Details for: CR2

Gene ID: 1380

Symbol: CR2

Ensembl ID: ENSG00000117322

Description: complement C3d receptor 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 3.71
    Marker Score: 11871.5
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.09
    Marker Score: 2105
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1173
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.59
    Marker Score: 2198
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.52
    Marker Score: 4497
  • Cell Name: centrocyte (CL0009111)
    Fold Change: 1.35
    Marker Score: 321
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 858
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 504
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.05
    Marker Score: 667
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.03
    Marker Score: 628
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71832
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48056
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 510
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 463
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.96
    Marker Score: 398
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 375
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5333
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 0.93
    Marker Score: 831.5
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.92
    Marker Score: 1601
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 327
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.9
    Marker Score: 1869
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.88
    Marker Score: 1785
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5289
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 610
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 705
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: centroblast (CL0009112)
    Fold Change: 0.74
    Marker Score: 365
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.74
    Marker Score: 1397
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 464
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2995
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.6
    Marker Score: 456
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 458
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.49
    Marker Score: 360
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.49
    Marker Score: 462
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.48
    Marker Score: 287
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.47
    Marker Score: 7377
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.43
    Marker Score: 135
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.42
    Marker Score: 176
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.41
    Marker Score: 95
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 0.4
    Marker Score: 846
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.38
    Marker Score: 92
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.38
    Marker Score: 1542
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.34
    Marker Score: 519
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.33
    Marker Score: 174.5
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.33
    Marker Score: 216
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.32
    Marker Score: 79
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.3
    Marker Score: 328
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.3
    Marker Score: 172
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.29
    Marker Score: 168
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.27
    Marker Score: 97
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.26
    Marker Score: 83
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.26
    Marker Score: 241
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.24
    Marker Score: 140
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.23
    Marker Score: 1530.5
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.21
    Marker Score: 98
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.18
    Marker Score: 79
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.17
    Marker Score: 619
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.17
    Marker Score: 63
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.16
    Marker Score: 212
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.16
    Marker Score: 80
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.16
    Marker Score: 38
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.16
    Marker Score: 163
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.14
    Marker Score: 35
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.14
    Marker Score: 1290
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 0.14
    Marker Score: 133
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.13
    Marker Score: 317
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.13
    Marker Score: 43
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.13
    Marker Score: 148
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.12
    Marker Score: 84
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.11
    Marker Score: 56
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.11
    Marker Score: 130
  • Cell Name: follicular dendritic cell (CL0000442)
    Fold Change: 0.11
    Marker Score: 40
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 0.11
    Marker Score: 269
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.11
    Marker Score: 40
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.11
    Marker Score: 195
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.11
    Marker Score: 110
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.1
    Marker Score: 129
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.1
    Marker Score: 68
  • Cell Name: B-2 B cell (CL0000822)
    Fold Change: 0.1
    Marker Score: 124
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.1
    Marker Score: 56
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.1
    Marker Score: 73.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.09
    Marker Score: 95
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 0.09
    Marker Score: 156
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.09
    Marker Score: 68
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.09
    Marker Score: 127
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.09
    Marker Score: 19
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 0.09
    Marker Score: 52
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.09
    Marker Score: 30
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.09
    Marker Score: 39
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 0.08
    Marker Score: 30
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.08
    Marker Score: 38

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Other Information

**Key characteristics:** * CR2 is a heterodimeric protein composed of two immunoglobulin heavy chains and two immunoglobulin light chains. * It is expressed on B cells, dendritic cells, macrophages, and macrophages. * It is a negative regulator of the classical pathway of complement. * It is a positive regulator of the alternative pathway of complement. * It is involved in the regulation of inflammation and immunity. **Pathways and functions:** * **Classical pathway:** CR2 binds to complement proteins C1q, C2, C3, C4, and C5, which are components of the classical pathway. This binding initiates a series of reactions that lead to the formation of the membrane attack complex (MAC), which is a pore-forming protein that can kill target cells. * **Alternative pathway:** CR2 also binds to C3b, which is a fragment of the antibody C3. This binding inhibits the alternative pathway of complement, which is a more specific pathway that is activated by antibodies. **Clinical significance:** * Mutations in the CR2 gene have been linked to several human diseases, including autoimmune disorders, inflammatory diseases, and cancer. * CR2 inhibitors are being developed as potential treatments for these diseases. **Additional points:** * CR2 is a key regulator of the immune response. * It is expressed in high levels in mucosal tissues, where it is involved in the regulation of inflammation and immunity. * It is a promising target for the development of novel therapeutic strategies for inflammatory diseases.

Genular Protein ID: 3025431652

Symbol: CR2_HUMAN

Name: Complement receptor type 2

UniProtKB Accession Codes:

P20023 C9JHD2 Q13866 Q14212 Q53EL2 Q5BKT9 Q5SR46 Q5SR48

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 24 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 7 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 RNAct 1 Reactome 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 2563370

Title: Genomic organization and polymorphisms of the human C3d/Epstein-Barr virus receptor.

PubMed ID: 2563370

DOI: 10.1016/s0021-9258(18)94149-9

PubMed ID: 2832506

Title: Structure of the human B lymphocyte receptor for C3d and the Epstein-Barr virus and relatedness to other members of the family of C3/C4 binding proteins.

PubMed ID: 2832506

DOI: 10.1084/jem.167.3.1047

PubMed ID: 2827171

Title: Molecular cloning of the cDNA encoding the Epstein-Barr virus.C3d receptor (complement receptor type 2) of human b lymphocytes.

PubMed ID: 2827171

DOI: 10.1073/pnas.84.24.9194

PubMed ID: 10068037

Title: Evidence for a new transcript of the Epstein-Barr virus/C3d receptor (CR2, CD21) which is due to alternative exon usage.

