Genular: Defining Cellular Identity and Function

Details for: Eif4ebp1

Gene ID: 13685

Symbol: Eif4ebp1

Ensembl ID: ENSMUSG00000031490

Description: eukaryotic translation initiation factor 4E binding protein 1

Associated with

Activation of the mrna upon binding of the cap-binding complex and eifs, and subsequent binding to 43s
(R-MMU-72662)
Cap-dependent translation initiation
(R-MMU-72737)
Eukaryotic translation initiation
(R-MMU-72613)
Metabolism of proteins
(R-MMU-392499)
Mtorc1-mediated signalling
(R-MMU-166208)
Mtor signalling
(R-MMU-165159)
Signal transduction
(R-MMU-162582)
Translation
(R-MMU-72766)
Cellular response to dexamethasone stimulus
(GO:0071549)
Cellular response to hypoxia
(GO:0071456)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Eukaryotic initiation factor 4e binding
(GO:0008190)
G1/s transition of mitotic cell cycle
(GO:0000082)
Glutamatergic synapse
(GO:0098978)
Insulin receptor signaling pathway
(GO:0008286)
Ires-dependent translational initiation of linear mrna
(GO:0002192)
Negative regulation of protein-containing complex assembly
(GO:0031333)
Negative regulation of translation
(GO:0017148)
Negative regulation of translational initiation
(GO:0045947)
Nucleus
(GO:0005634)
Positive regulation of mitotic cell cycle
(GO:0045931)
Postsynaptic cytosol
(GO:0099524)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein phosphatase 2a binding
(GO:0051721)
Regulation of translation
(GO:0006417)
Regulation of translational initiation
(GO:0006446)
Response to amino acid starvation
(GO:1990928)
Tor signaling
(GO:0031929)
Translation initiation factor binding
(GO:0031369)
Translation repressor activity
(GO:0030371)

Other Information

Proteins

Eukaryotic translation initiation factor 4E-binding protein 1

Genular Protein ID: 1481467277

Symbol: 4EBP1_MOUSE

Name: Eukaryotic translation initiation factor 4E-binding protein 1

UniProtKB Accession Codes:

Q60876 Q3TDS8 Q9CZ40

Database IDs:

Citations:

PubMed ID: 7629182

Title: Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway.

PubMed ID: 7629182

DOI: 10.1074/jbc.270.31.18531

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17273556

Title: Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2.

PubMed ID: 17273556

DOI: 10.1172/jci29528

PubMed ID: 18515545

Title: Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs.

PubMed ID: 18515545

DOI: 10.1261/rna.950608

PubMed ID: 19175792

Title: Impaired myelopoiesis in mice lacking the repressors of translation initiation, 4E-BP1 and 4E-BP2.

PubMed ID: 19175792

DOI: 10.1111/j.1365-2567.2008.02981.x

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.m800451-mcp200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 24139800

Title: mTORC1 targets the translational repressor 4E-BP2, but not S6 kinase 1/2, to regulate neural stem cell self-renewal in vivo.

PubMed ID: 24139800

DOI: 10.1016/j.celrep.2013.09.017

PubMed ID: 26359501

Title: Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation.

PubMed ID: 26359501

DOI: 10.1074/jbc.m115.678433

Sequence Information:

Length: 117
Mass: 12325
Checksum: 3458D5687468A7EA
Sequence:

MSAGSSCSQT PSRAIPTRRV ALGDGVQLPP GDYSTTPGGT LFSTTPGGTR IIYDRKFLME 
CRNSPVAKTP PKDLPAIPGV TSPTSDEPPM QASQSQLPSS PEDKRAGGEE SQFEMDI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Eif4ebp1

Associated with

Other Information

Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway. PubMed ID: 7629182

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2. PubMed ID: 17273556

Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs. PubMed ID: 18515545

Impaired myelopoiesis in mice lacking the repressors of translation initiation, 4E-BP1 and 4E-BP2. PubMed ID: 19175792

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. PubMed ID: 19131326

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

mTORC1 targets the translational repressor 4E-BP2, but not S6 kinase 1/2, to regulate neural stem cell self-renewal in vivo. PubMed ID: 24139800

Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation. PubMed ID: 26359501