CR2 | ENSG00000117322 | NCBI 1380

Details for: CR2

Gene ID: 1380

Symbol: CR2

Ensembl ID: ENSG00000117322

Description: complement C3d receptor 2

Associated with

Complement cascade
(R-HSA-166658)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Regulation of complement cascade
(R-HSA-977606)
B cell differentiation
(GO:0030183)
B cell proliferation
(GO:0042100)
Complement activation, alternative pathway
(GO:0006957)
Complement activation, classical pathway
(GO:0006958)
Complement binding
(GO:0001848)
Complement receptor activity
(GO:0004875)
Complement receptor mediated signaling pathway
(GO:0002430)
Dna binding
(GO:0003677)
Extracellular exosome
(GO:0070062)
Extracellular space
(GO:0005615)
Immune response
(GO:0006955)
Immunoglobulin receptor binding
(GO:0034987)
Membrane
(GO:0016020)
Negative regulation of complement activation, classical pathway
(GO:0045959)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Receptor complex
(GO:0043235)
Symbiont entry into host cell
(GO:0046718)
T cell mediated immunity
(GO:0002456)
Transmembrane signaling receptor activity
(GO:0004888)
Virus receptor activity
(GO:0001618)

Other Information

Proteins

Complement receptor type 2

Genular Protein ID: 3025431652

Symbol: CR2_HUMAN

Name: Complement receptor type 2

UniProtKB Accession Codes:

P20023 C9JHD2 Q13866 Q14212 Q53EL2 Q5BKT9 Q5SR46 Q5SR48

Database IDs:

Citations:

PubMed ID: 2563370

Title: Genomic organization and polymorphisms of the human C3d/Epstein-Barr virus receptor.

PubMed ID: 2563370

DOI: 10.1016/s0021-9258(18)94149-9

PubMed ID: 2832506

Title: Structure of the human B lymphocyte receptor for C3d and the Epstein-Barr virus and relatedness to other members of the family of C3/C4 binding proteins.

PubMed ID: 2832506

DOI: 10.1084/jem.167.3.1047

PubMed ID: 2827171

Title: Molecular cloning of the cDNA encoding the Epstein-Barr virus.C3d receptor (complement receptor type 2) of human b lymphocytes.

PubMed ID: 2827171

DOI: 10.1073/pnas.84.24.9194

PubMed ID: 10068037

Title: Evidence for a new transcript of the Epstein-Barr virus/C3d receptor (CR2, CD21) which is due to alternative exon usage.

PubMed ID: 10068037

DOI: 10.1016/s0161-5890(98)00098-4

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3016712

Title: Identification of a partial cDNA clone for the C3d/Epstein-Barr virus receptor of human B lymphocytes: homology with the receptor for fragments C3b and C4b of the third and fourth components of complement.

PubMed ID: 3016712

DOI: 10.1073/pnas.83.15.5639

PubMed ID: 8390533

Title: Characterization of the EBV/C3d receptor on the human Jurkat T cell line: evidence for a novel transcript.

PubMed ID: 8390533

PubMed ID: 2460635

Title: Soluble gp350/220 and deletion mutant glycoproteins block Epstein-Barr virus adsorption to lymphocytes.

PubMed ID: 2460635

DOI: 10.1128/jvi.62.12.4452-4464.1988

PubMed ID: 1702139

Title: Intersection of the complement and immune systems: a signal transduction complex of the B lymphocyte-containing complement receptor type 2 and CD19.

PubMed ID: 1702139

DOI: 10.1084/jem.173.1.55

PubMed ID: 1383329

Title: The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules.

PubMed ID: 1383329

PubMed ID: 7753047

Title: Binding sites of the Epstein-Barr virus and C3d receptor (CR2, CD21) for its three intracellular ligands, the p53 anti-oncoprotein, the p68 calcium binding protein and the nuclear p120 ribonucleoprotein.

PubMed ID: 7753047

DOI: 10.1016/0161-5890(95)00005-y

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 16172256

Title: The structure of human CD23 and its interactions with IgE and CD21.

PubMed ID: 16172256

DOI: 10.1084/jem.20050811

PubMed ID: 22035880

Title: Genetic CD21 deficiency is associated with hypogammaglobulinemia.

PubMed ID: 22035880

DOI: 10.1016/j.jaci.2011.09.027

PubMed ID: 11387479

Title: Structure of complement receptor 2 in complex with its C3d ligand.

PubMed ID: 11387479

DOI: 10.1126/science.1059118

PubMed ID: 12122212

Title: The crystal structure of human CD21: Implications for Epstein-Barr virus and C3d binding.

PubMed ID: 12122212

DOI: 10.1073/pnas.162360499

PubMed ID: 16950392

Title: The 15 SCR flexible extracellular domains of human complement receptor type 2 can mediate multiple ligand and antigen interactions.

PubMed ID: 16950392

DOI: 10.1016/j.jmb.2006.08.012

PubMed ID: 21527715

Title: A crystal structure of the complex between human complement receptor 2 and its ligand C3d.

PubMed ID: 21527715

DOI: 10.1126/science.1201954

PubMed ID: 17360460

Title: Association of a common complement receptor 2 haplotype with increased risk of systemic lupus erythematosus.

