ATF2 | ENSG00000115966 | NCBI 1386

Details for: ATF2

Gene ID: 1386

Symbol: ATF2

Ensembl ID: ENSG00000115966

Description: activating transcription factor 2

Associated with

Activation of the ap-1 family of transcription factors
(R-HSA-450341)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Chromatin modifying enzymes
(R-HSA-3247509)
Chromatin organization
(R-HSA-4839726)
Circadian clock
(R-HSA-400253)
Cytokine signaling in immune system
(R-HSA-1280215)
Esr-mediated signaling
(R-HSA-8939211)
Estrogen-dependent gene expression
(R-HSA-9018519)
Gene expression (transcription)
(R-HSA-74160)
Generic transcription pathway
(R-HSA-212436)
Hats acetylate histones
(R-HSA-3214847)
Heme signaling
(R-HSA-9707616)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Interleukin-17 signaling
(R-HSA-448424)
Intracellular signaling by second messengers
(R-HSA-9006925)
Map kinase activation
(R-HSA-450294)
Mapk targets/ nuclear events mediated by map kinases
(R-HSA-450282)
Mitochondrial biogenesis
(R-HSA-1592230)
Myd88 cascade initiated on plasma membrane
(R-HSA-975871)
Myd88 dependent cascade initiated on endosome
(R-HSA-975155)
Myd88-independent tlr4 cascade
(R-HSA-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-HSA-166058)
Ngf-stimulated transcription
(R-HSA-9031628)
Nuclear events (kinase and transcription factor activation)
(R-HSA-198725)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Pip3 activates akt signaling
(R-HSA-1257604)
Pten regulation
(R-HSA-6807070)
Regulation of pten gene transcription
(R-HSA-8943724)
Response of eif2ak4 (gcn2) to amino acid deficiency
(R-HSA-9633012)
Rna polymerase ii transcription
(R-HSA-73857)
Signaling by interleukins
(R-HSA-449147)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by nuclear receptors
(R-HSA-9006931)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Toll-like receptor cascades
(R-HSA-168898)
Toll like receptor 2 (tlr2) cascade
(R-HSA-181438)
Toll like receptor 3 (tlr3) cascade
(R-HSA-168164)
Toll like receptor 4 (tlr4) cascade
(R-HSA-166016)
Toll like receptor 5 (tlr5) cascade
(R-HSA-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-HSA-168181)
Toll like receptor 9 (tlr9) cascade
(R-HSA-168138)
Toll like receptor 10 (tlr10) cascade
(R-HSA-168142)
Toll like receptor tlr1:tlr2 cascade
(R-HSA-168179)
Toll like receptor tlr6:tlr2 cascade
(R-HSA-168188)
Tp53 regulates transcription of dna repair genes
(R-HSA-6796648)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-HSA-975138)
Transcriptional activation of mitochondrial biogenesis
(R-HSA-2151201)
Transcriptional regulation by tp53
(R-HSA-3700989)
Trif (ticam1)-mediated tlr4 signaling
(R-HSA-937061)
Brainstem development
(GO:0003360)
Camp response element binding
(GO:0035497)
Camp response element binding protein binding
(GO:0008140)
Cis-regulatory region sequence-specific dna binding
(GO:0000987)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna damage response
(GO:0006974)
Growth plate cartilage chondrocyte differentiation
(GO:0003418)
Growth plate cartilage chondrocyte proliferation
(GO:0003419)
Hematopoietic progenitor cell differentiation
(GO:0002244)
Histone acetyltransferase activity
(GO:0004402)
Histone h2b acetyltransferase activity
(GO:0044013)
Histone h4 acetyltransferase activity
(GO:0010485)
Identical protein binding
(GO:0042802)
In utero embryonic development
(GO:0001701)
Jnk cascade
(GO:0007254)
Leucine zipper domain binding
(GO:0043522)
Liver development
(GO:0001889)
Metal ion binding
(GO:0046872)
Negative regulation of angiogenesis
(GO:0016525)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nk t cell differentiation
(GO:0001865)
Outflow tract morphogenesis
(GO:0003151)
Peptidyl-threonine phosphorylation
(GO:0018107)
Positive regulation of gene expression
(GO:0010628)
Promoter-specific chromatin binding
(GO:1990841)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein homodimerization activity
(GO:0042803)
Protein import into nucleus
(GO:0006606)
Protein kinase binding
(GO:0019901)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to organic cyclic compound
(GO:0014070)
Response to osmotic stress
(GO:0006970)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific double-stranded dna binding
(GO:1990837)
Vacuole organization
(GO:0007033)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 320.6784
Cell Significance Index: -49.8800
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 193.5000
Cell Significance Index: -49.0800
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 123.6201
Cell Significance Index: -50.9300
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 109.4207
Cell Significance Index: -51.6600
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 99.2475
Cell Significance Index: -40.3200
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 77.0019
Cell Significance Index: -51.6700
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 42.3884
Cell Significance Index: -40.4700
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 41.1937
Cell Significance Index: -50.7900
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 17.6568
Cell Significance Index: -47.3000
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 14.5371
Cell Significance Index: -44.6500
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 12.9395
Cell Significance Index: -51.0600
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 9.9288
Cell Significance Index: -21.7300
Cell Name: neoplastic cell (CL0001063)
Fold Change: 2.2953
Cell Significance Index: 455.5100
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.0097
