CRABP2 | ENSG00000143320 | NCBI 1382

Details for: CRABP2

Gene ID: 1382

Symbol: CRABP2

Ensembl ID: ENSG00000143320

Description: cellular retinoic acid binding protein 2

Associated with

Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by retinoic acid
(R-HSA-5362517)
Cyclin binding
(GO:0030332)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Embryonic forelimb morphogenesis
(GO:0035115)
Endoplasmic reticulum
(GO:0005783)
Epidermis development
(GO:0008544)
Extracellular exosome
(GO:0070062)
Fatty acid binding
(GO:0005504)
Fatty acid transport
(GO:0015908)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of collateral sprouting
(GO:0048672)
Protein binding
(GO:0005515)
Regulation of dna-templated transcription
(GO:0006355)
Retinal binding
(GO:0016918)
Retinoic acid binding
(GO:0001972)
Retinoic acid metabolic process
(GO:0042573)
Retinoid binding
(GO:0005501)
Retinol binding
(GO:0019841)
Signal transduction
(GO:0007165)

Other Information

Proteins

Cellular retinoic acid-binding protein 2

Genular Protein ID: 1820161978

Symbol: RABP2_HUMAN

Name: Cellular retinoic acid-binding protein 2

UniProtKB Accession Codes:

P29373 B2R4Z8 D3DVC5 F1T098 Q6ICN6

Database IDs:

Citations:

PubMed ID: 1654334

Title: Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro.

PubMed ID: 1654334

DOI: 10.1016/s0021-9258(19)47422-x

PubMed ID: 1309505

Title: The molecular cloning and expression of two CRABP cDNAs from human skin.

PubMed ID: 1309505

DOI: 10.1016/0014-4827(92)90387-n

PubMed ID: 1334086

Title: Structure of the human cellular retinoic acid-binding protein II gene. Early transcriptional regulation by retinoic acid.

PubMed ID: 1334086

DOI: 10.1016/s0021-9258(19)74033-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 21697133

Title: Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.

PubMed ID: 21697133

DOI: 10.1167/iovs.11-7479

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11909957

Title: Direct channeling of retinoic acid between cellular retinoic acid-binding protein II and retinoic acid receptor sensitizes mammary carcinoma cells to retinoic acid-induced growth arrest.

PubMed ID: 11909957

DOI: 10.1128/mcb.22.8.2632-2641.2002

PubMed ID: 15866176

Title: A ligand-activated nuclear localization signal in cellular retinoic acid binding protein-II.

PubMed ID: 15866176

DOI: 10.1016/j.molcel.2005.03.026

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21998312

Title: Nuclear translocation of cellular retinoic acid-binding protein II is regulated by retinoic acid-controlled SUMOylation.

PubMed ID: 21998312

DOI: 10.1074/jbc.m111.293464

PubMed ID: 7704533

Title: Crystal structures of cellular retinoic acid binding proteins I and II in complex with all-trans-retinoic acid and a synthetic retinoid.

PubMed ID: 7704533

DOI: 10.1016/s0969-2126(94)00125-1

PubMed ID: 9600845

Title: Crystal structure of apo-cellular retinoic acid-binding protein type II (R111M) suggests a mechanism of ligand entry.

PubMed ID: 9600845

DOI: 10.1006/jmbi.1998.1734

PubMed ID: 10531482

Title: Structures of cellular retinoic acid binding proteins I and II in complex with synthetic retinoids.

PubMed ID: 10531482

DOI: 10.1107/s0907444999011026

PubMed ID: 9737849

Title: NMR solution structure of type II human cellular retinoic acid binding protein: implications for ligand binding.

PubMed ID: 9737849

DOI: 10.1021/bi9808924

PubMed ID: 9737883

Title: NMR study suggests a major role for Arg111 in maintaining the structure and dynamical properties of type II human cellular retinoic acid binding protein.

PubMed ID: 9737883

DOI: 10.1021/bi981021x

PubMed ID: 16979656

Title: The structure of apo-wild-type cellular retinoic acid binding protein II at 1.4 A and its relationship to ligand binding and nuclear translocation.

PubMed ID: 16979656

DOI: 10.1016/j.jmb.2006.08.059

PubMed ID: 17447762

Title: Protein design: reengineering cellular retinoic acid binding protein II into a rhodopsin protein mimic.

PubMed ID: 17447762

DOI: 10.1021/ja067546r

Sequence Information:

Length: 138
Mass: 15693
Checksum: 982833700775B377
Sequence:

MPNFSGNWKI IRSENFEELL KVLGVNVMLR KIAVAAASKP AVEIKQEGDT FYIKTSTTVR 
TTEINFKVGE EFEEQTVDGR PCKSLVKWES ENKMVCEQKL LKGEGPKTSW TRELTNDGEL 
ILTMTADDVV CTRVYVRE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CRABP2

Associated with

Other Information

Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro. PubMed ID: 1654334

The molecular cloning and expression of two CRABP cDNAs from human skin. PubMed ID: 1309505

Structure of the human cellular retinoic acid-binding protein II gene. Early transcriptional regulation by retinoic acid. PubMed ID: 1334086

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method. PubMed ID: 21697133

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Direct channeling of retinoic acid between cellular retinoic acid-binding protein II and retinoic acid receptor sensitizes mammary carcinoma cells to retinoic acid-induced growth arrest. PubMed ID: 11909957

A ligand-activated nuclear localization signal in cellular retinoic acid binding protein-II. PubMed ID: 15866176

Initial characterization of the human central proteome. PubMed ID: 21269460

Nuclear translocation of cellular retinoic acid-binding protein II is regulated by retinoic acid-controlled SUMOylation. PubMed ID: 21998312

Crystal structures of cellular retinoic acid binding proteins I and II in complex with all-trans-retinoic acid and a synthetic retinoid. PubMed ID: 7704533

Crystal structure of apo-cellular retinoic acid-binding protein type II (R111M) suggests a mechanism of ligand entry. PubMed ID: 9600845

Structures of cellular retinoic acid binding proteins I and II in complex with synthetic retinoids. PubMed ID: 10531482

NMR solution structure of type II human cellular retinoic acid binding protein: implications for ligand binding. PubMed ID: 9737849

NMR study suggests a major role for Arg111 in maintaining the structure and dynamical properties of type II human cellular retinoic acid binding protein. PubMed ID: 9737883

The structure of apo-wild-type cellular retinoic acid binding protein II at 1.4 A and its relationship to ligand binding and nuclear translocation. PubMed ID: 16979656

Protein design: reengineering cellular retinoic acid binding protein II into a rhodopsin protein mimic. PubMed ID: 17447762