Details for: CPN2

Gene ID: 1370

Symbol: CPN2

Ensembl ID: ENSG00000178772

Description: carboxypeptidase N subunit 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 17.6715
    Cell Significance Index: 520.5000
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 4.4823
    Cell Significance Index: 75.3900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.4476
    Cell Significance Index: 38.7900
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.8017
    Cell Significance Index: 7.4400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.5687
    Cell Significance Index: 13.7800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.4834
    Cell Significance Index: 95.9300
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.4089
    Cell Significance Index: 1.5400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.3885
    Cell Significance Index: 6.5500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.3645
    Cell Significance Index: 5.3800
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.3443
    Cell Significance Index: 4.9300
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.3107
    Cell Significance Index: 2.8200
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.1933
    Cell Significance Index: 0.5100
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.0929
    Cell Significance Index: 0.5400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0753
    Cell Significance Index: 1.6100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0743
    Cell Significance Index: 1.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0665
    Cell Significance Index: 6.8000
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.0080
    Cell Significance Index: 0.0800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0034
    Cell Significance Index: 0.6900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0002
    Cell Significance Index: 0.0500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0001
    Cell Significance Index: 0.2500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0002
    Cell Significance Index: -0.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0002
    Cell Significance Index: -0.2800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0004
    Cell Significance Index: -0.4900
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0010
    Cell Significance Index: -0.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0013
    Cell Significance Index: -0.8300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0014
    Cell Significance Index: -0.9900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0014
    Cell Significance Index: -0.8100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0015
    Cell Significance Index: -0.7000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0016
    Cell Significance Index: -0.4700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0032
    Cell Significance Index: -0.5400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0043
    Cell Significance Index: -0.7700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0050
    Cell Significance Index: -0.7200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0053
    Cell Significance Index: -0.1100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0055
    Cell Significance Index: -0.7500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0059
    Cell Significance Index: -0.1700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0064
    Cell Significance Index: -0.7300
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0065
    Cell Significance Index: -0.0500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0065
    Cell Significance Index: -0.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0076
    Cell Significance Index: -0.9400
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.0082
    Cell Significance Index: -0.0800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0085
    Cell Significance Index: -0.3000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0087
    Cell Significance Index: -0.5900
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: -0.0102
    Cell Significance Index: -0.1100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0105
    Cell Significance Index: -0.8300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0107
    Cell Significance Index: -0.6600
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0119
    Cell Significance Index: -0.1700
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0119
    Cell Significance Index: -0.1700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0128
    Cell Significance Index: -0.7200
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.0132
    Cell Significance Index: -0.1700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0145
    Cell Significance Index: -0.6800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0154
    Cell Significance Index: -0.7000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0155
    Cell Significance Index: -0.4900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0161
    Cell Significance Index: -0.7100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0177
    Cell Significance Index: -0.6700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0184
    Cell Significance Index: -0.3900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0185
    Cell Significance Index: -0.5900
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0186
    Cell Significance Index: -0.2100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0187
    Cell Significance Index: -0.5400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0188
    Cell Significance Index: -0.6600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0192
    Cell Significance Index: -0.6300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0213
    Cell Significance Index: -0.2900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0222
    Cell Significance Index: -0.3800
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0225
    Cell Significance Index: -0.3900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0237
    Cell Significance Index: -0.3100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0242
    Cell Significance Index: -0.6900
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: -0.0254
    Cell Significance Index: -0.2800
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0255
    Cell Significance Index: -0.5500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0256
    Cell Significance Index: -0.6400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0259
    Cell Significance Index: -0.5200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0259
    Cell Significance Index: -0.6200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0264
    Cell Significance Index: -0.3900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0265
    Cell Significance Index: -0.6600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0266
    Cell Significance Index: -0.6600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0267
    Cell Significance Index: -0.6800
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0273
    Cell Significance Index: -0.3500
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: -0.0274
    Cell Significance Index: -0.2700
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.0274
    Cell Significance Index: -0.2600
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0282
    Cell Significance Index: -0.4000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0283
    Cell Significance Index: -0.5600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0287
    Cell Significance Index: -0.6000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0288
    Cell Significance Index: -0.7400
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.0298
    Cell Significance Index: -0.2400
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0298
    Cell Significance Index: -0.3500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0299
    Cell Significance Index: -0.7300
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0310
    Cell Significance Index: -0.6300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0318
    Cell Significance Index: -0.8500
  • Cell Name: erythroblast (CL0000765)
    Fold Change: -0.0319
    Cell Significance Index: -0.3800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0335
    Cell Significance Index: -0.4900
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0337
    Cell Significance Index: -0.5400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0340
    Cell Significance Index: -0.7500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0340
    Cell Significance Index: -0.7100
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: -0.0343
    Cell Significance Index: -0.3500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0347
    Cell Significance Index: -0.9700
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0364
    Cell Significance Index: -0.5300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0368
    Cell Significance Index: -1.5100
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0376
    Cell Significance Index: -0.7400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0377
    Cell Significance Index: -0.3900
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.0382
    Cell Significance Index: -0.3500
  • Cell Name: precursor cell (CL0011115)
    Fold Change: -0.0382
    Cell Significance Index: -0.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Gene Expression:** CPN2 is significantly expressed in a diverse range of cells, including kidney epithelial cells, goblet cells, hepatocytes, plasma cells, absorptive cells, intestinal crypt stem cells, and neoplastic cells. This widespread expression suggests that CPN2 may have a broad range of functions in different tissues. 2. **Protein Structure:** The CPN2 protein is a subunit of the carboxypeptidase N enzyme, which is composed of four subunits. The subunit 2 (CPN2) is responsible for the enzymatic activity of the enzyme. 3. **Enzymatic Activity:** CPN2 is a peptidase that cleaves peptides at the carboxyl-terminal end, releasing amino acids. This activity is essential for various physiological processes, including protein regulation, cell signaling, and immune response. **Pathways and Functions:** 1. **Complement Cascade:** CPN2 is involved in the regulation of the complement cascade, a crucial component of the innate immune system. The complement cascade is activated in response to pathogens, leading to the formation of membrane attack complexes and the elimination of infected cells. 2. **Immune System Regulation:** CPN2 modulates immune responses by regulating the activity of various immune cells, including plasma cells, mast cells, and neutrophils. This regulation is essential for maintaining immune homeostasis and preventing excessive immune activation. 3. **Extracellular Matrix and Cell Signaling:** CPN2 is also involved in the regulation of extracellular matrix components and cell signaling pathways. This activity is crucial for maintaining tissue architecture and regulating cell behavior. 4. **Protein Stabilization:** CPN2 has been shown to stabilize proteins, preventing their degradation and maintaining their functional integrity. **Clinical Significance:** 1. **Autoimmune Diseases:** Dysregulation of the complement cascade and immune system has been implicated in various autoimmune diseases, including systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and multiple sclerosis (MS). CPN2 may play a role in modulating these diseases. 2. **Cancer:** Abnormal expression of CPN2 has been observed in various types of cancer, including colorectal cancer, breast cancer, and lung cancer. This suggests that CPN2 may be involved in cancer progression and metastasis. 3. **Neurological Disorders:** CPN2 has been implicated in neurological disorders, including Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS). Dysregulation of CPN2 may contribute to the pathogenesis of these diseases. In conclusion, the CPN2 gene plays a critical role in regulating various physiological and pathological processes, including the immune system, extracellular matrix, and cell signaling. Further research is needed to fully elucidate the functions of CPN2 and its potential implications in disease states.

