Details for: CR1

Gene ID: 1378

Symbol: CR1

Ensembl ID: ENSG00000203710

Description: complement C3b/C4b receptor 1 (Knops blood group)

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 22.2443
    Cell Significance Index: -3.4600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 20.1464
    Cell Significance Index: -5.1100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 11.6061
    Cell Significance Index: -5.9700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.2564
    Cell Significance Index: -4.0200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.1982
    Cell Significance Index: 34.0100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.7142
    Cell Significance Index: 13.2000
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 0.6293
    Cell Significance Index: 1.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5574
    Cell Significance Index: 65.7300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.0620
    Cell Significance Index: 1.5900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0531
    Cell Significance Index: 29.0100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0296
    Cell Significance Index: 5.8800
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.0129
    Cell Significance Index: 0.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0073
    Cell Significance Index: 2.6200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0007
    Cell Significance Index: -1.3300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0016
    Cell Significance Index: -0.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0025
    Cell Significance Index: -3.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0031
    Cell Significance Index: -5.7300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0045
    Cell Significance Index: -6.1000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0063
    Cell Significance Index: -4.0000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0068
    Cell Significance Index: -5.1200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0071
    Cell Significance Index: -5.2900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0103
    Cell Significance Index: -4.6700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0108
    Cell Significance Index: -6.0700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0134
    Cell Significance Index: -0.2300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0156
    Cell Significance Index: -1.2000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0162
    Cell Significance Index: -4.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0179
    Cell Significance Index: -3.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0186
    Cell Significance Index: -2.7100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0199
    Cell Significance Index: -3.5900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0257
    Cell Significance Index: -5.4200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0307
    Cell Significance Index: -0.4400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0312
    Cell Significance Index: -3.1900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0323
    Cell Significance Index: -4.4400
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0379
    Cell Significance Index: -1.6500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0402
    Cell Significance Index: -5.2000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0406
    Cell Significance Index: -4.9900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0438
    Cell Significance Index: -5.1100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0452
    Cell Significance Index: -5.8000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0475
    Cell Significance Index: -4.9500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0526
    Cell Significance Index: -6.0300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0551
    Cell Significance Index: -2.8700
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0598
    Cell Significance Index: -0.7400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0654
    Cell Significance Index: -1.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0703
    Cell Significance Index: -4.7300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0757
    Cell Significance Index: -1.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0769
    Cell Significance Index: -5.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0794
    Cell Significance Index: -4.8800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0825
    Cell Significance Index: -2.2100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0835
    Cell Significance Index: -5.2600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0872
    Cell Significance Index: -1.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0879
    Cell Significance Index: -5.6700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0920
    Cell Significance Index: -0.7500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0936
    Cell Significance Index: -4.8600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0949
    Cell Significance Index: -4.4600
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0964
    Cell Significance Index: -1.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1010
    Cell Significance Index: -5.6700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1024
    Cell Significance Index: -6.2800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1037
    Cell Significance Index: -1.3100
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: -0.1044
    Cell Significance Index: -0.9600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1048
    Cell Significance Index: -2.6200
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.1069
    Cell Significance Index: -1.4200
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1077
