CREB1 | ENSG00000118260 | NCBI 1385

Details for: CREB1

Gene ID: 1385

Symbol: CREB1

Ensembl ID: ENSG00000118260

Description: cAMP responsive element binding protein 1

Associated with

Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Adora2b mediated anti-inflammatory cytokines production
(R-HSA-9660821)
Akt phosphorylates targets in the nucleus
(R-HSA-198693)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Axon guidance
(R-HSA-422475)
Ca-dependent events
(R-HSA-111996)
Calmodulin induced events
(R-HSA-111933)
Camk iv-mediated phosphorylation of creb
(R-HSA-111932)
Cam pathway
(R-HSA-111997)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Circadian clock
(R-HSA-400253)
Constitutive signaling by akt1 e17k in cancer
(R-HSA-5674400)
Creb1 phosphorylation through nmda receptor-mediated activation of ras signaling
(R-HSA-442742)
Creb1 phosphorylation through the activation of adenylate cyclase
(R-HSA-442720)
Creb1 phosphorylation through the activation of camkii/camkk/camkiv cascasde
(R-HSA-442729)
Creb phosphorylation
(R-HSA-199920)
Cytokine signaling in immune system
(R-HSA-1280215)
Dag and ip3 signaling
(R-HSA-1489509)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent nuclear events downstream of esr-membrane signaling
(R-HSA-9634638)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
G-protein mediated events
(R-HSA-112040)
G alpha (i) signalling events
(R-HSA-418594)
G alpha (q) signalling events
(R-HSA-416476)
Gastrin-creb signalling pathway via pkc and mapk
(R-HSA-881907)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gpcr downstream signalling
(R-HSA-388396)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Heme signaling
(R-HSA-9707616)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-17 signaling
(R-HSA-448424)
Intracellular signaling by second messengers
(R-HSA-9006925)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Map kinase activation
(R-HSA-450294)
Mapk targets/ nuclear events mediated by map kinases
(R-HSA-450282)
Mecp2 regulates neuronal receptors and channels
(R-HSA-9022699)
Mecp2 regulates transcription factors
(R-HSA-9022707)
Mecp2 regulates transcription of neuronal ligands
(R-HSA-9022702)
Mitf-m-dependent gene expression
(R-HSA-9856651)
Mitf-m-regulated melanocyte development
(R-HSA-9730414)
Mitochondrial biogenesis
(R-HSA-1592230)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Ncam signaling for neurite out-growth
(R-HSA-375165)
Nervous system development
(R-HSA-9675108)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Ngf-stimulated transcription
(R-HSA-9031628)
Notch2 intracellular domain regulates transcription
(R-HSA-2197563)
Nuclear events (kinase and transcription factor activation)
(R-HSA-198725)
Opioid signalling
(R-HSA-111885)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Parasitic infection pathways
(R-HSA-9824443)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pip3 activates akt signaling
(R-HSA-1257604)
Pka-mediated phosphorylation of creb
(R-HSA-111931)
Plc beta mediated events
(R-HSA-112043)
Post nmda receptor activation events
(R-HSA-438064)
Regulation of mecp2 expression and activity
(R-HSA-9022692)
Regulation of mitf-m-dependent genes involved in pigmentation
(R-HSA-9824585)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by gpcr
(R-HSA-372790)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by notch2
(R-HSA-1980145)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Transcriptional activation of mitochondrial biogenesis
(R-HSA-2151201)
Transcriptional and post-translational regulation of mitf-m expression and activity
(R-HSA-9856649)
Transcriptional regulation by mecp2
(R-HSA-8986944)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Transmission across chemical synapses
(R-HSA-112315)
Trif (ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Viral infection pathways
(R-HSA-9824446)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 320.2284
Cell Significance Index: -49.8100
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 201.2274
Cell Significance Index: -51.0400
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 131.9828
Cell Significance Index: -54.3700
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 121.7692
Cell Significance Index: -57.4900
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 116.2318
Cell Significance Index: -47.2200
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 104.1437
Cell Significance Index: -53.5700
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 49.8616
Cell Significance Index: -47.6100
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 44.5190
Cell Significance Index: -54.8900
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 18.5788
Cell Significance Index: -49.7700
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 14.2586
Cell Significance Index: -56.2700
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 13.3259
Cell Significance Index: -40.9300
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 11.1442
Cell Significance Index: -24.3900
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 2.6205
Cell Significance Index: 147.0500
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.8276
Cell Significance Index: 362.7000
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.7607
Cell Significance Index: 353.1900
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.5052
Cell Significance Index: 115.5100