PubMed ID: 17360460

DOI: 10.1073/pnas.0609101104

Sequence Information:

Length: 1033
Mass: 112916
Checksum: 7D89DB4A07847E9A
Sequence:

MGAAGLLGVF LALVAPGVLG ISCGSPPPIL NGRISYYSTP IAVGTVIRYS CSGTFRLIGE 
KSLLCITKDK VDGTWDKPAP KCEYFNKYSS CPEPIVPGGY KIRGSTPYRH GDSVTFACKT 
NFSMNGNKSV WCQANNMWGP TRLPTCVSVF PLECPALPMI HNGHHTSENV GSIAPGLSVT 
YSCESGYLLV GEKIINCLSS GKWSAVPPTC EEARCKSLGR FPNGKVKEPP ILRVGVTANF 
FCDEGYRLQG PPSSRCVIAG QGVAWTKMPV CEEIFCPSPP PILNGRHIGN SLANVSYGSI 
VTYTCDPDPE EGVNFILIGE STLRCTVDSQ KTGTWSGPAP RCELSTSAVQ CPHPQILRGR 
MVSGQKDRYT YNDTVIFACM FGFTLKGSKQ IRCNAQGTWE PSAPVCEKEC QAPPNILNGQ 
KEDRHMVRFD PGTSIKYSCN PGYVLVGEES IQCTSEGVWT PPVPQCKVAA CEATGRQLLT 
KPQHQFVRPD VNSSCGEGYK LSGSVYQECQ GTIPWFMEIR LCKEITCPPP PVIYNGAHTG 
SSLEDFPYGT TVTYTCNPGP ERGVEFSLIG ESTIRCTSND QERGTWSGPA PLCKLSLLAV 
QCSHVHIANG YKISGKEAPY FYNDTVTFKC YSGFTLKGSS QIRCKADNTW DPEIPVCEKE 
TCQHVRQSLQ ELPAGSRVEL VNTSCQDGYQ LTGHAYQMCQ DAENGIWFKK IPLCKVIHCH 
PPPVIVNGKH TGMMAENFLY GNEVSYECDQ GFYLLGEKKL QCRSDSKGHG SWSGPSPQCL 
RSPPVTRCPN PEVKHGYKLN KTHSAYSHND IVYVDCNPGF IMNGSRVIRC HTDNTWVPGV 
PTCIKKAFIG CPPPPKTPNG NHTGGNIARF SPGMSILYSC DQGYLLVGEA LLLCTHEGTW 
SQPAPHCKEV NCSSPADMDG IQKGLEPRKM YQYGAVVTLE CEDGYMLEGS PQSQCQSDHQ 
WNPPLAVCRS RSLAPVLCGI AAGLILLTFL IVITLYVISK HRARNYYTDT SQKEAFHLEA 
REVYSVDPYN PAS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CR2

Associated with

Other Information

Genomic organization and polymorphisms of the human C3d/Epstein-Barr virus receptor. PubMed ID: 2563370

Structure of the human B lymphocyte receptor for C3d and the Epstein-Barr virus and relatedness to other members of the family of C3/C4 binding proteins. PubMed ID: 2832506

Molecular cloning of the cDNA encoding the Epstein-Barr virus.C3d receptor (complement receptor type 2) of human b lymphocytes. PubMed ID: 2827171

Evidence for a new transcript of the Epstein-Barr virus/C3d receptor (CR2, CD21) which is due to alternative exon usage. PubMed ID: 10068037

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of a partial cDNA clone for the C3d/Epstein-Barr virus receptor of human B lymphocytes: homology with the receptor for fragments C3b and C4b of the third and fourth components of complement. PubMed ID: 3016712

Characterization of the EBV/C3d receptor on the human Jurkat T cell line: evidence for a novel transcript. PubMed ID: 8390533

Soluble gp350/220 and deletion mutant glycoproteins block Epstein-Barr virus adsorption to lymphocytes. PubMed ID: 2460635

Intersection of the complement and immune systems: a signal transduction complex of the B lymphocyte-containing complement receptor type 2 and CD19. PubMed ID: 1702139

The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules. PubMed ID: 1383329

Binding sites of the Epstein-Barr virus and C3d receptor (CR2, CD21) for its three intracellular ligands, the p53 anti-oncoprotein, the p68 calcium binding protein and the nuclear p120 ribonucleoprotein. PubMed ID: 7753047

Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. PubMed ID: 19349973

The structure of human CD23 and its interactions with IgE and CD21. PubMed ID: 16172256

Genetic CD21 deficiency is associated with hypogammaglobulinemia. PubMed ID: 22035880

Structure of complement receptor 2 in complex with its C3d ligand. PubMed ID: 11387479

The crystal structure of human CD21: Implications for Epstein-Barr virus and C3d binding. PubMed ID: 12122212

The 15 SCR flexible extracellular domains of human complement receptor type 2 can mediate multiple ligand and antigen interactions. PubMed ID: 16950392

A crystal structure of the complex between human complement receptor 2 and its ligand C3d. PubMed ID: 21527715

Association of a common complement receptor 2 haplotype with increased risk of systemic lupus erythematosus. PubMed ID: 17360460