Details for: CR1

Gene ID: 1378

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: CR1

Ensembl ID: ENSG00000203710

Description: complement C3b/C4b receptor 1 (Knops blood group)

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • Hofbauer cell CL3000001
    CSI 11.21
    rCSI 21.17%
    PRS 92.99
  • podocyte CL0000653
    CSI 6.92
    rCSI 30.74%
    PRS 87.96
  • class switched memory B cell CL0000972
    CSI 4.82
    rCSI 3.6%
    PRS 95.15
  • unswitched memory B cell CL0000970
    CSI 4.22
    rCSI 3.55%
    PRS 95.95
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 3.49
    rCSI 9.1%
    PRS 88.52
  • immature B cell CL0000816
    CSI 3.41
    rCSI 2.53%
    PRS 94.42
  • naive B cell CL0000788
    CSI 3.26
    rCSI 2.8%
    PRS 91.16
  • CD14-positive monocyte CL0001054
    CSI 3.04
    rCSI 3.78%
    PRS 93.67
  • mature B cell CL0000785
    CSI 2.88
    rCSI 2.5%
    PRS 94.01
  • follicular dendritic cell CL0000442
    CSI 2.84
    rCSI 45.62%
    PRS 92.46
  • Kupffer cell CL0000091
    CSI 2.82
    rCSI 6.45%
    PRS 88.2
  • elicited macrophage CL0000861
    CSI 2.61
    rCSI 2.4%
    PRS 92.71
  • lung interstitial macrophage CL4033043
    CSI 2.56
    rCSI 5.75%
    PRS 95.31
  • plasmablast CL0000980
    CSI 2.36
    rCSI 1.86%
    PRS 90.4
  • neutrophil CL0000775
    CSI 2.05
    rCSI 11.45%
    PRS 85.6
  • erythrocyte CL0000232
    CSI 1.93
    rCSI 4.38%
    PRS 86.42
  • granulocyte CL0000094
    CSI 1.76
    rCSI 2.69%
    PRS 92.48
  • mononuclear phagocyte CL0000113
    CSI 1.75
    rCSI 3.86%
    PRS 90.03
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 1.72
    rCSI 1.33%
    PRS 90.44
  • basophil CL0000767
    CSI 1.72
    rCSI 3.63%
    PRS 94.04
  • CD14-positive, CD16-positive monocyte CL0002397
    CSI 1.65
    rCSI 2.16%
    PRS 94.51
  • lung macrophage CL1001603
    CSI 1.15
    rCSI 2.57%
    PRS 92.39
  • intermediate monocyte CL0002393
    CSI 1.11
    rCSI 1.68%
    PRS 91.71

