Details for: CRABP2

Gene ID: 1382

Symbol: CRABP2

Ensembl ID: ENSG00000143320

Description: cellular retinoic acid binding protein 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 3.77
    Marker Score: 5415
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.18
    Marker Score: 24803
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.8
    Marker Score: 24142
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.41
    Marker Score: 9287
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.37
    Marker Score: 8772.5
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.31
    Marker Score: 3926
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.28
    Marker Score: 4755
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.25
    Marker Score: 1772
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.11
    Marker Score: 2240
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.99
    Marker Score: 2932
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.92
    Marker Score: 12463
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.89
    Marker Score: 24868
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.88
    Marker Score: 667
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.87
    Marker Score: 4397
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.78
    Marker Score: 981
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.72
    Marker Score: 58636
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.66
    Marker Score: 1774
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.64
    Marker Score: 2909
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.57
    Marker Score: 1473
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.54
    Marker Score: 662
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 1.52
    Marker Score: 1488
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 1.4
    Marker Score: 1063
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.35
    Marker Score: 7105
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.35
    Marker Score: 264
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.33
    Marker Score: 2187
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.33
    Marker Score: 3251.5
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 1.29
    Marker Score: 312
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.28
    Marker Score: 14378
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.27
    Marker Score: 439
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.19
    Marker Score: 15964
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 1.15
    Marker Score: 658
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.13
    Marker Score: 603
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.07
    Marker Score: 241
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.04
    Marker Score: 333
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 1.03
    Marker Score: 4282
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.01
    Marker Score: 1129
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1
    Marker Score: 835
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71803
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48028
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.99
    Marker Score: 629
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.98
    Marker Score: 410
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.98
    Marker Score: 1344
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.96
    Marker Score: 642
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.95
    Marker Score: 1739
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.95
    Marker Score: 448
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.94
    Marker Score: 221
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.92
    Marker Score: 579
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5221
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2735
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.9
    Marker Score: 537
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.9
    Marker Score: 1389
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.88
    Marker Score: 364
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5278
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.87
    Marker Score: 329
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.8
    Marker Score: 321
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.8
    Marker Score: 292
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.79
    Marker Score: 928
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.79
    Marker Score: 345.5
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.79
    Marker Score: 408
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.78
    Marker Score: 2050
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1252
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 589
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 702
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.76
    Marker Score: 190
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.76
    Marker Score: 193
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.76
    Marker Score: 190
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3047
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.72
    Marker Score: 229
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.72
    Marker Score: 886
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.72
    Marker Score: 243
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.68
    Marker Score: 6874.5
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.65
    Marker Score: 150
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.65
    Marker Score: 737
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.63
    Marker Score: 2485
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.63
    Marker Score: 9825
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.59
    Marker Score: 346
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.58
    Marker Score: 453
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.58
    Marker Score: 1096
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.56
    Marker Score: 279
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.56
    Marker Score: 796
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.56
    Marker Score: 419
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 0.56
    Marker Score: 480
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.54
    Marker Score: 172
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.53
    Marker Score: 370
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.53
    Marker Score: 18442
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.53
    Marker Score: 153
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.52
    Marker Score: 1322
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.51
    Marker Score: 124597
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.51
    Marker Score: 437.5
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.51
    Marker Score: 484
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.51
    Marker Score: 102
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.5
    Marker Score: 241

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * CRABP2 is a protein of the Rab family, which are a large family of proteins that are involved in a variety of cellular processes, including cell growth, differentiation, and apoptosis. * CRABP2 is a protein that is highly expressed in the skin, eyes, and lungs. * It is also expressed in the developing immune system. * CRABP2 is a key regulator of retinal development. * It is involved in the regulation of the differentiation of retinal cells from progenitor cells. * It is also involved in the maintenance of retinal function. **Pathways and functions:** * CRABP2 is involved in a variety of cellular processes, including cell growth, differentiation, and apoptosis. * In the skin, CRABP2 is involved in the regulation of skin development and function. * In the eyes, CRABP2 is involved in the regulation of the development and function of the retina. * In the immune system, CRABP2 is involved in the regulation of the activation of T cells and B cells. **Clinical significance:** * Mutations in the CRABP2 gene have been linked to a number of human diseases, including retinitis pigmentosa, a genetic eye disorder that causes blindness. * CRABP2 is a potential target for the treatment of retinitis pigmentosa. * Studies of CRABP2 have also shown that it is involved in the development of other tissues, such as the skin and the immune system. **Additional notes:** * CRABP2 is a highly conserved protein, with a similar protein found in other vertebrates. * The CRABP2 gene is located on chromosome 13q13.3. * There are two isoforms of CRABP2, which are encoded by different genes.

