Details for: CRABP2

Gene ID: 1382

Symbol: CRABP2

Ensembl ID: ENSG00000143320

Description: cellular retinoic acid binding protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 139.9593
    Cell Significance Index: -21.7700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 85.8686
    Cell Significance Index: -21.7800
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 43.9376
    Cell Significance Index: -18.1000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 17.6730
    Cell Significance Index: -21.7900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 8.4977
    Cell Significance Index: 177.8700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 8.4893
    Cell Significance Index: 52.2500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 7.4035
    Cell Significance Index: 257.2700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 6.1207
    Cell Significance Index: 317.9500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 5.5220
    Cell Significance Index: -21.7900
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 4.6480
    Cell Significance Index: 26.4200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 4.5554
    Cell Significance Index: 58.3400
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 4.4778
    Cell Significance Index: 3.4200
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 4.2834
    Cell Significance Index: 35.4300
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 3.8430
    Cell Significance Index: 22.0400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.3817
    Cell Significance Index: 252.0400
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 3.2078
    Cell Significance Index: 18.8300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.1238
    Cell Significance Index: 403.5700
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 2.6999
    Cell Significance Index: 23.2000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.4705
    Cell Significance Index: 70.8200
  • Cell Name: peg cell (CL4033014)
    Fold Change: 2.4464
    Cell Significance Index: 56.5200
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.3917
    Cell Significance Index: 12.5900
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.3211
    Cell Significance Index: 14.3700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.3118
    Cell Significance Index: 108.6500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.3027
    Cell Significance Index: 21.2100
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.9174
    Cell Significance Index: 11.4900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.6952
    Cell Significance Index: -3.7100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.5388
    Cell Significance Index: 41.8900
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.2763
    Cell Significance Index: 10.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.2137
    Cell Significance Index: 33.9200
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.0716
    Cell Significance Index: 11.6500
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.7746
    Cell Significance Index: 8.2300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.6368
    Cell Significance Index: 81.6300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6207
    Cell Significance Index: 111.9000
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: 0.5404
    Cell Significance Index: 3.3100
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.5202
    Cell Significance Index: 2.4000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.4557
    Cell Significance Index: 7.2300
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.3321
    Cell Significance Index: 4.6700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3166
    Cell Significance Index: 172.9300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2891
    Cell Significance Index: 127.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2751
    Cell Significance Index: 33.8300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2224
    Cell Significance Index: 44.1400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1305
    Cell Significance Index: 1.7800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0768
    Cell Significance Index: 1.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0647
    Cell Significance Index: 8.8900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0507
    Cell Significance Index: 45.7900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0299
    Cell Significance Index: 6.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0054
    Cell Significance Index: 1.9400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0003
    Cell Significance Index: -0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0064
    Cell Significance Index: -12.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0171
    Cell Significance Index: -31.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0205
    Cell Significance Index: -31.6100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0207
    Cell Significance Index: -13.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0228
    Cell Significance Index: -17.2700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0231
    Cell Significance Index: -16.9300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0235
    Cell Significance Index: -31.9000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0291
    Cell Significance Index: -8.3700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0291
    Cell Significance Index: -21.5600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0375
    Cell Significance Index: -21.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0437
    Cell Significance Index: -5.0900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0485
    Cell Significance Index: -22.0100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0710
    Cell Significance Index: -11.5500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0758
    Cell Significance Index: -1.4800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0767
    Cell Significance Index: -7.5900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1093
    Cell Significance Index: -5.5300
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -0.1219
    Cell Significance Index: -1.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1222
    Cell Significance Index: -25.7300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1255
    Cell Significance Index: -18.2500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1355
    Cell Significance Index: -23.1300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1369
    Cell Significance Index: -4.8100
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1392
    Cell Significance Index: -5.7000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1430
    Cell Significance Index: -8.7700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1482
    Cell Significance Index: -7.7800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1585
    Cell Significance Index: -16.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1596
    Cell Significance Index: -18.2900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.1620
    Cell Significance Index: -17.6200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1671
    Cell Significance Index: -11.8200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1742
    Cell Significance Index: -20.5400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1822
    Cell Significance Index: -8.2600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2128
    Cell Significance Index: -22.1600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2236
    Cell Significance Index: -17.7100
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.2258
    Cell Significance Index: -1.4200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2305
    Cell Significance Index: -6.0600
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.2425
    Cell Significance Index: -1.1600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2668
    Cell Significance Index: -17.9400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2711
    Cell Significance Index: -3.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2905
    Cell Significance Index: -16.3000
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.2934
    Cell Significance Index: -1.8300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2966
    Cell Significance Index: -15.4500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3050
    Cell Significance Index: -19.6800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3050
    Cell Significance Index: -21.1000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3330
    Cell Significance Index: -20.4700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3331
    Cell Significance Index: -25.5600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3397
    Cell Significance Index: -21.4100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3507
    Cell Significance Index: -8.7600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.3582
    Cell Significance Index: -9.5700
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3648
    Cell Significance Index: -13.3900
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.3772
    Cell Significance Index: -5.3600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3851
    Cell Significance Index: -9.9000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4124
    Cell Significance Index: -12.1500
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: -0.4438
    Cell Significance Index: -2.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CRABP2 is a small, cytoplasmic protein that binds to all-trans retinoic acid (ATRA) and 9-cis retinoic acid (9-cis RA), which are metabolites of vitamin A. The protein's high affinity for these retinoids enables it to regulate their availability and activity in cells. CRABP2 is highly expressed in various cell types, including epithelial cells, progenitor cells, and immune cells, such as T cells and dendritic cells. Its expression is also elevated in certain tumor types, suggesting a potential role in cancer development and progression. **Pathways and Functions:** CRABP2 is involved in several signaling pathways that regulate cell growth, differentiation, and survival. These pathways include: 1. **Retinoic Acid Metabolic Process:** CRABP2 regulates the metabolism of RA and 9-cis RA, which are essential for embryonic development and tissue homeostasis. 2. **Signaling by Nuclear Receptors:** CRABP2 interacts with nuclear receptors, such as retinoic acid receptors (RARs) and retinoid X receptors (RXRs), to modulate gene expression and cell fate decisions. 3. **Protein Binding:** CRABP2 binds to various proteins, including RARs, RXRs, and other transcription factors, to regulate their activity and localization. 4. **Fatty Acid Transport:** CRABP2 is involved in the transport of fatty acids across cell membranes, which is essential for energy metabolism and cell survival. **Clinical Significance:** CRABP2 has significant implications for various diseases, including: 1. **Cancer:** Elevated CRABP2 expression has been observed in certain tumor types, suggesting a potential role in cancer development and progression. CRABP2 may serve as a biomarker for cancer diagnosis and prognosis. 2. **Immunodeficiency:** CRABP2 is expressed in immune cells, and its dysregulation may contribute to immunodeficiency disorders, such as Aplastic Anemia. 3. **Neurological Disorders:** CRABP2 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease, where retinoid signaling is disrupted. 4. **Developmental Disorders:** CRABP2 plays a crucial role in embryonic development, and its dysregulation may contribute to developmental disorders, such as craniofacial abnormalities and congenital heart defects. In conclusion, CRABP2 is a multifunctional protein that plays a critical role in various cellular processes, including retinoid metabolism, signaling, and protein binding. Its dysregulation has significant implications for disease prevention and treatment, highlighting the need for further research into the molecular mechanisms of CRABP2 and its potential applications in immunology and beyond.

