Genular: Defining Cellular Identity and Function

Details for: Erbb4

Gene ID: 13869

Symbol: Erbb4

Ensembl ID: ENSMUSG00000062209

Description: erb-b2 receptor tyrosine kinase 4

Associated with

Downregulation of erbb2 signaling
(R-MMU-8863795)
Downregulation of erbb4 signaling
(R-MMU-1253288)
Erbb2 activates ptk6 signaling
(R-MMU-8847993)
Erbb2 regulates cell motility
(R-MMU-6785631)
Esr-mediated signaling
(R-MMU-8939211)
Estrogen-dependent gene expression
(R-MMU-9018519)
Grb2 events in erbb2 signaling
(R-MMU-1963640)
Intracellular signaling by second messengers
(R-MMU-9006925)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Nuclear signaling by erbb4
(R-MMU-1251985)
Pi3k events in erbb2 signaling
(R-MMU-1963642)
Pi3k events in erbb4 signaling
(R-MMU-1250342)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-MMU-6811558)
Pip3 activates akt signaling
(R-MMU-1257604)
Raf/map kinase cascade
(R-MMU-5673001)
Shc1 events in erbb2 signaling
(R-MMU-1250196)
Shc1 events in erbb4 signaling
(R-MMU-1250347)
Signaling by erbb2
(R-MMU-1227986)
Signaling by erbb4
(R-MMU-1236394)
Signaling by non-receptor tyrosine kinases
(R-MMU-9006927)
Signaling by nuclear receptors
(R-MMU-9006931)
Signaling by ptk6
(R-MMU-8848021)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Apoptotic process
(GO:0006915)
Atp binding
(GO:0005524)
Cardiac muscle tissue regeneration
(GO:0061026)
Cell fate commitment
(GO:0045165)
Cell migration
(GO:0016477)
Cell surface receptor signaling pathway
(GO:0007166)
Cellular response to epidermal growth factor stimulus
(GO:0071364)
Central nervous system morphogenesis
(GO:0021551)
Embryonic pattern specification
(GO:0009880)
Epidermal growth factor receptor activity
(GO:0005006)
Epidermal growth factor receptor binding
(GO:0005154)
Erbb2-erbb4 signaling pathway
(GO:0038135)
Erbb4 signaling pathway
(GO:0038130)
Erbb4-erbb4 signaling pathway
(GO:0038138)
Establishment of planar polarity involved in nephron morphogenesis
(GO:0072046)
Gaba receptor binding
(GO:0050811)
Heart development
(GO:0007507)
Kinase activity
(GO:0016301)
Lactation
(GO:0007595)
Mammary gland alveolus development
(GO:0060749)
Mammary gland epithelial cell differentiation
(GO:0060644)
Mitochondrial fragmentation involved in apoptotic process
(GO:0043653)
Multicellular organism development
(GO:0007275)
Negative regulation of apoptotic process
(GO:0043066)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of muscle cell apoptotic process
(GO:0010656)
Nervous system development
(GO:0007399)
Neural crest cell migration
(GO:0001755)
Neuregulin binding
(GO:0038132)
Neuregulin receptor activity
(GO:0038131)
Neurogenesis
(GO:0022008)
Nucleotide binding
(GO:0000166)
Olfactory bulb interneuron differentiation
(GO:0021889)
Peptidyl-tyrosine phosphorylation
(GO:0018108)
Phosphorylation
(GO:0016310)
Positive regulation of cardiac muscle cell proliferation
(GO:0060045)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of epithelial cell proliferation
(GO:0050679)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of glucose import
(GO:0046326)
Positive regulation of kinase activity
(GO:0033674)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of phospholipid biosynthetic process
(GO:0071073)
Positive regulation of receptor signaling pathway via jak-stat
(GO:0046427)
Positive regulation of synaptic transmission, gabaergic
(GO:0032230)
Positive regulation of tyrosine phosphorylation of stat protein
(GO:0042531)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Protein kinase activity
(GO:0004672)
Protein phosphorylation
(GO:0006468)
Protein tyrosine kinase activity
(GO:0004713)
Receptor signaling pathway via jak-stat
(GO:0007259)
Regulation of cell migration
(GO:0030334)
Signal transduction
(GO:0007165)
Surfactant homeostasis
(GO:0043129)
Synapse assembly
(GO:0007416)
Synapse maturation
(GO:0060074)
Transcription cis-regulatory region binding
(GO:0000976)
Transferase activity
(GO:0016740)
Transmembrane receptor protein tyrosine kinase activity
(GO:0004714)
Transmembrane receptor protein tyrosine kinase signaling pathway
(GO:0007169)

Other Information

Proteins

Receptor tyrosine-protein kinase erbB-4

Genular Protein ID: 4103735285

Symbol: ERBB4_MOUSE

Name: Receptor tyrosine-protein kinase erbB-4

UniProtKB Accession Codes:

Q61527 B2KGF5 B2KGF6 O88460 Q3UNS6

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 9334263

Title: A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester.