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [CR1](/details-gene/1378), or Complement Receptor type 1, is a protein-coding gene located on chromosome 1q32.2. It functions as a key receptor for the complement components C3b and C4b, playing a central role in the innate immune system. As a member of the regulators of complement activation (RCA) family, [CR1](/details-gene/1378) is integral to the clearance of immune complexes and pathogens opsonized with complement fragments, as well as in the negative regulation of the complement cascade. Expression data reveals its significance not only in a wide range of myeloid and lymphoid cells, including B cells, monocytes, and macrophages, but also in specialized non-hematopoietic cells such as kidney [podocyte](/details-cell/CL0000653). Clinically, polymorphisms and expression levels of [CR1](/details-gene/1378) are associated with susceptibility to various autoimmune and infectious diseases ([120620](https://omim.org/entry/120620)). ## Cellular Roles and Expression Landscape **Overall**, the expression profile of [CR1](/details-gene/1378) highlights its multifaceted role in the immune system and in specific tissue-resident cell types. It exhibits its highest significance scores in cells central to immune surveillance and clearance. The gene is an exceptionally strong marker for placental [Hofbauer cell](/details-cell/CL3000001) (CSI: 11.21) and kidney [podocyte](/details-cell/CL0000653) (CSI: 6.92), suggesting highly specialized functions in maternal-fetal immunity and glomerular filtration barrier maintenance, respectively. Within the hematopoietic system, [CR1](/details-gene/1378) is a defining feature of the B cell lineage. It is highly significant across various developmental stages, including [class switched memory B cell](/details-cell/CL0000972) (CSI: 4.82), [unswitched memory B cell](/details-cell/CL0000970) (CSI: 4.22), [immature B cell](/details-cell/CL0000816) (CSI: 3.41), and [naive B cell](/details-cell/CL0000788) (CSI: 3.26). Its presence on [follicular dendritic cell](/details-cell/CL0000442) (CSI: 2.84) further supports its role in trapping and presenting antigen-antibody complexes during the germinal center reaction. Furthermore, [CR1](/details-gene/1378) is a prominent marker for various professional phagocytes. It shows high significance in tissue-resident macrophages like [kidney interstitial alternatively activated macrophage](/details-cell/CL1000695) (CSI: 3.49) and hepatic [Kupffer cell](/details-cell/CL0000091) (CSI: 2.82), as well as in circulating [CD14-positive monocyte](/details-cell/CL0001054) (CSI: 3.04) and granulocytic [neutrophil](/details-cell/CL0000775) (CSI: 2.05). This broad expression pattern is consistent with its canonical function in clearing opsonized particles from circulation and tissues. ## Pathways and Molecular Function The molecular functions of [CR1](/details-gene/1378) are centered on its ability to interact with the complement system. Its primary activities include [complement component c3b binding](/details-ontology/GO:0001851) and [complement component c4b binding](/details-ontology/GO:0001855), as established by mutagenesis studies ([Link](https://doi.org/10.1084/jem.168.5.1699)). These binding activities are crucial for its role as a receptor on the [plasma membrane](/details-ontology/GO:0005886). Biologically, [CR1](/details-gene/1378) is a key participant in the [Complement cascade](/details-pathway/R-HSA-166658) and its regulation ([R-HSA-977606](https://reactome.org/content/detail/R-HSA-977606)). It contributes to both the [complement activation, alternative pathway](/details-ontology/GO:0006957) and the [complement activation, classical pathway](/details-ontology/GO:0006958). A major role is the process of [immune complex clearance by