Genular: Defining Cellular Identity and Function

Details for: Epas1

Gene ID: 13819

Symbol: Epas1

Ensembl ID: ENSMUSG00000024140

Description: endothelial PAS domain protein 1

Associated with

Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Metabolism of proteins
(R-MMU-392499)
Neddylation
(R-MMU-8951664)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-MMU-1234176)
Post-translational protein modification
(R-MMU-597592)
Regulation of gene expression by hypoxia-inducible factor
(R-MMU-1234158)
Angiogenesis
(GO:0001525)
Blood vessel remodeling
(GO:0001974)
Cell differentiation
(GO:0030154)
Cellular response to hypoxia
(GO:0071456)
Cis-regulatory region sequence-specific dna binding
(GO:0000987)
Cobalt ion binding
(GO:0050897)
Cytoplasm
(GO:0005737)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Embryonic placenta development
(GO:0001892)
Epithelial cell maturation
(GO:0002070)
Erythrocyte differentiation
(GO:0030218)
Gene expression
(GO:0010467)
Hemopoiesis
(GO:0030097)
Lung development
(GO:0030324)
Mitochondrion organization
(GO:0007005)
Mrna transcription by rna polymerase ii
(GO:0042789)
Multicellular organismal-level iron ion homeostasis
(GO:0060586)
Multicellular organism development
(GO:0007275)
Myoblast fate commitment
(GO:0048625)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Norepinephrine biosynthetic process
(GO:0042421)
Norepinephrine metabolic process
(GO:0042415)
Nuclear speck
(GO:0016607)
Nucleus
(GO:0005634)
Positive regulation of cold-induced thermogenesis
(GO:0120162)
Positive regulation of dopamine biosynthetic process
(GO:1903181)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Protein heterodimerization activity
(GO:0046982)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of heart rate
(GO:0002027)
Regulation of protein neddylation
(GO:2000434)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to hypoxia
(GO:0001666)
Response to oxidative stress
(GO:0006979)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Surfactant homeostasis
(GO:0043129)
Transcription by rna polymerase ii
(GO:0006366)
Transcription coactivator binding
(GO:0001223)
Transcription factor binding
(GO:0008134)
Transcription regulator complex
(GO:0005667)
Visual perception
(GO:0007601)

Other Information

Proteins

Endothelial PAS domain-containing protein 1

Genular Protein ID: 3135989789

Symbol: EPAS1_MOUSE

Name: Endothelial PAS domain-containing protein 1

UniProtKB Accession Codes:

P97481 O08787 O55046

Database IDs:

Citations:

PubMed ID: 9000051

Title: Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.

PubMed ID: 9000051

DOI: 10.1101/gad.11.1.72

PubMed ID: 9113979

Title: A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development.

PubMed ID: 9113979

DOI: 10.1073/pnas.94.9.4273

PubMed ID: 9178256

Title: HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels.

PubMed ID: 9178256

DOI: 10.1016/s0925-4773(97)00674-6

PubMed ID: 12080085

Title: FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor.

PubMed ID: 12080085

DOI: 10.1101/gad.991402

PubMed ID: 11983697

Title: The transcriptional activation function of the HIF-like factor requires phosphorylation at a conserved threonine.

PubMed ID: 11983697

DOI: 10.1074/jbc.m201307200

PubMed ID: 11823643

Title: Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch.

PubMed ID: 11823643

DOI: 10.1126/science.1068592

PubMed ID: 21546903

Title: Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins.

PubMed ID: 21546903

DOI: 10.1038/cdd.2011.47

PubMed ID: 26245371

Title: Structural integration in hypoxia-inducible factors.

PubMed ID: 26245371

DOI: 10.1038/nature14883

Sequence Information:

Length: 874
Mass: 96712
Checksum: A6FFA490AE43640C
Sequence:

MTADKEKKRS SSELRKEKSR DAARCRRSKE TEVFYELAHE LPLPHSVSSH LDKASIMRLA 
ISFLRTHKLL SSVCSENESE AEADQQMDNL YLKALEGFIA VVTQDGDMIF LSENISKFMG 
LTQVELTGHS IFDFTHPCDH EEIRENLTLK NGSGFGKKSK DVSTERDFFM RMKCTVTNRG 
RTVNLKSATW KVLHCTGQVR VYNNCPPHSS LCGSKEPLLS CLIIMCEPIQ HPSHMDIPLD 
SKTFLSRHSM DMKFTYCDDR ILELIGYHPE ELLGRSAYEF YHALDSENMT KSHQNLCTKG 
QVVSGQYRML AKHGGYVWLE TQGTVIYNPR NLQPQCIMCV NYVLSEIEKN DVVFSMDQTE 
SLFKPHLMAM NSIFDSSDDV AVTEKSNYLF TKLKEEPEEL AQLAPTPGDA IISLDFGSQN 
FDEPSAYGKA ILPPGQPWVS GLRSHSAQSE SGSLPAFTVP QADTPGNTTP SASSSSSCST 
PSSPEDYYSS LENPLKIEVI EKLFAMDTEP RDPGSTQTDF SELDLETLAP YIPMDGEDFQ 
LSPICPEEPL MPESPQPTPQ HCFSTMTSIF QPLTPGATHG PFFLDKYPQQ LESRKTESEH 
WPMSSIFFDA GSKGSLSPCC GQASTPLSSM GGRSNTQWPP DPPLHFGPTK WPVGDQSAES 
LGALPVGSSQ LEPPSAPPHV SMFKMRSAKD FGARGPYMMS PAMIALSNKL KLKRQLEYEE 
QAFQDTSGGD PPGTSSSHLM WKRMKSLMGG TCPLMPDKTI SANMAPDEFT QKSMRGLGQP 
LRHLPPPQPP STRSSGENAK TGFPPQCYAS QFQDYGPPGA QKVSGVASRL LGPSFEPYLL 
PELTRYDCEV NVPVPGSSTL LQGRDLLRAL DQAT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Epas1

Associated with

Other Information

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. PubMed ID: 9000051

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development. PubMed ID: 9113979

HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1 alpha and developmentally expressed in blood vessels. PubMed ID: 9178256

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. PubMed ID: 12080085

The transcriptional activation function of the HIF-like factor requires phosphorylation at a conserved threonine. PubMed ID: 11983697

Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. PubMed ID: 11823643

Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins. PubMed ID: 21546903

Structural integration in hypoxia-inducible factors. PubMed ID: 26245371