Details for: CPT1B

Gene ID: 1375

Symbol: CPT1B

Ensembl ID: ENSG00000205560

Description: carnitine palmitoyltransferase 1B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.09
    Marker Score: 17090
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.05
    Marker Score: 1993
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 795
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71830
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48055
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5318
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.92
    Marker Score: 1869
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2739
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.76
    Marker Score: 691
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.71
    Marker Score: 283
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.69
    Marker Score: 413
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2863.5
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.63
    Marker Score: 484
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.59
    Marker Score: 247
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.57
    Marker Score: 188
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.5
    Marker Score: 238
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.48
    Marker Score: 17668
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.46
    Marker Score: 28068
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.44
    Marker Score: 4100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.43
    Marker Score: 657
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.41
    Marker Score: 111
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.38
    Marker Score: 168
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.36
    Marker Score: 3080
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.36
    Marker Score: 843
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.35
    Marker Score: 272
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.35
    Marker Score: 13402
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.35
    Marker Score: 3341
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.34
    Marker Score: 1325
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.34
    Marker Score: 6735
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.34
    Marker Score: 1394
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.33
    Marker Score: 129
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.33
    Marker Score: 6964
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.3
    Marker Score: 158
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.28
    Marker Score: 279
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.28
    Marker Score: 4128
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.27
    Marker Score: 86
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.27
    Marker Score: 2048
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.24
    Marker Score: 77
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 72
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.21
    Marker Score: 351
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.2
    Marker Score: 85
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.2
    Marker Score: 2690
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.2
    Marker Score: 174
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.2
    Marker Score: 696.5
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.19
    Marker Score: 759
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.18
    Marker Score: 49
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.18
    Marker Score: 482
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.18
    Marker Score: 82
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.18
    Marker Score: 136
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.17
    Marker Score: 117
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.16
    Marker Score: 405
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.16
    Marker Score: 50
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.15
    Marker Score: 193
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.15
    Marker Score: 141
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.14
    Marker Score: 51
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.14
    Marker Score: 338
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.14
    Marker Score: 55
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.14
    Marker Score: 53
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.13
    Marker Score: 42
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.13
    Marker Score: 33
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.13
    Marker Score: 53
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.13
    Marker Score: 82
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.13
    Marker Score: 41
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.13
    Marker Score: 89
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 0.12
    Marker Score: 443.5
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.12
    Marker Score: 54
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.12
    Marker Score: 81
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.12
    Marker Score: 79
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.11
    Marker Score: 3850
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.11
    Marker Score: 75
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.11
    Marker Score: 65
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.11
    Marker Score: 120
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.11
    Marker Score: 55
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.11
    Marker Score: 26
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.11
    Marker Score: 540
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.11
    Marker Score: 126
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.11
    Marker Score: 68
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.11
    Marker Score: 45
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.11
    Marker Score: 369
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.11
    Marker Score: 270
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.11
    Marker Score: 149
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1
    Marker Score: 43
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.1
    Marker Score: 45
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.1
    Marker Score: 2298
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.1
    Marker Score: 104
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.1
    Marker Score: 61
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.1
    Marker Score: 20
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.1
    Marker Score: 26

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Other Information

**Key characteristics:** - Function: Carnitine palmitoyltransferase 1B is an enzyme that catalyzes the transfer of a palmitoyl group from palmitate to a keto acid. - Subcellular localization: It is found in the mitochondria and the cytoplasm of eukaryotic cells. - Regulation: CPT1B expression is regulated by various factors, including nutrient availability, hormones, and environmental cues. **Pathways and functions:** - Carnitine metabolic process: CPT1B is involved in the biosynthesis of carnitine, a conjugate of acetyl-CoA and palmitate. - Carnitine shuttle: Carnitine acts as a shuttle molecule, transporting carnitine between the mitochondria and the cytoplasm. - Fatty acid beta-oxidation: CPT1B is involved in the beta-oxidation of fatty acids, a process that generates energy and reduces the ketone body. - Fatty acid metabolism: Carnitine is also involved in the metabolism of fatty acids, including the synthesis of ketone bodies and the production of energy. **Clinical significance:** - Carnitine palmitoyltransferase 1B gene variants have been linked to various diseases, including heart disease, stroke, and metabolic disorders. - Mutations in CPT1B can lead to the accumulation of carnitine in the blood, which can result in conditions such as carnitine palmitoyltransferase deficiency. - Understanding the role of CPT1B in carnitine metabolism may lead to the development of new therapeutic strategies for diseases associated with carnitine deficiency.

