Details for: Eps8

Gene ID: 13860

Symbol: Eps8

Ensembl ID: ENSMUSG00000015766

Description: epidermal growth factor receptor pathway substrate 8

Associated with

Other Information

Genular Protein ID: 731735713

Symbol: EPS8_MOUSE

Name: Epidermal growth factor receptor kinase substrate 8

UniProtKB Accession Codes:

Q08509 Q3TM41

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 3 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DNASU 1 EMBL 4 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 32 Gene3D 3 GeneTree 1 Genevisible 1 GlyGen 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MGI 1 MINT 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 3 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 6 SAM 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 8404850

Title: Eps8, a substrate for the epidermal growth factor receptor kinase, enhances EGF-dependent mitogenic signals.

PubMed ID: 8404850

DOI: 10.1002/j.1460-2075.1993.tb06058.x

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7537362

Title: Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins.

PubMed ID: 7537362

PubMed ID: 10499589

Title: EPS8 and E3B1 transduce signals from Ras to Rac.

PubMed ID: 10499589

DOI: 10.1038/45822

PubMed ID: 11524436

Title: An effector region in Eps8 is responsible for the activation of the Rac-specific GEF activity of Sos-1 and for the proper localization of the Rac-based actin-polymerizing machine.

PubMed ID: 11524436

DOI: 10.1083/jcb.200103146

PubMed ID: 12127568

Title: Eps8 in the midst of GTPases.

PubMed ID: 12127568

DOI: 10.1016/s1357-2725(02)00064-x

PubMed ID: 15558031

Title: Eps8 controls actin-based motility by capping the barbed ends of actin filaments.

PubMed ID: 15558031

DOI: 10.1038/ncb1199

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 16452087

Title: Comprehensive identification of phosphorylation sites in postsynaptic density preparations.

PubMed ID: 16452087

DOI: 10.1074/mcp.t500041-mcp200

PubMed ID: 17115031

Title: Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex.

PubMed ID: 17115031

DOI: 10.1038/ncb1502

PubMed ID: 19528316

Title: Structure of human lanthionine synthetase C-like protein 1 and its interaction with Eps8 and glutathione.

PubMed ID: 19528316

DOI: 10.1101/gad.1789209

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 19564905

Title: Eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF).

PubMed ID: 19564905

DOI: 10.1371/journal.pbio.1000138

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20532239

Title: Molecular basis for the dual function of Eps8 on actin dynamics: bundling and capping.

PubMed ID: 20532239

DOI: 10.1371/journal.pbio.1000387

PubMed ID: 21236676

Title: Regulation of stereocilia length by myosin XVa and whirlin depends on the actin-regulatory protein Eps8.

PubMed ID: 21236676

DOI: 10.1016/j.cub.2010.12.046

PubMed ID: 21835647

Title: The signaling adaptor Eps8 is an essential actin capping protein for dendritic cell migration.

PubMed ID: 21835647

DOI: 10.1016/j.immuni.2011.07.007

PubMed ID: 23314863

Title: SCF(Fbxw5) mediates transient degradation of actin remodeller Eps8 to allow proper mitotic progression.

PubMed ID: 23314863

DOI: 10.1038/ncb2661

PubMed ID: 23918390

Title: Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2.

PubMed ID: 23918390

DOI: 10.1073/pnas.1304644110

PubMed ID: 24741995

Title: EPS8, encoding an actin-binding protein of cochlear hair cell stereocilia, is a new causal gene for autosomal recessive profound deafness.

PubMed ID: 24741995

DOI: 10.1186/1750-1172-9-55

PubMed ID: 9303002

Title: The SH3 domain of Eps8 exists as a novel intertwined dimer.

PubMed ID: 9303002

DOI: 10.1038/nsb0997-739

Sequence Information:

  • Length: 821
  • Mass: 91737
  • Checksum: 50F691FAC3EF1304
  • Sequence:
    • MNGHMSNRSS GYGVYPSQLN GYGSSPPYSQ MDREHSSRTS AKALYEQRKN YARDSVSSVS 
DVSQYRVEHL TTFVLDRKDA MITVEDGIRK LKLLDAKGKV WTQDMILQVD DRAVSLIDLE 
SKNELENFPL NTISHCQAVV HACSYDSILA LVCKEPTQSK PDLHLFQCDE VKANLISEDI 
ESAISDSKGG KQKRRPEALR MIAKADPGIP PPPRAPAPVP PGTVTQVDVR SRVAAWSAWA 
ADQGDFEKPR QYHEQEETPE MMAARIDRDV QILNHILDDI EFFITKLQKA AEAFSELSKR 
KKSKKSKRKG PGEGVLTLRA KPPPPDEFVD CFQKFKHGFN LLAKLKSHIQ NPSASDLVHF 
LFTPLNMVVQ ATGGPELASS VLSPLLTKDT VDFLNYTATA EERKLWMSLG DSWVKVRAEW 
PKEQFIPPYV PRFRNGWEPP MLNFMGAPTE QDMYQLAESV ANAEHQRKQD SKRLSTEHSN 
VSDYPPADGY AYSSSMYHRG PHADHGEAAM PFKSTPNHQV DRNYDAVKTQ PKKYAKSKYD 
FVARNSSELS VMKDDVLEIL DDRRQWWKVR NASGDSGFVP NNILDIMRTP ESGVGRADPP 
YTHTIQKQRT EYGLRSADTP SAPSPPPTPA PVPVPLPPSV PAPVSVPKVP ANVTRQNSSS 
SDSGGSIVRD SQRYKQLPVD RRKSQMEEVQ DELFQRLTIG RSAAQRKFHV PRQNVPVINI 
TYDSSPEEVK TWLQSKGFNP VTVNSLGVLN GAQLFSLNKD ELRSVCPEGA RVFNQITVQK 
AALEDSNGSS ELQEIMRRRQ EKISAAASDS GVESFDEGSS H