Cell Significance Index: 403.1500
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 1.7563
Cell Significance Index: 98.5600
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 1.2477
Cell Significance Index: 76.6900
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.2476
Cell Significance Index: 447.4900
Cell Name: cortical interneuron (CL0008031)
Fold Change: 1.0426
Cell Significance Index: 25.0100
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.8857
Cell Significance Index: 67.9700
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.7764
Cell Significance Index: 29.4000
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.7603
Cell Significance Index: 33.6300
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.7239
Cell Significance Index: 500.6600
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 0.7125
Cell Significance Index: 47.9100
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.6837
Cell Significance Index: 8.4800
Cell Name: preadipocyte (CL0002334)
Fold Change: 0.6400
Cell Significance Index: 12.4900
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.5012
Cell Significance Index: 452.5100
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.4351
Cell Significance Index: 53.5100
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 0.4310
Cell Significance Index: 22.4500
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.4191
Cell Significance Index: 28.9800
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.4060
Cell Significance Index: 73.1900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.3563
Cell Significance Index: 48.9300
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.2902
Cell Significance Index: 7.4600
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2752
Cell Significance Index: 150.2900
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 0.2625
Cell Significance Index: 7.4900
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 0.2551
Cell Significance Index: 3.4800
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.2303
Cell Significance Index: 10.4400
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.2246
Cell Significance Index: 4.8000
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2176
Cell Significance Index: 96.2100
Cell Name: odontoblast (CL0000060)
Fold Change: 0.2108
Cell Significance Index: 27.0200
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.2092
Cell Significance Index: 393.9700
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.2082
Cell Significance Index: 4.5100
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1912
Cell Significance Index: 5.5100
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.1798
Cell Significance Index: 114.1900
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.1249
Cell Significance Index: 3.4900
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.1179
Cell Significance Index: 2.0200
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.1059
Cell Significance Index: 48.0700
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.1027
Cell Significance Index: 189.3800
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0969
Cell Significance Index: 149.1800
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.0869
Cell Significance Index: 1.4600
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.0761
Cell Significance Index: 3.5500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0576
Cell Significance Index: 78.2700
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0490
Cell Significance Index: 5.7800
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.0281
Cell Significance Index: 2.7800
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.0160
Cell Significance Index: 3.0500
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0259
Cell Significance Index: -1.6300
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0269
Cell Significance Index: -3.9100
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.0297
Cell Significance Index: -5.0700
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0301
Cell Significance Index: -22.0800
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0301
Cell Significance Index: -22.2600
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0346
Cell Significance Index: -21.5800
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0557
Cell Significance Index: -42.1300
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0661
Cell Significance Index: -37.2600
Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.0675
Cell Significance Index: -0.8100
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.1090
Cell Significance Index: -7.0400
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.1128
Cell Significance Index: -18.3500
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.1297
Cell Significance Index: -2.8400
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1336
Cell Significance Index: -28.1300
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1366
Cell Significance Index: -13.9500
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1428
Cell Significance Index: -6.7100
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1509
Cell Significance Index: -43.4200
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.1636
Cell Significance Index: -19.0700
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.1852
Cell Significance Index: -5.3100
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1874
Cell Significance Index: -21.4700
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.1960
Cell Significance Index: -10.2900
