Genular: Defining Cellular Identity and Function

Details for: Ephb2

Gene ID: 13844

Symbol: Ephb2

Ensembl ID: ENSMUSG00000028664

Description: Eph receptor B2

Associated with

Developmental biology
(R-MMU-1266738)
Eph-ephrin mediated repulsion of cells
(R-MMU-3928665)
Eph-ephrin signaling
(R-MMU-2682334)
Ephb-mediated forward signaling
(R-MMU-3928662)
Ephrin signaling
(R-MMU-3928664)
Amyloid-beta binding
(GO:0001540)
Angiogenesis
(GO:0001525)
Animal organ morphogenesis
(GO:0009887)
Atp binding
(GO:0005524)
Axonal fasciculation
(GO:0007413)
Axon guidance
(GO:0007411)
Axon guidance receptor activity
(GO:0008046)
Axonogenesis
(GO:0007409)
B cell activation
(GO:0042113)
Camera-type eye morphogenesis
(GO:0048593)
Cell morphogenesis
(GO:0000902)
Central nervous system projection neuron axonogenesis
(GO:0021952)
Commissural neuron axon guidance
(GO:0071679)
Corpus callosum development
(GO:0022038)
Dendritic spine development
(GO:0060996)
Dendritic spine morphogenesis
(GO:0060997)
Ephrin receptor activity
(GO:0005003)
Ephrin receptor signaling pathway
(GO:0048013)
Hindbrain tangential cell migration
(GO:0021934)
Identical protein binding
(GO:0042802)
Inner ear morphogenesis
(GO:0042472)
Kinase activity
(GO:0016301)
Learning
(GO:0007612)
Learning or memory
(GO:0007611)
Multicellular organism development
(GO:0007275)
Negative regulation of axonogenesis
(GO:0050771)
Negative regulation of cell adhesion
(GO:0007162)
Negative regulation of cytokine production involved in inflammatory response
(GO:1900016)
Negative regulation of erk1 and erk2 cascade
(GO:0070373)
Negative regulation of nmda glutamate receptor activity
(GO:1904782)
Negative regulation of protein kinase activity
(GO:0006469)
Negative regulation of protein phosphorylation
(GO:0001933)
Negative regulation of ras protein signal transduction
(GO:0046580)
Nervous system development
(GO:0007399)
Neuron projection retraction
(GO:0106028)
Nucleotide binding
(GO:0000166)
Optic nerve morphogenesis
(GO:0021631)
Peptidyl-tyrosine phosphorylation
(GO:0018108)
Phosphorylation
(GO:0016310)
Positive regulation of b cell proliferation
(GO:0030890)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of dendritic spine morphogenesis
(GO:0061003)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of immunoglobulin production
(GO:0002639)
Positive regulation of long-term neuronal synaptic plasticity
(GO:0048170)
Positive regulation of long-term synaptic potentiation
(GO:1900273)
Positive regulation of nmda glutamate receptor activity
(GO:1904783)
Positive regulation of protein localization to cell surface
(GO:2000010)
Positive regulation of protein localization to plasma membrane
(GO:1903078)
Positive regulation of synapse assembly
(GO:0051965)
Positive regulation of synaptic plasticity
(GO:0031915)
Positive regulation of tumor necrosis factor production
(GO:0032760)
Postsynaptic membrane assembly
(GO:0097104)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein tyrosine kinase activity
(GO:0004713)
Regulation of autophagosome assembly
(GO:2000785)
Regulation of axonogenesis
(GO:0050770)
Regulation of blood coagulation
(GO:0030193)
Regulation of body fluid levels
(GO:0050878)
Regulation of filopodium assembly
(GO:0051489)
Regulation of neuronal synaptic plasticity
(GO:0048168)
Regulation of receptor signaling pathway via jak-stat
(GO:0046425)
Regulation of synapse assembly
(GO:0051963)
Regulation of t-helper 17 type immune response
(GO:2000316)
Retinal ganglion cell axon guidance
(GO:0031290)
Roof of mouth development
(GO:0060021)
Signaling receptor activity
(GO:0038023)
Signaling receptor binding
(GO:0005102)
Tight junction assembly
(GO:0120192)
Trans-synaptic signaling by trans-synaptic complex, modulating synaptic transmission
(GO:0099557)
Transferase activity
(GO:0016740)
Transmembrane-ephrin receptor activity
(GO:0005005)
Transmembrane receptor protein tyrosine kinase activity
(GO:0004714)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)
Urogenital system development
(GO:0001655)
Vesicle-mediated intercellular transport
(GO:0110077)