erythrocytes](/details-ontology/GO:0002435), which prevents the deposition of immune complexes in tissues ([Link](https://pubmed.ncbi.nlm.nih.gov/2963069/)). Beyond its direct role in the complement cascade, [CR1](/details-gene/1378) also modulates adaptive immune responses. Functional annotations suggest it is involved in the [negative regulation of immunoglobulin production](/details-ontology/GO:0002638) and [negative regulation of t cell proliferation](/details-ontology/GO:0042130). This is further supported by its involvement in the Reactome pathway [Runx1 and foxp3 control the development of regulatory t lymphocytes (tregs)](https://reactome.org/content/detail/R-HSA-8877330), indicating a role in maintaining immune homeostasis. ## Research Directions The expression and functional data for [CR1](/details-gene/1378) point toward several compelling areas for future investigation, particularly concerning its role in tissue-specific pathology and immune regulation. ### Testable Hypotheses 1. **Hypothesis 1:** Given its exceptionally high significance in [podocyte](/details-cell/CL0000653) and its function in regulating complement, we hypothesize that [CR1](/details-gene/1378) acts as a critical cytoprotective factor for the glomerulus. Reduced expression or functional polymorphisms in [CR1](/details-gene/1378) on podocytes may lead to increased susceptibility to complement-mediated injury in diseases like lupus nephritis or membranous nephropathy. 2. **Hypothesis 2:** The high CSI of [CR1](/details-gene/1378) in placental [Hofbauer cell](/details-cell/CL3000001), combined with its annotated [virus receptor activity](/details-ontology/GO:0001618), suggests a vital role in defending the fetal-maternal interface. We hypothesize that [CR1](/details-gene/1378) on these placental macrophages is essential for the capture and clearance of opsonized pathogens, thereby preventing vertical transmission and managing local inflammation during gestation. ### Proposed Experiment To test **Hypothesis 1**, one could utilize an *in vitro* model of complement-mediated podocyte injury. Human primary podocytes or an immortalized podocyte cell line would be transfected with siRNA or modified using CRISPR-Cas9 to knock down [CR1](/details-gene/1378) expression. These [CR1](/details-gene/1378)-deficient podocytes, along with control cells, would then be exposed to complement-fixing immune complexes or serum from patients with active lupus nephritis. The primary readouts would be: (i) quantification of C3b and C5b-9 (membrane attack complex) deposition on the cell surface using immunofluorescence microscopy, (ii) assessment of cell viability and apoptosis via assays for LDH release and cleaved caspase-3, and (iii) analysis of podocyte stress marker expression (e.g., desmin) and cytoskeletal integrity using Western blotting and phalloidin staining. A significant increase in complement deposition and cell injury in the knockdown cells would validate the protective role of [CR1](/details-gene/1378). ### Therapeutic Potential The function of [CR1](/details-gene/1378) as a negative regulator of the complement cascade makes it an attractive therapeutic candidate. The strategy would not be to inhibit the receptor but rather to leverage its function. A soluble, recombinant form of [CR1](/details-gene/1378) could act as a potent systemic inhibitor of complement activation. This approach holds promise for acute and chronic inflammatory conditions driven by excessive complement activity, such as ischemia-reperfusion injury, autoimmune diseases like systemic lupus erythematosus, and complement-mediated renal disorders. By mimicking the natural regulatory mechanism, a soluble [CR1](/details-gene/1378) therapeutic could dampen inflammation and prevent tissue damage with high specificity.

