Details for: Eif4e

Gene ID: 13684

Symbol: Eif4e

Ensembl ID: ENSMUSG00000028156

Description: eukaryotic translation initiation factor 4E

Associated with

Other Information

Genular Protein ID: 1486516250

Symbol: IF4E_MOUSE

Name: eIF-4F 25 kDa subunit

UniProtKB Accession Codes:

P63073 P20415

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChEBI 8 ChEMBL 1 ChiTaRS 1 ComplexPortal 4 DIP 1 DNASU 1 EMBL 3 EPD 1 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 37 Gene3D 1 GeneTree 1 Genevisible 1 HOGENOM 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MGI 2 MINT 1 NCBI Taxonomy 1 OMA 1 PANTHER 2 PDB 28 PDBsum 24 PIR 2 PRO 1 PROSITE 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 11 RefSeq 1 SAM 1 SMR 1 STRING 1 SUPFAM 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 2663851

Title: A mammalian translation initiation factor can substitute for its yeast homologue in vivo.

PubMed ID: 2663851

DOI: 10.1016/s0021-9258(18)63833-5

PubMed ID: 2037592

Title: Multiple mRNAs encode the murine translation initiation factor eIF-4E.

PubMed ID: 2037592

DOI: 10.1016/s0021-9258(18)99245-8

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8577715

Title: Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 mRNA are increased in cells overexpressing eukaryotic initiation factor 4E.

PubMed ID: 8577715

DOI: 10.1073/pnas.93.3.1065

PubMed ID: 11500381

Title: PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA.

PubMed ID: 11500381

DOI: 10.1093/emboj/20.16.4547

PubMed ID: 11575918

Title: The RING domains of the promyelocytic leukemia protein PML and the arenaviral protein Z repress translation by directly inhibiting translation initiation factor eIF4E.

PubMed ID: 11575918

DOI: 10.1006/jmbi.2001.5003

PubMed ID: 12554669

Title: The proline-rich homeodomain protein, PRH, is a tissue-specific inhibitor of eIF4E-dependent cyclin D1 mRNA transport and growth.

PubMed ID: 12554669

DOI: 10.1093/emboj/cdg069

PubMed ID: 15574771

Title: Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities.

PubMed ID: 15574771

DOI: 10.1158/0008-5472.can-04-2677

PubMed ID: 15247416

Title: Emx2 homeodomain transcription factor interacts with eukaryotic translation initiation factor 4E (eIF4E) in the axons of olfactory sensory neurons.

PubMed ID: 15247416

DOI: 10.1073/pnas.0403824101

PubMed ID: 15657436

Title: Eukaryotic translation initiation factor 4E activity is modulated by HOXA9 at multiple levels.

PubMed ID: 15657436

DOI: 10.1128/mcb.25.3.1100-1112.2005

PubMed ID: 17074885

Title: eIF4E is a central node of an RNA regulon that governs cellular proliferation.

PubMed ID: 17074885

DOI: 10.1083/jcb.200607020

PubMed ID: 16705177

Title: Translational control by neuroguidin, a eukaryotic initiation factor 4E and CPEB binding protein.

PubMed ID: 16705177

DOI: 10.1128/mcb.02470-05

PubMed ID: 17689282

Title: Roles of mitogen-activated protein kinase signal-integrating kinases 1 and 2 in oxidant-mediated eIF4E phosphorylation.

PubMed ID: 17689282

DOI: 10.1016/j.biocel.2007.05.001

PubMed ID: 18805096

Title: The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP.

PubMed ID: 18805096

DOI: 10.1016/j.cell.2008.07.031

PubMed ID: 18391071

Title: The eIF4E RNA regulon promotes the Akt signaling pathway.

PubMed ID: 18391071

DOI: 10.1083/jcb.200707018

PubMed ID: 18515545

Title: Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs.

PubMed ID: 18515545

DOI: 10.1261/rna.950608

PubMed ID: 19262567

Title: Molecular dissection of the eukaryotic initiation factor 4E (eIF4E) export-competent RNP.

PubMed ID: 19262567

DOI: 10.1038/emboj.2009.53

PubMed ID: 19114715

Title: MILI, a PIWI-interacting RNA-binding protein, is required for germ Line stem cell self-renewal and appears to positively regulate translation.

PubMed ID: 19114715

DOI: 10.1074/jbc.m809104200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22902403

Title: The oncogene eIF4E reprograms the nuclear pore complex to promote mRNA export and oncogenic transformation.