    Cell Significance Index: -2.1100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1147
    Cell Significance Index: -6.0200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1151
    Cell Significance Index: -3.7700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1165
    Cell Significance Index: -4.0800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1181
    Cell Significance Index: -3.7600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1185
    Cell Significance Index: -5.2400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1210
    Cell Significance Index: -3.2300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1296
    Cell Significance Index: -2.1800
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.1403
    Cell Significance Index: -1.7800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1417
    Cell Significance Index: -5.3700
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1422
    Cell Significance Index: -2.0700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1495
    Cell Significance Index: -6.9700
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: -0.1509
    Cell Significance Index: -0.6800
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1511
    Cell Significance Index: -3.6600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1531
    Cell Significance Index: -5.3200
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.1549
    Cell Significance Index: -2.6300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1557
    Cell Significance Index: -4.3500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1588
    Cell Significance Index: -3.1000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1636
    Cell Significance Index: -4.0800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1658
    Cell Significance Index: -3.4700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1717
    Cell Significance Index: -4.9000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1779
    Cell Significance Index: -6.5300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1793
    Cell Significance Index: -6.3000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1844
    Cell Significance Index: -4.8500
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1907
    Cell Significance Index: -6.0300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1927
    Cell Significance Index: -5.6800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1950
    Cell Significance Index: -5.5900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1972
    Cell Significance Index: -4.2600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1986
    Cell Significance Index: -1.2000
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.2009
    Cell Significance Index: -1.7700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2011
    Cell Significance Index: -10.1600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2031
    Cell Significance Index: -4.3100
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.2043
    Cell Significance Index: -1.6600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2043
    Cell Significance Index: -6.0000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2050
    Cell Significance Index: -5.2700
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2114
    Cell Significance Index: -4.1800
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2130
    Cell Significance Index: -2.9900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2176
    Cell Significance Index: -6.2700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2207
    Cell Significance Index: -4.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** CR1 is a transmembrane receptor with a single chain of approximately 200 amino acids. 2. **Expression:** CR1 is widely expressed in various tissues, including the immune system, epithelial tissues, and the central nervous system. 3. **Function:** CR1 regulates the complement cascade, modulating immune responses and preventing excessive tissue damage. 4. **Regulation:** CR1 is negatively regulated by various mechanisms, including the binding of complement components C3b and C4b, which inhibit its activation. **Pathways and Functions:** 1. **Complement Activation:** CR1 is involved in the regulation of the complement cascade, including the alternative and classical pathways. 2. **Immune Complex Clearance:** CR1 helps to clear immune complexes from tissues, preventing autoimmune responses and inflammation. 3. **Negative Regulation of Activation of Membrane Attack Complex (MAC):** CR1 inhibits the activation of MAC, a key component of the complement system that can cause cell lysis. 4. **Negative Regulation of Complement-Dependent Cytotoxicity:** CR1 reduces the cytotoxic effects of complement-mediated killing. 5. **Regulation of Immune System:** CR1 modulates immune responses, including the regulation of plasma cell differentiation, interleukin-2 production, and type II interferon production. **Clinical Significance:** 1. **Autoimmune Diseases:** Dysregulation of CR1 has been implicated in autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). 2. **Complement Dysregulation:** CR1 dysfunction can lead to complement dysregulation, resulting in increased susceptibility to infections and inflammation. 3. **Cancer:** CR1 has been linked to cancer progression and metastasis, suggesting its potential as a therapeutic target. 4. **Neurological Disorders:** CR1 has been implicated in neurological disorders, such as Alzheimer's disease and multiple sclerosis, highlighting its importance in central nervous system function. In conclusion, CR1 is a vital component of the immune system, playing a crucial role in regulating the complement cascade and maintaining immune homeostasis. Understanding the complexities of CR1 and its dysregulation can provide valuable insights into the development of novel therapeutic strategies for autoimmune diseases, cancer, and neurological disorders.

