Details for: Eng

Gene ID: 13805

Symbol: Eng

Ensembl ID: ENSMUSG00000026814

Description: endoglin

Associated with

  • Angiogenesis
    (GO:0001525)
  • Artery morphogenesis
    (GO:0048844)
  • Atrial cardiac muscle tissue morphogenesis
    (GO:0055009)
  • Atrioventricular canal morphogenesis
    (GO:1905222)
  • Bmp binding
    (GO:0036122)
  • Branching involved in blood vessel morphogenesis
    (GO:0001569)
  • Cardiac atrium morphogenesis
    (GO:0003209)
  • Cardiac jelly development
    (GO:1905072)
  • Cardiac ventricle morphogenesis
    (GO:0003208)
  • Cell adhesion
    (GO:0007155)
  • Cell chemotaxis
    (GO:0060326)
  • Cell migration
    (GO:0016477)
  • Cell migration involved in endocardial cushion formation
    (GO:0003273)
  • Cell motility
    (GO:0048870)
  • Cell surface
    (GO:0009986)
  • Central nervous system vasculogenesis
    (GO:0022009)
  • Coreceptor activity
    (GO:0015026)
  • Detection of hypoxia
    (GO:0070483)
  • Dorsal aorta morphogenesis
    (GO:0035912)
  • Endocardial cushion morphogenesis
    (GO:0003203)
  • Endocardial cushion to mesenchymal transition
    (GO:0090500)
  • Endothelial microparticle
    (GO:0072563)
  • Epithelial to mesenchymal transition
    (GO:0001837)
  • Epithelial to mesenchymal transition involved in endocardial cushion formation
    (GO:0003198)
  • External side of plasma membrane
    (GO:0009897)
  • Extracellular matrix constituent secretion
    (GO:0070278)
  • Extracellular matrix disassembly
    (GO:0022617)
  • Extracellular space
    (GO:0005615)
  • Galactose binding
    (GO:0005534)
  • Glycosaminoglycan binding
    (GO:0005539)
  • Heart development
    (GO:0007507)
  • Heart looping
    (GO:0001947)
  • Identical protein binding
    (GO:0042802)
  • Membrane
    (GO:0016020)
  • Negative regulation of cell migration
    (GO:0030336)
  • Negative regulation of endothelial cell proliferation
    (GO:0001937)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of nitric-oxide synthase activity
    (GO:0051001)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nuclear body
    (GO:0016604)
  • Outflow tract septum morphogenesis
    (GO:0003148)
  • Plasma membrane
    (GO:0005886)
  • Positive regulation of angiogenesis
    (GO:0045766)
  • Positive regulation of bmp signaling pathway
    (GO:0030513)
  • Positive regulation of collagen biosynthetic process
    (GO:0032967)
  • Positive regulation of epithelial to mesenchymal transition involved in endocardial cushion formation
    (GO:1905007)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of protein phosphorylation
    (GO:0001934)
  • Positive regulation of smad protein signal transduction
    (GO:0060391)
  • Positive regulation of systemic arterial blood pressure
    (GO:0003084)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Positive regulation of vascular associated smooth muscle cell differentiation
    (GO:1905065)
  • Protein binding
    (GO:0005515)
  • Protein homodimerization activity
    (GO:0042803)
  • Receptor complex
    (GO:0043235)
  • Regulation of cardiac muscle cell apoptotic process
    (GO:0010665)
  • Regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis
    (GO:1905310)
  • Regulation of cell proliferation involved in heart morphogenesis
    (GO:2000136)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transforming growth factor beta receptor signaling pathway
    (GO:0017015)
  • Response to hypoxia
    (GO:0001666)
  • Signaling receptor activator activity
    (GO:0030546)
  • Smooth muscle tissue development
    (GO:0048745)
  • Sprouting angiogenesis
    (GO:0002040)
  • Transforming growth factor beta binding
    (GO:0050431)
  • Transforming growth factor beta receptor activity
    (GO:0005024)
  • Transforming growth factor beta receptor signaling pathway
    (GO:0007179)
  • Type ii transforming growth factor beta receptor binding
    (GO:0005114)
  • Type i transforming growth factor beta receptor binding
    (GO:0034713)
  • Vascular associated smooth muscle cell development
    (GO:0097084)
  • Vasculogenesis
    (GO:0001570)
  • Venous blood vessel morphogenesis
    (GO:0048845)
  • Ventricular trabecula myocardium morphogenesis
    (GO:0003222)
  • Wound healing
    (GO:0042060)

