CREB1 | ENSG00000118260 | NCBI 1385

Details for: CREB1

Gene ID: 1385

Symbol: CREB1

Ensembl ID: ENSG00000118260

Description: cAMP responsive element binding protein 1

Associated with

Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Adora2b mediated anti-inflammatory cytokines production
(R-HSA-9660821)
Akt phosphorylates targets in the nucleus
(R-HSA-198693)
Anti-inflammatory response favouring leishmania parasite infection
(R-HSA-9662851)
Axon guidance
(R-HSA-422475)
Ca-dependent events
(R-HSA-111996)
Calmodulin induced events
(R-HSA-111933)
Camk iv-mediated phosphorylation of creb
(R-HSA-111932)
Cam pathway
(R-HSA-111997)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Circadian clock
(R-HSA-400253)
Constitutive signaling by akt1 e17k in cancer
(R-HSA-5674400)
Creb1 phosphorylation through nmda receptor-mediated activation of ras signaling
(R-HSA-442742)
Creb1 phosphorylation through the activation of adenylate cyclase
(R-HSA-442720)
Creb1 phosphorylation through the activation of camkii/camkk/camkiv cascasde
(R-HSA-442729)
Creb phosphorylation
(R-HSA-199920)
Cytokine signaling in immune system
(R-HSA-1280215)
Dag and ip3 signaling
(R-HSA-1489509)
Developmental biology
(R-HSA-1266738)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent nuclear events downstream of esr-membrane signaling
(R-HSA-9634638)
Extra-nuclear estrogen signaling
(R-HSA-9009391)
Fcgr3a-mediated il10 synthesis
(R-HSA-9664323)
G-protein mediated events
(R-HSA-112040)
G alpha (i) signalling events
(R-HSA-418594)
G alpha (q) signalling events
(R-HSA-416476)
Gastrin-creb signalling pathway via pkc and mapk
(R-HSA-881907)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Gpcr downstream signalling
(R-HSA-388396)
Hcmv early events
(R-HSA-9609690)
Hcmv infection
(R-HSA-9609646)
Heme signaling
(R-HSA-9707616)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Interleukin-17 signaling
(R-HSA-448424)
Intracellular signaling by second messengers
(R-HSA-9006925)
Leishmania infection
(R-HSA-9658195)
Leishmania parasite growth and survival
(R-HSA-9664433)
Map kinase activation
(R-HSA-450294)
Mapk targets/ nuclear events mediated by map kinases
(R-HSA-450282)
Mecp2 regulates neuronal receptors and channels
(R-HSA-9022699)
Mecp2 regulates transcription factors
(R-HSA-9022707)
Mecp2 regulates transcription of neuronal ligands
(R-HSA-9022702)
Mitochondrial biogenesis
(R-HSA-1592230)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Ncam signaling for neurite out-growth
(R-HSA-375165)
Nervous system development
(R-HSA-9675108)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Ngf-stimulated transcription
(R-HSA-9031628)
Notch2 intracellular domain regulates transcription
(R-HSA-2197563)
Nuclear events (kinase and transcription factor activation)
(R-HSA-198725)
Opioid signalling
(R-HSA-111885)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Parasitic infection pathways
(R-HSA-9824443)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pip3 activates akt signaling
(R-HSA-1257604)
Pka-mediated phosphorylation of creb
(R-HSA-111931)
Plc beta mediated events
(R-HSA-112043)
Post nmda receptor activation events
(R-HSA-438064)
Regulation of mecp2 expression and activity
(R-HSA-9022692)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by gpcr
(R-HSA-372790)
Signaling by interleukins
(R-HSA-449147)
Signaling by notch
(R-HSA-157118)
Signaling by notch2
(R-HSA-1980145)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Transcriptional activation of mitochondrial biogenesis
(R-HSA-2151201)
Transcriptional regulation by mecp2
(R-HSA-8986944)
Transcriptional regulation of granulopoiesis
(R-HSA-9616222)
Transmission across chemical synapses
(R-HSA-112315)
Trif(ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Viral infection pathways
(R-HSA-9824446)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)

Other Information

Proteins

Genular Protein ID: 3729862135

Symbol: CREB1_HUMAN

Name: Cyclic AMP-responsive element-binding protein 1

UniProtKB Accession Codes:

P16220 P21934 Q6V963 Q9UMA7

Database IDs:

Citations:

PubMed ID: 2142528

Title: Two distinct forms of active transcription factor CREB (cAMP response element binding protein).