Genular Protein ID: 2037846987

Symbol: CR1_HUMAN

Name: Complement receptor type 1

UniProtKB Accession Codes:

P17927 Q16744 Q16745 Q5SR43 Q5SR45 Q9UQV2

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 83 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 35 Gene3D 1 GeneCards 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NIAGADS 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 7 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2972794

Title: Identification of distinct C3b and C4b recognition sites in the human C3b/C4b receptor (CR1, CD35) by deletion mutagenesis.

PubMed ID: 2972794

DOI: 10.1084/jem.168.5.1699

PubMed ID: 8245463

Title: Structure of the gene for the F allele of complement receptor type 1 and sequence of the coding region unique to the S allele.

PubMed ID: 8245463

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 2564414

Title: Structure of the human CR1 gene. Molecular basis of the structural and quantitative polymorphisms and identification of a new CR1-like allele.

PubMed ID: 2564414

DOI: 10.1084/jem.169.3.847

PubMed ID: 2971757

Title: Identification of an alternative polyadenylation site in the human C3b/C4b receptor (complement receptor type 1) transcriptional unit and prediction of a secreted form of complement receptor type 1.

PubMed ID: 2971757

DOI: 10.1084/jem.168.4.1255

PubMed ID: 2951479

Title: Human C3b/C4b receptor (CR1). Demonstration of long homologous repeating domains that are composed of the short consensus repeats characteristics of C3/C4 binding proteins.

PubMed ID: 2951479

DOI: 10.1084/jem.165.4.1095

PubMed ID: 2933745

Title: Identification of a partial cDNA clone for the human receptor for complement fragments C3b/C4b.

PubMed ID: 2933745

DOI: 10.1073/pnas.82.22.7711

PubMed ID: 6233222

Title: C3b receptor (CR1) on erythrocytes in various diseases.

PubMed ID: 6233222

DOI: 10.1016/0165-2478(84)90089-0

PubMed ID: 2963069

Title: The clearance of tetanus toxoid/anti-tetanus toxoid immune complexes from the circulation of humans. Complement- and erythrocyte complement receptor 1-dependent mechanisms.

PubMed ID: 2963069

PubMed ID: 1708808

Title: Molecular interactions of complement receptors on B lymphocytes: a CR1/CR2 complex distinct from the CR2/CD19 complex.

PubMed ID: 1708808

DOI: 10.1084/jem.173.5.1083

PubMed ID: 1385479

Title: Expression and localization of proteins of the complement system in human skin.

PubMed ID: 1385479

DOI: 10.1172/jci116080

PubMed ID: 1534036

Title: Distribution and quantitative expression of the complement receptor type 1 (CR1) on human peripheral blood T lymphocytes.

PubMed ID: 1534036

DOI: 10.1016/0008-8749(92)90277-v

PubMed ID: 8175757

Title: Analysis of the functional domains of complement receptor type 1 (C3b/C4b receptor; CD35) by substitution mutagenesis.

PubMed ID: 8175757

DOI: 10.1016/s0021-9258(17)36829-1

PubMed ID: 8706338

Title: Structural polymorphisms of complement receptor 1 (CR1) in systemic lupus erythematosus (SLE) patients and normal controls of three ethnic groups.

PubMed ID: 8706338

DOI: 10.1046/j.1365-2249.1996.d01-748.x

PubMed ID: 9324355

Title: Complement receptor type 1 (CR1, CD35) is a receptor for C1q.

PubMed ID: 9324355

DOI: 10.1016/s1074-7613(00)80356-8

PubMed ID: 14694201

Title: A human complement receptor 1 polymorphism that reduces Plasmodium falciparum rosetting confers protection against severe malaria.

PubMed ID: 14694201

DOI: 10.1073/pnas.0305306101

PubMed ID: 23416052

Title: Human complement receptor type 1/CD35 is an Epstein-Barr Virus receptor.

PubMed ID: 23416052

DOI: 10.1016/j.celrep.2013.01.023

PubMed ID: 23460739

Title: Deciphering complement receptor type 1 interactions with recognition proteins of the lectin complement pathway.

PubMed ID: 23460739

DOI: 10.4049/jimmunol.1202451

PubMed ID: 25742728

Title: Complement receptor type 1 (CR1/CD35) expressed on activated human CD4+ T cells contributes to generation of regulatory T cells.

PubMed ID: 25742728

DOI: 10.1016/j.imlet.2015.02.009

PubMed ID: 29563915

Title: C1q and Mannose-Binding Lectin Interact with CR1 in the Same Region on CCP24-25 Modules.

PubMed ID: 29563915

DOI: 10.3389/fimmu.2018.00453

PubMed ID: 11313284

Title: Molecular identification of Knops blood group polymorphisms found in long homologous region D of complement receptor 1.

