Details for: ATF2

Gene ID: 1386

Symbol: ATF2

Ensembl ID: ENSG00000115966

Description: activating transcription factor 2

Associated with

Other Information

Genular Protein ID: 1468645262

Symbol: ATF2_HUMAN

Name: Cyclic AMP-dependent transcription factor ATF-2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2529117

Title: Leucine zipper structure of the protein CRE-BP1 binding to the cyclic AMP response element in brain.

PubMed ID: 2529117

DOI: 10.1002/j.1460-2075.1989.tb03610.x

PubMed ID: 9058782

Title: Identification of a novel, spliced variant of CREB that is preferentially expressed in the thymus.

PubMed ID: 9058782

PubMed ID: 11932306

Title: Characterization and functional analysis of cAMP response element modulator protein and activating transcription factor 2 (ATF2) isoforms in the human myometrium during pregnancy and labor: identification of a novel ATF2 species with potent transactivation properties.

PubMed ID: 11932306

DOI: 10.1210/jcem.87.4.8360

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2320002

Title: A cDNA for a human cyclic AMP response element-binding protein which is distinct from CREB and expressed preferentially in brain.

PubMed ID: 2320002

DOI: 10.1128/mcb.10.4.1347-1357.1990

PubMed ID: 8855261

Title: Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade.

PubMed ID: 8855261

DOI: 10.1073/pnas.93.20.10803

PubMed ID: 9430721

Title: Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6.

PubMed ID: 9430721

DOI: 10.1074/jbc.273.3.1741

PubMed ID: 9748258

Title: Characterization of functional domains of an embryonic stem cell coactivator UTF1 which are conserved and essential for potentiation of ATF-2 activity.

PubMed ID: 9748258

DOI: 10.1074/jbc.273.40.25840

PubMed ID: 10821277

Title: ATF-2 has intrinsic histone acetyltransferase activity which is modulated by phosphorylation.

PubMed ID: 10821277

DOI: 10.1038/35012097

PubMed ID: 12110590

Title: Growth factors can activate ATF2 via a two-step mechanism: phosphorylation of Thr71 through the Ras-MEK-ERK pathway and of Thr69 through RalGDS-Src-p38.

PubMed ID: 12110590

DOI: 10.1093/emboj/cdf361

PubMed ID: 15105425

Title: Human vaccinia-related kinase 1 (VRK1) activates the ATF2 transcriptional activity by novel phosphorylation on Thr-73 and Ser-62 and cooperates with JNK.

PubMed ID: 15105425

DOI: 10.1074/jbc.m401009200

PubMed ID: 15916964

Title: ATM-dependent phosphorylation of ATF2 is required for the DNA damage response.

PubMed ID: 15916964

DOI: 10.1016/j.molcel.2005.04.015

PubMed ID: 17590016

Title: Multiple roles for acetylation in the interaction of p300 HAT with ATF-2.

PubMed ID: 17590016

DOI: 10.1021/bi7000054

PubMed ID: 18677098

Title: ATF2: a transcription factor that elicits oncogenic or tumor suppressor activities.

PubMed ID: 18677098

DOI: 10.4161/cc.6388

PubMed ID: 18397884

Title: Regulation of TIP60 by ATF2 modulates ATM activation.

PubMed ID: 18397884

DOI: 10.1074/jbc.m802030200

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19176525

Title: Phosphorylation of activation transcription factor-2 at serine 121 by protein kinase c controls c-Jun-mediated activation of transcription.

PubMed ID: 19176525

DOI: 10.1074/jbc.m808719200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21098032

Title: Hyperosmotic stress-induced ATF-2 activation through Polo-like kinase 3 in human corneal epithelial cells.

PubMed ID: 21098032

DOI: 10.1074/jbc.m110.166009

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22304920

Title: PKCepsilon promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria.

PubMed ID: 22304920

DOI: 10.1016/j.cell.2012.01.016

PubMed ID: 22275354

Title: Critical role of N-terminal end-localized nuclear export signal in regulation of activating transcription factor 2 (ATF2) subcellular localization and transcriptional activity.

PubMed ID: 22275354

DOI: 10.1074/jbc.m111.294272

PubMed ID: 22685333

Title: ATF2-at the crossroad of nuclear and cytosolic functions.

PubMed ID: 22685333

DOI: 10.1242/jcs.095000

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 10092462

Title: Solution structure of the transactivation domain of ATF-2 comprising a zinc finger-like subdomain and a flexible subdomain.

PubMed ID: 10092462

DOI: 10.1006/jmbi.1999.2620

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 505
  • Mass: 54537
  • Checksum: 0190EEFAEC8891A7
  • Sequence:
  • MKFKLHVNSA RQYKDLWNMS DDKPFLCTAP GCGQRFTNED HLAVHKHKHE MTLKFGPARN 
    DSVIVADQTP TPTRFLKNCE EVGLFNELAS PFENEFKKAS EDDIKKMPLD LSPLATPIIR 
    SKIEEPSVVE TTHQDSPLPH PESTTSDEKE VPLAQTAQPT SAIVRPASLQ VPNVLLTSSD 
    SSVIIQQAVP SPTSSTVITQ APSSNRPIVP VPGPFPLLLH LPNGQTMPVA IPASITSSNV 
    HVPAAVPLVR PVTMVPSVPG IPGPSSPQPV QSEAKMRLKA ALTQQHPPVT NGDTVKGHGS 
    GLVRTQSEES RPQSLQQPAT STTETPASPA HTTPQTQSTS GRRRRAANED PDEKRRKFLE 
    RNRAAASRCR QKRKVWVQSL EKKAEDLSSL NGQLQSEVTL LRNEVAQLKQ LLLAHKDCPV 
    TAMQKKSGYH TADKDDSSED ISVPSSPHTE AIQHSSVSTS NGVSSTSKAE AVATSVLTQM 
    ADQSTEPALS QIVMAPSSQS QPSGS

Genular Protein ID: 2859593863

Symbol: A4D7V5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 326
  • Mass: 35056
  • Checksum: 83BB2A42DE5CD583
  • Sequence:
  • MPLDLSPLAT PIIRSKIEEP SVVETTHQDS PLPHPESTTS DEKEVPLAQT AQPTSAIVRP 
    ASLQVPNVLL TSSDSSVIIQ QAVPSPTSST VITQAPSSNR PIVPVPGPFP LLLHLPSGQT 
    MPVAIPASIT SSNVHVPAAV PLVRPVTMVP SVPGIPGPSS PQPVQSEAKM RLKAALTQQH 
    PPVTNGDTVK GHGSGLVRTQ SEESRPQSLQ QPATSTTETP ASPAHTTPQT QSTSGRRRRA 
    ANEDPDEKRR KFLERNRAAA SRCRQKRKVW VQSLEKKAED LSSLNGQLQS EVTLLRNEVA 
    QLKQLLLAHK DCPVTAMQKK SGYHRK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.