PubMed ID: 2142528

DOI: 10.1073/pnas.87.14.5258

PubMed ID: 2196176

Title: Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain.

PubMed ID: 2196176

DOI: 10.1002/j.1460-2075.1990.tb07434.x

PubMed ID: 1966745

Title: Diversification of cyclic AMP-responsive enhancer binding proteins-generated by alternative exon splicing.

PubMed ID: 1966745

PubMed ID: 2974179

Title: Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA.

PubMed ID: 2974179

DOI: 10.1126/science.2974179

PubMed ID: 1831258

Title: Nucleotide and derived amino-acid sequences of the CRE-binding proteins from rat C6 glioma and HeLa cells.

PubMed ID: 1831258

DOI: 10.1093/nar/19.15.4290

PubMed ID: 15579595

Title: Cloning and expression of a novel CREB mRNA splice variant in human testis.

PubMed ID: 15579595

DOI: 10.1530/rep.1.00036

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8381074

Title: The promoter of the gene encoding 3',5'-cyclic adenosine monophosphate (cAMP) response element binding protein contains cAMP response elements: evidence for positive autoregulation of gene transcription.

PubMed ID: 8381074

DOI: 10.1210/endo.132.2.8381074

PubMed ID: 1827531

Title: HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions.

PubMed ID: 1827531

DOI: 10.1126/science.1827531

PubMed ID: 1386673

Title: Human T-cell lymphotropic virus type I (HTLV-I) transcriptional activator, Tax, enhances CREB binding to HTLV-I 21-base-pair repeats by protein-protein interaction.

PubMed ID: 1386673

DOI: 10.1073/pnas.89.15.7070

PubMed ID: 8065343

Title: Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression.

PubMed ID: 8065343

DOI: 10.1128/mcb.14.9.6107-6116.1994

PubMed ID: 7608156

Title: Transcriptional activation of egr-1 by granulocyte-macrophage colony-stimulating factor but not interleukin 3 requires phosphorylation of cAMP response element-binding protein (CREB) on serine 133.

PubMed ID: 7608156

DOI: 10.1074/jbc.270.27.15979

PubMed ID: 9829964

Title: CREB is a regulatory target for the protein kinase Akt/PKB.

PubMed ID: 9829964

DOI: 10.1074/jbc.273.49.32377

PubMed ID: 9770464

Title: Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene.

PubMed ID: 9770464

DOI: 10.1073/pnas.95.21.12202

PubMed ID: 14536081

Title: TORCs: transducers of regulated CREB activity.

PubMed ID: 14536081

DOI: 10.1016/j.molcel.2003.08.013

PubMed ID: 12552083

Title: Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia.

PubMed ID: 12552083

DOI: 10.1073/pnas.0337412100

PubMed ID: 14506290

Title: Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells.

PubMed ID: 14506290

DOI: 10.1073/pnas.1932773100

PubMed ID: 15454081

Title: The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector.

PubMed ID: 15454081

DOI: 10.1016/j.cell.2004.09.015

PubMed ID: 15964553

Title: TSSK5, a novel member of the testis-specific serine/threonine kinase family, phosphorylates CREB at Ser-133, and stimulates the CRE/CREB responsive pathway.

PubMed ID: 15964553

DOI: 10.1016/j.bbrc.2005.05.157

PubMed ID: 16325578

Title: A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription.

PubMed ID: 16325578

DOI: 10.1016/j.cell.2005.09.011

PubMed ID: 15733869

Title: Serum/glucocorticoid-inducible kinase can phosphorylate the cyclic AMP response element binding protein, CREB.

PubMed ID: 15733869

DOI: 10.1016/j.febslet.2005.01.040

PubMed ID: 16908542

Title: PGC-1-related coactivator: immediate early expression and characterization of a CREB/NRF-1 binding domain associated with cytochrome c promoter occupancy and respiratory growth.