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.0469
Cell Significance Index: 113.8800
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.9464
Cell Significance Index: 58.1700
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.8517
Cell Significance Index: 305.5000
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.7969
Cell Significance Index: 19.9200
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.7639
Cell Significance Index: 45.8600
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.7575
Cell Significance Index: 93.1400
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7483
Cell Significance Index: 675.6300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.7053
Cell Significance Index: 127.1400
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.6981
Cell Significance Index: 482.8400
Cell Name: early pro-B cell (CL0002046)
Fold Change: 0.5440
Cell Significance Index: 35.1000
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.5385
Cell Significance Index: 15.0500
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.4880
Cell Significance Index: 67.0100
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.4639
Cell Significance Index: 54.7100
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.4251
Cell Significance Index: 232.1700
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3704
Cell Significance Index: 163.7700
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.3184
Cell Significance Index: 51.7900
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.3134
Cell Significance Index: 8.5300
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.2785
Cell Significance Index: 8.0300
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2626
Cell Significance Index: 25.9800
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.2449
Cell Significance Index: 4.7800
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.2202
Cell Significance Index: 10.3500
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2133
Cell Significance Index: 9.6700
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.2115
Cell Significance Index: 14.2200
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2010
Cell Significance Index: 38.2600
Cell Name: odontoblast (CL0000060)
Fold Change: 0.1628
Cell Significance Index: 20.8700
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.1587
Cell Significance Index: 4.0800
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.1424
Cell Significance Index: 7.4200
Cell Name: retinal rod cell (CL0000604)
Fold Change: 0.1342
Cell Significance Index: 1.6000
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.1184
Cell Significance Index: 222.9400
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.1115
Cell Significance Index: 1.9100
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0968
Cell Significance Index: 61.5000
Cell Name: cortical interneuron (CL0008031)
Fold Change: 0.0890
Cell Significance Index: 2.1400
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.0458
Cell Significance Index: 1.5900
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0447
Cell Significance Index: 68.7800
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0397
Cell Significance Index: 18.0400
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0333
Cell Significance Index: 2.1000
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0319
Cell Significance Index: 58.8600
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.0249
Cell Significance Index: 0.5400
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0153
Cell Significance Index: 20.8500
Cell Name: lactocyte (CL0002325)
Fold Change: 0.0038
Cell Significance Index: 0.4900
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.0034
Cell Significance Index: 0.0900
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0096
Cell Significance Index: -1.6400
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0279
Cell Significance Index: -20.6700
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.0300
Cell Significance Index: -1.4000
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0420
Cell Significance Index: -30.7700
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0423
Cell Significance Index: -6.1500
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0423
Cell Significance Index: -26.4400
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0565
Cell Significance Index: -31.8400
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0606
Cell Significance Index: -45.8800
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.0850
Cell Significance Index: -3.7600
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.1117
Cell Significance Index: -1.8700
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.1171
Cell Significance Index: -8.2800
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1186
Cell Significance Index: -13.5900
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.1532
Cell Significance Index: -5.8000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.1652
Cell Significance Index: -8.5800
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1661
Cell Significance Index: -47.8000
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1683
Cell Significance Index: -35.4400
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1805
Cell Significance Index: -21.0400
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1818
Cell Significance Index: -18.5700
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.2225