PubMed ID: 10068037

DOI: 10.1016/s0161-5890(98)00098-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3016712

Title: Identification of a partial cDNA clone for the C3d/Epstein-Barr virus receptor of human B lymphocytes: homology with the receptor for fragments C3b and C4b of the third and fourth components of complement.

PubMed ID: 3016712

DOI: 10.1073/pnas.83.15.5639

PubMed ID: 8390533

Title: Characterization of the EBV/C3d receptor on the human Jurkat T cell line: evidence for a novel transcript.

PubMed ID: 8390533

PubMed ID: 2460635

Title: Soluble gp350/220 and deletion mutant glycoproteins block Epstein-Barr virus adsorption to lymphocytes.

PubMed ID: 2460635

DOI: 10.1128/jvi.62.12.4452-4464.1988

PubMed ID: 1702139

Title: Intersection of the complement and immune systems: a signal transduction complex of the B lymphocyte-containing complement receptor type 2 and CD19.

PubMed ID: 1702139

DOI: 10.1084/jem.173.1.55

PubMed ID: 1383329

Title: The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules.

PubMed ID: 1383329

PubMed ID: 7753047

Title: Binding sites of the Epstein-Barr virus and C3d receptor (CR2, CD21) for its three intracellular ligands, the p53 anti-oncoprotein, the p68 calcium binding protein and the nuclear p120 ribonucleoprotein.

PubMed ID: 7753047

DOI: 10.1016/0161-5890(95)00005-y

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 16172256

Title: The structure of human CD23 and its interactions with IgE and CD21.

PubMed ID: 16172256

DOI: 10.1084/jem.20050811

PubMed ID: 22035880

Title: Genetic CD21 deficiency is associated with hypogammaglobulinemia.

PubMed ID: 22035880

DOI: 10.1016/j.jaci.2011.09.027

PubMed ID: 11387479

Title: Structure of complement receptor 2 in complex with its C3d ligand.

PubMed ID: 11387479

DOI: 10.1126/science.1059118

PubMed ID: 12122212

Title: The crystal structure of human CD21: Implications for Epstein-Barr virus and C3d binding.

PubMed ID: 12122212

DOI: 10.1073/pnas.162360499

PubMed ID: 16950392

Title: The 15 SCR flexible extracellular domains of human complement receptor type 2 can mediate multiple ligand and antigen interactions.

PubMed ID: 16950392

DOI: 10.1016/j.jmb.2006.08.012

PubMed ID: 21527715

Title: A crystal structure of the complex between human complement receptor 2 and its ligand C3d.

PubMed ID: 21527715

DOI: 10.1126/science.1201954

PubMed ID: 17360460

Title: Association of a common complement receptor 2 haplotype with increased risk of systemic lupus erythematosus.

PubMed ID: 17360460

DOI: 10.1073/pnas.0609101104

Sequence Information:

  • Length: 1033
  • Mass: 112916
  • Checksum: 7D89DB4A07847E9A
  • Sequence:
    • MGAAGLLGVF LALVAPGVLG ISCGSPPPIL NGRISYYSTP IAVGTVIRYS CSGTFRLIGE 
KSLLCITKDK VDGTWDKPAP KCEYFNKYSS CPEPIVPGGY KIRGSTPYRH GDSVTFACKT 
NFSMNGNKSV WCQANNMWGP TRLPTCVSVF PLECPALPMI HNGHHTSENV GSIAPGLSVT 
YSCESGYLLV GEKIINCLSS GKWSAVPPTC EEARCKSLGR FPNGKVKEPP ILRVGVTANF 
FCDEGYRLQG PPSSRCVIAG QGVAWTKMPV CEEIFCPSPP PILNGRHIGN SLANVSYGSI 
VTYTCDPDPE EGVNFILIGE STLRCTVDSQ KTGTWSGPAP RCELSTSAVQ CPHPQILRGR 
MVSGQKDRYT YNDTVIFACM FGFTLKGSKQ IRCNAQGTWE PSAPVCEKEC QAPPNILNGQ 
KEDRHMVRFD PGTSIKYSCN PGYVLVGEES IQCTSEGVWT PPVPQCKVAA CEATGRQLLT 
KPQHQFVRPD VNSSCGEGYK LSGSVYQECQ GTIPWFMEIR LCKEITCPPP PVIYNGAHTG 
SSLEDFPYGT TVTYTCNPGP ERGVEFSLIG ESTIRCTSND QERGTWSGPA PLCKLSLLAV 
QCSHVHIANG YKISGKEAPY FYNDTVTFKC YSGFTLKGSS QIRCKADNTW DPEIPVCEKE 
TCQHVRQSLQ ELPAGSRVEL VNTSCQDGYQ LTGHAYQMCQ DAENGIWFKK IPLCKVIHCH 
PPPVIVNGKH TGMMAENFLY GNEVSYECDQ GFYLLGEKKL QCRSDSKGHG SWSGPSPQCL 
RSPPVTRCPN PEVKHGYKLN KTHSAYSHND IVYVDCNPGF IMNGSRVIRC HTDNTWVPGV 
PTCIKKAFIG CPPPPKTPNG NHTGGNIARF SPGMSILYSC DQGYLLVGEA LLLCTHEGTW 
SQPAPHCKEV NCSSPADMDG IQKGLEPRKM YQYGAVVTLE CEDGYMLEGS PQSQCQSDHQ 
WNPPLAVCRS RSLAPVLCGI AAGLILLTFL IVITLYVISK HRARNYYTDT SQKEAFHLEA 
REVYSVDPYN PAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.