PubMed ID: 11313284

DOI: 10.1182/blood.v97.9.2879

PubMed ID: 11896343

Title: Expansion of the Knops blood group system and subdivision of Sl(a).

PubMed ID: 11896343

DOI: 10.1046/j.1537-2995.2002.00002.x

PubMed ID: 11955431

Title: Structure of the C3b binding site of CR1 (CD35), the immune adherence receptor.

PubMed ID: 11955431

DOI: 10.1016/s0092-8674(02)00672-4

Sequence Information:

  • Length: 2039
  • Mass: 223663
  • Checksum: FB01870F19D5E6DD
  • Sequence:
    • MGASSPRSPE PVGPPAPGLP FCCGGSLLAV VVLLALPVAW GQCNAPEWLP FARPTNLTDE 
FEFPIGTYLN YECRPGYSGR PFSIICLKNS VWTGAKDRCR RKSCRNPPDP VNGMVHVIKG 
IQFGSQIKYS CTKGYRLIGS SSATCIISGD TVIWDNETPI CDRIPCGLPP TITNGDFIST 
NRENFHYGSV VTYRCNPGSG GRKVFELVGE PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP 
PNVENGILVS DNRSLFSLNE VVEFRCQPGF VMKGPRRVKC QALNKWEPEL PSCSRVCQPP 
PDVLHAERTQ RDKDNFSPGQ EVFYSCEPGY DLRGAASMRC TPQGDWSPAA PTCEVKSCDD 
FMGQLLNGRV LFPVNLQLGA KVDFVCDEGF QLKGSSASYC VLAGMESLWN SSVPVCEQIF 
CPSPPVIPNG RHTGKPLEVF PFGKTVNYTC DPHPDRGTSF DLIGESTIRC TSDPQGNGVW 
SSPAPRCGIL GHCQAPDHFL FAKLKTQTNA SDFPIGTSLK YECRPEYYGR PFSITCLDNL 
VWSSPKDVCK RKSCKTPPDP VNGMVHVITD IQVGSRINYS CTTGHRLIGH SSAECILSGN 
AAHWSTKPPI CQRIPCGLPP TIANGDFIST NRENFHYGSV VTYRCNPGSG GRKVFELVGE 
PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP PNVENGILVS DNRSLFSLNE VVEFRCQPGF 
VMKGPRRVKC QALNKWEPEL PSCSRVCQPP PDVLHAERTQ RDKDNFSPGQ EVFYSCEPGY 
DLRGAASMRC TPQGDWSPAA PTCEVKSCDD FMGQLLNGRV LFPVNLQLGA KVDFVCDEGF 
QLKGSSASYC VLAGMESLWN SSVPVCEQIF CPSPPVIPNG RHTGKPLEVF PFGKAVNYTC 
DPHPDRGTSF DLIGESTIRC TSDPQGNGVW SSPAPRCGIL GHCQAPDHFL FAKLKTQTNA 
SDFPIGTSLK YECRPEYYGR PFSITCLDNL VWSSPKDVCK RKSCKTPPDP VNGMVHVITD 
IQVGSRINYS CTTGHRLIGH SSAECILSGN TAHWSTKPPI CQRIPCGLPP TIANGDFIST 
NRENFHYGSV VTYRCNLGSR GRKVFELVGE PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP 
PNVENGILVS DNRSLFSLNE VVEFRCQPGF VMKGPRRVKC QALNKWEPEL PSCSRVCQPP 
PEILHGEHTP SHQDNFSPGQ EVFYSCEPGY DLRGAASLHC TPQGDWSPEA PRCAVKSCDD 
FLGQLPHGRV LFPLNLQLGA KVSFVCDEGF RLKGSSVSHC VLVGMRSLWN NSVPVCEHIF 
CPNPPAILNG RHTGTPSGDI PYGKEISYTC DPHPDRGMTF NLIGESTIRC TSDPHGNGVW 
SSPAPRCELS VRAGHCKTPE QFPFASPTIP INDFEFPVGT SLNYECRPGY FGKMFSISCL 
ENLVWSSVED NCRRKSCGPP PEPFNGMVHI NTDTQFGSTV NYSCNEGFRL IGSPSTTCLV 
SGNNVTWDKK APICEIISCE PPPTISNGDF YSNNRTSFHN GTVVTYQCHT GPDGEQLFEL 
VGERSIYCTS KDDQVGVWSS PPPRCISTNK CTAPEVENAI RVPGNRSFFS LTEIIRFRCQ 
PGFVMVGSHT VQCQTNGRWG PKLPHCSRVC QPPPEILHGE HTLSHQDNFS PGQEVFYSCE 
PSYDLRGAAS LHCTPQGDWS PEAPRCTVKS CDDFLGQLPH GRVLLPLNLQ LGAKVSFVCD 
EGFRLKGRSA SHCVLAGMKA LWNSSVPVCE QIFCPNPPAI LNGRHTGTPF GDIPYGKEIS 
YACDTHPDRG MTFNLIGESS IRCTSDPQGN GVWSSPAPRC ELSVPAACPH PPKIQNGHYI 
GGHVSLYLPG MTISYICDPG YLLVGKGFIF CTDQGIWSQL DHYCKEVNCS FPLFMNGISK 
ELEMKKVYHY GDYVTLKCED GYTLEGSPWS QCQADDRWDP PLAKCTSRTH DALIVGTLSG 
TIFFILLIIF LSWIILKHRK GNNAHENPKE VAIHLHSQGG SSVHPRTLQT NEENSRVLP

