Genular: Defining Cellular Identity and Function

Details for: Ereg

Gene ID: 13874

Symbol: Ereg

Ensembl ID: ENSMUSG00000029377

Description: epiregulin

Associated with

Cargo recognition for clathrin-mediated endocytosis
(R-MMU-8856825)
Clathrin-mediated endocytosis
(R-MMU-8856828)
Downregulation of erbb2 signaling
(R-MMU-8863795)
Egfr downregulation
(R-MMU-182971)
Egfr interacts with phospholipase c-gamma
(R-MMU-212718)
Erbb2 activates ptk6 signaling
(R-MMU-8847993)
Erbb2 regulates cell motility
(R-MMU-6785631)
Esr-mediated signaling
(R-MMU-8939211)
Extra-nuclear estrogen signaling
(R-MMU-9009391)
Gab1 signalosome
(R-MMU-180292)
Grb2 events in egfr signaling
(R-MMU-179812)
Grb2 events in erbb2 signaling
(R-MMU-1963640)
Intracellular signaling by second messengers
(R-MMU-9006925)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Membrane trafficking
(R-MMU-199991)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Pi3k events in erbb2 signaling
(R-MMU-1963642)
Pi3k events in erbb4 signaling
(R-MMU-1250342)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-MMU-6811558)
Pip3 activates akt signaling
(R-MMU-1257604)
Raf/map kinase cascade
(R-MMU-5673001)
Shc1 events in egfr signaling
(R-MMU-180336)
Shc1 events in erbb2 signaling
(R-MMU-1250196)
Shc1 events in erbb4 signaling
(R-MMU-1250347)
Signaling by egfr
(R-MMU-177929)
Signaling by erbb2
(R-MMU-1227986)
Signaling by erbb4
(R-MMU-1236394)
Signaling by non-receptor tyrosine kinases
(R-MMU-9006927)
Signaling by nuclear receptors
(R-MMU-9006931)
Signaling by ptk6
(R-MMU-8848021)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signal transduction
(R-MMU-162582)
Vesicle-mediated transport
(R-MMU-5653656)
Anatomical structure morphogenesis
(GO:0009653)
Angiogenesis
(GO:0001525)
Animal organ morphogenesis
(GO:0009887)
Cell-cell signaling
(GO:0007267)
Cell differentiation
(GO:0030154)
Cytokine-mediated signaling pathway
(GO:0019221)
Epidermal growth factor receptor binding
(GO:0005154)
Epidermal growth factor receptor signaling pathway
(GO:0007173)
Erbb2-egfr signaling pathway
(GO:0038134)
Erbb2-erbb4 signaling pathway
(GO:0038135)
Erbb4-erbb4 signaling pathway
(GO:0038138)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Female meiotic nuclear division
(GO:0007143)
Growth factor activity
(GO:0008083)
Keratinocyte proliferation
(GO:0043616)
Luteinizing hormone signaling pathway
(GO:0042700)
Membrane
(GO:0016020)
Mrna transcription
(GO:0009299)
Multicellular organism development
(GO:0007275)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of smooth muscle cell differentiation
(GO:0051151)
Oocyte maturation
(GO:0001556)
Ovarian cumulus expansion
(GO:0001550)
Ovulation
(GO:0030728)
Plasma membrane
(GO:0005886)
Positive regulation of cell division
(GO:0051781)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of dna replication
(GO:0045740)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of innate immune response
(GO:0045089)
Positive regulation of interleukin-6 production
(GO:0032755)
Positive regulation of mitotic nuclear division
(GO:0045840)
Positive regulation of phosphorylation
(GO:0042327)
Positive regulation of protein kinase activity
(GO:0045860)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Primary follicle stage
(GO:0048160)
Receptor ligand activity
(GO:0048018)
Transmembrane receptor protein tyrosine kinase activator activity
(GO:0030297)

Other Information

Proteins

Proepiregulin

Genular Protein ID: 3897443194

Symbol: EREG_MOUSE

Name: Proepiregulin

UniProtKB Accession Codes:

Q61521 Q7M0A8

Database IDs:

Citations:

PubMed ID: 8549764

Title: Molecular cloning of mouse epiregulin, a novel epidermal growth factor-related protein, expressed in the early stage of development.

PubMed ID: 8549764

DOI: 10.1016/0014-5793(95)01403-9

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7706296

Title: Epiregulin, a novel epidermal growth factor with mitogenic activity for rat primary hepatocytes.

PubMed ID: 7706296

DOI: 10.1074/jbc.270.13.7495

PubMed ID: 24631357

Title: Epiregulin: roles in normal physiology and cancer.

PubMed ID: 24631357

DOI: 10.1016/j.semcdb.2014.03.005

Sequence Information:

Length: 162
Mass: 18474
Checksum: DA50A10C9386B97D
Sequence:

METLPASWVL TLLCLGSHLL QAVISTTVIP SCIPGESEDN CTALVQMEDD PRVAQVQITK 
CSSDMDGYCL HGQCIYLVDM REKFCRCEVG YTGLRCEHFF LTVHQPLSKE YVALTVILIF 
LFLIITAGCI YYFCRWYKNR KSKKSREEYE RVTSGDPVLP QV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ereg

Associated with

Other Information

Molecular cloning of mouse epiregulin, a novel epidermal growth factor-related protein, expressed in the early stage of development. PubMed ID: 8549764

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Epiregulin, a novel epidermal growth factor with mitogenic activity for rat primary hepatocytes. PubMed ID: 7706296

Epiregulin: roles in normal physiology and cancer. PubMed ID: 24631357

Database document:

PubMed ID: 8549764

PubMed ID: 15489334

PubMed ID: 7706296

PubMed ID: 24631357