Genular: Defining Cellular Identity and Function

Details for: Erbb2

Gene ID: 13866

Symbol: Erbb2

Ensembl ID: ENSMUSG00000062312

Description: erb-b2 receptor tyrosine kinase 2

Associated with

Axon guidance
(R-MMU-422475)
Developmental biology
(R-MMU-1266738)
Downregulation of erbb2 signaling
(R-MMU-8863795)
Downregulation of erbb2:erbb3 signaling
(R-MMU-1358803)
Drug-mediated inhibition of erbb2 signaling
(R-MMU-9652282)
Erbb2 activates ptk6 signaling
(R-MMU-8847993)
Erbb2 regulates cell motility
(R-MMU-6785631)
Grb2 events in erbb2 signaling
(R-MMU-1963640)
Grb7 events in erbb2 signaling
(R-MMU-1306955)
Intracellular signaling by second messengers
(R-MMU-9006925)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Pi3k events in erbb2 signaling
(R-MMU-1963642)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-MMU-6811558)
Pip3 activates akt signaling
(R-MMU-1257604)
Raf/map kinase cascade
(R-MMU-5673001)
Sema4d induced cell migration and growth-cone collapse
(R-MMU-416572)
Sema4d in semaphorin signaling
(R-MMU-400685)
Semaphorin interactions
(R-MMU-373755)
Shc1 events in erbb2 signaling
(R-MMU-1250196)
Signaling by erbb2
(R-MMU-1227986)
Signaling by non-receptor tyrosine kinases
(R-MMU-9006927)
Signaling by ptk6
(R-MMU-8848021)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Atp binding
(GO:0005524)
Cell surface receptor signaling pathway
(GO:0007166)
Coreceptor activity
(GO:0015026)
Erbb-3 class receptor binding
(GO:0043125)
Erbb2-egfr signaling pathway
(GO:0038134)
Erbb2-erbb3 signaling pathway
(GO:0038133)
Erbb2-erbb4 signaling pathway
(GO:0038135)
Estrous cycle
(GO:0044849)
Glial cell differentiation
(GO:0010001)
Growth factor binding
(GO:0019838)
Heart development
(GO:0007507)
Hsp90 protein binding
(GO:0051879)
Identical protein binding
(GO:0042802)
Immature t cell proliferation in thymus
(GO:0033080)
Intracellular signal transduction
(GO:0035556)
Kinase activity
(GO:0016301)
Motor neuron axon guidance
(GO:0008045)
Multicellular organism development
(GO:0007275)
Myelination
(GO:0042552)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of immature t cell proliferation in thymus
(GO:0033088)
Nervous system development
(GO:0007399)
Neurogenesis
(GO:0022008)
Neuromuscular junction development
(GO:0007528)
Neuron differentiation
(GO:0030182)
Nucleotide binding
(GO:0000166)
Oligodendrocyte differentiation
(GO:0048709)
Peptidyl-tyrosine phosphorylation
(GO:0018108)
Peripheral nervous system development
(GO:0007422)
Phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0043491)
Phosphorylation
(GO:0016310)
Positive regulation of cell adhesion
(GO:0045785)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of epithelial cell proliferation
(GO:0050679)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of kinase activity
(GO:0033674)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of map kinase activity
(GO:0043406)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of ras protein signal transduction
(GO:0046579)
Positive regulation of rho protein signal transduction
(GO:0035025)
Positive regulation of transcription by rna polymerase i
(GO:0045943)
Positive regulation of translation
(GO:0045727)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein tyrosine kinase activity
(GO:0004713)
Receptor tyrosine kinase binding
(GO:0030971)
Regulation of microtubule-based process
(GO:0032886)
Response to axon injury
(GO:0048678)
Rna polymerase i core binding
(GO:0001042)
Schwann cell development
(GO:0014044)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)
Sympathetic nervous system development
(GO:0048485)
Transferase activity
(GO:0016740)
Transmembrane receptor protein tyrosine kinase activity
(GO:0004714)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)
Transmembrane signaling receptor activity
(GO:0004888)
Ubiquitin protein ligase binding
(GO:0031625)
Wound healing
(GO:0042060)

Other Information

Proteins

Receptor tyrosine-protein kinase erbB-2

Genular Protein ID: 4203071278

Symbol: ERBB2_MOUSE

Name: Receptor tyrosine-protein kinase erbB-2

UniProtKB Accession Codes:

P70424 Q61525 Q6ZPE0

Database IDs:

Citations:

PubMed ID: 14621295

Title: Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PubMed ID: 14621295

DOI: 10.1093/dnares/10.4.167

PubMed ID: 9048643

Title: Differential expression of the erbB2 gene in the periimplantation mouse uterus: potential mediator of signaling by epidermal growth factor-like growth factors.