Genular Protein ID: 1820161978

Symbol: RABP2_HUMAN

Name: Cellular retinoic acid-binding protein 2

UniProtKB Accession Codes:

P29373 B2R4Z8 D3DVC5 F1T098 Q6ICN6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CPTC 1 CTD 1 ChEBI 1 ChEMBL 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 5 EMBL 11 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 92 PDBsum 81 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1654334

Title: Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro.

PubMed ID: 1654334

DOI: 10.1016/s0021-9258(19)47422-x

PubMed ID: 1309505

Title: The molecular cloning and expression of two CRABP cDNAs from human skin.

PubMed ID: 1309505

DOI: 10.1016/0014-4827(92)90387-n

PubMed ID: 1334086

Title: Structure of the human cellular retinoic acid-binding protein II gene. Early transcriptional regulation by retinoic acid.

PubMed ID: 1334086

DOI: 10.1016/s0021-9258(19)74033-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 21697133

Title: Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.

PubMed ID: 21697133

DOI: 10.1167/iovs.11-7479

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11909957

Title: Direct channeling of retinoic acid between cellular retinoic acid-binding protein II and retinoic acid receptor sensitizes mammary carcinoma cells to retinoic acid-induced growth arrest.

PubMed ID: 11909957

DOI: 10.1128/mcb.22.8.2632-2641.2002

PubMed ID: 15866176

Title: A ligand-activated nuclear localization signal in cellular retinoic acid binding protein-II.

PubMed ID: 15866176

DOI: 10.1016/j.molcel.2005.03.026

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21998312

Title: Nuclear translocation of cellular retinoic acid-binding protein II is regulated by retinoic acid-controlled SUMOylation.

PubMed ID: 21998312

DOI: 10.1074/jbc.m111.293464

PubMed ID: 7704533

Title: Crystal structures of cellular retinoic acid binding proteins I and II in complex with all-trans-retinoic acid and a synthetic retinoid.

PubMed ID: 7704533

DOI: 10.1016/s0969-2126(94)00125-1

PubMed ID: 9600845

Title: Crystal structure of apo-cellular retinoic acid-binding protein type II (R111M) suggests a mechanism of ligand entry.

PubMed ID: 9600845

DOI: 10.1006/jmbi.1998.1734

PubMed ID: 10531482

Title: Structures of cellular retinoic acid binding proteins I and II in complex with synthetic retinoids.

PubMed ID: 10531482

DOI: 10.1107/s0907444999011026

PubMed ID: 9737849

Title: NMR solution structure of type II human cellular retinoic acid binding protein: implications for ligand binding.

PubMed ID: 9737849

DOI: 10.1021/bi9808924

PubMed ID: 9737883

Title: NMR study suggests a major role for Arg111 in maintaining the structure and dynamical properties of type II human cellular retinoic acid binding protein.

PubMed ID: 9737883

DOI: 10.1021/bi981021x

PubMed ID: 16979656

Title: The structure of apo-wild-type cellular retinoic acid binding protein II at 1.4 A and its relationship to ligand binding and nuclear translocation.

PubMed ID: 16979656

DOI: 10.1016/j.jmb.2006.08.059

PubMed ID: 17447762

Title: Protein design: reengineering cellular retinoic acid binding protein II into a rhodopsin protein mimic.

PubMed ID: 17447762

DOI: 10.1021/ja067546r

Sequence Information:

  • Length: 138
  • Mass: 15693
  • Checksum: 982833700775B377
  • Sequence:
    • MPNFSGNWKI IRSENFEELL KVLGVNVMLR KIAVAAASKP AVEIKQEGDT FYIKTSTTVR 
TTEINFKVGE EFEEQTVDGR PCKSLVKWES ENKMVCEQKL LKGEGPKTSW TRELTNDGEL 
ILTMTADDVV CTRVYVRE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.