Details for: CR1L

Gene ID: 1379

Symbol: CR1L

Ensembl ID: ENSG00000197721

Description: complement C3b/C4b receptor 1 like

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 15.3365
    Cell Significance Index: -3.8900
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 9.5080
    Cell Significance Index: 4.3300
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 4.2802
    Cell Significance Index: 25.8600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 3.9727
    Cell Significance Index: 56.9300
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.5535
    Cell Significance Index: 22.5600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.4011
    Cell Significance Index: 24.0100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.6232
    Cell Significance Index: 15.5400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1726
    Cell Significance Index: 3.5800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0963
    Cell Significance Index: 2.5800
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0892
    Cell Significance Index: 1.5000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: 0.0852
    Cell Significance Index: 1.2100
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.0843
    Cell Significance Index: 0.5200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0697
    Cell Significance Index: 1.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0531
    Cell Significance Index: 10.5400
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.0518
    Cell Significance Index: 0.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0515
    Cell Significance Index: 28.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0339
    Cell Significance Index: 6.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0243
    Cell Significance Index: 8.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0147
    Cell Significance Index: 2.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0107
    Cell Significance Index: 1.5500
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.0053
    Cell Significance Index: 0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0048
    Cell Significance Index: 9.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0040
    Cell Significance Index: 5.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0036
    Cell Significance Index: 5.5400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0033
    Cell Significance Index: 6.0600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0009
    Cell Significance Index: 0.0600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0007
    Cell Significance Index: -0.0100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0018
    Cell Significance Index: -1.1500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0021
    Cell Significance Index: -0.1300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0048
    Cell Significance Index: -3.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0050
    Cell Significance Index: -2.2900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0051
    Cell Significance Index: -3.8300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0059
    Cell Significance Index: -4.3500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0064
    Cell Significance Index: -4.0000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0074
    Cell Significance Index: -0.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0078
    Cell Significance Index: -0.9600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0080
    Cell Significance Index: -4.5300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0084
    Cell Significance Index: -2.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0146
    Cell Significance Index: -2.4900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0151
    Cell Significance Index: -0.3000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0177
    Cell Significance Index: -1.3600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0209
    Cell Significance Index: -4.4000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0225
    Cell Significance Index: -1.1700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0237
    Cell Significance Index: -1.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0241
    Cell Significance Index: -1.3500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0249
    Cell Significance Index: -3.2200
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.0254
    Cell Significance Index: -0.3200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0275
    Cell Significance Index: -3.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0291
    Cell Significance Index: -3.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0323
    Cell Significance Index: -3.3600
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0331
    Cell Significance Index: -0.2700
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.0337
    Cell Significance Index: -0.3200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0345
    Cell Significance Index: -3.9500
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.0372
    Cell Significance Index: -0.4600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0377
    Cell Significance Index: -1.7600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0403
    Cell Significance Index: -0.4800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0428
    Cell Significance Index: -1.6200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0470
    Cell Significance Index: -3.5000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0498
    Cell Significance Index: -2.3400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0498
    Cell Significance Index: -1.3300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0604
    Cell Significance Index: -1.9100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0609
    Cell Significance Index: -2.1400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0620
    Cell Significance Index: -3.2300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0628
    Cell Significance Index: -1.8000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0674
    Cell Significance Index: -2.9300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0700
    Cell Significance Index: -1.8000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0702
    Cell Significance Index: -2.4600
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.0732
    Cell Significance Index: -1.0800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0737
    Cell Significance Index: -2.0600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0745
    Cell Significance Index: -1.1000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0749
    Cell Significance Index: -2.0400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0753
    Cell Significance Index: -3.9600
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.0776
    Cell Significance Index: -1.0000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0799
    Cell Significance Index: -2.2800
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0807
    Cell Significance Index: -1.6900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0841
    Cell Significance Index: -2.6800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0867
    Cell Significance Index: -2.8400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0903
    Cell Significance Index: -2.3000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0980
    Cell Significance Index: -2.3500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0981
    Cell Significance Index: -2.1200
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: -0.0982
    Cell Significance Index: -0.9400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1004
    Cell Significance Index: -1.3700
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1017
    Cell Significance Index: -1.0600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1036
    Cell Significance Index: -2.5100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1048
    Cell Significance Index: -2.6200
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.1081
    Cell Significance Index: -1.5000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1090
    Cell Significance Index: -4.0000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.1100
    Cell Significance Index: -1.5800
  • Cell Name: reticulocyte (CL0000558)
    Fold Change: -0.1103
    Cell Significance Index: -0.5800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.1127
    Cell Significance Index: -1.5800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1134
    Cell Significance Index: -3.3400
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1140
    Cell Significance Index: -2.4200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.1147
    Cell Significance Index: -1.5300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.1166
    Cell Significance Index: -1.8700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1195
    Cell Significance Index: -2.4000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1199
    Cell Significance Index: -2.4400
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: -0.1250
    Cell Significance Index: -1.6900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1305
    Cell Significance Index: -3.2600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.1308
    Cell Significance Index: -2.7300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1314
    Cell Significance Index: -3.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CR1L is a member of the complement receptor family, which plays a crucial role in the immune system. The protein shares structural similarities with the classical complement receptor 1 (CR1), but its exact function remains unclear. CR1L is characterized by its expression in multiple cell types, including amacrine cells, retinal cells, erythroblasts, and epithelial cells of the lung. Its expression pattern suggests a broad range of functions, from immune regulation to tissue repair. **Pathways and Functions:** CR1L is involved in several key pathways, including: 1. **Negative regulation of complement activation**: CR1L may act as a decoy receptor, binding to complement components and preventing their activation. 2. **Regulation of complement-dependent cytotoxicity**: CR1L may modulate the activity of complement-dependent cytotoxicity, a process by which the complement system can induce cell death. 3. **T cell-mediated immunity**: CR1L may interact with T cells, influencing their activation and function. 4. **Regulation of complement activation**: CR1L may participate in the regulation of complement activation, potentially modulating the immune response. **Clinical Significance:** CR1L's involvement in immune regulation and disease makes it a promising target for therapeutic interventions. Some potential clinical applications of CR1L include: 1. **Autoimmune diseases**: CR1L's role in regulating complement activation and immune responses may make it a useful target for treating autoimmune diseases, such as rheumatoid arthritis or lupus. 2. **Infectious diseases**: CR1L's involvement in complement-dependent cytotoxicity may make it a potential therapeutic target for treating infections, such as sepsis or meningitis. 3. **Cancer**: CR1L's interaction with T cells may influence cancer immune evasion, making it a potential target for immunotherapy. In conclusion, CR1L is a complex protein with a multifaceted role in immune regulation and disease. Further research is needed to fully elucidate its functions and potential therapeutic applications. As an expert immunologist, I emphasize the importance of continued investigation into the mysteries of CR1L, with the ultimate goal of harnessing its potential to improve human health.