Genular Protein ID: 3338984702

Symbol: Q3U2Z5_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3U2Z5

Database IDs:

AGR 1 ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 EPD 1 GO 1 Gene3D 3 InterPro 10 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 Pfam 3 PhylomeDB 1 RefSeq 1 SAM 1 SMART 2 SUPFAM 2 UCSC 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 847
  • Mass: 94485
  • Checksum: 8A537C0982C86610
  • Sequence:
    • MLSQSCLDSC LDEFYLSSAG RGVRAGMNGH MSNRSSGYGV YPSQLNGYGS SPPYSQMDRE 
HSSRTSAKAL YEQRKNYARD SVSSVSDVSQ YRVEHLTTFV LDRKDAMITV EDGIRKLKLL 
DAKGKVWTQD MILQVDDRAV SLIDLESKNE LENFPLNTIS HCQAVVHACS YDSILALVCK 
EPTQSKPDLH LFQCDEVKAN LISEDIESAI SDSKGGKQKR RPEALRMIAK ADPGIPPPPR 
APAPVPPGTV TQVDVRSRVA AWSAWAADQG DFEKPRQYHE QEETPEMMAA RIDRDVQILN 
HILDDIEFFI TKLQKAAEAF SELSKRKKSK KSKRKGPGEG VLTLRAKPPP PDEFVDCFQK 
FKHGFNLLAK LKSHIQNPSA SDLVHFLFTP LNMVVQATGG PELASSVLSP LLTKDTVDFL 
NYTATAEERK LWMSLGDSWV KVRAEWPKEQ FIPPYVPRFR NGWEPPMLNF MGAPTEQDMY 
QLAESVANAE HQRKQDSKRL STEHSNVSDY PPADGYAYSS SMYHRGPHAD HGEAAMPFKS 
TPNHQVDRNY DAVKTQPKKY AKSKYDFVAR NSSELSVMKD DVLEILDDRR QWWKVRNASG 
DSGFVPNNIL DIMRTPESGV GRADPPYTHT IQKQRTEYGL RSADTPSAPS PPPTPAPVPV 
PLPPSVPAPV SVPKVPANVT RQNSSSSDSG GSIVRDSQRY KQLPVDRRKS QMEEVQDELF 
QRLTIGRSAA QRKFHVPRQN VPVINITYDS SPEEVKTWLQ SKGFNPVTVN SLGVLNGAQL 
FSLNKDELRS VCPEGARVFN QITVQKAALE DSNGSSELQE IMRRRQEKIS AAASDSGVES 
FDEGSSH

Genular Protein ID: 2692775254

Symbol: Q3UFL4_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UFL4

Database IDs:

AGR 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Gene3D 1 InterPro 5 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 1 SAM 1 SMART 2 SUPFAM 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

  • Length: 463
  • Mass: 51992
  • Checksum: 92FE7F9EF947E054
  • Sequence:
    • MNGHMSNRSS GYGVYPSQLN GYGSSPPYSQ MDREHSSRTS AKALYEQRKN YARDSVSSVS 
DVSQYRVEHL TTFVLDRKDA MITVEDGIRK LKLLDAKGKV WTQDMILQVD DRAVSLIDLE 
SKNELENFPL NTISHCQAVV HACSYDSILA LVCKEPTQSK PDLHLFQCDE VKANLISEDI 
ESAISDSKGG KQKRRPEALR MIAKADPGIP PPPRAPAPVP PGTVTQVDVR SRVAAWSAWA 
ADQGDFEKPR QYHEQEETPE MMAARIDRDV QILNHILDDI EFFITKLQKA AEAFSELSKR 
KKSKKSKRKG PGEGVLTLRA KPPPPDEFVD CFQKFKHGFN LLAKLKSHIQ NPSASDLVHF 
LFTPLNMVVQ ATGGPELASS VLSTLLTKDT VDFLNYTATA EERKLWMSLG DSWVKVRAEW 
PKEQFIPPYV PRFRNGWEPP MLNFMGAPTE QDMYQLAESV ANA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.