Genular: Defining Cellular Identity and Function

Details for: Erbb3

Gene ID: 13867

Symbol: Erbb3

Ensembl ID: ENSMUSG00000018166

Description: erb-b2 receptor tyrosine kinase 3

Associated with

Downregulation of erbb2 signaling
(R-MMU-8863795)
Downregulation of erbb2:erbb3 signaling
(R-MMU-1358803)
Erbb2 activates ptk6 signaling
(R-MMU-8847993)
Erbb2 regulates cell motility
(R-MMU-6785631)
Grb7 events in erbb2 signaling
(R-MMU-1306955)
Intracellular signaling by second messengers
(R-MMU-9006925)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Pi3k events in erbb2 signaling
(R-MMU-1963642)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-MMU-6811558)
Pip3 activates akt signaling
(R-MMU-1257604)
Raf/map kinase cascade
(R-MMU-5673001)
Shc1 events in erbb2 signaling
(R-MMU-1250196)
Signaling by erbb2
(R-MMU-1227986)
Signaling by erbb4
(R-MMU-1236394)
Signaling by non-receptor tyrosine kinases
(R-MMU-9006927)
Signaling by ptk6
(R-MMU-8848021)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Apical plasma membrane
(GO:0016324)
Atp binding
(GO:0005524)
Basal plasma membrane
(GO:0009925)
Basolateral plasma membrane
(GO:0016323)
Cranial nerve development
(GO:0021545)
Endocardial cushion development
(GO:0003197)
Epidermal growth factor receptor signaling pathway
(GO:0007173)
Erbb-3 class receptor binding
(GO:0043125)
Erbb2-erbb3 signaling pathway
(GO:0038133)
Erbb3:erbb2 complex
(GO:0038143)
Extracellular space
(GO:0005615)
Extrinsic apoptotic signaling pathway in absence of ligand
(GO:0097192)
Growth factor binding
(GO:0019838)
Identical protein binding
(GO:0042802)
Kinase activity
(GO:0016301)
Lateral plasma membrane
(GO:0016328)
Membrane
(GO:0016020)
Motor neuron apoptotic process
(GO:0097049)
Multicellular organism development
(GO:0007275)
Myelination
(GO:0042552)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cell adhesion
(GO:0007162)
Negative regulation of motor neuron apoptotic process
(GO:2000672)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of secretion
(GO:0051048)
Negative regulation of signal transduction
(GO:0009968)
Neuregulin binding
(GO:0038132)
Neuregulin receptor activity
(GO:0038131)
Neurogenesis
(GO:0022008)
Neuron apoptotic process
(GO:0051402)
Nucleotide binding
(GO:0000166)
Peripheral nervous system development
(GO:0007422)
Phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0043491)
Phosphorylation
(GO:0016310)
Plasma membrane
(GO:0005886)
Positive regulation of calcineurin-nfat signaling cascade
(GO:0070886)
Positive regulation of cardiac muscle tissue development
(GO:0055025)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of glucose import
(GO:0046326)
Positive regulation of kinase activity
(GO:0033674)
Postsynaptic membrane
(GO:0045211)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein tyrosine kinase activator activity
(GO:0030296)
Protein tyrosine kinase activity
(GO:0004713)
Receptor complex
(GO:0043235)
Regulation of cell population proliferation
(GO:0042127)
Schwann cell development
(GO:0014044)
Schwann cell differentiation
(GO:0014037)
Signaling receptor activity
(GO:0038023)
Signal transduction
(GO:0007165)
Transferase activity
(GO:0016740)
Transmembrane receptor protein tyrosine kinase activity
(GO:0004714)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)
Transmembrane signaling receptor activity
(GO:0004888)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

Receptor tyrosine-protein kinase erbB-3

Genular Protein ID: 637047524

Symbol: ERBB3_MOUSE

Name: Receptor tyrosine-protein kinase erbB-3

UniProtKB Accession Codes:

Q61526 Q3KQR1 Q68J64 Q810U8 Q8K317

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7589796

Title: Synapse-associated expression of an acetylcholine receptor-inducing protein, ARIA/heregulin, and its putative receptors, ErbB2 and ErbB3, in developing mammalian muscle.