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.2234
Cell Significance Index: -5.9900
Cell Name: lactocyte (CL0002325)
Fold Change: -0.2276
Cell Significance Index: -29.4000
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.2294
Cell Significance Index: -8.0600
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2848
Cell Significance Index: -32.5100
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2856
Cell Significance Index: -21.2900
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: -0.3009
Cell Significance Index: -15.6300
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.3128
Cell Significance Index: -1.8900
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.3336
Cell Significance Index: -34.7400
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.3357
Cell Significance Index: -5.6600
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3376
Cell Significance Index: -7.1900
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.3410
Cell Significance Index: -24.1200
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.3695
Cell Significance Index: -12.8400
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.3873
Cell Significance Index: -5.5700
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.4257
Cell Significance Index: -8.8300
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.4986
Cell Significance Index: -13.1100
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5039
Cell Significance Index: -39.9100
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.5063
Cell Significance Index: -13.5200
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.6217
Cell Significance Index: -5.0700
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.6868
Cell Significance Index: -10.1400
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.6988
Cell Significance Index: -22.3800
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: -0.7144
Cell Significance Index: -19.4500
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -0.7325
Cell Significance Index: -18.3100
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.7639
Cell Significance Index: -10.9700
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.8332
Cell Significance Index: -51.0800
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.9259
Cell Significance Index: -30.3200
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.9551
Cell Significance Index: -30.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** 1. **Transcriptional regulation**: ATF2 acts as a transcription factor, binding to specific DNA sequences to regulate the expression of target genes. 2. **AP-1 family member**: ATF2 is a member of the AP-1 family of transcription factors, which are involved in regulating cell proliferation, differentiation, and survival. 3. **Cyclic AMP-dependent**: ATF2 is activated by cyclic AMP (cAMP), a secondary messenger molecule involved in various cellular signaling pathways. 4. **DNA-binding activity**: ATF2 exhibits DNA-binding activity, which enables it to regulate gene expression by interacting with specific DNA sequences. 5. **Regulation of stress responses**: ATF2 is involved in regulating cellular responses to stress, including heat shock, oxidative stress, and DNA damage. **Pathways and Functions** 1. **Cellular responses to stimuli**: ATF2 regulates cellular responses to various stimuli, including heat shock, oxidative stress, and DNA damage. 2. **Growth plate cartilage development**: ATF2 is involved in regulating the development and proliferation of chondrocytes in the growth plate cartilage. 3. **Immune system regulation**: ATF2 plays a role in regulating immune responses, including the activation of immune cells and the production of cytokines. 4. **Circadian clock regulation**: ATF2 is involved in regulating the circadian clock, which controls various physiological processes, including sleep-wake cycles and hormone secretion. 5. **Tumor suppression**: ATF2 acts as a tumor suppressor by regulating the expression of genes involved in cell proliferation and survival. **Clinical Significance** 1. **Neurological disorders**: ATF2 has been implicated in various neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. 2. **Cancer**: ATF2 has been found to be overexpressed in certain types of cancer, including breast cancer, lung cancer, and colon cancer. 3. **Inflammatory diseases**: ATF2 has been shown to play a role in regulating inflammatory responses, which are involved in various inflammatory diseases, including rheumatoid arthritis and atherosclerosis. 4. **Metabolic disorders**: ATF2 has been implicated in regulating metabolic processes, including glucose and lipid metabolism, which are involved in various metabolic disorders, including diabetes and obesity. 5. **Neurodegenerative diseases**: ATF2 has been found to be involved in regulating the progression of neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS). In conclusion, ATF2 is a multifunctional transcription factor involved in regulating various cellular processes, including transcription, cell proliferation, differentiation, and survival. Its dysregulation has been implicated in various diseases, including neurological disorders, cancer, inflammatory diseases, metabolic disorders, and neurodegenerative diseases. Further studies are needed to fully understand the role of ATF2 in human disease and to develop therapeutic strategies to target this transcription factor.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Cyclic AMP-dependent transcription factor ATF-2
A4D7V5_HUMAN