Cell Significance Index: -7.8200
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2501
Cell Significance Index: -13.1300
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2917
Cell Significance Index: -33.3000
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.3206
Cell Significance Index: -23.9000
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.4012
Cell Significance Index: -5.7700
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.4149
Cell Significance Index: -6.1300
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4294
Cell Significance Index: -44.7100
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.4727
Cell Significance Index: -12.4300
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.5837
Cell Significance Index: -4.7600
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.6003
Cell Significance Index: -47.5400
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.6179
Cell Significance Index: -13.1600
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.6240
Cell Significance Index: -3.7700
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.6418
Cell Significance Index: -18.3200
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.7281
Cell Significance Index: -15.2400
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.7817
Cell Significance Index: -20.9500
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.7850
Cell Significance Index: -10.7100
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.7876
Cell Significance Index: -17.2500
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.7926
Cell Significance Index: -22.7200
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.7972
Cell Significance Index: -17.0400
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.8073
Cell Significance Index: -49.5000
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.8819
Cell Significance Index: -22.5300
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.9224
Cell Significance Index: -14.0100
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: -0.9248
Cell Significance Index: -27.1600
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -1.0159
Cell Significance Index: -27.1800
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -1.0540
Cell Significance Index: -33.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Transcriptional regulation:** CREB1 is a transcription factor that regulates the expression of target genes by binding to specific DNA sequences, known as cAMP response elements (CRE). 2. **Signal transduction:** CREB1 is involved in signal transduction pathways, including the activation of NMDA receptors, adenylyl cyclase, and Ca-dependent events. 3. **Immunological responses:** CREB1 regulates immune responses, including the production of anti-inflammatory cytokines and the activation of immune cells. 4. **Cancer:** CREB1 has been implicated in cancer, including the regulation of cell growth, apoptosis, and metastasis. 5. **Neurological disorders:** CREB1 is involved in neurological disorders, including neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. **Pathways and Functions:** 1. **Akt signaling pathway:** CREB1 is phosphorylated and activated by Akt, leading to the regulation of target genes involved in cell survival, proliferation, and apoptosis. 2. **NMDA receptor signaling:** CREB1 is activated by NMDA receptor-mediated signaling, leading to the regulation of neuronal excitability and synaptic plasticity. 3. **Adenylyl cyclase signaling:** CREB1 is activated by adenylyl cyclase, leading to the regulation of cAMP levels and the activation of downstream signaling pathways. 4. **Ca-dependent events:** CREB1 is involved in Ca-dependent events, including the regulation of cell growth, apoptosis, and immune responses. 5. **Cytokine signaling:** CREB1 regulates cytokine signaling, including the production of anti-inflammatory cytokines and the activation of immune cells. **Clinical Significance:** 1. **Cancer:** CREB1 has been implicated in cancer, including the regulation of cell growth, apoptosis, and metastasis. 2. **Neurological disorders:** CREB1 is involved in neurological disorders, including neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 3. **Inflammatory disorders:** CREB1 regulates immune responses, including the production of anti-inflammatory cytokines and the activation of immune cells, making it a potential target for the treatment of inflammatory disorders. 4. **Cardiovascular disease:** CREB1 has been implicated in cardiovascular disease, including the regulation of cardiac myocyte function and the development of cardiac fibrosis. 5. **Infectious diseases:** CREB1 is involved in the regulation of immune responses, including the production of anti-inflammatory cytokines and the activation of immune cells, making it a potential target for the treatment of infectious diseases. In conclusion, CREB1 is a key regulator of cellular responses to stimuli, including stress, cytokines, and growth factors, and its dysregulation has been implicated in several diseases, including cancer, inflammatory disorders, and neurodegenerative diseases. Further research is needed to fully understand the role of CREB1 in various physiological and pathological processes and to identify potential therapeutic targets for the treatment of these diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Genular Protein ID: 3729862135