Other Information

Proteins

Neural kinase

Genular Protein ID: 3949639425

Symbol: EPHB2_MOUSE

Name: Neural kinase

UniProtKB Accession Codes:

P54763 A3KG00 A3KG01 A3KG02 A3KG89 A3KG90 Q62213 Q6GTQ7 Q6P5F1 Q9QVY4

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8134103

Title: Immunolocalization of the Nuk receptor tyrosine kinase suggests roles in segmental patterning of the brain and axonogenesis.

PubMed ID: 8134103

PubMed ID: 7947319

Title: Several receptor tyrosine kinase genes of the Eph family are segmentally expressed in the developing hindbrain.

PubMed ID: 7947319

DOI: 10.1016/0925-4773(94)90091-4

PubMed ID: 8689685

Title: Nuk controls pathfinding of commissural axons in the mammalian central nervous system.

PubMed ID: 8689685

DOI: 10.1016/s0092-8674(00)80075-6

PubMed ID: 8947026

Title: Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation.

PubMed ID: 8947026

DOI: 10.1002/j.1460-2075.1996.tb00992.x

PubMed ID: 9883737

Title: PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands.

PubMed ID: 9883737

DOI: 10.1016/s0896-6273(00)80663-7

PubMed ID: 9990854

Title: Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis.

PubMed ID: 9990854

DOI: 10.1101/gad.13.3.295

PubMed ID: 10542222

Title: A novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1A.

PubMed ID: 10542222

DOI: 10.1074/jbc.274.45.31941

PubMed ID: 10704386

Title: Complementary expression of transmembrane ephrins and their receptors in the mouse spinal cord: a possible role in constraining the orientation of longitudinally projecting axons.

PubMed ID: 10704386

DOI: 10.1242/dev.127.7.1397

PubMed ID: 10839360

Title: EphB2 guides axons at the midline and is necessary for normal vestibular function.

PubMed ID: 10839360

DOI: 10.1016/s0896-6273(00)81174-5

PubMed ID: 14691139

Title: Multiple EphB receptor tyrosine kinases shape dendritic spines in the hippocampus.

PubMed ID: 14691139

DOI: 10.1083/jcb.200306033

PubMed ID: 15223334

Title: Bidirectional signaling mediated by ephrin-B2 and EphB2 controls urorectal development.

PubMed ID: 15223334

DOI: 10.1016/j.ydbio.2004.03.027

PubMed ID: 17428795

Title: Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor.

PubMed ID: 17428795

DOI: 10.1074/jbc.m611449200

PubMed ID: 19656770

Title: The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation.

PubMed ID: 19656770

DOI: 10.1074/mcp.m900195-mcp200

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21029865

Title: EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation.

PubMed ID: 21029865

DOI: 10.1016/j.cell.2010.09.038

PubMed ID: 27446912

Title: Gene expression profiling of muscle stem cells identifies novel regulators of postnatal myogenesis.

PubMed ID: 27446912

DOI: 10.3389/fcell.2016.00058

PubMed ID: 28931592

Title: Ubiquitin ligase SPSB4 diminishes cell repulsive responses mediated by EphB2.

PubMed ID: 28931592

DOI: 10.1091/mbc.e17-07-0450

PubMed ID: 9853759

Title: Crystal structure of the ligand-binding domain of the receptor tyrosine kinase EphB2.

PubMed ID: 9853759

DOI: 10.1038/24904

PubMed ID: 11780069

Title: Crystal structure of an Eph receptor-ephrin complex.

PubMed ID: 11780069

DOI: 10.1038/414933a

PubMed ID: 15107857

Title: Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling.

