Details for: CRABP1

Gene ID: 1381

Symbol: CRABP1

Ensembl ID: ENSG00000166426

Description: cellular retinoic acid binding protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 115.7220
    Cell Significance Index: -18.0000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 70.7292
    Cell Significance Index: -17.9400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 43.8769
    Cell Significance Index: -18.0800
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 16.2026
    Cell Significance Index: 172.1500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 11.6381
    Cell Significance Index: 243.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 5.7077
    Cell Significance Index: 731.6900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 4.5514
    Cell Significance Index: -17.9600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 3.8282
    Cell Significance Index: 214.8200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.7063
    Cell Significance Index: 41.8700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.5000
    Cell Significance Index: 131.2600
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 2.3152
    Cell Significance Index: 13.5900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.9742
    Cell Significance Index: 124.4300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.6421
    Cell Significance Index: 212.1500
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.5290
    Cell Significance Index: 21.4800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.0105
    Cell Significance Index: 192.3100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.9949
    Cell Significance Index: 11.8600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.8005
    Cell Significance Index: 12.7000
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.7160
    Cell Significance Index: 4.0700
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.5644
    Cell Significance Index: 4.3500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4842
    Cell Significance Index: 437.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.4419
    Cell Significance Index: 20.7700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.4088
    Cell Significance Index: 8.4800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3881
    Cell Significance Index: 38.3900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3655
    Cell Significance Index: 7.7900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.3431
    Cell Significance Index: 3.7300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3281
    Cell Significance Index: 35.6900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.3189
    Cell Significance Index: 51.8700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2595
    Cell Significance Index: 15.5800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1656
    Cell Significance Index: 4.7700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1058
    Cell Significance Index: 73.1600
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.1055
    Cell Significance Index: 0.8200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0833
    Cell Significance Index: 5.7600
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.0702
    Cell Significance Index: 0.5400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.0642
    Cell Significance Index: 1.5600
  • Cell Name: ganglion interneuron (CL0000397)
    Fold Change: 0.0421
    Cell Significance Index: 0.3400
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.0283
    Cell Significance Index: 0.2100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0279
    Cell Significance Index: 0.9800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0028
    Cell Significance Index: -2.0800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0038
    Cell Significance Index: -2.4000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0055
    Cell Significance Index: -10.4000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0056
    Cell Significance Index: -2.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0112
    Cell Significance Index: -20.6000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0135
    Cell Significance Index: -20.8600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0153
    Cell Significance Index: -20.8200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0158
    Cell Significance Index: -6.9700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0258
    Cell Significance Index: -19.0900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0294
    Cell Significance Index: -16.0300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0316
    Cell Significance Index: -0.7900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0333
    Cell Significance Index: -20.7900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0347
    Cell Significance Index: -19.5600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0356
    Cell Significance Index: -1.5500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0388
    Cell Significance Index: -17.6300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0408
    Cell Significance Index: -2.5000
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0425
    Cell Significance Index: -0.4100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0464
    Cell Significance Index: -13.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0470
    Cell Significance Index: -9.4300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0526
    Cell Significance Index: -1.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0571
    Cell Significance Index: -2.5900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0634
    Cell Significance Index: -11.4300
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0691
    Cell Significance Index: -0.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0751
    Cell Significance Index: -1.9300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0755
    Cell Significance Index: -2.1100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0769
    Cell Significance Index: -8.9600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0779
    Cell Significance Index: -15.4600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0831
    Cell Significance Index: -2.6600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0875
    Cell Significance Index: -18.4400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1066
    Cell Significance Index: -15.5000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1147
    Cell Significance Index: -19.5900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1148
    Cell Significance Index: -15.7600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1162
    Cell Significance Index: -7.1400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1189
    Cell Significance Index: -2.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1316
    Cell Significance Index: -16.1800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1361
    Cell Significance Index: -10.7800
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1424
    Cell Significance Index: -2.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1444
    Cell Significance Index: -10.7600
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1623
    Cell Significance Index: -1.3400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1709
    Cell Significance Index: -17.4600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1709
    Cell Significance Index: -19.5800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1746
    Cell Significance Index: -18.1800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.2072
    Cell Significance Index: -2.5700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2268
    Cell Significance Index: -3.8000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2649
    Cell Significance Index: -17.8200
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.2788
    Cell Significance Index: -3.1500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2937
    Cell Significance Index: -1.9900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3012
    Cell Significance Index: -15.6900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3020
    Cell Significance Index: -4.1200
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.3091
    Cell Significance Index: -14.4100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3280
    Cell Significance Index: -9.6600
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3346
    Cell Significance Index: -17.3800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3444
    Cell Significance Index: -5.1900
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.3612
    Cell Significance Index: -2.3500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3759
    Cell Significance Index: -4.2700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3797
    Cell Significance Index: -10.8900
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.3800
    Cell Significance Index: -1.9900
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: -0.3905
    Cell Significance Index: -2.9800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3922
    Cell Significance Index: -13.6300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3977
    Cell Significance Index: -17.5900
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.4181
    Cell Significance Index: -4.8600
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: -0.4268
    Cell Significance Index: -3.7600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4366
    Cell Significance Index: -10.4700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CRABP1 is a cytosolic protein that belongs to the retinoic acid-binding protein family. It possesses a high affinity for retinoids, including retinoic acid, and regulates their cellular uptake, storage, and degradation. CRABP1 is characterized by its ability to bind to retinoids in a non-covalent manner, which allows for the regulation of retinoid activity and availability. The protein also interacts with various nuclear receptors, including retinoic acid receptors (RARs) and retinoid X receptors (RXRs), to modulate gene expression. **Pathways and Functions:** CRABP1 is involved in several retinoid signaling pathways, including: 1. **Retinal biosynthesis pathway**: CRABP1 regulates the conversion of retinaldehyde to retinoic acid, a key step in the biosynthesis of retinoic acid. 2. **Retinoid binding**: CRABP1 binds to retinoids, regulating their availability and activity. 3. **Signaling by nuclear receptors**: CRABP1 interacts with RARs and RXRs to modulate gene expression in response to retinoid binding. 4. **Signal transduction**: CRABP1 regulates the activity of various signaling pathways, including those involved in cell proliferation, differentiation, and survival. **Clinical Significance:** CRABP1 plays a critical role in various physiological processes, including: 1. **Thyroid function**: CRABP1 is highly expressed in thyroid follicular cells and regulates thyroid hormone synthesis and metabolism. 2. **Neurodevelopment**: CRABP1 is involved in the development and maintenance of neural cells, including neurons and glial cells. 3. **Vascular development**: CRABP1 regulates the development and function of blood vessel endothelial cells. 4. **Cancer**: CRABP1 has been implicated in the development and progression of various cancers, including retinoblastoma and thyroid cancer. In summary, CRABP1 is a multifunctional protein that plays a crucial role in regulating retinoid signaling pathways and its clinical significance extends to various tissue types, including thyroid follicular cells, neural cells, and blood vessel endothelial cells. Further research is needed to fully elucidate the mechanisms by which CRABP1 regulates retinoid signaling and its implications in human disease.

