Genular: Defining Cellular Identity and Function

Details for: Epha4

Gene ID: 13838

Symbol: Epha4

Ensembl ID: ENSMUSG00000026235

Description: Eph receptor A4

Associated with

Developmental biology
(R-MMU-1266738)
Eph-ephrin mediated repulsion of cells
(R-MMU-3928665)
Eph-ephrin signaling
(R-MMU-2682334)
Epha-mediated growth cone collapse
(R-MMU-3928663)
Adherens junction organization
(GO:0034332)
Adult walking behavior
(GO:0007628)
Atp binding
(GO:0005524)
Axon
(GO:0030424)
Axonal growth cone
(GO:0044295)
Axon guidance
(GO:0007411)
Axon terminus
(GO:0043679)
Cell adhesion
(GO:0007155)
Cell body
(GO:0044297)
Cell projection
(GO:0042995)
Cell surface
(GO:0009986)
Cellular response to amyloid-beta
(GO:1904646)
Cochlea development
(GO:0090102)
Corticospinal tract morphogenesis
(GO:0021957)
Cytoplasm
(GO:0005737)
Dendrite
(GO:0030425)
Dendritic shaft
(GO:0043198)
Dendritic spine
(GO:0043197)
Dh domain binding
(GO:0097161)
Early endosome membrane
(GO:0031901)
Endosome
(GO:0005768)
Ephrin receptor activity
(GO:0005003)
Ephrin receptor binding
(GO:0046875)
Ephrin receptor signaling pathway
(GO:0048013)
Fasciculation of motor neuron axon
(GO:0097156)
Fasciculation of sensory neuron axon
(GO:0097155)
Filopodium
(GO:0030175)
Glial cell migration
(GO:0008347)
Gpi-linked ephrin receptor activity
(GO:0005004)
Identical protein binding
(GO:0042802)
Kinase activity
(GO:0016301)
Membrane
(GO:0016020)
Mitochondrial outer membrane
(GO:0005741)
Motor neuron axon guidance
(GO:0008045)
Multicellular organism development
(GO:0007275)
Negative regulation of axon regeneration
(GO:0048681)
Negative regulation of cell adhesion
(GO:0007162)
Negative regulation of cell migration
(GO:0030336)
Negative regulation of cellular response to hypoxia
(GO:1900038)
Negative regulation of epithelial to mesenchymal transition
(GO:0010719)
Negative regulation of erk1 and erk2 cascade
(GO:0070373)
Negative regulation of long-term synaptic potentiation
(GO:1900272)
Negative regulation of neuron projection development
(GO:0010977)
Negative regulation of proteolysis involved in protein catabolic process
(GO:1903051)
Nephric duct morphogenesis
(GO:0072178)
Nervous system development
(GO:0007399)
Neuromuscular junction
(GO:0031594)
Neuron projection fasciculation
(GO:0106030)
Neuron projection guidance
(GO:0097485)
Nucleotide binding
(GO:0000166)
Peptidyl-tyrosine phosphorylation
(GO:0018108)
Perikaryon
(GO:0043204)
Ph domain binding
(GO:0042731)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Positive regulation of amyloid-beta formation
(GO:1902004)
Positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
(GO:1902961)
Positive regulation of cell adhesion
(GO:0045785)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dendrite morphogenesis
(GO:0050775)
Positive regulation of jun kinase activity
(GO:0043507)
Positive regulation of protein tyrosine kinase activity
(GO:0061098)
Positive regulation of rho guanyl-nucleotide exchange factor activity
(GO:2001108)
Postsynaptic density
(GO:0014069)
Postsynaptic membrane
(GO:0045211)
Presynaptic membrane
(GO:0042734)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein stabilization
(GO:0050821)
Protein tyrosine kinase activity
(GO:0004713)
Protein tyrosine kinase binding
(GO:1990782)
Regulation of astrocyte differentiation
(GO:0048710)
Regulation of axonogenesis
(GO:0050770)
Regulation of dendritic spine morphogenesis
(GO:0061001)
Regulation of gtpase activity
(GO:0043087)
Regulation of modification of synaptic structure
(GO:1905244)
Regulation of synapse pruning
(GO:1905806)
Synapse
(GO:0045202)
Synapse pruning
(GO:0098883)
Transferase activity
(GO:0016740)
Transmembrane-ephrin receptor activity
(GO:0005005)
Transmembrane receptor protein tyrosine kinase activity
(GO:0004714)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)