PubMed ID: 16908542

DOI: 10.1128/mcb.00585-06

PubMed ID: 17724745

Title: EWSR1-CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma.

PubMed ID: 17724745

DOI: 10.1002/gcc.20491

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20573984

Title: Regulation of genotoxic stress response by homeodomain-interacting protein kinase 2 through phosphorylation of cyclic AMP response element-binding protein at serine 271.

PubMed ID: 20573984

DOI: 10.1091/mbc.e10-01-0015

PubMed ID: 21172805

Title: TOX3 is a neuronal survival factor that induces transcription depending on the presence of CITED1 or phosphorylated CREB in the transcriptionally active complex.

PubMed ID: 21172805

DOI: 10.1242/jcs.068759

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22267179

Title: A p.D116G mutation in CREB1 leads to novel multiple malformation syndrome resembling CrebA knockout mouse.

PubMed ID: 22267179

DOI: 10.1002/humu.22027

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 23651431

Title: Allosteric communication in the KIX domain proceeds through dynamic repacking of the hydrophobic core.

PubMed ID: 23651431

DOI: 10.1021/cb4002188

Sequence Information:

Length: 327
Mass: 35136
Checksum: F5BA8200EE5184B7
Sequence:

MTMESGAENQ QSGDAAVTEA ENQQMTVQAQ PQIATLAQVS MPAAHATSSA PTVTLVQLPN 
GQTVQVHGVI QAAQPSVIQS PQVQTVQIST IAESEDSQES VDSVTDSQKR REILSRRPSY 
RKILNDLSSD APGVPRIEEE KSEEETSAPA ITTVTVPTPI YQTSSGQYIA ITQGGAIQLA 
NNGTDGVQGL QTLTMTNAAA TQPGTTILQY AQTTDGQQIL VPSNQVVVQA ASGDVQTYQI 
RTAPTSTIAP GVVMASSPAL PTQPAEEAAR KREVRLMKNR EAARECRRKK KEYVKCLENR 
VAVLENQNKT LIEELKALKD LYCHKSD

Genular Protein ID: 2984114285

Symbol: Q5U0J5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q5U0J5 A0A024R401

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

Length: 341
Mass: 36688
Checksum: D5E989AE40BF69AF
Sequence:

MTMESGAENQ QSGDAAVTEA ENQQMTVQAQ PQIATLAQVS MPAAHATSSA PTVTLVQLPN 
GQTVQVHGVI QAAQPSVIQS PQVQTVQSSC KDLKRLFSGT QISTIAESED SQESVDSVTD 
SQKRREILSR RPSYRKILND LSSDAPGVPR IEEEKSEEET SAPAITTVTV PTPIYQTSSG 
QYIAITQGGA IQLANNGTDG VQGLQTLTMT NAAATQPGTT ILQYAQTTDG QQILVPSNQV 
VVQAASGDVQ TYQIRTAPTS TIAPGVVMAS SPALPTQPAE EAARKREVRL MKNREAAREC 
RRKKKEYVKC LENRVAVLEN QNKTLIEELK ALKDLYCHKS D

Genular Protein ID: 4055913484

Symbol: B7Z5C6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z5C6

Database IDs:

Sequence Information:

Length: 234
Mass: 24653
Checksum: 1ED57E58A3FBC079
Sequence:

MTMESGAENQ QSGDAAVTEA ENQQMTVQAL PQIATLAQVS MPAAHATSSA PTVTLVQLPN 
GQTVQVHGVI QAAQPSVIQS PQVQTVQIST IAESEDSQES VDSVTDSQKR REILSRRPSY 
RKILNDLSSD APGVPRIEEE KSEEETSAPA ITTVTVPTPI YQTSSGQYIA ITQGGAIQLA 
NNGTDGVQGL QTLTMTNAAA TQPGTTILQY AQTTDGQQIL VPSNQVVVQG TQKL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CREB1

Associated with

Other Information

Two distinct forms of active transcription factor CREB (cAMP response element binding protein). PubMed ID: 2142528

Multiple cDNA clones encoding nuclear proteins that bind to the tax-dependent enhancer of HTLV-1: all contain a leucine zipper structure and basic amino acid domain. PubMed ID: 2196176