Symbol: CREB1_HUMAN

Name: Cyclic AMP-responsive element-binding protein 1

UniProtKB Accession Codes:

P16220 P21934 Q6V963 Q9UMA7

Database IDs:

Citations:

PubMed ID: 2142528

Title: Two distinct forms of active transcription factor CREB (cAMP response element binding protein).

PubMed ID: 2142528

DOI: 10.1073/pnas.87.14.5258

PubMed ID: 2196176

Title: Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain.

PubMed ID: 2196176

DOI: 10.1002/j.1460-2075.1990.tb07434.x

PubMed ID: 1966745

Title: Diversification of cyclic AMP-responsive enhancer binding proteins-generated by alternative exon splicing.

PubMed ID: 1966745

PubMed ID: 2974179

Title: Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA.

PubMed ID: 2974179

DOI: 10.1126/science.2974179

PubMed ID: 1831258

Title: Nucleotide and derived amino-acid sequences of the CRE-binding proteins from rat C6 glioma and HeLa cells.

PubMed ID: 1831258

DOI: 10.1093/nar/19.15.4290

PubMed ID: 15579595

Title: Cloning and expression of a novel CREB mRNA splice variant in human testis.

PubMed ID: 15579595

DOI: 10.1530/rep.1.00036

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8381074

Title: The promoter of the gene encoding 3',5'-cyclic adenosine monophosphate (cAMP) response element binding protein contains cAMP response elements: evidence for positive autoregulation of gene transcription.

PubMed ID: 8381074

DOI: 10.1210/endo.132.2.8381074

PubMed ID: 1827531

Title: HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions.

PubMed ID: 1827531

DOI: 10.1126/science.1827531

PubMed ID: 1386673

Title: Human T-cell lymphotropic virus type I (HTLV-I) transcriptional activator, Tax, enhances CREB binding to HTLV-I 21-base-pair repeats by protein-protein interaction.

PubMed ID: 1386673

DOI: 10.1073/pnas.89.15.7070

PubMed ID: 8065343

Title: Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression.

PubMed ID: 8065343

DOI: 10.1128/mcb.14.9.6107-6116.1994

PubMed ID: 7608156

Title: Transcriptional activation of egr-1 by granulocyte-macrophage colony-stimulating factor but not interleukin 3 requires phosphorylation of cAMP response element-binding protein (CREB) on serine 133.

PubMed ID: 7608156

DOI: 10.1074/jbc.270.27.15979

PubMed ID: 9829964

Title: CREB is a regulatory target for the protein kinase Akt/PKB.

PubMed ID: 9829964

DOI: 10.1074/jbc.273.49.32377

PubMed ID: 9770464

Title: Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene.

PubMed ID: 9770464

DOI: 10.1073/pnas.95.21.12202

PubMed ID: 14536081

Title: TORCs: transducers of regulated CREB activity.

PubMed ID: 14536081

DOI: 10.1016/j.molcel.2003.08.013

PubMed ID: 12552083

Title: Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia.

PubMed ID: 12552083

DOI: 10.1073/pnas.0337412100

PubMed ID: 14506290

Title: Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells.

PubMed ID: 14506290

DOI: 10.1073/pnas.1932773100

PubMed ID: 15454081

Title: The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector.

PubMed ID: 15454081

DOI: 10.1016/j.cell.2004.09.015

PubMed ID: 15964553

Title: TSSK5, a novel member of the testis-specific serine/threonine kinase family, phosphorylates CREB at Ser-133, and stimulates the CRE/CREB responsive pathway.

PubMed ID: 15964553

DOI: 10.1016/j.bbrc.2005.05.157

PubMed ID: 16325578

Title: A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription.

PubMed ID: 16325578

DOI: 10.1016/j.cell.2005.09.011

PubMed ID: 15733869

Title: Serum/glucocorticoid-inducible kinase can phosphorylate the cyclic AMP response element binding protein, CREB.

PubMed ID: 15733869

DOI: 10.1016/j.febslet.2005.01.040

PubMed ID: 16908542

Title: PGC-1-related coactivator: immediate early expression and characterization of a CREB/NRF-1 binding domain associated with cytochrome c promoter occupancy and respiratory growth.