PubMed ID: 9334263

DOI: 10.1074/jbc.272.42.26761

PubMed ID: 7589796

Title: Synapse-associated expression of an acetylcholine receptor-inducing protein, ARIA/heregulin, and its putative receptors, ErbB2 and ErbB3, in developing mammalian muscle.

PubMed ID: 7589796

DOI: 10.1006/dbio.1995.0012

PubMed ID: 7477376

Title: Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor.

PubMed ID: 7477376

DOI: 10.1038/378390a0

PubMed ID: 10508857

Title: ErbB4 signaling in the mammary gland is required for lobuloalveolar development and Stat5 activation during lactation.

PubMed ID: 10508857

DOI: 10.1083/jcb.147.1.77

PubMed ID: 10353604

Title: Characterization of a naturally occurring ErbB4 isoform that does not bind or activate phosphatidyl inositol 3-kinase.

PubMed ID: 10353604

DOI: 10.1038/sj.onc.1202612

PubMed ID: 10655590

Title: Defects in pathfinding by cranial neural crest cells in mice lacking the neuregulin receptor ErbB4.

PubMed ID: 10655590

DOI: 10.1038/35000058

PubMed ID: 12954715

Title: Impaired differentiation and lactational failure of Erbb4-deficient mammary glands identify ERBB4 as an obligate mediator of STAT5.

PubMed ID: 12954715

DOI: 10.1242/dev.00715

PubMed ID: 12824469

Title: Neural and mammary gland defects in ErbB4 knockout mice genetically rescued from embryonic lethality.

PubMed ID: 12824469

DOI: 10.1073/pnas.1436402100

PubMed ID: 15543145

Title: Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain.

PubMed ID: 15543145

DOI: 10.1038/nn1345

PubMed ID: 15863494

Title: ERBB4/HER4 potentiates STAT5A transcriptional activity by regulating novel STAT5A serine phosphorylation events.

PubMed ID: 15863494

DOI: 10.1074/jbc.m414044200

PubMed ID: 16815842

Title: ErbB-4 s80 intracellular domain abrogates ETO2-dependent transcriptional repression.

PubMed ID: 16815842

DOI: 10.1074/jbc.m603998200

PubMed ID: 16837552

Title: The intracellular domain of ErbB4 induces differentiation of mammary epithelial cells.

PubMed ID: 16837552

DOI: 10.1091/mbc.e06-02-0101

PubMed ID: 19596786

Title: ErbB4 splice variants Cyt1 and Cyt2 differ by 16 amino acids and exert opposing effects on the mammary epithelium in vivo.

PubMed ID: 19596786

DOI: 10.1128/mcb.01705-08

PubMed ID: 19632177

Title: Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury.

PubMed ID: 19632177

DOI: 10.1016/j.cell.2009.04.060

PubMed ID: 14504474

Title: ErbB4 signaling during breast and neural development: novel genetic models reveal unique ErbB4 activities.

PubMed ID: 14504474

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21295966

Title: Neuregulin signaling, cortical circuitry development and schizophrenia.

PubMed ID: 21295966

DOI: 10.1016/j.gde.2010.12.010

Sequence Information:

Length: 1308
Mass: 146855
Checksum: 65943278A7E7F2F6
Sequence:

MKLATGLWVW GSLLMAAGTV QPSASQSVCA GTENKLSSLS DLEQQYRALR KYYENCEVVM 
GNLEITSIEH NRDLSFLRSI REVTGYVLVA LNQFRYLPLE NLRIIRGTKL YEDRYALAIF 
LNYRKDGNFG LQELGLKNLT EILNGGVYVD QNKFLCYADT IHWQDIVRNP WPSNMTLVST 
NGSSGCGRCH KSCTGRCWGP TENHCQTLTR TVCAEQCDGR CYGPYVSDCC HRECAGGCSG 
PKDTDCFACM NFNDSGACVT QCPQTFVYNP TTFQLEHNFN AKYTYGAFCV KKCPHNFVVD 
SSSCVRACPS SKMEVEENGI KMCKPCTDIC PKACDGIGTG SLMSAQTVDS SNIDKFINCT 
KINGNLIFLV TGIHGDPYNA IDAIDPEKLN VFRTVREITG FLNIQSWPPN MTDFSVFSNL 
VTIGGRVLYS GLSLLILKQQ GITSLQFQSL KEISAGNIYI TDNSNLCYYH TINWTTLFST 
INQRIVIRDN RRAENCTAEG MVCNHLCSND GCWGPGPDQC LSCRRFSRGK ICIESCNLYD 
GEFREFENGS ICVECDSQCE KMEDGLLTCH GPGPDNCTKC SHFKDGPNCV EKCPDGLQGA 
NSFIFKYADQ DRECHPCHPN CTQGCNGPTS HDCIYYPWTG HSTLPQHART PLIAAGVIGG 
LFILVIMALT FAVYVRRKSI KKKRALRRFL ETELVEPLTP SGTAPNQAQL RILKETELKR 
VKVLGSGAFG TVYKGIWVPE GETVKIPVAI KILNETTGPK ANVEFMDEAL IMASMDHPHL 
VRLLGVCLSP TIQLVTQLMP HGCLLDYVHE HKDNIGSQLL LNWCVQIAKG MMYLEERRLV 
HRDLAARNVL VKSPNHVKIT DFGLARLLEG DEKEYNADGG KMPIKWMALE CIHYRKFTHQ 
SDVWSYGVTI WELMTFGGKP YDGIPTREIP DLLEKGERLP QPPICTIDVY MVMVKCWMID 
ADSRPKFKEL AAEFSRMARD PQRYLVIQGD DRMKLPSPND SKFFQNLLDE EDLEDMMDAE 
EYLVPQAFNI PPPIYTSRTR IDSNRSEIGH SPPPAYTPMS GNQFVYQDGG FATQQGMPMP 
YRATTSTIPE APVAQGATAE MFDDSCCNGT LRKPVAPHVQ EDSSTQRYSA DPTVFAPERN 
PRGELDEEGY MTPMHDKPKQ EYLNPVEENP FVSRRKNGDL QALDNPEYHS ASSGPPKAED 
EYVNEPLYLN TFANALGSAE YMKNSVLSVP EKAKKAFDNP DYWNHSLPPR STLQHPDYLQ 
EYSTKYFYKQ NGRIRPIVAE NPEYLSEFSL KPGTMLPPPP YRHRNTVV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Erbb4

Associated with

Other Information

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester. PubMed ID: 9334263

Synapse-associated expression of an acetylcholine receptor-inducing protein, ARIA/heregulin, and its putative receptors, ErbB2 and ErbB3, in developing mammalian muscle. PubMed ID: 7589796

Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor. PubMed ID: 7477376

ErbB4 signaling in the mammary gland is required for lobuloalveolar development and Stat5 activation during lactation. PubMed ID: 10508857

Characterization of a naturally occurring ErbB4 isoform that does not bind or activate phosphatidyl inositol 3-kinase. PubMed ID: 10353604

Defects in pathfinding by cranial neural crest cells in mice lacking the neuregulin receptor ErbB4. PubMed ID: 10655590

Impaired differentiation and lactational failure of Erbb4-deficient mammary glands identify ERBB4 as an obligate mediator of STAT5. PubMed ID: 12954715

Neural and mammary gland defects in ErbB4 knockout mice genetically rescued from embryonic lethality. PubMed ID: 12824469

Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain. PubMed ID: 15543145

ERBB4/HER4 potentiates STAT5A transcriptional activity by regulating novel STAT5A serine phosphorylation events. PubMed ID: 15863494

ErbB-4 s80 intracellular domain abrogates ETO2-dependent transcriptional repression. PubMed ID: 16815842

The intracellular domain of ErbB4 induces differentiation of mammary epithelial cells. PubMed ID: 16837552

ErbB4 splice variants Cyt1 and Cyt2 differ by 16 amino acids and exert opposing effects on the mammary epithelium in vivo. PubMed ID: 19596786

Neuregulin1/ErbB4 signaling induces cardiomyocyte proliferation and repair of heart injury. PubMed ID: 19632177

ErbB4 signaling during breast and neural development: novel genetic models reveal unique ErbB4 activities. PubMed ID: 14504474

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Neuregulin signaling, cortical circuitry development and schizophrenia. PubMed ID: 21295966