Details for: ATF6B

Gene ID: 1388

Symbol: ATF6B

Ensembl ID: ENSG00000213676

Description: activating transcription factor 6 beta

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 2.41
    Marker Score: 2150
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 2.19
    Marker Score: 1331
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 2.09
    Marker Score: 27788.5
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.92
    Marker Score: 1358
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.64
    Marker Score: 913.5
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.6
    Marker Score: 6287
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.56
    Marker Score: 1941
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.49
    Marker Score: 4118
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.41
    Marker Score: 751
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.41
    Marker Score: 413
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.4
    Marker Score: 16299
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.39
    Marker Score: 1184
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 1.38
    Marker Score: 925
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.36
    Marker Score: 13743
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.35
    Marker Score: 5532
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.32
    Marker Score: 5708
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.28
    Marker Score: 2674
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.28
    Marker Score: 1289
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.26
    Marker Score: 840
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.24
    Marker Score: 604
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.24
    Marker Score: 5144
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.23
    Marker Score: 3353
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.23
    Marker Score: 1783.5
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.23
    Marker Score: 1487
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.23
    Marker Score: 1156
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.22
    Marker Score: 3843
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.22
    Marker Score: 9044
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.21
    Marker Score: 1357
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.21
    Marker Score: 880
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.21
    Marker Score: 873
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.2
    Marker Score: 660
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 1.19
    Marker Score: 1651
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.18
    Marker Score: 413
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.18
    Marker Score: 1109.5
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.18
    Marker Score: 1998
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.17
    Marker Score: 3195
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.17
    Marker Score: 2383
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.17
    Marker Score: 703
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.16
    Marker Score: 410
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.15
    Marker Score: 4427
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.15
    Marker Score: 274
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.15
    Marker Score: 1128
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.14
    Marker Score: 324
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.14
    Marker Score: 1213
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.14
    Marker Score: 63664
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.14
    Marker Score: 1016
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.14
    Marker Score: 11439
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 1.13
    Marker Score: 1188
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 1.13
    Marker Score: 473
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.13
    Marker Score: 3347
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.13
    Marker Score: 3286
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.12
    Marker Score: 351
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.12
    Marker Score: 376
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.12
    Marker Score: 1647
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 1.12
    Marker Score: 679
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.11
    Marker Score: 284
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.11
    Marker Score: 270
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.11
    Marker Score: 736
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.11
    Marker Score: 1041
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.1
    Marker Score: 969
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.1
    Marker Score: 1467
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.1
    Marker Score: 580
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.09
    Marker Score: 9423
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.09
    Marker Score: 10367.5
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.09
    Marker Score: 349
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.08
    Marker Score: 2124
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.08
    Marker Score: 1125
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.08
    Marker Score: 374
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.08
    Marker Score: 1157
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.08
    Marker Score: 57064
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.08
    Marker Score: 294
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.08
    Marker Score: 988
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.07
    Marker Score: 2093
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.07
    Marker Score: 1267
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.07
    Marker Score: 2613
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.07
    Marker Score: 2717.5
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.07
    Marker Score: 607
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.07
    Marker Score: 588
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.07
    Marker Score: 806
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 1.06
    Marker Score: 260
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.06
    Marker Score: 1137.5
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.05
    Marker Score: 13908
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.05
    Marker Score: 247
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.05
    Marker Score: 857
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.04
    Marker Score: 612
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.04
    Marker Score: 6661
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.04
    Marker Score: 475
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 1.04
    Marker Score: 238
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 1.04
    Marker Score: 777
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.04
    Marker Score: 361
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.03
    Marker Score: 419
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1.03
    Marker Score: 355
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.02
    Marker Score: 1113
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.02
    Marker Score: 384
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.02
    Marker Score: 200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.02
    Marker Score: 1152
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.02
    Marker Score: 4358
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.02
    Marker Score: 956
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.01
    Marker Score: 62376
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 1.01
    Marker Score: 2025.5