Genular Protein ID: 2037846987

Symbol: CR1_HUMAN

Name: Complement receptor type 1

UniProtKB Accession Codes:

P17927 Q16744 Q16745 Q5SR43 Q5SR45 Q9UQV2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 83 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 35 Gene3D 1 GeneCards 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NIAGADS 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2972794

Title: Identification of distinct C3b and C4b recognition sites in the human C3b/C4b receptor (CR1, CD35) by deletion mutagenesis.

PubMed ID: 2972794

DOI: 10.1084/jem.168.5.1699

PubMed ID: 8245463

Title: Structure of the gene for the F allele of complement receptor type 1 and sequence of the coding region unique to the S allele.

PubMed ID: 8245463

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 2564414

Title: Structure of the human CR1 gene. Molecular basis of the structural and quantitative polymorphisms and identification of a new CR1-like allele.

PubMed ID: 2564414

DOI: 10.1084/jem.169.3.847

PubMed ID: 2971757

Title: Identification of an alternative polyadenylation site in the human C3b/C4b receptor (complement receptor type 1) transcriptional unit and prediction of a secreted form of complement receptor type 1.

PubMed ID: 2971757

DOI: 10.1084/jem.168.4.1255

PubMed ID: 2951479

Title: Human C3b/C4b receptor (CR1). Demonstration of long homologous repeating domains that are composed of the short consensus repeats characteristics of C3/C4 binding proteins.

PubMed ID: 2951479

DOI: 10.1084/jem.165.4.1095

PubMed ID: 2933745

Title: Identification of a partial cDNA clone for the human receptor for complement fragments C3b/C4b.

PubMed ID: 2933745

DOI: 10.1073/pnas.82.22.7711

PubMed ID: 6233222

Title: C3b receptor (CR1) on erythrocytes in various diseases.

PubMed ID: 6233222

DOI: 10.1016/0165-2478(84)90089-0

PubMed ID: 2963069

Title: The clearance of tetanus toxoid/anti-tetanus toxoid immune complexes from the circulation of humans. Complement- and erythrocyte complement receptor 1-dependent mechanisms.

PubMed ID: 2963069

PubMed ID: 1708808

Title: Molecular interactions of complement receptors on B lymphocytes: a CR1/CR2 complex distinct from the CR2/CD19 complex.

PubMed ID: 1708808

DOI: 10.1084/jem.173.5.1083

PubMed ID: 1385479

Title: Expression and localization of proteins of the complement system in human skin.

PubMed ID: 1385479

DOI: 10.1172/jci116080

PubMed ID: 1534036

Title: Distribution and quantitative expression of the complement receptor type 1 (CR1) on human peripheral blood T lymphocytes.

PubMed ID: 1534036

DOI: 10.1016/0008-8749(92)90277-v

PubMed ID: 8175757

Title: Analysis of the functional domains of complement receptor type 1 (C3b/C4b receptor; CD35) by substitution mutagenesis.

PubMed ID: 8175757

DOI: 10.1016/s0021-9258(17)36829-1

PubMed ID: 8706338

Title: Structural polymorphisms of complement receptor 1 (CR1) in systemic lupus erythematosus (SLE) patients and normal controls of three ethnic groups.

PubMed ID: 8706338

DOI: 10.1046/j.1365-2249.1996.d01-748.x

PubMed ID: 9324355

Title: Complement receptor type 1 (CR1, CD35) is a receptor for C1q.