Genular Protein ID: 285912690

Symbol: E9PDY4_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PDY4

Database IDs:

ARBA 2 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 MANE-Select 1 MassIVE 1 NCBI Taxonomy 1 NIAGADS 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 2 Pfam 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 3 SMART 1 SMR 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 2489
  • Mass: 272924
  • Checksum: B80E2DBF555E6B54
  • Sequence:
    • MGASSPRSPE PVGPPAPGLP FCCGGSLLAV VVLLALPVAW GQCNAPEWLP FARPTNLTDE 
FEFPIGTYLN YECRPGYSGR PFSIICLKNS VWTGAKDRCR RKSCRNPPDP VNGMVHVIKG 
IQFGSQIKYS CTKGYRLIGS SSATCIISGD TVIWDNETPI CDRIPCGLPP TITNGDFIST 
NRENFHYGSV VTYRCNPGSG GRKVFELVGE PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP 
PNVENGILVS DNRSLFSLNE VVEFRCQPGF VMKGPRRVKC QALNKWEPEL PSCSRVCQPP 
PDVLHAERTQ RDKDNFSPGQ EVFYSCEPGY DLRGAASMRC TPQGDWSPAA PTCEVKSCDD 
FMGQLLNGRV LFPVNLQLGA KVDFVCDEGF QLKGSSASYC VLAGMESLWN SSVPVCEQIF 
CPSPPVIPNG RHTGKPLEVF PFGKTVNYTC DPHPDRGTSF DLIGESTIRC TSDPQGNGVW 
SSPAPRCGIL GHCQAPDHFL FAKLKTQTNA SDFPIGTSLK YECRPEYYGR PFSITCLDNL 
VWSSPKDVCK RKSCKTPPDP VNGMVHVITD IQVGSRINYS CTTGHRLIGH SSAECILSGN 
AAHWSTKPPI CQRIPCGLPP TIANGDFIST NRENFHYGSV VTYRCNPGSG GRKVFELVGE 
PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP PNVENGILVS DNRSLFSLNE VVEFRCQPGF 
VMKGPRRVKC QALNKWEPEL PSCSRVCQPP PDVLHAERTQ RDKDNFSPGQ EVFYSCEPGY 
DLRGAASMRC TPQGDWSPAA PTCEVKSCDD FMGQLLNGRV LFPVNLQLGA KVDFVCDEGF 
QLKGSSASYC VLAGMESLWN SSVPVCEQIF CPSPPVIPNG RHTGKPLEVF PFGKTVNYTC 
DPHPDRGTSF DLIGESTIRC TSDPQGNGVW SSPAPRCGIL GHCQAPDHFL FAKLKTQTNA 
SDFPIGTSLK YECRPEYYGR PFSITCLDNL VWSSPKDVCK RKSCKTPPDP VNGMVHVITD 