PubMed ID: 15107857

DOI: 10.1038/nn1237

Sequence Information:

Length: 986
Mass: 109899
Checksum: 92DB5234F18758A7
Sequence:

MAVRRLGAAL LLLPLLAAVE ETLMDSTTAT AELGWMVHPP SGWEEVSGYD ENMNTIRTYQ 
VCNVFESSQN NWLRTKFIRR RGAHRIHVEM KFSVRDCSSI PSVPGSCKET FNLYYYEADF 
DLATKTFPNW MENPWVKVDT IAADESFSQV DLGGRVMKIN TEVRSFGPVS RNGFYLAFQD 
YGGCMSLIAV RVFYRKCPRI IQNGAIFQET LSGAESTSLV AARGSCIANA EEVDVPIKLY 
CNGDGEWLVP IGRCMCKAGF EAVENGTVCR GCPSGTFKAN QGDEACTHCP INSRTTSEGA 
TNCVCRNGYY RADLDPLDMP CTTIPSAPQA VISSVNETSL MLEWTPPRDS GGREDLVYNI 
ICKSCGSGRG ACTRCGDNVQ YAPRQLGLTE PRIYISDLLA HTQYTFEIQA VNGVTDQSPF 
SPQFASVNIT TNQAAPSAVS IMHQVSRTVD SITLSWSQPD QPNGVILDYE LQYYEKELSE 
YNATAIKSPT NTVTVQGLKA GAIYVFQVRA RTVAGYGRYS GKMYFQTMTE AEYQTSIKEK 
LPLIVGSSAA GLVFLIAVVV IAIVCNRRGF ERADSEYTDK LQHYTSGHMT PGMKIYIDPF 
TYEDPNEAVR EFAKEIDISC VKIEQVIGAG EFGEVCSGHL KLPGKREIFV AIKTLKSGYT 
EKQRRDFLSE ASIMGQFDHP NVIHLEGVVT KSTPVMIITE FMENGSLDSF LRQNDGQFTV 
IQLVGMLRGI AAGMKYLADM NYVHRDLAAR NILVNSNLVC KVSDFGLSRF LEDDTSDPTY 
TSALGGKIPI RWTAPEAIQY RKFTSASDVW SYGIVMWEVM SYGERPYWDM TNQDVINAIE 
QDYRLPPPMD CPSALHQLML DCWQKDRNHR PKFGQIVNTL DKMIRNPNSL KAMAPLSSGI 
NLPLLDRTIP DYTSFNTVDE WLEAIKMGQY KESFANAGFT SFDVVSQMMM EDILRVGVTL 
AGHQKKILNS IQVMRAQMNQ IQSVEV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ephb2

Associated with

Other Information

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Immunolocalization of the Nuk receptor tyrosine kinase suggests roles in segmental patterning of the brain and axonogenesis. PubMed ID: 8134103

Several receptor tyrosine kinase genes of the Eph family are segmentally expressed in the developing hindbrain. PubMed ID: 7947319

Nuk controls pathfinding of commissural axons in the mammalian central nervous system. PubMed ID: 8689685

Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation. PubMed ID: 8947026

PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands. PubMed ID: 9883737

Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis. PubMed ID: 9990854

A novel signaling intermediate, SHEP1, directly couples Eph receptors to R-Ras and Rap1A. PubMed ID: 10542222

Complementary expression of transmembrane ephrins and their receptors in the mouse spinal cord: a possible role in constraining the orientation of longitudinally projecting axons. PubMed ID: 10704386

EphB2 guides axons at the midline and is necessary for normal vestibular function. PubMed ID: 10839360

Multiple EphB receptor tyrosine kinases shape dendritic spines in the hippocampus. PubMed ID: 14691139

Bidirectional signaling mediated by ephrin-B2 and EphB2 controls urorectal development. PubMed ID: 15223334

Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor. PubMed ID: 17428795

The mouse C2C12 myoblast cell surface N-linked glycoproteome: identification, glycosite occupancy, and membrane orientation. PubMed ID: 19656770

Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. PubMed ID: 19349973

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation. PubMed ID: 21029865

Gene expression profiling of muscle stem cells identifies novel regulators of postnatal myogenesis. PubMed ID: 27446912

Ubiquitin ligase SPSB4 diminishes cell repulsive responses mediated by EphB2. PubMed ID: 28931592

Crystal structure of the ligand-binding domain of the receptor tyrosine kinase EphB2. PubMed ID: 9853759

Crystal structure of an Eph receptor-ephrin complex. PubMed ID: 11780069

Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signaling. PubMed ID: 15107857