PubMed ID: 9324355

DOI: 10.1016/s1074-7613(00)80356-8

PubMed ID: 14694201

Title: A human complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria.

PubMed ID: 14694201

DOI: 10.1073/pnas.0305306101

PubMed ID: 23416052

Title: Human complement receptor type 1/CD35 is an Epstein-Barr Virus receptor.

PubMed ID: 23416052

DOI: 10.1016/j.celrep.2013.01.023

PubMed ID: 23460739

Title: Deciphering complement receptor type 1 interactions with recognition proteins of the lectin complement pathway.

PubMed ID: 23460739

DOI: 10.4049/jimmunol.1202451

PubMed ID: 25742728

Title: Complement receptor type 1 (CR1/CD35) expressed on activated human CD4+ T cells contributes to generation of regulatory T cells.

PubMed ID: 25742728

DOI: 10.1016/j.imlet.2015.02.009

PubMed ID: 29563915

Title: C1q and Mannose-Binding Lectin Interact with CR1 in the Same Region on CCP24-25 Modules.

PubMed ID: 29563915

DOI: 10.3389/fimmu.2018.00453

PubMed ID: 11313284

Title: Molecular identification of Knops blood group polymorphisms found in long homologous region D of complement receptor 1.

PubMed ID: 11313284

DOI: 10.1182/blood.v97.9.2879

PubMed ID: 11896343

Title: Expansion of the Knops blood group system and subdivision of Sl(a).

PubMed ID: 11896343

DOI: 10.1046/j.1537-2995.2002.00002.x

PubMed ID: 11955431

Title: Structure of the C3b binding site of CR1 (CD35), the immune adherence receptor.

PubMed ID: 11955431

DOI: 10.1016/s0092-8674(02)00672-4

Sequence Information:

  • Length: 2039
  • Mass: 223663
  • Checksum: FB01870F19D5E6DD
  • Sequence:
    • MGASSPRSPE PVGPPAPGLP FCCGGSLLAV VVLLALPVAW GQCNAPEWLP FARPTNLTDE 
FEFPIGTYLN YECRPGYSGR PFSIICLKNS VWTGAKDRCR RKSCRNPPDP VNGMVHVIKG 
IQFGSQIKYS CTKGYRLIGS SSATCIISGD TVIWDNETPI CDRIPCGLPP TITNGDFIST 
NRENFHYGSV VTYRCNPGSG GRKVFELVGE PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP 
PNVENGILVS DNRSLFSLNE VVEFRCQPGF VMKGPRRVKC QALNKWEPEL PSCSRVCQPP 
PDVLHAERTQ RDKDNFSPGQ EVFYSCEPGY DLRGAASMRC TPQGDWSPAA PTCEVKSCDD 
FMGQLLNGRV LFPVNLQLGA KVDFVCDEGF QLKGSSASYC VLAGMESLWN SSVPVCEQIF 
CPSPPVIPNG RHTGKPLEVF PFGKTVNYTC DPHPDRGTSF DLIGESTIRC TSDPQGNGVW 
SSPAPRCGIL GHCQAPDHFL FAKLKTQTNA SDFPIGTSLK YECRPEYYGR PFSITCLDNL 
VWSSPKDVCK RKSCKTPPDP VNGMVHVITD IQVGSRINYS CTTGHRLIGH SSAECILSGN 
AAHWSTKPPI CQRIPCGLPP TIANGDFIST NRENFHYGSV VTYRCNPGSG GRKVFELVGE 
PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP PNVENGILVS DNRSLFSLNE VVEFRCQPGF 
VMKGPRRVKC QALNKWEPEL PSCSRVCQPP PDVLHAERTQ RDKDNFSPGQ EVFYSCEPGY 
DLRGAASMRC TPQGDWSPAA PTCEVKSCDD FMGQLLNGRV LFPVNLQLGA KVDFVCDEGF 
QLKGSSASYC VLAGMESLWN SSVPVCEQIF CPSPPVIPNG RHTGKPLEVF PFGKAVNYTC 
DPHPDRGTSF DLIGESTIRC TSDPQGNGVW SSPAPRCGIL GHCQAPDHFL FAKLKTQTNA 
SDFPIGTSLK YECRPEYYGR PFSITCLDNL VWSSPKDVCK RKSCKTPPDP VNGMVHVITD 
IQVGSRINYS CTTGHRLIGH SSAECILSGN TAHWSTKPPI CQRIPCGLPP TIANGDFIST 
NRENFHYGSV VTYRCNLGSR GRKVFELVGE PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP 
PNVENGILVS DNRSLFSLNE VVEFRCQPGF VMKGPRRVKC QALNKWEPEL PSCSRVCQPP 
PEILHGEHTP SHQDNFSPGQ EVFYSCEPGY DLRGAASLHC TPQGDWSPEA PRCAVKSCDD 
FLGQLPHGRV LFPLNLQLGA KVSFVCDEGF RLKGSSVSHC VLVGMRSLWN NSVPVCEHIF 
CPNPPAILNG RHTGTPSGDI PYGKEISYTC DPHPDRGMTF NLIGESTIRC TSDPHGNGVW 
SSPAPRCELS VRAGHCKTPE QFPFASPTIP INDFEFPVGT SLNYECRPGY FGKMFSISCL 
ENLVWSSVED NCRRKSCGPP PEPFNGMVHI NTDTQFGSTV NYSCNEGFRL IGSPSTTCLV 
SGNNVTWDKK APICEIISCE PPPTISNGDF YSNNRTSFHN GTVVTYQCHT GPDGEQLFEL 
VGERSIYCTS KDDQVGVWSS PPPRCISTNK CTAPEVENAI RVPGNRSFFS LTEIIRFRCQ 
PGFVMVGSHT VQCQTNGRWG PKLPHCSRVC QPPPEILHGE HTLSHQDNFS PGQEVFYSCE 
PSYDLRGAAS LHCTPQGDWS PEAPRCTVKS CDDFLGQLPH GRVLLPLNLQ LGAKVSFVCD 
EGFRLKGRSA SHCVLAGMKA LWNSSVPVCE QIFCPNPPAI LNGRHTGTPF GDIPYGKEIS 
YACDTHPDRG MTFNLIGESS IRCTSDPQGN GVWSSPAPRC ELSVPAACPH PPKIQNGHYI 
GGHVSLYLPG MTISYICDPG YLLVGKGFIF CTDQGIWSQL DHYCKEVNCS FPLFMNGISK 
ELEMKKVYHY GDYVTLKCED GYTLEGSPWS QCQADDRWDP PLAKCTSRTH DALIVGTLSG 
TIFFILLIIF LSWIILKHRK GNNAHENPKE VAIHLHSQGG SSVHPRTLQT NEENSRVLP