Genular Protein ID: 1820161978

Symbol: RABP2_HUMAN

Name: Cellular retinoic acid-binding protein 2

UniProtKB Accession Codes:

P29373 B2R4Z8 D3DVC5 F1T098 Q6ICN6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 2 CPTC 1 CTD 1 ChEBI 1 ChEMBL 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EMBL 11 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 81 PDBsum 81 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1654334

Title: Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro.

PubMed ID: 1654334

DOI: 10.1016/s0021-9258(19)47422-x

PubMed ID: 1309505

Title: The molecular cloning and expression of two CRABP cDNAs from human skin.

PubMed ID: 1309505

DOI: 10.1016/0014-4827(92)90387-n

PubMed ID: 1334086

Title: Structure of the human cellular retinoic acid-binding protein II gene. Early transcriptional regulation by retinoic acid.

PubMed ID: 1334086

DOI: 10.1016/s0021-9258(19)74033-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 21697133

Title: Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method.

PubMed ID: 21697133

DOI: 10.1167/iovs.11-7479

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11909957

Title: Direct channeling of retinoic acid between cellular retinoic acid-binding protein II and retinoic acid receptor sensitizes mammary carcinoma cells to retinoic acid-induced growth arrest.

PubMed ID: 11909957

DOI: 10.1128/mcb.22.8.2632-2641.2002

PubMed ID: 15866176

Title: A ligand-activated nuclear localization signal in cellular retinoic acid binding protein-II.

PubMed ID: 15866176

DOI: 10.1016/j.molcel.2005.03.026

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21998312

Title: Nuclear translocation of cellular retinoic acid-binding protein II is regulated by retinoic acid-controlled SUMOylation.

PubMed ID: 21998312

DOI: 10.1074/jbc.m111.293464

PubMed ID: 7704533

Title: Crystal structures of cellular retinoic acid binding proteins I and II in complex with all-trans-retinoic acid and a synthetic retinoid.

PubMed ID: 7704533

DOI: 10.1016/s0969-2126(94)00125-1

PubMed ID: 9600845

Title: Crystal structure of apo-cellular retinoic acid-binding protein type II (R111M) suggests a mechanism of ligand entry.

PubMed ID: 9600845

DOI: 10.1006/jmbi.1998.1734

PubMed ID: 10531482

Title: Structures of cellular retinoic acid binding proteins I and II in complex with synthetic retinoids.

PubMed ID: 10531482

DOI: 10.1107/s0907444999011026

PubMed ID: 9737849

Title: NMR solution structure of type II human cellular retinoic acid binding protein: implications for ligand binding.

PubMed ID: 9737849

DOI: 10.1021/bi9808924

PubMed ID: 9737883

Title: NMR study suggests a major role for Arg111 in maintaining the structure and dynamical properties of type II human cellular retinoic acid binding protein.

PubMed ID: 9737883

DOI: 10.1021/bi981021x

PubMed ID: 16979656

Title: The structure of apo-wild-type cellular retinoic acid binding protein II at 1.4 A and its relationship to ligand binding and nuclear translocation.

PubMed ID: 16979656

DOI: 10.1016/j.jmb.2006.08.059

PubMed ID: 17447762

Title: Protein design: reengineering cellular retinoic acid binding protein II into a rhodopsin protein mimic.

PubMed ID: 17447762

DOI: 10.1021/ja067546r

Sequence Information:

  • Length: 138
  • Mass: 15693
  • Checksum: 982833700775B377
  • Sequence:
    • MPNFSGNWKI IRSENFEELL KVLGVNVMLR KIAVAAASKP AVEIKQEGDT FYIKTSTTVR 
TTEINFKVGE EFEEQTVDGR PCKSLVKWES ENKMVCEQKL LKGEGPKTSW TRELTNDGEL 
ILTMTADDVV CTRVYVRE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.