Genular Protein ID: 3003127712

Symbol: CPT1B_HUMAN

Name: Carnitine O-palmitoyltransferase 1, muscle isoform

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8679700

Title: Isolation and characterization of cDNA and genomic clones encoding human muscle type carnitine palmitoyltransferase I.

PubMed ID: 8679700

DOI: 10.1016/0167-4781(96)00069-3

PubMed ID: 9344464

Title: Functional studies of yeast-expressed human heart muscle carnitine palmitoyltransferase I.

PubMed ID: 9344464

DOI: 10.1006/abbi.1997.0314

PubMed ID: 9070950

Title: Fine chromosome mapping of the genes for human liver and muscle carnitine palmitoyltransferase I (CPT1A and CPT1B).

PubMed ID: 9070950

DOI: 10.1006/geno.1996.4539

PubMed ID: 9199240

Title: Localization and intron usage analysis of the human CPT1B gene for muscle type carnitine palmitoyltransferase I.

PubMed ID: 9199240

DOI: 10.1016/s0167-4781(97)00037-7

PubMed ID: 9224698

Title: Structural features of the gene encoding human muscle type carnitine palmitoyltransferase I.

PubMed ID: 9224698

DOI: 10.1016/s0014-5793(97)00561-9

PubMed ID: 11258795

Title: Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping.

PubMed ID: 11258795

DOI: 10.1093/dnares/8.1.1

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

Sequence Information:

  • Length: 772
  • Mass: 87801
  • Checksum: F7E3ED40643DFC81
  • Sequence:
  • MAEAHQAVAF QFTVTPDGVD FRLSREALKH VYLSGINSWK KRLIRIKNGI LRGVYPGSPT 
    SWLVVIMATV GSSFCNVDIS LGLVSCIQRC LPQGCGPYQT PQTRALLSMA IFSTGVWVTG 
    IFFFRQTLKL LLCYHGWMFE MHGKTSNLTR IWAMCIRLLS SRHPMLYSFQ TSLPKLPVPR 
    VSATIQRYLE SVRPLLDDEE YYRMELLAKE FQDKTAPRLQ KYLVLKSWWA SNYVSDWWEE 
    YIYLRGRSPL MVNSNYYVMD LVLIKNTDVQ AARLGNIIHA MIMYRRKLDR EEIKPVMALG 
    IVPMCSYQME RMFNTTRIPG KDTDVLQHLS DSRHVAVYHK GRFFKLWLYE GARLLKPQDL 
    EMQFQRILDD PSPPQPGEEK LAALTAGGRV EWAQARQAFF SSGKNKAALE AIERAAFFVA 
    LDEESYSYDP EDEASLSLYG KALLHGNCYN RWFDKSFTLI SFKNGQLGLN AEHAWADAPI 
    IGHLWEFVLG TDSFHLGYTE TGHCLGKPNP ALAPPTRLQW DIPKQCQAVI ESSYQVAKAL 
    ADDVELYCFQ FLPFGKGLIK KCRTSPDAFV QIALQLAHFR DRGKFCLTYE ASMTRMFREG 
    RTETVRSCTS ESTAFVQAMM EGSHTKADLR DLFQKAAKKH QNMYRLAMTG AGIDRHLFCL 
    YLVSKYLGVS SPFLAEVLSE PWRLSTSQIP QSQIRMFDPE QHPNHLGAGG GFGPVADDGY 
    GVSYMIAGEN TIFFHISSKF SSSETNAQRF GNHIRKALLD IADLFQVPKA YS

