Details for: Epor

Gene ID: 13857

Symbol: Epor

Ensembl ID: ENSMUSG00000006235

Description: erythropoietin receptor

Associated with

Other Information

Genular Protein ID: 922028029

Symbol: EPOR_MOUSE

Name: Erythropoietin receptor

UniProtKB Accession Codes:

P14753 Q63852

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CORUM 1 CTD 1 DIP 1 DNASU 1 EMBL 7 Ensembl 1 ExpressionAtlas 1 GO 25 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MGI 1 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 2 PIRSF 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 1 SABIO-RK 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 2 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 2539263

Title: Expression cloning of the murine erythropoietin receptor.

PubMed ID: 2539263

DOI: 10.1016/0092-8674(89)90965-3

PubMed ID: 2175360

Title: Characterization of murine erythropoietin receptor genes.

PubMed ID: 2175360

DOI: 10.1016/0022-2836(90)90384-x

PubMed ID: 1656233

Title: Unregulated expression of the erythropoietin receptor gene caused by insertion of spleen focus-forming virus long terminal repeat in a murine erythroleukemia cell line.

PubMed ID: 1656233

DOI: 10.1128/mcb.11.11.5527-5533.1991

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2162479

Title: Structure and transcription of the mouse erythropoietin receptor gene.

PubMed ID: 2162479

DOI: 10.1128/mcb.10.7.3675-3682.1990

PubMed ID: 1849897

Title: Spleen focus-forming virus long terminal repeat insertional activation of the murine erythropoietin receptor gene in the T3Cl-2 friend leukemia cell line.

PubMed ID: 1849897

DOI: 10.1016/s0021-9258(20)89595-7

PubMed ID: 8382775

Title: Inactivation of erythropoietin receptor function by point mutations in a region having homology with other cytokine receptors.

PubMed ID: 8382775

DOI: 10.1128/mcb.13.3.1788-1795.1993

PubMed ID: 8068943

Title: Erythropoietin induces association of the JAK2 protein tyrosine kinase with the erythropoietin receptor in vivo.

PubMed ID: 8068943

PubMed ID: 7889566

Title: Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals.

PubMed ID: 7889566

DOI: 10.1016/0092-8674(95)90351-8

PubMed ID: 8639815

Title: Tyrosine 425 within the activated erythropoietin receptor binds Syp, reduces the erythropoietin required for Syp tyrosine phosphorylation, and promotes mitogenesis.

PubMed ID: 8639815

PubMed ID: 8665851

Title: Identification of tyrosine residues within the intracellular domain of the erythropoietin receptor crucial for STAT5 activation.

PubMed ID: 8665851

DOI: 10.1002/j.1460-2075.1996.tb00601.x

PubMed ID: 8617735

Title: Saturation mutagenesis of the WSXWS motif of the erythropoietin receptor.

PubMed ID: 8617735

DOI: 10.1074/jbc.271.9.4699

PubMed ID: 8657137

Title: Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response.

PubMed ID: 8657137

DOI: 10.1128/mcb.16.4.1622

PubMed ID: 9573010

Title: Lyn physically associates with the erythropoietin receptor and may play a role in activation of the Stat5 pathway.

PubMed ID: 9573010

PubMed ID: 10660611

Title: The SH2 inositol 5-phosphatase Ship1 is recruited in an SH2-dependent manner to the erythropoietin receptor.

PubMed ID: 10660611

DOI: 10.1074/jbc.275.6.4398

PubMed ID: 11290583

Title: A common epitope is shared by activated signal transducer and activator of transcription-5 (STAT5) and the phosphorylated erythropoietin receptor: implications for the docking model of STAT activation.

PubMed ID: 11290583

DOI: 10.1182/blood.v97.8.2230

PubMed ID: 11443118

Title: CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling.

PubMed ID: 11443118

DOI: 10.1074/jbc.m102924200

PubMed ID: 12444928

Title: The adapter protein APS associates with the multifunctional docking sites Tyr-568 and Tyr-936 in c-Kit.

PubMed ID: 12444928

DOI: 10.1042/bj20020716

PubMed ID: 12859190

Title: The WSAWS motif is C-hexosylated in a soluble form of the erythropoietin receptor.

PubMed ID: 12859190

DOI: 10.1021/bi034112p

PubMed ID: 12930840

Title: The erythropoietin receptor transmembrane domain mediates complex formation with viral anemic and polycythemic gp55 proteins.

PubMed ID: 12930840

DOI: 10.1074/jbc.m302974200

PubMed ID: 21183685

Title: Ubiquitination regulates the internalization, endolysosomal sorting, and signaling of the erythropoietin receptor.

PubMed ID: 21183685

DOI: 10.1074/jbc.m110.186890

Sequence Information:

  • Length: 507
  • Mass: 55194
  • Checksum: 067657A2E26451CA
  • Sequence:
    • MDKLRVPLWP RVGPLCLLLA GAAWAPSPSL PDPKFESKAA LLASRGSEEL LCFTQRLEDL 
VCFWEEAASS GMDFNYSFSY QLEGESRKSC SLHQAPTVRG SVRFWCSLPT ADTSSFVPLE 
LQVTEASGSP RYHRIIHINE VVLLDAPAGL LARRAEEGSH VVLRWLPPPG APMTTHIRYE 
VDVSAGNRAG GTQRVEVLEG RTECVLSNLR GGTRYTFAVR ARMAEPSFSG FWSAWSEPAS 
LLTASDLDPL ILTLSLILVL ISLLLTVLAL LSHRRTLQQK IWPGIPSPES EFEGLFTTHK 
GNFQLWLLQR DGCLWWSPGS SFPEDPPAHL EVLSEPRWAV TQAGDPGADD EGPLLEPVGS 
EHAQDTYLVL DKWLLPRTPC SENLSGPGGS VDPVTMDEAS ETSSCPSDLA SKPRPEGTSP 
SSFEYTILDP SSQLLCPRAL PPELPPTPPH LKYLYLVVSD SGISTDYSSG GSQGVHGDSS 
DGPYSHPYEN SLVPDSEPLH PGYVACS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.