PubMed ID: 7589796

DOI: 10.1006/dbio.1995.0012

PubMed ID: 23897819

Title: Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling.

PubMed ID: 23897819

DOI: 10.1074/jbc.m112.446138

Sequence Information:

Length: 1339
Mass: 147613
Checksum: 59D56FD9C9536FBE
Sequence:

MSAIGTLQVL GFLLSLARGS EMGNSQAVCP GTLNGLSVTG DADNQYQTLY KLYEKCEVVM 
GNLEIVLTGH NADLSFLQWI REVTGYVLVA MNEFSVLPLP NLRVVRGTQV YDGKFAIFVM 
LNYNTNSSHA LRQLRFTQLT EILLGGVYIE KNDKLCHMDT IDWRDIVRVP DAEIVVKNNG 
GNCPPCHEVC KGRCWGPGPE DCQILTKTIC APQCNGRCFG PNPNQCCHDE CAGGCSGPQD 
TDCFACRHFN DSGACVPRCP APLVYNKLTF QLEPNPHIKY QYGGVCVASC PHNFVVDQTF 
CVRACPADKM EVDKNGLKMC EPCRGLCPKA CEGTGSGSRY QTVDSSNIDG FVNCTKILGN 
LDFLITGLNG DPWHKIPALD PEKLNVFRTV REITGYLNIQ SWPPHMHNFS VFSNLTTIGG 
RSLYNRGFSL LIMKNLNVTS LGFRSLKEIS AGRVYISANQ QLCYHHSLNW TRLLRGPAEE 
RLDIKYNRPL GECVAEGKVC DPLCSSGGCW GPGPGQCLSC RNYSREGVCV THCNVLQGEP 
REFVHEAHCF SCHPECQPME GTSTCNGSGS DACARCAHFR DGPHCVNSCP HGILGAKGPI 
YKYPDAQNEC RPCHENCTQG CKGPELQDCL GQAEVLMSKP HLVIAVTVGL TVIFLILGGS 
FLYWRGRRIQ NKRAMRRYLE RGESIEPLDP SEKANKVLAR IFKETELRKL KVLGSGVFGT 
VHKGIWIPEG ESIKIPVCIK VIEDKSGRQS FQAVTDHMLA VGSLDHAHIV RLLGLCPGSS 
LQLVTQYLPL GSLLDHVRQH RETLGPQLLL NWGVQIAKGM YYLEEHSMVH RDLALRNVML 
KSPSQVQVAD FGVADLLPPD DKQLLHSEAK TPIKWMALES IHFGKYTHQS DVWSYGVTVW 
ELMTFGAEPY AGLRLAEIPD LLEKGERLAQ PQICTIDVYM VMVKCWMIDE NIRPTFKELA 
NEFTRMARDP PRYLVIKRAS GPGIPPAAEP SALSTKELQD AELEPDLDLD LDVEVEEEGL 
ATTLGSALSL PTGTLTRPRG SQSLLSPSSG YMPMNQSNLG EACLDSAVLG GREQFSRPIS 
LHPIPRGRQT SESSEGHVTG SEAELQERVS MCRSRSRSRS PRPRGDSAYH SQRHSLLTPV 
TPLSPPGLEE EDGNGYVMPD THLRGTSSSR EGTLSSVGLS SVLGTEEEDE DEEYEYMNRK 
RRGSPARPPR PGSLEELGYE YMDVGSDLSA SLGSTQSCPL HPMAIVPSAG TTPDEDYEYM 
NRRRGAGGSG GDYAAMGACP AAEQGYEEMR AFQGPGHQAP HVRYARLKTL RSLEATDSAF 
DNPDYWHSRL FPKANAQRI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.