IQVGSRINYS CTTGHRLIGH SSAECILSGN AAHWSTKPPI CQRIPCGLPP TIANGDFIST 
NRENFHYGSV VTYRCNPGSG GRKVFELVGE PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP 
PNVENGILVS DNRSLFSLNE VVEFRCQPGF VMKGPRRVKC QALNKWEPEL PSCSRVCQPP 
PDVLHAERTQ RDKDNFSPGQ EVFYSCEPGY DLRGAASMRC TPQGDWSPAA PTCEVKSCDD 
FMGQLLNGRV LFPVNLQLGA KVDFVCDEGF QLKGSSASYC VLAGMESLWN SSVPVCEQIF 
CPSPPVIPNG RHTGKPLEVF PFGKAVNYTC DPHPDRGTSF DLIGESTIRC TSDPQGNGVW 
SSPAPRCGIL GHCQAPDHFL FAKLKTQTNA SDFPIGTSLK YECRPEYYGR PFSITCLDNL 
VWSSPKDVCK RKSCKTPPDP VNGMVHVITD IQVGSRINYS CTTGHRLIGH SSAECILSGN 
TAHWSTKPPI CQRIPCGLPP TIANGDFIST NRENFHYGSV VTYRCNLGSR GRKVFELVGE 
PSIYCTSNDD QVGIWSGPAP QCIIPNKCTP PNVENGILVS DNRSLFSLNE VVEFRCQPGF 
VMKGPRRVKC QALNKWEPEL PSCSRVCQPP PEILHGEHTP SHQDNFSPGQ EVFYSCEPGY 
DLRGAASLHC TPQGDWSPEA PRCAVKSCDD FLGQLPHGRV LFPLNLQLGA KVSFVCDEGF 
RLKGSSVSHC VLVGMRSLWN NSVPVCEHIF CPNPPAILNG RHTGTPSGDI PYGKEISYTC 
DPHPDRGMTF NLIGESTIRC TSDPHGNGVW SSPAPRCELS VRAGHCKTPE QFPFASPTIP 
INDFEFPVGT SLNYECRPGY FGKMFSISCL ENLVWSSVED NCRRKSCGPP PEPFNGMVHI 
NTDTQFGSTV NYSCNEGFRL IGSPSTTCLV SGNNVTWDKK APICEIISCE PPPTISNGDF 
YSNNRTSFHN GTVVTYQCHT GPDGEQLFEL VGERSIYCTS KDDQVGVWSS PPPRCISTNK 
CTAPEVENAI RVPGNRSFFT LTEIIRFRCQ PGFVMVGSHT VQCQTNGRWG PKLPHCSRVC 
QPPPEILHGE HTLSHQDNFS PGQEVFYSCE PSYDLRGAAS LHCTPQGDWS PEAPRCTVKS 
CDDFLGQLPH GRVLLPLNLQ LGAKVSFVCD EGFRLKGRSA SHCVLAGMKA LWNSSVPVCE 
QIFCPNPPAI LNGRHTGTPF GDIPYGKEIS YACDTHPDRG MTFNLIGESS IRCTSDPQGN 
GVWSSPAPRC ELSVPAACPH PPKIQNGHYI GGHVSLYLPG MTISYICDPG YLLVGKGFIF 
CTDQGIWSQL DHYCKEVNCS FPLFMNGISK ELEMKKVYHY GDYVTLKCED GYTLEGSPWS 
QCQADDRWDP PLAKCTSRTH DALIVGTLSG TIFFILLIIF LSWIILKHRK GNNAHENPKE 
VAIHLHSQGG SSVHPRTLQT NEENSRVLP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.