Genular Protein ID: 1492668767

Symbol: CR1L_HUMAN

Name: Complement component receptor 1-like protein

UniProtKB Accession Codes:

Q2VPA4 Q32MC9 Q8NEU7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14687939

Title: A human CR1-like transcript containing sequence for a binding protein for iC4 is expressed in hematopoietic and fetal lymphoid tissue.

PubMed ID: 14687939

DOI: 10.1016/j.molimm.2003.09.010

Sequence Information:

  • Length: 569
  • Mass: 62714
  • Checksum: D49F7517E1347A5D
  • Sequence:
    • MAPPVRLERP FPSRRFPGLL LAALVLLLSS FSDQCNVPEW LPFARPTNLT DDFEFPIGTY 
LNYECRPGYS GRPFSIICLK NSVWTSAKDK CKRKSCRNPP DPVNGMAHVI KDIQFRSQIK 
YSCPKGYRLI GSSSATCIIS GNTVIWDNKT PVCDRIICGL PPTIANGDFT SISREYFHYG 
SVVTYHCNLG SRGKKVFELV GEPSIYCTSK DDQVGIWSGP APQCIIPNKC TPPNVENGIL 
VSDNRSLFSL NEVVEFRCQP GFGMKGPSHV KCQALNKWEP ELPSCSRVCQ PPPDVLHAER 
TQRDKDNFSP GQEVFYSCEP GYDLRGSTYL HCTPQGDWSP AAPRCEVKSC DDFLGQLPNG 
HVLFPLNLQL GAKVDFVCDE GFQLKGSSAS YCVLAGMESL WNSSVPVCER KSCETPPVPV 
NGMVHVITDI HVGSRINYSC TTGHRLIGHS SAECILSGNT AHWSMKPPIC QQIFCPNPPA 
ILNGRHTGTP LGDIPYGKEV SYTCDPHPDR GMTFNLIGES TIRRTSEPHG NGVWSSPAPR 
CELPVGAGSH DALIVGKFYE VFAEEFCHL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.