubMed ID: 3840589

Title: Cloning of eukaryotic protein synthesis initiation factor genes: isolation and characterization of cDNA clones encoding factor eIF-4A.

PubMed ID: 3840589

DOI: 10.1093/nar/13.19.6867

PubMed ID: 3215517

Title: Isolation and mapping of a gene for protein synthesis initiation factor 4A and its expression during differentiation of murine erythroleukemia cells.

PubMed ID: 3215517

DOI: 10.1016/0378-1119(88)90195-3

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1378397

Title: Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A.

PubMed ID: 1378397

DOI: 10.1002/j.1460-2075.1992.tb05330.x

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

Sequence Information:

Length: 406
Mass: 46154
Checksum: 6EF89939F3045420
Sequence:

MSASQDSRSR DNGPDGMEPE GVIESNWNEI VDSFDDMNLS ESLLRGIYAY GFEKPSAIQQ 
RAILPCIKGY DVIAQAQSGT GKTATFAISI LQQIELDLKA TQALVLAPTR ELAQQIQKVV 
MALGDYMGAS CHACIGGTNV RAEVQKLQME APHIIVGTPG RVFDMLNRRY LSPKYIKMFV 
LDEADEMLSR GFKDQIYDIF QKLNSNTQVV LLSATMPSDV LEVTKKFMRD PIRILVKKEE 
LTLEGIRQFY INVEREEWKL DTLCDLYETL TITQAVIFIN TRRKVDWLTE KMHARDFTVS 
AMHGDMDQKE RDVIMREFRS GSSRVLITTD LLARGIDVQQ VSLVINYDLP TNRENYIHRI 
GRGGRFGRKG VAINMVTEED KRTLRDIETF YNTSIEEMPL NVADLI

Genular Protein ID: 942572102

Symbol: Q3TLL6_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3TLL6

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 364
Mass: 41491
Checksum: C9F26E5517D33A86
Sequence:

MSASQDSRSR DNGPDGMEPE GVIESNWNEI VDSFDDMNLS ESLLRGIYAY GFEKPSAIQQ 
RAILPCIKGY DVIAQAQSGT GKTATFAISI LQQIELDLKA TQALVLAPTR ELAQQIQKVV 
MALGDYMGAS CHACIGGTNV RAEVQKLQME APHIIVGTPG RVFDMLNRRY LSPKYIKMFV 
LDEADEMLSR GFKDQIYDIF QKLNSNTQVV LLSATMPSDV LEVTKKFMRD PIRILVKKEE 
LTLEGIRQFY INVEREEWKL DTLCDLYETL TITQAVIFIN TRRKVDWLTE KMHARDFTVS 
AMHGDMDQKE RDVIMREFRS GSSRVLITTD LLARGIDVQQ VSLVINYDLP TNRENYIHRW 
SVWS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Eif4a1

Associated with

Other Information

Cloning of eukaryotic protein synthesis initiation factor genes: isolation and characterization of cDNA clones encoding factor eIF-4A. PubMed ID: 3840589

Isolation and mapping of a gene for protein synthesis initiation factor 4A and its expression during differentiation of murine erythroleukemia cells. PubMed ID: 3215517

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A. PubMed ID: 1378397

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073