Genular Protein ID: 1248533555

Symbol: A5PLL0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 772
  • Mass: 87702
  • Checksum: 887E0F85537222C6
  • Sequence:
  • MAEAHQAVAF QFTVTPDGVD FRLSREALKH VYLSGINSWK KRLIRIKNGI LRGVYPGSPT 
    SWLVVIMATV GSSFCNVDIS LGLVSCIQRC LPQGCGPYQT PQTRALLSMA IFSTGVWVTG 
    IFFFRQTLKL LLCYHGWMFE MHGKTSNLTR IWAMCIRLLS SRHPMLYSFQ TSLPKLPVPR 
    VSATIQRYLE SVRPLLDDEE YYRMELLAKE FQDKTAPRLQ KYLVLKSWWA SNYVSDWWEE 
    YIYLRGRSPL MVNSNYYVMD LVLIKNTDVQ AARLGNIIHA MIMYRRKLDR EEIKPVMALG 
    IVPMCSYQME GMFNTTRIPG KDTDVLQHLS DSRHVAVYHK GRFFKLWLYE GARLLKPQDL 
    EMQFQRILDD PSPPQPGEEK LAALTAGGRV EWAQARQAFF SSGKNKAALE AIERAAFFVA 
    LDEESYSYDP EDEASLSLYG KALLHGNCYN RWFDKSFTLI SFKNGQLGLN AEHAWADAPI 
    IGHLWEFVLG TDSFHLGYTE TGHCLGKPNP ALAPPTRLQW DIPKQCQAVI ESSYQVAKAL 
    ADDVELYCFQ FLPFGKGLIK KCRTSPDAFV QIALQLAHFR DRGKFCLTYE ASMTRMFREG 
    RTETVRSCTS ESTAFVQAMM EGSHTKADLR DLFQKAAKKH QNMYRLAMTG AGIDRHLFCL 
    YLVSKYLGVS SPFLAEVLSE PWRLSTSQIP QSQIRMFDPE QHPNHLGAGG GFGPVADDGY 
    GVSYMIAGEN TIFFHISSKF SSSETNAQRF GNHIRKALLD IADLFQVPKA YS

Genular Protein ID: 1268362392

Symbol: Q53FV7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8125298

Title: Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.

PubMed ID: 8125298

DOI: 10.1016/0378-1119(94)90802-8

PubMed ID: 9373149

Title: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.

PubMed ID: 9373149

DOI: 10.1016/S0378-1119(97)00411-3

Sequence Information:

  • Length: 772
  • Mass: 87786
  • Checksum: 70B6F159BB023883
  • Sequence:
  • MAEAHQAVAF QFTVTPDGVD FRLSREALKH VYLSGINSWK KRLIRIKNGI LRGVYPGSPT 
    SWLVVIMATV GSSFCNVDIS LGLVSCIQRC LPQGCGPYQT PQTRALLSMA IFSTGVWVTG 
    IFFFRQTLKL LLCYHGWMFE MHGKTSNLTR IWAMCIRLLS SRHPMLYSFQ TSLPKLPVPR 
    VSATIQRYLE SVRPLLDDEE YYRMELLAKE FQDKTAPRLQ KYLVLKSWWA SNYVSDWWEE 
    YIYLRGRSPL MVNSNYYVMD LVLIKNTDVQ AARLGNIIHA MIMYRRKLDR EEIKPVMALG 
    IVPMCSYQME RMFNTTRIPG NDTDVLQHLS DSRHVAVYHK GRFFKLWLYE GARLLKPQDL 
    EMQFQRILDD PSPPQPGEEK LAALTAGGRV EWAQARQAFF SSGKNKAALE AIERAAFFVA 
    LDEESYSYDP EDEASLSLYG KALLHGNCYN RWFDKSFTLI SFKNGQLGLN AEHAWADAPI 
    IGHLWEFVLG TDSFHLGYTE TGHCLGKPNP ALAPPTRLQW DIPKQCQAVI KSSYQVAKAL 
    ADDVELYCFQ FLPFGKGLIK KCRTSPDAFV QIALQLAHFR DRGKFCLTYE ASMTRMFREG 
    RTETVRSCTS ESTAFVQAMM EGSHTKADLR DLFQKAAKKH QNMYRLAMTG AGIDRHLFCL 
    YLVSKYLGVS SPFLAEVLSE PWRLSTSQIP QSQIRMFDPE QHPNHLGAGG GFGPVADDGY 
    GVSYMIAGEN TIFFHISSKF SSSETNAQRF GNHIRKALLD IADLFQVPKA YS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.