Other Information

Genular Protein ID: 3990405716

Symbol: EGLN_MOUSE

Name: Endoglin

UniProtKB Accession Codes:

Q63961 Q61520 Q8K100

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 EMBL 5 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 70 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 InParanoid 1 IntAct 1 KEGG 1 MGI 1 MINT 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE-ProRule 1 PaxDb 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SMR 1 STRING 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 8125301

Title: Cloning and expression of a cDNA encoding mouse endoglin, an endothelial cell TGF-beta ligand.

PubMed ID: 8125301

DOI: 10.1016/0378-1119(94)90808-7

PubMed ID: 8194490

Title: Molecular characterization and in situ localization of murine endoglin reveal that it is a transforming growth factor-beta binding protein of endothelial and stromal cells.

PubMed ID: 8194490

DOI: 10.1210/endo.134.6.8194490

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17540773

Title: The interaction of endoglin with beta-arrestin2 regulates transforming growth factor-beta-mediated ERK activation and migration in endothelial cells.

PubMed ID: 17540773

DOI: 10.1074/jbc.m700176200

PubMed ID: 10625534

Title: Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development.

PubMed ID: 10625534

DOI: 10.1006/dbio.1999.9534

PubMed ID: 20042635

Title: ALK5 phosphorylation of the endoglin cytoplasmic domain regulates Smad1/5/8 signaling and endothelial cell migration.

PubMed ID: 20042635

DOI: 10.1093/carcin/bgp327

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21737454

Title: Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth.

PubMed ID: 21737454

DOI: 10.1074/jbc.m111.260133

PubMed ID: 23300529

Title: Endoglin requirement for BMP9 signaling in endothelial cells reveals new mechanism of action for selective anti-endoglin antibodies.

PubMed ID: 23300529

DOI: 10.1371/journal.pone.0050920

PubMed ID: 28530658

Title: Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues.

PubMed ID: 28530658

DOI: 10.1038/ncb3528

Sequence Information:

  • Length: 653
  • Mass: 70021
  • Checksum: AD9DD2F823FB06A1
  • Sequence:
    • MDRGVLPLPI TLLFVIYSFV PTTGLAERVG CDLQPVDPTR GEVTFTTSQV SEGCVAQAAN 
AVREVHVLFL DFPGMLSHLE LTLQASKQNG TETQEVFLVL VSNKNVFVKF QAPEIPLHLA 
YDSSLVIFQG QPRVNITVLP SLTSRKQILD WAATKGAITS IAALDDPQSI VLQLGQDPKA 
PFLCLPEAHK DMGATLEWQP RAQTPVQSCR LEGVSGHKEA YILRILPGSE AGPRTVTVMM 
ELSCTSGDAI LILHGPPYVS WFIDINHSMQ ILTTGEYSVK IFPGSKVKGV ELPDTPQGLI 
AEARKLNASI VTSFVELPLV SNVSLRASSC GGVFQTTPAP VVTTPPKDTC SPVLLMSLIQ 
PKCGNQVMTL ALNKKHVQTL QCTITGLTFW DSSCQAEDTD DHLVLSSAYS SCGMKVTAHV 
VSNEVIISFP SGSPPLRKKV QCIDMDSLSF QLGLYLSPHF LQASNTIELG QQAFVQVSVS 
PLTSEVTVQL DSCHLDLGPE GDMVELIQSR TAKGSCVTLL SPSPEGDPRF SFLLRVYMVP 
TPTAGTLSCN LALRPSTLSQ EVYKTVSMRL NIVSPDLSGK GLVLPSVLGI TFGAFLIGAL 
LTAALWYIYS HTRGPSKREP VVAVAAPASS ESSSTNHSIG STQSTPCSTS SMA