Other Information

Proteins

Ephrin type-A receptor 4

Genular Protein ID: 2857442625

Symbol: EPHA4_MOUSE

Name: Ephrin type-A receptor 4

UniProtKB Accession Codes:

Q03137 Q80VZ2

Database IDs:

Citations:

PubMed ID: 1281307

Title: An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain.

PubMed ID: 1281307

PubMed ID: 8455939

Title:

PubMed ID: 8455939

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8622893

Title: A juxtamembrane autophosphorylation site in the Eph family receptor tyrosine kinase, Sek, mediates high affinity interaction with p59fyn.

PubMed ID: 8622893

PubMed ID: 9789074

Title: EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract.

PubMed ID: 9789074

DOI: 10.1073/pnas.95.22.13248

PubMed ID: 11336673

Title: EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin.

PubMed ID: 11336673

DOI: 10.1016/s0092-8674(01)00314-2

PubMed ID: 14516691

Title: Developmental expression of EphA4-tyrosine kinase receptor in the mouse brain and spinal cord.

PubMed ID: 14516691

DOI: 10.1016/s0925-4773(03)00122-9

PubMed ID: 15537875

Title: Axonal regeneration and lack of astrocytic gliosis in EphA4-deficient mice.

PubMed ID: 15537875

DOI: 10.1523/jneurosci.2981-04.2004

PubMed ID: 16802330

Title: EphA4 regulates central nervous system vascular formation.

PubMed ID: 16802330

DOI: 10.1002/cne.21029

PubMed ID: 16818734

Title: Thymic alterations in EphA4-deficient mice.

PubMed ID: 16818734

DOI: 10.4049/jimmunol.177.2.804

PubMed ID: 17719550

Title: Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of EphrinB3/EphA4 forward signaling.

PubMed ID: 17719550

DOI: 10.1016/j.cell.2007.07.022

PubMed ID: 18094260

Title: The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases.

PubMed ID: 18094260

DOI: 10.1523/jneurosci.2746-07.2007

PubMed ID: 17143272

Title: Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism.

PubMed ID: 17143272

DOI: 10.1038/nn1811

PubMed ID: 17785183

Title: alpha2-Chimaerin is an essential EphA4 effector in the assembly of neuronal locomotor circuits.

PubMed ID: 17785183

DOI: 10.1016/j.neuron.2007.07.036

PubMed ID: 18034455

Title: Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.

PubMed ID: 18034455

DOI: 10.1021/pr0701254

PubMed ID: 18403711

Title: Segregation of axial motor and sensory pathways via heterotypic trans-axonal signaling.

PubMed ID: 18403711

DOI: 10.1126/science.1153758

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 27446912

Title: Gene expression profiling of muscle stem cells identifies novel regulators of postnatal myogenesis.

PubMed ID: 27446912

DOI: 10.3389/fcell.2016.00058

PubMed ID: 30639848

Title: EphA4-ADAM10 Interplay Patterns the Cochlear Sensory Epithelium through Local Disruption of Adherens Junctions.

PubMed ID: 30639848

DOI: 10.1016/j.isci.2018.12.017

PubMed ID: 31439799

Title: Phospho-dependent phase separation of FMRP and CAPRIN1 recapitulates regulation of translation and deadenylation.