Genular Protein ID: 1626644585

Symbol: CPN2_HUMAN

Name: Carboxypeptidase N subunit 2

UniProtKB Accession Codes:

P22792 B2RPE7 Q86SU4 Q8N5V4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EMBL 7 Ensembl 2 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 2 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 3 SMART 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2378615

Title: The deduced protein sequence of the human carboxypeptidase N high molecular weight subunit reveals the presence of leucine-rich tandem repeats.

PubMed ID: 2378615

DOI: 10.1016/s0021-9258(19)40187-7

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3408501

Title: Amino acid sequence of the N-terminus and selected tryptic peptides of the active subunit of human plasma carboxypeptidase N: comparison with other carboxypeptidases.

PubMed ID: 3408501

DOI: 10.1016/0006-291x(88)90284-7

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

Sequence Information:

  • Length: 545
  • Mass: 60557
  • Checksum: 221AAF04413665AF
  • Sequence:
    • MLPGAWLLWT SLLLLARPAQ PCPMGCDCFV QEVFCSDEEL ATVPLDIPPY TKNIIFVETS 
FTTLETRAFG SNPNLTKVVF LNTQLCQFRP DAFGGLPRLE DLEVTGSSFL NLSTNIFSNL 
TSLGKLTLNF NMLEALPEGL FQHLAALESL HLQGNQLQAL PRRLFQPLTH LKTLNLAQNL 
LAQLPEELFH PLTSLQTLKL SNNALSGLPQ GVFGKLGSLQ ELFLDSNNIS ELPPQVFSQL 
FCLERLWLQR NAITHLPLSI FASLGNLTFL SLQWNMLRVL PAGLFAHTPC LVGLSLTHNQ 
LETVAEGTFA HLSNLRSLML SYNAITHLPA GIFRDLEELV KLYLGSNNLT ALHPALFQNL 
SKLELLSLSK NQLTTLPEGI FDTNYNLFNL ALHGNPWQCD CHLAYLFNWL QQYTDRLLNI 
QTYCAGPAYL KGQVVPALNE KQLVCPVTRD HLGFQVTWPD ESKAGGSWDL AVQERAARSQ 
CTYSNPEGTV VLACDQAQCR WLNVQLSPQQ GSLGLQYNAS QEWDLRSSCG SLRLTVSIEA 
RAAGP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.