Genular: Defining Cellular Identity and Function

Details for: Emp2

Gene ID: 13731

Symbol: Emp2

Ensembl ID: ENSMUSG00000022505

Description: epithelial membrane protein 2

Associated with

Actin-mediated cell contraction
(GO:0070252)
Actin filament organization
(GO:0007015)
Activation of protein kinase activity
(GO:0032147)
Apical part of cell
(GO:0045177)
Apical plasma membrane
(GO:0016324)
Apoptotic process
(GO:0006915)
Bleb assembly
(GO:0032060)
Blood vessel endothelial cell migration
(GO:0043534)
Caveola
(GO:0005901)
Caveola assembly
(GO:0070836)
Cell-matrix adhesion
(GO:0007160)
Cell adhesion
(GO:0007155)
Cell migration
(GO:0016477)
Cell surface
(GO:0009986)
Cytoplasm
(GO:0005737)
Cytoplasmic vesicle
(GO:0031410)
Early endosome to late endosome transport
(GO:0045022)
Embryo implantation
(GO:0007566)
Embryonic process involved in female pregnancy
(GO:0060136)
Golgi apparatus
(GO:0005794)
Heart formation
(GO:0060914)
Integrin binding
(GO:0005178)
Kinase binding
(GO:0019900)
Membrane
(GO:0016020)
Membrane raft
(GO:0045121)
Membrane raft assembly
(GO:0001765)
Natural killer cell proliferation
(GO:0001787)
Neutrophil migration
(GO:1990266)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Plasma membrane raft assembly
(GO:0044854)
Positive regulation of angiogenesis
(GO:0045766)
Positive regulation of cardiac epithelial to mesenchymal transition
(GO:0062043)
Positive regulation of cell-matrix adhesion
(GO:0001954)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of integrin-mediated signaling pathway
(GO:2001046)
Protein kinase binding
(GO:0019901)
Protein localization to cell surface
(GO:0034394)
Protein localization to plasma membrane
(GO:0072659)
Regulation of angiogenesis
(GO:0045765)
Regulation of cell-matrix adhesion
(GO:0001952)
Regulation of endothelial cell migration
(GO:0010594)
Regulation of glomerular filtration
(GO:0003093)
Regulation of kinase activity
(GO:0043549)
Regulation of vasculogenesis
(GO:2001212)
T cell mediated cytotoxicity
(GO:0001913)

Other Information

Proteins

Epithelial membrane protein 2
Q8BPC2_MOUSE

Genular Protein ID: 969102657

Symbol: EMP2_MOUSE

Name: Epithelial membrane protein 2

UniProtKB Accession Codes:

O88662

Database IDs:

Citations:

PubMed ID: 9615230

Title: Chromosomal mapping of Tmp (Emp1), Xmp (Emp2), and Ymp (Emp3), genes encoding membrane proteins related to Pmp22.

PubMed ID: 9615230

DOI: 10.1006/geno.1998.5238

PubMed ID: 12189152

Title: The tetraspan protein epithelial membrane protein-2 interacts with beta1 integrins and regulates adhesion.

PubMed ID: 12189152

DOI: 10.1074/jbc.m206868200

PubMed ID: 12763482

Title: The tetraspan protein EMP2 increases surface expression of class I major histocompatibility complex proteins and susceptibility to CTL-mediated cell death.

PubMed ID: 12763482

DOI: 10.1016/s1521-6616(03)00048-2

PubMed ID: 12710941

Title: Epithelial membrane protein-2 is expressed in discrete anatomical regions of the eye.

PubMed ID: 12710941

DOI: 10.1016/s0014-4800(03)00009-1

PubMed ID: 14978215

Title: The tetraspan protein EMP2 modulates the surface expression of caveolins and glycosylphosphatidyl inositol-linked proteins.

PubMed ID: 14978215

DOI: 10.1091/mbc.e03-07-0488

PubMed ID: 16216233

Title: Epithelial membrane protein-2 regulates surface expression of alphavbeta3 integrin in the endometrium.