Genular Protein ID: 285912690

Symbol: E9PDY4_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PDY4

Database IDs:

ARBA 2 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 NIAGADS 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 2 Pfam 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 3 SMART 1 SMR 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 2489
  • Mass: 272924
  • Checksum: B80E2DBF555E6B54
  • Sequence:
    • MGASSPRSPE PVGPPAPGLP FCCGGSLLAV VVLLALPVAW GQCNAPEWLP FARPTNLTDE 
FEFPIGTYLN YECRPGYSGR PFSIICLKNS VWTGAKDRCR RKSCRNPPDP VNGMVHVIKG 
IQFGSQIKYS CTKGYRLIGS SSATCIISGD TVIWDNETPI CDRIPCGLPP TITNGDFIST 
NRENFHYGSV VTYRCNPGSG GRKVFELVGE PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP 
PNVENGILVS DNRSLFSLNE VVEFRCQPGF VMKGPRRVKC QALNKWEPEL PSCSRVCQPP 
PDVLHAERTQ RDKDNFSPGQ EVFYSCEPGY DLRGAASMRC TPQGDWSPAA PTCEVKSCDD 
FMGQLLNGRV LFPVNLQLGA KVDFVCDEGF QLKGSSASYC VLAGMESLWN SSVPVCEQIF 
CPSPPVIPNG RHTGKPLEVF PFGKTVNYTC DPHPDRGTSF DLIGESTIRC TSDPQGNGVW 
SSPAPRCGIL GHCQAPDHFL FAKLKTQTNA SDFPIGTSLK YECRPEYYGR PFSITCLDNL 
VWSSPKDVCK RKSCKTPPDP VNGMVHVITD IQVGSRINYS CTTGHRLIGH SSAECILSGN 
AAHWSTKPPI CQRIPCGLPP TIANGDFIST NRENFHYGSV VTYRCNPGSG GRKVFELVGE 
PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP PNVENGILVS DNRSLFSLNE VVEFRCQPGF 
VMKGPRRVKC QALNKWEPEL PSCSRVCQPP PDVLHAERTQ RDKDNFSPGQ EVFYSCEPGY 
DLRGAASMRC TPQGDWSPAA PTCEVKSCDD FMGQLLNGRV LFPVNLQLGA KVDFVCDEGF 
QLKGSSASYC VLAGMESLWN SSVPVCEQIF CPSPPVIPNG RHTGKPLEVF PFGKTVNYTC 
DPHPDRGTSF DLIGESTIRC TSDPQGNGVW SSPAPRCGIL GHCQAPDHFL FAKLKTQTNA 
SDFPIGTSLK YECRPEYYGR PFSITCLDNL VWSSPKDVCK RKSCKTPPDP VNGMVHVITD 
IQVGSRINYS CTTGHRLIGH SSAECILSGN AAHWSTKPPI CQRIPCGLPP TIANGDFIST 
NRENFHYGSV VTYRCNPGSG GRKVFELVGE PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP 
PNVENGILVS DNRSLFSLNE VVEFRCQPGF VMKGPRRVKC QALNKWEPEL PSCSRVCQPP 
PDVLHAERTQ RDKDNFSPGQ EVFYSCEPGY DLRGAASMRC TPQGDWSPAA PTCEVKSCDD 
FMGQLLNGRV LFPVNLQLGA KVDFVCDEGF QLKGSSASYC VLAGMESLWN SSVPVCEQIF 
CPSPPVIPNG RHTGKPLEVF PFGKAVNYTC DPHPDRGTSF DLIGESTIRC TSDPQGNGVW 
SSPAPRCGIL GHCQAPDHFL FAKLKTQTNA SDFPIGTSLK YECRPEYYGR PFSITCLDNL 
VWSSPKDVCK RKSCKTPPDP VNGMVHVITD IQVGSRINYS CTTGHRLIGH SSAECILSGN 
TAHWSTKPPI CQRIPCGLPP TIANGDFIST NRENFHYGSV VTYRCNLGSR GRKVFELVGE 
PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP PNVENGILVS DNRSLFSLNE VVEFRCQPGF 
VMKGPRRVKC QALNKWEPEL PSCSRVCQPP PEILHGEHTP SHQDNFSPGQ EVFYSCEPGY 
DLRGAASLHC TPQGDWSPEA PRCAVKSCDD FLGQLPHGRV LFPLNLQLGA KVSFVCDEGF 
RLKGSSVSHC VLVGMRSLWN NSVPVCEHIF CPNPPAILNG RHTGTPSGDI PYGKEISYTC 
DPHPDRGMTF NLIGESTIRC TSDPHGNGVW SSPAPRCELS VRAGHCKTPE QFPFASPTIP 
INDFEFPVGT SLNYECRPGY FGKMFSISCL ENLVWSSVED NCRRKSCGPP PEPFNGMVHI 
NTDTQFGSTV NYSCNEGFRL IGSPSTTCLV SGNNVTWDKK APICEIISCE PPPTISNGDF 
YSNNRTSFHN GTVVTYQCHT GPDGEQLFEL VGERSIYCTS KDDQVGVWSS PPPRCISTNK 
CTAPEVENAI RVPGNRSFFT LTEIIRFRCQ PGFVMVGSHT VQCQTNGRWG PKLPHCSRVC 
QPPPEILHGE HTLSHQDNFS PGQEVFYSCE PSYDLRGAAS LHCTPQGDWS PEAPRCTVKS 
CDDFLGQLPH GRVLLPLNLQ LGAKVSFVCD EGFRLKGRSA SHCVLAGMKA LWNSSVPVCE 
QIFCPNPPAI LNGRHTGTPF GDIPYGKEIS YACDTHPDRG MTFNLIGESS IRCTSDPQGN 
GVWSSPAPRC ELSVPAACPH PPKIQNGHYI GGHVSLYLPG MTISYICDPG YLLVGKGFIF 
CTDQGIWSQL DHYCKEVNCS FPLFMNGISK ELEMKKVYHY GDYVTLKCED GYTLEGSPWS 
QCQADDRWDP PLAKCTSRTH DALIVGTLSG TIFFILLIIF LSWIILKHRK GNNAHENPKE 
VAIHLHSQGG SSVHPRTLQT NEENSRVLP