Genular Protein ID: 1468645262

Symbol: ATF2_HUMAN

Name: Cyclic AMP-dependent transcription factor ATF-2

UniProtKB Accession Codes:

P15336 A1L3Z2 A4D7U4 A4D7U5 A4D7V1 D3DPE9 G8JLM5 Q13000 Q3B7B7 Q4ZFU9 Q53RY2 Q8TAR1 Q96JT8

Database IDs:

Citations:

PubMed ID: 2529117

Title: Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brain.

PubMed ID: 2529117

DOI: 10.1002/j.1460-2075.1989.tb03610.x

PubMed ID: 9058782

Title: Identification of a novel, spliced variant of CREB that is preferentially expressed in the thymus.

PubMed ID: 9058782

PubMed ID: 11932306

Title: Characterization and functional analysis of cAMP response element modulator protein and activating transcription factor 2 (ATF2) isoforms in the human myometrium during pregnancy and labor: identification of a novel ATF2 species with potent transactivation properties.

PubMed ID: 11932306

DOI: 10.1210/jcem.87.4.8360

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2320002

Title: A cDNA for a human cyclic AMP response element-binding protein which is distinct from CREB and expressed preferentially in brain.

PubMed ID: 2320002

DOI: 10.1128/mcb.10.4.1347-1357.1990

PubMed ID: 8855261

Title: Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade.

PubMed ID: 8855261

DOI: 10.1073/pnas.93.20.10803

PubMed ID: 9430721

Title: Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6.

PubMed ID: 9430721

DOI: 10.1074/jbc.273.3.1741

PubMed ID: 9748258

Title: Characterization of functional domains of an embryonic stem cell coactivator UTF1 which are conserved and essential for potentiation of ATF-2 activity.

PubMed ID: 9748258

DOI: 10.1074/jbc.273.40.25840

PubMed ID: 10821277

Title: ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation.

PubMed ID: 10821277

DOI: 10.1038/35012097

PubMed ID: 12110590

Title: Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38.

PubMed ID: 12110590

DOI: 10.1093/emboj/cdf361

PubMed ID: 15105425

Title: Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK.

PubMed ID: 15105425

DOI: 10.1074/jbc.m401009200

PubMed ID: 15916964

Title: ATM-dependent phosphorylation of ATF2 is required for the DNA damage response.

PubMed ID: 15916964

DOI: 10.1016/j.molcel.2005.04.015

PubMed ID: 17590016

Title: Multiple roles for acetylation in the interaction of p300 HAT with ATF-2.

PubMed ID: 17590016

DOI: 10.1021/bi7000054

PubMed ID: 18677098

Title: ATF2: a transcription factor that elicits oncogenic or tumor suppressor activities.

PubMed ID: 18677098

DOI: 10.4161/cc.6388

PubMed ID: 18397884

Title: Regulation of TIP60 by ATF2 modulates ATM activation.

PubMed ID: 18397884

DOI: 10.1074/jbc.m802030200

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19176525

Title: Phosphorylation of activation transcription factor-2 at serine 121 by protein kinase c controls c-Jun-mediated activation of transcription.

PubMed ID: 19176525

DOI: 10.1074/jbc.m808719200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21098032

Title: Hyperosmotic stress-induced ATF-2 activation through Polo-like kinase 3 in human corneal epithelial cells.

PubMed ID: 21098032

DOI: 10.1074/jbc.m110.166009

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22304920

Title: PKCepsilon promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria.

PubMed ID: 22304920

DOI: 10.1016/j.cell.2012.01.016

PubMed ID: 22275354

Title: Critical role of N-terminal end-localized nuclear export signal in regulation of activating transcription factor 2 (ATF2) subcellular localization and transcriptional activity.

PubMed ID: 22275354

DOI: 10.1074/jbc.m111.294272

PubMed ID: 22685333

Title: ATF2-at the crossroad of nuclear and cytosolic functions.

PubMed ID: 22685333

DOI: 10.1242/jcs.095000

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 10092462

Title: Solution structure of the transactivation domain of ATF-2 comprising a zinc finger-like subdomain and a flexible subdomain.