PubMed ID: 16908542

DOI: 10.1128/mcb.00585-06

PubMed ID: 17724745

Title: EWSR1-CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma.

PubMed ID: 17724745

DOI: 10.1002/gcc.20491

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20573984

Title: Regulation of genotoxic stress response by homeodomain-interacting protein kinase 2 through phosphorylation of cyclic AMP response element-binding protein at serine 271.

PubMed ID: 20573984

DOI: 10.1091/mbc.e10-01-0015

PubMed ID: 21172805

Title: TOX3 is a neuronal survival factor that induces transcription depending on the presence of CITED1 or phosphorylated CREB in the transcriptionally active complex.

PubMed ID: 21172805

DOI: 10.1242/jcs.068759

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22267179

Title: A p.D116G mutation in CREB1 leads to novel multiple malformation syndrome resembling CrebA knockout mouse.

PubMed ID: 22267179

DOI: 10.1002/humu.22027

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23651431

Title: Allosteric communication in the KIX domain proceeds through dynamic repacking of the hydrophobic core.

PubMed ID: 23651431

DOI: 10.1021/cb4002188

Sequence Information:

Length: 327
Mass: 35136
Checksum: F5BA8200EE5184B7
Sequence:

MTMESGAENQ QSGDAAVTEA ENQQMTVQAQ PQIATLAQVS MPAAHATSSA PTVTLVQLPN 
GQTVQVHGVI QAAQPSVIQS PQVQTVQIST IAESEDSQES VDSVTDSQKR REILSRRPSY 
RKILNDLSSD APGVPRIEEE KSEEETSAPA ITTVTVPTPI YQTSSGQYIA ITQGGAIQLA 
NNGTDGVQGL QTLTMTNAAA TQPGTTILQY AQTTDGQQIL VPSNQVVVQA ASGDVQTYQI 
RTAPTSTIAP GVVMASSPAL PTQPAEEAAR KREVRLMKNR EAARECRRKK KEYVKCLENR 
VAVLENQNKT LIEELKALKD LYCHKSD

Genular Protein ID: 4055913484

Symbol: B7Z5C6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z5C6

Database IDs:

Sequence Information:

Length: 234
Mass: 24653
Checksum: 1ED57E58A3FBC079
Sequence:

MTMESGAENQ QSGDAAVTEA ENQQMTVQAL PQIATLAQVS MPAAHATSSA PTVTLVQLPN 
GQTVQVHGVI QAAQPSVIQS PQVQTVQIST IAESEDSQES VDSVTDSQKR REILSRRPSY 
RKILNDLSSD APGVPRIEEE KSEEETSAPA ITTVTVPTPI YQTSSGQYIA ITQGGAIQLA 
NNGTDGVQGL QTLTMTNAAA TQPGTTILQY AQTTDGQQIL VPSNQVVVQG TQKL

Genular Protein ID: 2984114285

Symbol: Q5U0J5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5U0J5 A0A024R401

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

Length: 341
Mass: 36688
Checksum: D5E989AE40BF69AF
Sequence:

MTMESGAENQ QSGDAAVTEA ENQQMTVQAQ PQIATLAQVS MPAAHATSSA PTVTLVQLPN 
GQTVQVHGVI QAAQPSVIQS PQVQTVQSSC KDLKRLFSGT QISTIAESED SQESVDSVTD 
SQKRREILSR RPSYRKILND LSSDAPGVPR IEEEKSEEET SAPAITTVTV PTPIYQTSSG 
QYIAITQGGA IQLANNGTDG VQGLQTLTMT NAAATQPGTT ILQYAQTTDG QQILVPSNQV 
VVQAASGDVQ TYQIRTAPTS TIAPGVVMAS SPALPTQPAE EAARKREVRL MKNREAAREC 
RRKKKEYVKC LENRVAVLEN QNKTLIEELK ALKDLYCHKS D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CREB1

Associated with

Cells (max top 100)