PubMed ID: 9048643

DOI: 10.1210/endo.138.3.4991

PubMed ID: 7589796

Title: Synapse-associated expression of an acetylcholine receptor-inducing protein, ARIA/heregulin, and its putative receptors, ErbB2 and ErbB3, in developing mammalian muscle.

PubMed ID: 7589796

DOI: 10.1006/dbio.1995.0012

PubMed ID: 7542762

Title: Direct and specific interaction of c-Src with Neu is involved in signaling by the epidermal growth factor receptor.

PubMed ID: 7542762

PubMed ID: 11278603

Title: The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins.

PubMed ID: 11278603

DOI: 10.1074/jbc.m010032200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23897819

Title: Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling.

PubMed ID: 23897819

DOI: 10.1074/jbc.m112.446138

Sequence Information:

Length: 1256
Mass: 138579
Checksum: 6040978428B93A28
Sequence:

MELAAWCRWG FLLALLSPGA AGTQVCTGTD MKLRLPASPE THLDMLRHLY QGCQVVQGNL 
ELTYLPANAS LSFLQDIQEV QGYMLIAHNR VKHVPLQRLR IVRGTQLFED KYALAVLDNR 
DPLDNVTTAA PGRTPEGLRE LQLRSLTEIL KGGVLIRGNP QLCYQDMVLW KDVLRKNNQL 
APVDMDTNRS RACPPCAPTC KDNHCWGESP EDCQILTGTI CTSGCARCKG RLPTDCCHEQ 
CAAGCTGPKH SDCLACLHFN HSGICELHCP ALITYNTDTF ESMLNPEGRY TFGASCVTTC 
PYNYLSTEVG SCTLVCPPNN QEVTAEDGTQ RCEKCSKPCA GVCYGLGMEH LRGARAITSD 
NIQEFAGCKK IFGSLAFLPE SFDGNPSSGV APLKPEHLQV FETLEEITGY LYISAWPESF 
QDLSVFQNLR VIRGRILHDG AYSLTLQGLG IHSLGLRSLR ELGSGLALIH RNTHLCFVNT 
VPWDQLFRNP HQALLHSGNR PEEACGLEGL VCNSLCARGH CWGPGPTQCV NCSQFLRGQE 
CVEECRVWKG LPREYVRGKH CLPCHPECQP QNSSETCYGS EADQCEACAH YKDSSSCVAR 
CPSGVKPDLS YMPIWKYPDE EGICQPCPIN CTHSCVDLDE RGCPAEQRAS PVTFIIATVV 
GVLLFLIIVV VIGILIKRRR QKIRKYTMRR LLQETELVEP LTPSGAVPNQ AQMRILKETE 
LRKLKVLGSG AFGTVYKGIW IPDGENVKIP VAIKVLRENT SPKANKEILD EAYVMAGVGS 
PYVSRLLGIC LTSTVQLVTQ LMPYGCLLDH VREHRGRLGS QDLLNWCVQI AKGMSYLEEV 
RLVHRDLAAR NVLVKSPNHV KITDFGLARL LDIDETEYHA DGGKVPIKWM ALESILRRRF 
THQSDVWSYG VTVWELMTFG AKPYDGIPAR EIPDLLEKGE RLPQPPICTI DVYMIMVKCW 
MIDSECRPRF RELVSEFSRM ARDPQRFVVI QNEDLGPSSP MDSTFYRSLL EDDDMGELVD 
AEEYLVPQQG FFSPDPALGT GSTAHRRHRS SSARSGGGEL TLGLEPSEEE PPRSPLAPSE 
GAGSDVFDGD LAVGVTKGLQ SLSPHDLSPL QRYSEDPTLP LPPETDGYVA PLACSPQPEY 
VNQPEVRPQS PLTPEGPPPP IRPAGATLER PKTLSPGKNG VVKDVFAFGG AVENPEYLAP 
RAGTASQPHP SPAFSPAFDN LYYWDQNSSE QGPPPSTFEG TPTAENPEYL GLDVPV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Erbb2

Associated with

Other Information

Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. PubMed ID: 14621295

Differential expression of the erbB2 gene in the periimplantation mouse uterus: potential mediator of signaling by epidermal growth factor-like growth factors. PubMed ID: 9048643

Synapse-associated expression of an acetylcholine receptor-inducing protein, ARIA/heregulin, and its putative receptors, ErbB2 and ErbB3, in developing mammalian muscle. PubMed ID: 7589796

Direct and specific interaction of c-Src with Neu is involved in signaling by the epidermal growth factor receptor. PubMed ID: 7542762

The ERBB2/HER2 receptor differentially interacts with ERBIN and PICK1 PSD-95/DLG/ZO-1 domain proteins. PubMed ID: 11278603

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling. PubMed ID: 23897819