Diversification of cyclic AMP-responsive enhancer binding proteins-generated by alternative exon splicing. PubMed ID: 1966745

Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA. PubMed ID: 2974179

Nucleotide and derived amino-acid sequences of the CRE-binding proteins from rat C6 glioma and HeLa cells. PubMed ID: 1831258

Cloning and expression of a novel CREB mRNA splice variant in human testis. PubMed ID: 15579595

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The promoter of the gene encoding 3',5'-cyclic adenosine monophosphate (cAMP) response element binding protein contains cAMP response elements: evidence for positive autoregulation of gene transcription. PubMed ID: 8381074

HBV X protein alters the DNA binding specificity of CREB and ATF-2 by protein-protein interactions. PubMed ID: 1827531

Human T-cell lymphotropic virus type I (HTLV-I) transcriptional activator, Tax, enhances CREB binding to HTLV-I 21-base-pair repeats by protein-protein interaction. PubMed ID: 1386673

Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression. PubMed ID: 8065343

Transcriptional activation of egr-1 by granulocyte-macrophage colony-stimulating factor but not interleukin 3 requires phosphorylation of cAMP response element-binding protein (CREB) on serine 133. PubMed ID: 7608156

CREB is a regulatory target for the protein kinase Akt/PKB. PubMed ID: 9829964

Rsk-2 activity is necessary for epidermal growth factor-induced phosphorylation of CREB protein and transcription of c-fos gene. PubMed ID: 9770464

TORCs: transducers of regulated CREB activity. PubMed ID: 14536081

Small ubiquitin-related modifier-1 modification mediates resolution of CREB-dependent responses to hypoxia. PubMed ID: 12552083

Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. PubMed ID: 14506290

The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. PubMed ID: 15454081

TSSK5, a novel member of the testis-specific serine/threonine kinase family, phosphorylates CREB at Ser-133, and stimulates the CRE/CREB responsive pathway. PubMed ID: 15964553

A nuclear function of beta-arrestin1 in GPCR signaling: regulation of histone acetylation and gene transcription. PubMed ID: 16325578

Serum/glucocorticoid-inducible kinase can phosphorylate the cyclic AMP response element binding protein, CREB. PubMed ID: 15733869

PGC-1-related coactivator: immediate early expression and characterization of a CREB/NRF-1 binding domain associated with cytochrome c promoter occupancy and respiratory growth. PubMed ID: 16908542

EWSR1-CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma. PubMed ID: 17724745

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Regulation of genotoxic stress response by homeodomain-interacting protein kinase 2 through phosphorylation of cyclic AMP response element-binding protein at serine 271. PubMed ID: 20573984

TOX3 is a neuronal survival factor that induces transcription depending on the presence of CITED1 or phosphorylated CREB in the transcriptionally active complex. PubMed ID: 21172805

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

A p.D116G mutation in CREB1 leads to novel multiple malformation syndrome resembling CrebA knockout mouse. PubMed ID: 22267179

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

Allosteric communication in the KIX domain proceeds through dynamic repacking of the hydrophobic core. PubMed ID: 23651431

The sequence of the human genome. PubMed ID: 11181995

Database document:

PubMed ID: 2142528

PubMed ID: 2196176

PubMed ID: 1966745

PubMed ID: 2974179

PubMed ID: 1831258

PubMed ID: 15579595

PubMed ID: 15489334

PubMed ID: 8381074

PubMed ID: 1827531

PubMed ID: 1386673

PubMed ID: 8065343

PubMed ID: 7608156

PubMed ID: 9829964

PubMed ID: 9770464

PubMed ID: 14536081

PubMed ID: 12552083

PubMed ID: 14506290

PubMed ID: 15454081

PubMed ID: 15964553

PubMed ID: 16325578

PubMed ID: 15733869

PubMed ID: 16908542

PubMed ID: 17724745

PubMed ID: 17525332

PubMed ID: 18669648

PubMed ID: 19690332

PubMed ID: 20573984

PubMed ID: 21172805

PubMed ID: 21406692

PubMed ID: 22267179

PubMed ID: 23186163

PubMed ID: 24275569

PubMed ID: 28112733

PubMed ID: 23651431

PubMed ID: 11181995