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Other Information

**Key characteristics:** * The ATF6B protein is a transcription factor that is activated by unfolded proteins. * It is a key regulator of the unfolded protein response (upr), a cellular stress response that is triggered by the accumulation of unfolded or misfolded proteins in the endoplasmic reticulum. * ATF6B is also involved in the regulation of other cellular processes, including cell cycle regulation, apoptosis, and differentiation. **Pathways and functions:** * ATF6B is a key regulator of the unfolded protein response (upr). * In the upr, ATF6B binds to the Rna polymerase ii cis-regulatory region sequence in the DNA of chaperones and other unfolded proteins. * This binding activates transcription of these genes, which helps to restore the folding and function of the unfolded proteins. * ATF6B also binds to the rna polymerase ii cis-regulatory region sequence in the DNA of other transcription factors, such as p53 and Hsp70. * These bindings activate transcription of these genes, which helps to promote cell survival and resistance to stress. **Clinical significance:** Mutations in the ATF6B gene have been linked to a number of human diseases, including liver disease, cancer, and diabetes. These mutations can lead to the accumulation of unfolded proteins in the endoplasmic reticulum, which can damage cells and tissues. ATF6B is a promising target for the treatment of these diseases. Inhibition of ATF6B has been shown to be effective in protecting cells from damage and restoring their function.

Genular Protein ID: 2277922464

Symbol: ATF6B_HUMAN

Name: Cyclic AMP-dependent transcription factor ATF-6 beta

UniProtKB Accession Codes:

Q99941 B0UYX6 Q13269 Q14343 Q14345 Q5SSW7 Q99635 Q99637 Q9H3V9 Q9H3W1 Q9NPL0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 2 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 4 DMDM 1 DNASU 1 DisGeNET 1 EMBL 15 EPD 1 Ensembl 8 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8586413

Title: A novel Creb family gene telomeric of HLA-DRA in the HLA complex.

PubMed ID: 8586413

DOI: 10.1006/geno.1995.9891

PubMed ID: 8870652

Title: The gene G13 in the class III region of the human MHC encodes a potential DNA-binding protein.

PubMed ID: 8870652

DOI: 10.1042/bj3190081

PubMed ID: 14656967

Title: Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.

PubMed ID: 14656967

DOI: 10.1101/gr.1736803

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 8923003

Title: Alternate promoters and alternate splicing of human tenascin-X, a gene with 5' and 3' ends buried in other genes.

PubMed ID: 8923003

DOI: 10.1093/hmg/5.11.1749

PubMed ID: 11256944

Title: Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response.

PubMed ID: 11256944

DOI: 10.1042/0264-6021:3550019

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 703
  • Mass: 76709
  • Checksum: B04C7B23E7D83F82
  • Sequence:
    • MAELMLLSEI ADPTRFFTDN LLSPEDWGLQ NSTLYSGLDE VAEEQTQLFR CPEQDVPFDG 
SSLDVGMDVS PSEPPWELLP IFPDLQVKSE PSSPCSSSSL SSESSRLSTE PSSEALGVGE 
VLHVKTESLA PPLCLLGDDP TSSFETVQIN VIPTSDDSSD VQTKIEPVSP CSSVNSEASL 
LSADSSSQAF IGEEVLEVKT ESLSPSGCLL WDVPAPSLGA VQISMGPSLD GSSGKALPTR 
KPPLQPKPVV LTTVPMPSRA VPPSTTVLLQ SLVQPPPVSP VVLIQGAIRV QPEGPAPSLP 
RPERKSIVPA PMPGNSCPPE VDAKLLKRQQ RMIKNRESAC QSRRKKKEYL QGLEARLQAV 
LADNQQLRRE NAALRRRLEA LLAENSELKL GSGNRKVVCI MVFLLFIAFN FGPVSISEPP 
SAPISPRMNK GEPQPRRHLL GFSEQEPVQG VEPLQGSSQG PKEPQPSPTD QPSFSNLTAF 
PGGAKELLLR DLDQLFLSSD CRHFNRTESL RLADELSGWV QRHQRGRRKI PQRAQERQKS 
QPRKKSPPVK AVPIQPPGPP ERDSVGQLQL YRHPDRSQPA FLDAIDRRED TFYVVSFRRD 
HLLLPAISHN KTSRPKMSLV MPAMAPNETL SGRGAPGDYE EMMQIECEVM DTRVIHIKTS 
TVPPSLRKQP SPTPGNATGG PLPVSAASQA HQASHQPLYL NHP