PubMed ID: 22902403

DOI: 10.1016/j.celrep.2012.07.007

PubMed ID: 22900038

Title: Circadian proteins CLOCK and BMAL1 in the chromatoid body, a RNA processing granule of male germ cells.

PubMed ID: 22900038

DOI: 10.1371/journal.pone.0042695

PubMed ID: 25456498

Title: An eIF4E1/4E-T complex determines the genesis of neurons from precursors by translationally repressing a proneurogenic transcription program.

PubMed ID: 25456498

DOI: 10.1016/j.neuron.2014.10.022

PubMed ID: 27065194

Title: BTG4 is a meiotic cell cycle-coupled maternal-zygotic-transition licensing factor in oocytes.

PubMed ID: 27065194

DOI: 10.1038/nsmb.3204

PubMed ID: 28325843

Title: A biochemical framework for eIF4E-dependent mRNA export and nuclear recycling of the export machinery.

PubMed ID: 28325843

DOI: 10.1261/rna.060137.116

PubMed ID: 31042468

Title: Nuclear eIF4E Stimulates 3'-End Cleavage of Target RNAs.

PubMed ID: 31042468

DOI: 10.1016/j.celrep.2019.04.008

PubMed ID: 33055213

Title: The eukaryotic translation initiation factor eIF4E elevates steady-state m7G capping of coding and noncoding transcripts.

PubMed ID: 33055213

DOI: 10.1073/pnas.2002360117

PubMed ID: 36843541

Title: The eukaryotic translation initiation factor eIF4E reprograms alternative splicing.

PubMed ID: 36843541

DOI: 10.15252/embj.2021110496

PubMed ID: 9200613

Title: Cocrystal structure of the messenger RNA 5' cap-binding protein (eIF4E) bound to 7-methyl-GDP.

PubMed ID: 9200613

DOI: 10.1016/s0092-8674(00)80280-9

PubMed ID: 10394359

Title: Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G.

PubMed ID: 10394359

DOI: 10.1016/s1097-2765(01)80003-4

Sequence Information:

  • Length: 217
  • Mass: 25053
  • Checksum: FC61D0FB337BCD8F
  • Sequence:
    • MATVEPETTP TTNPPPAEEE KTESNQEVAN PEHYIKHPLQ NRWALWFFKN DKSKTWQANL 
RLISKFDTVE DFWALYNHIQ LSSNLMPGCD YSLFKDGIEP MWEDEKNKRG GRWLITLNKQ 
QRRSDLDRFW LETLLCLIGE SFDDYSDDVC GAVVNVRAKG DKIAIWTTEC ENRDAVTHIG 
RVYKERLGLP PKIVIGYQSH ADTATKSGST TKNRFVV

Genular Protein ID: 895856332

Symbol: Q8C470_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8C470

Database IDs:

AGR 1 ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 7 Gene3D 1 Genevisible 1 InterPro 3 KEGG 1 MGI 2 NCBI Taxonomy 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 1 RefSeq 1 RuleBase 1 SAM 1 SUPFAM 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 217
  • Mass: 25037
  • Checksum: E1D717FB337BCD9A
  • Sequence:
    • MATVEPETTP TTNPPPAEEE KTESNQEVAN PEHYIKHPLQ NRWALWFFKN DKSKTWQANL 
RLISKFDTVE DFWALYNHIQ LSSNLMPGCD YSLFKDGIEP MWEDEKNKRG GRWLITLNKQ 
QRRSDLDRFW LETLLCLIGE SFDDYSDDVC GAVVNVRAKG DKIAIWTTES ENRDAVTHIG 
RVYKERLGLP PKIVIGYQSH ADTATKSGST TKNRFVV

Genular Protein ID: 3248344846

Symbol: A0A0G2JFB4_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A0G2JFB4

Database IDs:

AGR 1 ARBA 4 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 InterPro 3 MGI 2 MaxQB 1 NCBI Taxonomy 1 OMA 1 PANTHER 2 PROSITE 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 2 RuleBase 1 SMR 1 SUPFAM 1 VEuPathDB 1 jPOST 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 132
  • Mass: 15057
  • Checksum: EE9C85F876B50315
  • Sequence:
    • MPGCDYSLFK DGIEPMWEDE KNKRGGRWLI TLNKQQRRSD LDRFWLETLL CLIGESFDDY 
SDDVCGAVVN VRAKGDKIAI WTTECENRDA VTHIGRVYKE RLGLPPKIVI GYQSHADTAT 
KSGSTTKNRF VV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.