PubMed ID: 16216233

DOI: 10.1016/j.ydbio.2005.09.003

PubMed ID: 16487956

Title: Knockdown of the tetraspan protein epithelial membrane protein-2 inhibits implantation in the mouse.

PubMed ID: 16487956

DOI: 10.1016/j.ydbio.2006.01.015

PubMed ID: 17609206

Title: The tetraspan protein EMP2 regulates expression of caveolin-1.

PubMed ID: 17609206

DOI: 10.1074/jbc.m702117200

PubMed ID: 18400107

Title: Steroid hormone regulation of EMP2 expression and localization in the endometrium.

PubMed ID: 18400107

DOI: 10.1186/1477-7827-6-15

PubMed ID: 28295343

Title: Epithelial membrane protein 2 (EMP2) deficiency alters placental angiogenesis, mimicking features of human placental insufficiency.

PubMed ID: 28295343

DOI: 10.1002/path.4893

PubMed ID: 30773261

Title: Loss of Emp2 compromises cardiogenic differentiation in mouse embryonic stem cells.

PubMed ID: 30773261

DOI: 10.1016/j.bbrc.2019.02.048

PubMed ID: 31550239

Title: Epithelial membrane protein 2 governs transepithelial migration of neutrophils into the airspace.

PubMed ID: 31550239

DOI: 10.1172/jci127144

Sequence Information:

Length: 172
Mass: 19747
Checksum: 6110C073BC75FB6D
Sequence:

MLVILAFIIV FHIVSTALLF ISTIDNAWWV GDSFSADLWR VCTNSTNCTE INELTGPEAF 
EGYSVMQAVQ ATMILSTILS CISFLIFLLQ LFRLKQGERF VLTSIIQLMS CLCVMIGASI 
YTDRRQDLHQ QNRKLYYLLQ EGSYGYSFIL AWVAFAFTFI SGLMYMILRK RK

Genular Protein ID: 4182635530

Symbol: Q8BPC2_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8BPC2

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 171
Mass: 19447
Checksum: 08EDE86A0FDC5034
Sequence:

MLVILAFIIV FHIVSTALLF ISTIDNAWWV GDSFSADLWR VCTNSTNCTE INELTGPEAF 
EGYSVMQAVQ ATMILSTILS CISFLIFLLQ LFRLKQGERF VLTSIIQLMS CLCVMIGASI 
YTDRRQDLHQ QNRKLYYLLQ EGSYGYSFIL GLGGLCLHFH QRPHVHDPEE A

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Emp2

Associated with

Other Information

Chromosomal mapping of Tmp (Emp1), Xmp (Emp2), and Ymp (Emp3), genes encoding membrane proteins related to Pmp22. PubMed ID: 9615230

The tetraspan protein epithelial membrane protein-2 interacts with beta1 integrins and regulates adhesion. PubMed ID: 12189152

The tetraspan protein EMP2 increases surface expression of class I major histocompatibility complex proteins and susceptibility to CTL-mediated cell death. PubMed ID: 12763482

Epithelial membrane protein-2 is expressed in discrete anatomical regions of the eye. PubMed ID: 12710941

The tetraspan protein EMP2 modulates the surface expression of caveolins and glycosylphosphatidyl inositol-linked proteins. PubMed ID: 14978215

Epithelial membrane protein-2 regulates surface expression of alphavbeta3 integrin in the endometrium. PubMed ID: 16216233

Knockdown of the tetraspan protein epithelial membrane protein-2 inhibits implantation in the mouse. PubMed ID: 16487956

The tetraspan protein EMP2 regulates expression of caveolin-1. PubMed ID: 17609206

Steroid hormone regulation of EMP2 expression and localization in the endometrium. PubMed ID: 18400107

Epithelial membrane protein 2 (EMP2) deficiency alters placental angiogenesis, mimicking features of human placental insufficiency. PubMed ID: 28295343

Loss of Emp2 compromises cardiogenic differentiation in mouse embryonic stem cells. PubMed ID: 30773261

Epithelial membrane protein 2 governs transepithelial migration of neutrophils into the airspace. PubMed ID: 31550239

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073