Genular: Defining Cellular Identity and Function

Details for: Ercc2

Gene ID: 13871

Symbol: Ercc2

Ensembl ID: ENSMUSG00000030400

Description: excision repair cross-complementing rodent repair deficiency, complementation group 2

Associated with

Dual incision in gg-ner
(R-MMU-5696400)
Dual incision in tc-ner
(R-MMU-6782135)
Formation of incision complex in gg-ner
(R-MMU-5696395)
Formation of rna pol ii elongation complex
(R-MMU-112382)
Formation of tc-ner pre-incision complex
(R-MMU-6781823)
Formation of the early elongation complex
(R-MMU-113418)
Gap-filling dna repair synthesis and ligation in tc-ner
(R-MMU-6782210)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Global genome nucleotide excision repair (gg-ner)
(R-MMU-5696399)
Metabolism of rna
(R-MMU-8953854)
Mrna capping
(R-MMU-72086)
Nucleotide excision repair
(R-MMU-5696398)
Rna pol ii ctd phosphorylation and interaction with ce
(R-MMU-77075)
Rna polymerase ii pre-transcription events
(R-MMU-674695)
Rna polymerase ii promoter escape
(R-MMU-73776)
Rna polymerase ii transcription
(R-MMU-73857)
Rna polymerase ii transcription elongation
(R-MMU-75955)
Rna polymerase ii transcription initiation
(R-MMU-75953)
Rna polymerase ii transcription initiation and promoter clearance
(R-MMU-76042)
Rna polymerase ii transcription pre-initiation and promoter opening
(R-MMU-73779)
Rna polymerase i promoter clearance
(R-MMU-73854)
Rna polymerase i promoter escape
(R-MMU-73772)
Rna polymerase i transcription
(R-MMU-73864)
Rna polymerase i transcription initiation
(R-MMU-73762)
Rna polymerase i transcription termination
(R-MMU-73863)
Tp53 regulates transcription of dna repair genes
(R-MMU-6796648)
Transcription-coupled nucleotide excision repair (tc-ner)
(R-MMU-6781827)
Transcriptional regulation by tp53
(R-MMU-3700989)
4 iron, 4 sulfur cluster binding
(GO:0051539)
5'-3' dna helicase activity
(GO:0043139)
Apoptotic process
(GO:0006915)
Atp binding
(GO:0005524)
Bone mineralization
(GO:0030282)
Cak-ercc2 complex
(GO:0070516)
Central nervous system myelin formation
(GO:0032289)
Chromosome segregation
(GO:0007059)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Damaged dna binding
(GO:0003684)
Determination of adult lifespan
(GO:0008340)
Dna binding
(GO:0003677)
Dna damage response
(GO:0006974)
Dna helicase activity
(GO:0003678)
Dna repair
(GO:0006281)
Embryonic cleavage
(GO:0040016)
Erythrocyte maturation
(GO:0043249)
Extracellular matrix organization
(GO:0030198)
Hair cell differentiation
(GO:0035315)
Hair cycle process
(GO:0022405)
Hair follicle maturation
(GO:0048820)
Helicase activity
(GO:0004386)
Hematopoietic stem cell differentiation
(GO:0060218)
Hematopoietic stem cell proliferation
(GO:0071425)
Hydrolase activity
(GO:0016787)
Hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
(GO:0016818)
Insulin-like growth factor receptor signaling pathway
(GO:0048009)
Intrinsic apoptotic signaling pathway by p53 class mediator
(GO:0072332)
In utero embryonic development
(GO:0001701)
Iron-sulfur cluster binding
(GO:0051536)
Maturation of ssu-rrna from tricistronic rrna transcript (ssu-rrna, 5.8s rrna, lsu-rrna)
(GO:0000462)
Metal ion binding
(GO:0046872)
Mmxd complex
(GO:0071817)
Multicellular organism growth
(GO:0035264)
Nucleic acid binding
(GO:0003676)
Nucleobase-containing compound metabolic process
(GO:0006139)
Nucleoplasm
(GO:0005654)
Nucleotide-excision repair
(GO:0006289)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Positive regulation of dna binding
(GO:0043388)
Positive regulation of mitotic recombination
(GO:0045951)
Post-embryonic development
(GO:0009791)
Protein-macromolecule adaptor activity
(GO:0030674)
Regulation of mitotic cell cycle phase transition
(GO:1901990)
Response to oxidative stress
(GO:0006979)
Response to uv
(GO:0009411)
Ribosomal small subunit biogenesis
(GO:0042274)
Skin development
(GO:0043588)
Spinal cord development
(GO:0021510)
Spindle
(GO:0005819)
Transcription-coupled nucleotide-excision repair
(GO:0006283)
Transcription by rna polymerase ii
(GO:0006366)
Transcription elongation by rna polymerase i
(GO:0006362)
Transcription factor tfiid complex
(GO:0005669)
Transcription factor tfiih core complex
(GO:0000439)
Transcription factor tfiih holo complex
(GO:0005675)
Uv protection
(GO:0009650)

Other Information

Proteins

General transcription and DNA repair factor IIH helicase subunit XPD

Genular Protein ID: 863093758

Symbol: ERCC2_MOUSE

Name: General transcription and DNA repair factor IIH helicase subunit XPD

UniProtKB Accession Codes:

O08811 Q8C487 Q9DC01

Database IDs:

Citations:

PubMed ID: 9426063

Title: Disruption of the mouse xeroderma pigmentosum group D DNA repair/basal transcription gene results in preimplantation lethality.

PubMed ID: 9426063

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 760
Mass: 86842
Checksum: 02B2E116792D4E44
Sequence:

MKLNVDGLLV YFPYDYIYPE QFSYMLELKR TLDAKGHGVL EMPSGTGKTV SLLALIVAYQ 
RAYPLEVTKL IYCSRTVPEI EKVIEELRKL LSFYEQQEGE KLPFLGLALS SRKNLCIHPE 
VTPLRFGKDV DGKCHSLTAS YVRAQYQQDA SLPHCRFYEE FDIHGRQMPL PAGIYNLDDL 
KALGQRQGWC PYFLARYSIL HANVVVYSYH YLLDPKIADL VSKELARKAV VVFDEAHNID 
NVCIDSMSVN LTRRTLDRCQ SNLDTLQKTV LRIKETDEQR LRDEYRRLVE GLREASVARE 
TDAHLANPVL PDEVLQEAVP GSIRTAEHFL GFLRRLLEYV KWRLRVQHVV QESPPAFLSG 
LAQRVCIQRK PLRFCAERLR SLLHTLEIAD LADFSPLTLL ANFATLVSTY AKGFTIIIEP 
FDDRTPTIAN PVLHFSCMDA SLAIKPVFER FQSVIITSGT LSPLDIYPKI LDFHPVTMAT 
FTMTLARVCL CPMIIGRGND QVAISSKFET REDIAVIRNY GNLLLEMSAV VPDGIVAFFT 
SYQYMESTVA SWYEQGILEN IQRNKLLFIE TQDGAETSVA LEKYQEACEN GRGAILLSVA 
RGKVSEGIDF VHHYGRAVIM FGVPYVYTQS RILKARLEYL RDQFQIREND FLTFDAMRHA 
AQCVGRAIRG KTDYGLMVFA DKRFARADKR GKLPRWIQEH LTDSNLNLTV DEGVQVAKYF 
LRQMAQPFHR EDQLGLSLLS LEQLQSEETL QRIEQIAQQL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.