Genular Protein ID: 3235779539

Symbol: Q3UAM9_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UAM9 E9Q5I7

Database IDs:

AGR 1 ARBA 2 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 1 GeneTree 1 HOGENOM 1 KEGG 1 MGI 2 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Proteomes 2 ProteomicsDB 1 RefSeq 3 SAM 3 SMR 1 UCSC 2 VEuPathDB 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 652
  • Mass: 69950
  • Checksum: 75A4466376F1EA54
  • Sequence:
    • MDRGVLPLPI TLLFVIYSFV PTSLAERVGC DLQPVDPTRG EVTFTTSQVS EGCVAQAANA 
VREVHVLFLD FPGMLSHLEL TLQASKQNGT ETQEVFLVLV SNKNVFVKFQ APEIPLHLAY 
DSSLVIFQGQ PRVNITVLPS LTSRKQILDW AATKGAITSI AALDDPQSIV LQLGQDPKAP 
FLCLPEAHKD MGATLEWQPR AQTPVQSCRL EGVSGHKEAY ILRILPGSEA GPRTVTVMME 
LSCTSGDAIL ILHGPPYVSW FIDINHSMQI LTTGEYSVKI FPGSKVKGVE LPDTPQGLIA 
EARKLNASIV TSFVELPLVS NVSLRASSCG GVFQTTPAPV VTTPPKDTCS PVLLMSLIQP 
KCGNQVMTLA LNKKHVQTLQ CTITGLTFWD SSCQAEDTDD HLVLSSAYSS CGMKVTAHVV 
SNEVIISFPS GSPPLRKKVQ CIDMDSLSFQ LGLYLSPHFL QASNTIELGQ QAFVQVSVSP 
LTSEVTVQLD SCHLDLGPEG DMVELIQSRT AKGSCVTLLS PSPEGDPRFS FLLRVYMVPT 
PTAGTLSCNL ALRPSTLSQE VYKTVSMRLN IVSPDLSGKG LVLPSVLGIT FGAFLIGALL 
TAALWYIYSH TRGPSKREPV VAVAAPASSE SSSTNHSIGS TQSTPCSTSS MA

Genular Protein ID: 2971195861

Symbol: F7A1B4_MOUSE

Name: N/A

UniProtKB Accession Codes:

F7A1B4

Database IDs:

AGR 1 ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 1 GeneTree 1 InterPro 1 MGI 2 MaxQB 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 3 SMR 1 VEuPathDB 1 jPOST 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 641
  • Mass: 69275
  • Checksum: A60EBD20463B75A8
  • Sequence:
    • MDRGVLPLPI TLLFVIYSFV PTTGLAERVG CDLQPVDPTR GEVTFTTSQV SEGCVAQAAN 
AVREVHVLFL DFPGMLSHLE LTLQASKQNG TETQEVFLVL VSNKNVFVKF QAPEIPLHLA 
YDSSLVIFQG QPRVNITVLP SLTSRKQILD WAATKGAITS IAALDDPQSI VLQLGQDPKA 
PFLCLPEAHK DMGATLEWQP RAQTPVQSCR LEGVSGHKEA YILRILPGSE AGPRTVTVMM 
ELSCTSGDAI LILHGPPYVS WFIDINHSMQ ILTTGEYSVK IFPGSKVKGV ELPDTPQGLI 
AEARKLNASI VTSFVELPLV SNVSLRASSC GGVFQTTPAP VVTTPPKDTC SPVLLMSLIQ 
PKCGNQVMTL ALNKKHVQTL QCTITGLTFW DSSCQAEDTD DHLVLSSAYS SCGMKVTAHV 
VSNEVIISFP SGSPPLRKKV QCIDMDSLSF QLGLYLSPHF LQASNTIELG QQAFVQVSVS 
PLTSEVTVQL DSCHLDLGPE GDMVELIQSR TAKGSCVTLL SPSPEGDPRF SFLLRVYMVP 
TPTAGTLSCN LALRPSTLSQ EVYKTVSMRL NIVSPDLSGK GLVLPSVLGI TFGAFLIGAL 
LTAALWYIYS HTREYPKPPP HSHSKRSGPV HTTPGHTQWS L

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.