Genular: Defining Cellular Identity and Function

Details for: Eomes

Gene ID: 13813

Symbol: Eomes

Ensembl ID: ENSMUSG00000032446

Description: eomesodermin

Associated with

Adaptive immune response
(GO:0002250)
Anatomical structure morphogenesis
(GO:0009653)
Astrocyte differentiation
(GO:0048708)
Blastocyst development
(GO:0001824)
Brain development
(GO:0007420)
Cardioblast differentiation
(GO:0010002)
Cd8-positive, alpha-beta t cell differentiation involved in immune response
(GO:0002302)
Cell differentiation
(GO:0030154)
Cell differentiation involved in embryonic placenta development
(GO:0060706)
Cerebral cortex development
(GO:0021987)
Cerebral cortex neuron differentiation
(GO:0021895)
Cerebral cortex regionalization
(GO:0021796)
Chromatin
(GO:0000785)
Chromatin binding
(GO:0003682)
Chromatin dna binding
(GO:0031490)
Chromatin remodeling
(GO:0006338)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Dna demethylation
(GO:0080111)
Dna methylation
(GO:0006306)
Endodermal cell fate specification
(GO:0001714)
Endoderm development
(GO:0007492)
Endoderm formation
(GO:0001706)
Gastrulation
(GO:0007369)
Gene expression
(GO:0010467)
Immune system process
(GO:0002376)
Intracellular anatomical structure
(GO:0005622)
Mesendoderm development
(GO:0048382)
Mesodermal to mesenchymal transition involved in gastrulation
(GO:0060809)
Mesoderm formation
(GO:0001707)
Multicellular organism development
(GO:0007275)
Negative regulation of dna-binding transcription factor activity
(GO:0043433)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neurogenesis
(GO:0022008)
Neuron differentiation
(GO:0030182)
Neuron migration
(GO:0001764)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Olfactory bulb development
(GO:0021772)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of gene expression
(GO:0010468)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Skeletal muscle cell differentiation
(GO:0035914)
Stem cell population maintenance
(GO:0019827)
Trophectodermal cell differentiation
(GO:0001829)
Type ii interferon production
(GO:0032609)

Other Information

Proteins

Eomesodermin homolog

Genular Protein ID: 1346102851

Symbol: EOMES_MOUSE

Name: Eomesodermin homolog

UniProtKB Accession Codes:

O54839 Q3UPL1 Q52KJ1 Q8BN22 Q9JJL1 Q9QYG7

Database IDs:

Citations:

PubMed ID: 10407135

Title: A novel mammalian T-box-containing gene, Tbr2, expressed in mouse developing brain.

PubMed ID: 10407135

DOI: 10.1016/s0165-3806(99)00064-4

PubMed ID: 10974533

Title: Genomic organization, sequence and chromosomal localization of the mouse Tbr2 gene and a comparative study with Tbr1.

PubMed ID: 10974533

DOI: 10.1016/s0378-1119(00)00290-0

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9503012

Title: A combined analysis of genomic and primary protein structure defines the phylogenetic relationship of new members of the T-box family.

PubMed ID: 9503012

DOI: 10.1006/geno.1997.5150

PubMed ID: 10716450

Title: Eomesodermin is required for mouse trophoblast development and mesoderm formation.

PubMed ID: 10716450

DOI: 10.1038/35003601

PubMed ID: 14605368

Title: Control of effector CD8+ T cell function by the transcription factor Eomesodermin.

PubMed ID: 14605368

DOI: 10.1126/science.1090148

PubMed ID: 18171685

Title: Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse.

PubMed ID: 18171685

DOI: 10.1242/dev.014357

PubMed ID: 18940588

Title: Tbr2 directs conversion of radial glia into basal precursors and guides neuronal amplification by indirect neurogenesis in the developing neocortex.

PubMed ID: 18940588

DOI: 10.1016/j.neuron.2008.09.028

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 707
Mass: 74801
Checksum: 277AA462E214A927
Sequence:

MQLGEQLLVS SVNLPGAHFY SLESARGGGG GGGGGGGGGG GSVSLLPGAA PSPQRLDLDK 
ASKKFPGSLP CQAGSAEPAG AGAGAPAAML SDADAGDTFG STSAVAKPGP PDGRKGSPCA 
EEELPSAATA AATARYSMDS LSSERYYLPS PGPQGSELAA PCSLFQYPAA AGAAHGPVYP 
ASNGARYPYG SMLPPGGFPA AVCPPARAQF GPAAGSGSGA GSSGGGAGGP GAYPYGQGSP 
LYGPYAGTSA AGSCGGLGGL GVPGSGFRAH VYLCNRPLWL KFHRHQTEMI ITKQGRRMFP 
FLSFNINGLN PTAHYNVFVE VVLADPNHWR FQGGKWVTCG KADNNMQGNK MYVHPESPNT 
GSHWMRQEIS FGKLKLTNNK GANNNNTQMI VLQSLHKYQP RLHIVEVTED GVEDLNEPSK 
TQTFTFSETQ FIAVTAYQNT DITQLKIDHN PFAKGFRDNY DSMYTASEND RLTPSPTDSP 
RSHQIVPGGR YGVQNFFPEP FVNTLPQARY YNGERTVPQT NGLLSPQQSE EVANPPQRWL 
VTPVQQPVTN KLDIGSYESE YTSSTLLPYG IKSLPLQTSH ALGYYPDPTF PAMAGWGGRG 
AYQRKMAAGL PWTSRMSPPV FPEDQLAKEK VKEEISSSWI ETPPSIKSLD SSDSGVYNSA 
CKRKRLSPST PSNGNSPPIK CEDINTEEYS KDTSKGMGAY YAFYTSP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Eomes

Associated with

Other Information

A novel mammalian T-box-containing gene, Tbr2, expressed in mouse developing brain. PubMed ID: 10407135

Genomic organization, sequence and chromosomal localization of the mouse Tbr2 gene and a comparative study with Tbr1. PubMed ID: 10974533

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A combined analysis of genomic and primary protein structure defines the phylogenetic relationship of new members of the T-box family. PubMed ID: 9503012

Eomesodermin is required for mouse trophoblast development and mesoderm formation. PubMed ID: 10716450

Control of effector CD8+ T cell function by the transcription factor Eomesodermin. PubMed ID: 14605368

Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse. PubMed ID: 18171685

Tbr2 directs conversion of radial glia into basal precursors and guides neuronal amplification by indirect neurogenesis in the developing neocortex. PubMed ID: 18940588

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079