Other Information

Two distinct forms of active transcription factor CREB (cAMP response element binding protein). PubMed ID: 2142528

Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain. PubMed ID: 2196176

Diversification of cyclic AMP-responsive enhancer binding proteins-generated by alternative exon splicing. PubMed ID: 1966745

Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA. PubMed ID: 2974179

Nucleotide and derived amino-acid sequences of the CRE-binding proteins from rat C6 glioma and HeLa cells. PubMed ID: 1831258

Cloning and expression of a novel CREB mRNA splice variant in human testis. PubMed ID: 15579595

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The promoter of the gene encoding 3',5'-cyclic adenosine monophosphate (cAMP) response element binding protein contains cAMP response elements: evidence for positive autoregulation of gene transcription. PubMed ID: 8381074

HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions. PubMed ID: 1827531

Human T-cell lymphotropic virus type I (HTLV-I) transcriptional activator, Tax, enhances CREB binding to HTLV-I 21-base-pair repeats by protein-protein interaction. PubMed ID: 1386673

Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression. PubMed ID: 8065343

Transcriptional activation of egr-1 by granulocyte-macrophage colony-stimulating factor but not interleukin 3 requires phosphorylation of cAMP response element-binding protein (CREB) on serine 133. PubMed ID: 7608156

CREB is a regulatory target for the protein kinase Akt/PKB. PubMed ID: 9829964

Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene. PubMed ID: 9770464

TORCs: transducers of regulated CREB activity. PubMed ID: 14536081

Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia. PubMed ID: 12552083

Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. PubMed ID: 14506290

The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. PubMed ID: 15454081

TSSK5, a novel member of the testis-specific serine/threonine kinase family, phosphorylates CREB at Ser-133, and stimulates the CRE/CREB responsive pathway. PubMed ID: 15964553

A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription. PubMed ID: 16325578

Serum/glucocorticoid-inducible kinase can phosphorylate the cyclic AMP response element binding protein, CREB. PubMed ID: 15733869

PGC-1-related coactivator: immediate early expression and characterization of a CREB/NRF-1 binding domain associated with cytochrome c promoter occupancy and respiratory growth. PubMed ID: 16908542

EWSR1-CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma. PubMed ID: 17724745

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Regulation of genotoxic stress response by homeodomain-interacting protein kinase 2 through phosphorylation of cyclic AMP response element-binding protein at serine 271. PubMed ID: 20573984

TOX3 is a neuronal survival factor that induces transcription depending on the presence of CITED1 or phosphorylated CREB in the transcriptionally active complex. PubMed ID: 21172805

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

A p.D116G mutation in CREB1 leads to novel multiple malformation syndrome resembling CrebA knockout mouse. PubMed ID: 22267179

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Allosteric communication in the KIX domain proceeds through dynamic repacking of the hydrophobic core. PubMed ID: 23651431

The sequence of the human genome. PubMed ID: 11181995

Database document:

PubMed ID: 2142528

PubMed ID: 2196176

PubMed ID: 1966745

PubMed ID: 2974179

PubMed ID: 1831258

PubMed ID: 15579595

PubMed ID: 15489334

PubMed ID: 8381074

PubMed ID: 1827531

PubMed ID: 1386673

PubMed ID: 8065343

PubMed ID: 7608156

PubMed ID: 9829964

PubMed ID: 9770464

PubMed ID: 14536081

PubMed ID: 12552083

PubMed ID: 14506290

PubMed ID: 15454081

PubMed ID: 15964553

PubMed ID: 16325578

PubMed ID: 15733869

PubMed ID: 16908542

PubMed ID: 17724745

PubMed ID: 17525332

PubMed ID: 18669648

PubMed ID: 19690332

PubMed ID: 20573984

PubMed ID: 21172805

PubMed ID: 21406692

PubMed ID: 22267179

PubMed ID: 23186163

PubMed ID: 24275569

PubMed ID: 28112733

PubMed ID: 23651431

PubMed ID: 11181995