PubMed ID: 10092462

DOI: 10.1006/jmbi.1999.2620

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

Length: 505
Mass: 54537
Checksum: 0190EEFAEC8891A7
Sequence:

MKFKLHVNSA RQYKDLWNMS DDKPFLCTAP GCGQRFTNED HLAVHKHKHE MTLKFGPARN 
DSVIVADQTP TPTRFLKNCE EVGLFNELAS PFENEFKKAS EDDIKKMPLD LSPLATPIIR 
SKIEEPSVVE TTHQDSPLPH PESTTSDEKE VPLAQTAQPT SAIVRPASLQ VPNVLLTSSD 
SSVIIQQAVP SPTSSTVITQ APSSNRPIVP VPGPFPLLLH LPNGQTMPVA IPASITSSNV 
HVPAAVPLVR PVTMVPSVPG IPGPSSPQPV QSEAKMRLKA ALTQQHPPVT NGDTVKGHGS 
GLVRTQSEES RPQSLQQPAT STTETPASPA HTTPQTQSTS GRRRRAANED PDEKRRKFLE 
RNRAAASRCR QKRKVWVQSL EKKAEDLSSL NGQLQSEVTL LRNEVAQLKQ LLLAHKDCPV 
TAMQKKSGYH TADKDDSSED ISVPSSPHTE AIQHSSVSTS NGVSSTSKAE AVATSVLTQM 
ADQSTEPALS QIVMAPSSQS QPSGS

Genular Protein ID: 2859593863

Symbol: A4D7V5_HUMAN

Name: N/A

UniProtKB Accession Codes:

A4D7V5

Database IDs:

Sequence Information:

Length: 326
Mass: 35056
Checksum: 83BB2A42DE5CD583
Sequence:

MPLDLSPLAT PIIRSKIEEP SVVETTHQDS PLPHPESTTS DEKEVPLAQT AQPTSAIVRP 
ASLQVPNVLL TSSDSSVIIQ QAVPSPTSST VITQAPSSNR PIVPVPGPFP LLLHLPSGQT 
MPVAIPASIT SSNVHVPAAV PLVRPVTMVP SVPGIPGPSS PQPVQSEAKM RLKAALTQQH 
PPVTNGDTVK GHGSGLVRTQ SEESRPQSLQ QPATSTTETP ASPAHTTPQT QSTSGRRRRA 
ANEDPDEKRR KFLERNRAAA SRCRQKRKVW VQSLEKKAED LSSLNGQLQS EVTLLRNEVA 
QLKQLLLAHK DCPVTAMQKK SGYHRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ATF2

Associated with

Cells (max top 100)

Other Information

Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brain. PubMed ID: 2529117

Identification of a novel, spliced variant of CREB that is preferentially expressed in the thymus. PubMed ID: 9058782

Characterization and functional analysis of cAMP response element modulator protein and activating transcription factor 2 (ATF2) isoforms in the human myometrium during pregnancy and labor: identification of a novel ATF2 species with potent transactivation properties. PubMed ID: 11932306

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A cDNA for a human cyclic AMP response element-binding protein which is distinct from CREB and expressed preferentially in brain. PubMed ID: 2320002

Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade. PubMed ID: 8855261

Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6. PubMed ID: 9430721

Characterization of functional domains of an embryonic stem cell coactivator UTF1 which are conserved and essential for potentiation of ATF-2 activity. PubMed ID: 9748258

ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation. PubMed ID: 10821277

Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38. PubMed ID: 12110590

Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK. PubMed ID: 15105425

ATM-dependent phosphorylation of ATF2 is required for the DNA damage response. PubMed ID: 15916964

Multiple roles for acetylation in the interaction of p300 HAT with ATF-2. PubMed ID: 17590016

ATF2: a transcription factor that elicits oncogenic or tumor suppressor activities. PubMed ID: 18677098

Regulation of TIP60 by ATF2 modulates ATM activation. PubMed ID: 18397884

Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. PubMed ID: 18220336

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Phosphorylation of activation transcription factor-2 at serine 121 by protein kinase c controls c-Jun-mediated activation of transcription. PubMed ID: 19176525

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Hyperosmotic stress-induced ATF-2 activation through Polo-like kinase 3 in human corneal epithelial cells. PubMed ID: 21098032

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

PKCepsilon promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. PubMed ID: 22304920

Critical role of N-terminal end-localized nuclear export signal in regulation of activating transcription factor 2 (ATF2) subcellular localization and transcriptional activity. PubMed ID: 22275354

ATF2-at the crossroad of nuclear and cytosolic functions. PubMed ID: 22685333

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

Solution structure of the transactivation domain of ATF-2 comprising a zinc finger-like subdomain and a flexible subdomain. PubMed ID: 10092462

The consensus coding sequences of human breast and colorectal cancers. PubMed ID: 16959974