PubMed ID: 31439799

DOI: 10.1126/science.aax4240

Sequence Information:

Length: 986
Mass: 109814
Checksum: 89BEB2C7CDB54A55
Sequence:

MAGIFYFILF SFLFGICDAV TGSRVYPANE VTLLDSRSVQ GELGWIASPL EGGWEEVSIM 
DEKNTPIRTY QVCNVMEASQ NNWLRTDWIT REGAQRVYIE IKFTLRDCNS LPGVMGTCKE 
TFNLYYYESD NDKERFIRES QFGKIDTIAA DESFTQVDIG DRIMKLNTEI RDVGPLSKKG 
FYLAFQDVGA CIALVSVRVF YKKCPLTVRN LAQFPDTITG ADTSSLVEVR GSCVNNSEEK 
DVPKMYCGAD GEWLVPIGNC LCNAGHEEQN GECQACKIGY YKALSTDASC AKCPPHSYSV 
WEGATSCTCD RGFFRADNDA ASMPCTRPPS APLNLISNVN ETSVNLEWSS PQNTGGRQDI 
SYNVVCKKCG AGDPSKCRPC GSGVHYTPQQ NGLKTTRVSI TDLLAHTNYT FEIWAVNGVS 
KYNPSPDQSV SVTVTTNQAA PSSIALVQAK EVTRYSVALA WLEPDRPNGV ILEYEVKYYE 
KDQNERSYRI VRTAARNTDI KGLNPLTSYV FHVRARTAAG YGDFSEPLEV TTNTVPSRII 
GDGANSTVLL VSVSGSVVLV VILIAAFVIS RRRSKYSKAK QEADEEKHLN QGVRTYVDPF 
TYEDPNQAVR EFAKEIDASC IKIEKVIGVG EFGEVCSGRL KVPGKREICV AIKTLKAGYT 
DKQRRDFLSE ASIMGQFDHP NIIHLEGVVT KCKPVMIITE YMENGSLDAF LRKNDGRFTV 
IQLVGMLRGI GSGMKYLSDM SYVHRDLAAR NILVNSNLVC KVSDFGMSRV LEDDPEAAYT 
TRGGKIPIRW TAPEAIAYRK FTSASDVWSY GIVMWEVMSY GERPYWDMSN QDVIKAIEEG 
YRLPPPMDCP IALHQLMLDC WQKERSDRPK FGQIVNMLDK LIRNPNSLKR TGSESSRPNT 
ALLDPSSPEF SAVVSVGDWL QAIKMDRYKD NFTAAGYTTL EAVVHMSQDD LARIGITAIT 
HQNKILSSVQ AMRTQMQQMH GRMVPV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Epha4

Associated with

Other Information

An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain. PubMed ID: 1281307

PubMed ID: 8455939

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A juxtamembrane autophosphorylation site in the Eph family receptor tyrosine kinase, Sek, mediates high affinity interaction with p59fyn. PubMed ID: 8622893

EphA4 (Sek1) receptor tyrosine kinase is required for the development of the corticospinal tract. PubMed ID: 9789074

EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexin. PubMed ID: 11336673

Developmental expression of EphA4-tyrosine kinase receptor in the mouse brain and spinal cord. PubMed ID: 14516691

Axonal regeneration and lack of astrocytic gliosis in EphA4-deficient mice. PubMed ID: 15537875

EphA4 regulates central nervous system vascular formation. PubMed ID: 16802330

Thymic alterations in EphA4-deficient mice. PubMed ID: 16818734

Rac-GAP alpha-chimerin regulates motor-circuit formation as a key mediator of EphrinB3/EphA4 forward signaling. PubMed ID: 17719550

The EphA4 receptor regulates neuronal morphology through SPAR-mediated inactivation of Rap GTPases. PubMed ID: 18094260

Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. PubMed ID: 17143272

alpha2-Chimaerin is an essential EphA4 effector in the assembly of neuronal locomotor circuits. PubMed ID: 17785183

Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain. PubMed ID: 18034455

Segregation of axial motor and sensory pathways via heterotypic trans-axonal signaling. PubMed ID: 18403711

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Gene expression profiling of muscle stem cells identifies novel regulators of postnatal myogenesis. PubMed ID: 27446912

EphA4-ADAM10 Interplay Patterns the Cochlear Sensory Epithelium through Local Disruption of Adherens Junctions. PubMed ID: 30639848

Phospho-dependent phase separation of FMRP and CAPRIN1 recapitulates regulation of translation and deadenylation. PubMed ID: 31439799