Details for: CPN2

Gene ID: 1370

Symbol: CPN2

Ensembl ID: ENSG00000178772

Description: carboxypeptidase N subunit 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.15
    Marker Score: 1212
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.13
    Marker Score: 7518
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.1
    Marker Score: 753
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.08
    Marker Score: 1205
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5356
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5296
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.84
    Marker Score: 489
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.69
    Marker Score: 1435
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.69
    Marker Score: 2984
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.64
    Marker Score: 1044
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.64
    Marker Score: 508
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.55
    Marker Score: 319
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.46
    Marker Score: 1520
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.44
    Marker Score: 6906.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.44
    Marker Score: 834
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.43
    Marker Score: 697
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.43
    Marker Score: 1006
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.41
    Marker Score: 2645
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.39
    Marker Score: 2099
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.28
    Marker Score: 105
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.28
    Marker Score: 565
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.26
    Marker Score: 244
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.23
    Marker Score: 802
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.2
    Marker Score: 215
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.18
    Marker Score: 58
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.17
    Marker Score: 64
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.16
    Marker Score: 44
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.15
    Marker Score: 72
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.14
    Marker Score: 84
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.13
    Marker Score: 72
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.13
    Marker Score: 129
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.12
    Marker Score: 139
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.12
    Marker Score: 171
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.12
    Marker Score: 37
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.12
    Marker Score: 78
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.12
    Marker Score: 42
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.11
    Marker Score: 29
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.11
    Marker Score: 1901
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.11
    Marker Score: 33
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.1
    Marker Score: 71
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.1
    Marker Score: 45
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.1
    Marker Score: 96
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.09
    Marker Score: 29
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.09
    Marker Score: 40
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.08
    Marker Score: 48
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.07
    Marker Score: 19
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.07
    Marker Score: 16
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.07
    Marker Score: 43
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.07
    Marker Score: 30
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.07
    Marker Score: 25
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.07
    Marker Score: 21
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.07
    Marker Score: 17
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.06
    Marker Score: 110
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.06
    Marker Score: 21
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.06
    Marker Score: 17.5
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.06
    Marker Score: 40
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.06
    Marker Score: 101
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.05
    Marker Score: 34
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.05
    Marker Score: 48
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.05
    Marker Score: 49
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.05
    Marker Score: 21
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.05
    Marker Score: 20
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.05
    Marker Score: 2545
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.05
    Marker Score: 605
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.04
    Marker Score: 70
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.04
    Marker Score: 55
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.04
    Marker Score: 20
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.04
    Marker Score: 14
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.04
    Marker Score: 11
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.04
    Marker Score: 76
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.04
    Marker Score: 91
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.04
    Marker Score: 38
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.04
    Marker Score: 19
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.04
    Marker Score: 21
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.04
    Marker Score: 42
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.03
    Marker Score: 20
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.03
    Marker Score: 36
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.03
    Marker Score: 420
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.03
    Marker Score: 18
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.03
    Marker Score: 19
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.03
    Marker Score: 44

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * Protein type: Membrane protein * Ensembl ID: ENSG00000178772 * Molecular weight: 110 kDa * Subcellular localization: Cytoplasm * Tissue expression: Kidney, liver, and other tissues * Functional domains: * Catalytic domain: Located in the central region of the protein, responsible for protein-protein interactions. * Cysteine-rich domain: Located on the N-terminus, involved in protein-protein interactions and regulation. * Thrombin-binding domain: Located on the C-terminus, involved in the regulation of the complement cascade. **Pathways and functions:** * **Protein stability:** CPN2 is a chaperone protein that helps to maintain the correct folding and stability of other proteins in the endoplasmic reticulum. * **Complement cascade:** CPN2 is a regulator of the complement cascade, a complex network of proteins involved in the innate immune response. It acts as a negative regulator of the cascade, preventing the formation of harmful complement fragments that could damage tissues. * **Extracellular matrix remodeling:** CPN2 is involved in the remodeling of the extracellular matrix, a network of proteins and proteoglycans that supports cell adhesion and migration. **Clinical significance:** * Mutations in the CPN2 gene have been linked to several human diseases, including kidney disease, liver disease, and cancer. * CPN2 inhibitors are being investigated as potential treatments for these diseases, as they could potentially slow or prevent the progression of these conditions. **Additional notes:** * CPN2 is a highly conserved protein, with similar sequences found in organisms from yeast to humans. * It is a member of the carboxypeptidase family of enzymes, which are involved in a variety of cellular processes, including protein degradation, cell signaling, and extracellular matrix remodeling.

Genular Protein ID: 1626644585

Symbol: CPN2_HUMAN

Name: Carboxypeptidase N subunit 2

UniProtKB Accession Codes:

P22792 B2RPE7 Q86SU4 Q8N5V4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EMBL 7 Ensembl 2 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MEROPS 2 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 3 SMART 4 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2378615

Title: The deduced protein sequence of the human carboxypeptidase N high molecular weight subunit reveals the presence of leucine-rich tandem repeats.

PubMed ID: 2378615

DOI: 10.1016/s0021-9258(19)40187-7

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3408501

Title: Amino acid sequence of the N-terminus and selected tryptic peptides of the active subunit of human plasma carboxypeptidase N: comparison with other carboxypeptidases.

PubMed ID: 3408501

DOI: 10.1016/0006-291x(88)90284-7

PubMed ID: 14760718

Title: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry.

PubMed ID: 14760718

DOI: 10.1002/pmic.200300556

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

Sequence Information:

  • Length: 545
  • Mass: 60557
  • Checksum: 221AAF04413665AF
  • Sequence:
    • MLPGAWLLWT SLLLLARPAQ PCPMGCDCFV QEVFCSDEEL ATVPLDIPPY TKNIIFVETS 
FTTLETRAFG SNPNLTKVVF LNTQLCQFRP DAFGGLPRLE DLEVTGSSFL NLSTNIFSNL 
TSLGKLTLNF NMLEALPEGL FQHLAALESL HLQGNQLQAL PRRLFQPLTH LKTLNLAQNL 
LAQLPEELFH PLTSLQTLKL SNNALSGLPQ GVFGKLGSLQ ELFLDSNNIS ELPPQVFSQL 
FCLERLWLQR NAITHLPLSI FASLGNLTFL SLQWNMLRVL PAGLFAHTPC LVGLSLTHNQ 
LETVAEGTFA HLSNLRSLML SYNAITHLPA GIFRDLEELV KLYLGSNNLT ALHPALFQNL 
SKLELLSLSK NQLTTLPEGI FDTNYNLFNL ALHGNPWQCD CHLAYLFNWL QQYTDRLLNI 
QTYCAGPAYL KGQVVPALNE KQLVCPVTRD HLGFQVTWPD ESKAGGSWDL AVQERAARSQ 
CTYSNPEGTV VLACDQAQCR WLNVQLSPQQ GSLGLQYNAS QEWDLRSSCG SLRLTVSIEA 
RAAGP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.