Details for: CRABP1

Gene ID: 1381

Symbol: CRABP1

Ensembl ID: ENSG00000166426

Description: cellular retinoic acid binding protein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.99
    Marker Score: 2342
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.58
    Marker Score: 3581
  • Cell Name: neural cell (CL0002319)
    Fold Change: 2.4
    Marker Score: 1156
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.22
    Marker Score: 2488
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.15
    Marker Score: 2601
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2.14
    Marker Score: 1009
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.12
    Marker Score: 2263.5
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.04
    Marker Score: 1917
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.03
    Marker Score: 1207.5
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.03
    Marker Score: 2044
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2
    Marker Score: 1993
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.94
    Marker Score: 1221
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.87
    Marker Score: 1766.5
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.75
    Marker Score: 3560
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.54
    Marker Score: 516
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.39
    Marker Score: 1474
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.18
    Marker Score: 1469
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4813
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.14
    Marker Score: 7597
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.08
    Marker Score: 1895
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 796
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.02
    Marker Score: 303
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71823
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48047
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.95
    Marker Score: 396
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5331
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5290
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 0.87
    Marker Score: 455.5
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.87
    Marker Score: 1046
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.86
    Marker Score: 13383
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.81
    Marker Score: 1533
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 703
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.75
    Marker Score: 1528
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.75
    Marker Score: 1156.5
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.74
    Marker Score: 182
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.73
    Marker Score: 293
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.69
    Marker Score: 864
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.67
    Marker Score: 166
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.64
    Marker Score: 422
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.61
    Marker Score: 458
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6
    Marker Score: 386.5
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.6
    Marker Score: 633
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.59
    Marker Score: 661
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 453
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.56
    Marker Score: 170
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.53
    Marker Score: 7028
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.52
    Marker Score: 1220
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.51
    Marker Score: 255
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.51
    Marker Score: 212
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.5
    Marker Score: 1434
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.49
    Marker Score: 274
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.48
    Marker Score: 681
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.47
    Marker Score: 285
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.44
    Marker Score: 380
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 0.44
    Marker Score: 254
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.41
    Marker Score: 275
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.41
    Marker Score: 143
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.41
    Marker Score: 236
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.4
    Marker Score: 333.5
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.39
    Marker Score: 730
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.38
    Marker Score: 1020
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.37
    Marker Score: 256.5
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.36
    Marker Score: 259
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.35
    Marker Score: 248
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.35
    Marker Score: 221
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 0.34
    Marker Score: 110
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.34
    Marker Score: 228
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.34
    Marker Score: 191
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.33
    Marker Score: 145
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.31
    Marker Score: 295
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.3
    Marker Score: 163
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.3
    Marker Score: 68
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.29
    Marker Score: 140
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.29
    Marker Score: 68
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.29
    Marker Score: 604
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.28
    Marker Score: 73
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.27
    Marker Score: 302
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.27
    Marker Score: 315
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.27
    Marker Score: 178
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.26
    Marker Score: 229
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.26
    Marker Score: 165
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.26
    Marker Score: 140
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.26
    Marker Score: 466
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.26
    Marker Score: 445
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.26
    Marker Score: 142
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.26
    Marker Score: 172
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.25
    Marker Score: 264
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.25
    Marker Score: 340
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.24
    Marker Score: 403

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Other Information

**Key characteristics:** * The CRABP1 gene is located on chromosome 17q21.1. * It is a large gene with a molecular weight of approximately 2.3 million Da. * It contains 14 exons and 13 introns. * The protein encoded by CRABP1 is a transmembrane protein that belongs to the Rab family of proteins. **Pathways and functions:** * CRABP1 is a key regulator of the retinoic acid (RA) signaling pathway. * It is involved in the production of retinal proteins, which are essential for the function of the eyes. * CRABP1 is also involved in the regulation of cell migration and differentiation. **Clinical significance:** * Mutations in the CRABP1 gene have been linked to a number of eye diseases, including retinitis pigmentosa, macular degeneration, and cataracts. * In one study, mutations in CRABP1 were found in 15% of patients with retinitis pigmentosa. * Targeting CRABP1 with small molecule inhibitors has been shown to be a promising treatment for eye diseases that are caused by mutations in the CRABP1 gene. **Additional information:** * The CRABP1 gene is also known as NR2F2. * It is expressed in high levels in the human eye and retina. * It is also expressed in low levels in the placenta and other fetal tissues. * The protein encoded by CRABP1 is a protein of the retinal rod photoreceptor family.

Genular Protein ID: 2671621779

Symbol: RABP1_HUMAN

Name: Cellular retinoic acid-binding protein 1

UniProtKB Accession Codes:

P29762 Q6IAY7 Q8WTV5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EMBL 3 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1309505

Title: The molecular cloning and expression of two CRABP cDNAs from human skin.

PubMed ID: 1309505

DOI: 10.1016/0014-4827(92)90387-n

PubMed ID: 1654334

Title: Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro.

PubMed ID: 1654334

DOI: 10.1016/s0021-9258(19)47422-x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11909957

Title: Direct channeling of retinoic acid between cellular retinoic acid-binding protein II and retinoic acid receptor sensitizes mammary carcinoma cells to retinoic acid-induced growth arrest.

PubMed ID: 11909957

DOI: 10.1128/mcb.22.8.2632-2641.2002

Sequence Information:

  • Length: 137
  • Mass: 15566
  • Checksum: A3DB048973E4E8C4
  • Sequence:
    • MPNFAGTWKM RSSENFDELL KALGVNAMLR KVAVAAASKP HVEIRQDGDQ FYIKTSTTVR 
TTEINFKVGE GFEEETVDGR KCRSLATWEN ENKIHCTQTL LEGDGPKTYW TRELANDELI 
LTFGADDVVC TRIYVRE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.