Genular Protein ID: 2671621779

Symbol: RABP1_HUMAN

Name: Cellular retinoic acid-binding protein 1

UniProtKB Accession Codes:

P29762 Q6IAY7 Q8WTV5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 4 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1309505

Title: The molecular cloning and expression of two CRABP cDNAs from human skin.

PubMed ID: 1309505

DOI: 10.1016/0014-4827(92)90387-n

PubMed ID: 1654334

Title: Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro.

PubMed ID: 1654334

DOI: 10.1016/s0021-9258(19)47422-x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11909957

Title: Direct channeling of retinoic acid between cellular retinoic acid-binding protein II and retinoic acid receptor sensitizes mammary carcinoma cells to retinoic acid-induced growth arrest.

PubMed ID: 11909957

DOI: 10.1128/mcb.22.8.2632-2641.2002

Sequence Information:

  • Length: 137
  • Mass: 15566
  • Checksum: A3DB048973E4E8C4
  • Sequence:
    • MPNFAGTWKM RSSENFDELL KALGVNAMLR KVAVAAASKP HVEIRQDGDQ FYIKTSTTVR 
TTEINFKVGE GFEEETVDGR KCRSLATWEN ENKIHCTQTL LEGDGPKTYW TRELANDELI 
LTFGADDVVC TRIYVRE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.