Genular Protein ID: 3803416418

Symbol: Q6AZW6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6AZW6

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 2 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 703
  • Mass: 76721
  • Checksum: B04C7B23FC52173B
  • Sequence:
    • MAELMLLSEI ADPTRFFTDN LLSPEDWGLQ NSTLYSGLDE VAEEQTQLFR CPEQDVPFDG 
SSLDVGMDVS PSEPPWELLP IFPDLQVKSE PSSPCSSSSL SSESSRLSTE PSSEALGVGE 
VLHVKTESLA PPLCLLGDDP TSSFETVQIN VIPTSDDSSD VQTKIEPVSP CSSVNSEASL 
LSADSSSQAF IGEEVLEVKT ESLSPSGCLL WDVPAPSLGA VQISMGPSLD GSSGKALPTR 
KPPLQPKPVV LTTVPMPSRA VPPSTTVLLQ SLVQPPPVSP VVLIQGAIRV QPEGPAPSLP 
RPERKSIVPA PMPGNSCPPE VDAKLLKRQQ RMIKNRESAC QSRRKKKEYL QGLEARLQAV 
LADNQQLRRE NAALRRRLEA LLAENSELKL GSGNRKVVCI MVFLLFIAFN FGPVSISEPP 
SAPISPRMNK GEPQPRRHLL GFSEQEPVQG VEPLQGSSQG PKEPQPSPTD QPSFSNLTAF 
PGGAKELLLR DLDQLFLSSD CRHFNRTESL RLADELSGWV QRHQRGRRKI PQRAQERQKS 
QPRKKSPPVK AVPIQPPGPP ERDSVGQLQL YRHPDRSQPA FLDAIDRRED TFYVVSFRRD 
HLLLPAISHN KTSRPKMSLV MPAMAPNETL SGRGAPGDYE EMMQIECEVM DTRVIHIKIS 
TVPPSLRKQP SPTPGNATGG PLPVSAASQA HQASHQPLYL NHP

Genular Protein ID: 1024807362

Symbol: A0A1U9X796_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A1U9X796

Database IDs:

ARBA 5 AlphaFoldDB 1 Antibodypedia 2 CDD 1 CTD 1 DNASU 1 EMBL 4 ExpressionAtlas 1 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 Pfam 1 RefSeq 1 SAM 2 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Sequence Information:

  • Length: 700
  • Mass: 76412
  • Checksum: 54C077BF95309216
  • Sequence:
    • MAELMLLSEI ADPTRFFTDN LLSPEDWDST LYSGLDEVAE EQTQLFRCPE QDVPFDGSSL 
DVGMDVSPSE PPWELLPIFP DLQVKSEPSS PCSSSSLSSE SSRLSTEPSS EALGVGEVLH 
VKTESLAPPL CLLGDDPTSS FETVQINVIP TSDDSSDVQT KIEPVSPCSS VNSEASLLSA 
DSSSQAFIGE EVLEVKTESL SPSGCLLWDV PAPSLGAVQI SMGPSLDGSS GKALPTRKPP 
LQPKPVVLTT VPMPSRAVPP STTVLLQSLV QPPPVSPVVL IQGAIRVQPE GPAPSLPRPE 
RKSIVPAPMP GNSCPPEVDA KLLKRQQRMI KNRESACQSR RKKKEYLQGL EARLQAVLAD 
NQQLRRENAA LRRRLEALLA ENSELKLGSG NRKVVCIMVF LLFIAFNFGP VSISEPPSAP 
ISPRMNKGEP QPRRHLLGFS EQEPVQGVEP LQGSSQGPKE PQPSPTDQPS FSNLTAFPGG 
AKELLLRDLD QLFLSSDCRH FNRTESLRLA DELSGWVQRH QRGRRKIPQR AQERQKSQPR 
KKSPPVKAVP IQPPGPPERD SVGQLQLYRH PDRSQPAFLD AIDRREDTFY VVSFRRDHLL 
LPAISHNKTS RPKMSLVMPA MAPNETLSGR GAPGDYEEMM QIECEVMDTR VIHIKTSTVP 
PSLRKQPSPT PGNATGGPLP VSAASQAHQA SHQPLYLNHP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.