Details for: CREBL2

Gene ID: 1389

Symbol: CREBL2

Ensembl ID: ENSG00000111269

Description: cAMP responsive element binding protein like 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 157.8158
    Cell Significance Index: -24.5500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 97.5385
    Cell Significance Index: -24.7400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 63.2362
    Cell Significance Index: -26.0500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 56.3682
    Cell Significance Index: -22.9000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 55.6423
    Cell Significance Index: -26.2700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 49.1072
    Cell Significance Index: -25.2600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.3373
    Cell Significance Index: -25.0800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.3473
    Cell Significance Index: -25.0400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.5217
    Cell Significance Index: -25.7400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 5.6292
    Cell Significance Index: -12.3200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.0645
    Cell Significance Index: 55.3200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.1498
    Cell Significance Index: 69.0300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1289
    Cell Significance Index: 122.7900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9848
    Cell Significance Index: 160.1800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7377
    Cell Significance Index: 147.9900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.5875
    Cell Significance Index: 8.0200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5262
    Cell Significance Index: 94.8600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5151
    Cell Significance Index: 102.2300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5129
    Cell Significance Index: 63.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3858
    Cell Significance Index: 20.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3693
    Cell Significance Index: 17.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3204
    Cell Significance Index: 114.9300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.3145
    Cell Significance Index: 16.5100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3077
    Cell Significance Index: 277.8500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3023
    Cell Significance Index: 19.0500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2623
    Cell Significance Index: 33.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2483
    Cell Significance Index: 47.2600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2369
    Cell Significance Index: 10.7400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1881
    Cell Significance Index: 83.1500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1869
    Cell Significance Index: 18.4900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.1835
    Cell Significance Index: 126.9100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1781
    Cell Significance Index: 5.1300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1514
    Cell Significance Index: 82.6900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1209
    Cell Significance Index: 16.6000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1133
    Cell Significance Index: 3.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1075
    Cell Significance Index: 6.6100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.1054
    Cell Significance Index: 18.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0591
    Cell Significance Index: 111.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0562
    Cell Significance Index: 2.6400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0257
    Cell Significance Index: 1.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0157
    Cell Significance Index: 9.9400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0103
    Cell Significance Index: 0.7700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0042
    Cell Significance Index: 5.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0004
    Cell Significance Index: -0.6400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0005
    Cell Significance Index: -0.3500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0029
    Cell Significance Index: -5.3600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0034
    Cell Significance Index: -0.0900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0046
    Cell Significance Index: -0.1600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0047
    Cell Significance Index: -0.0800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0077
    Cell Significance Index: -0.4300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0085
    Cell Significance Index: -6.4600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0123
    Cell Significance Index: -1.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0131
    Cell Significance Index: -9.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0142
    Cell Significance Index: -0.6300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0157
    Cell Significance Index: -1.6000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0169
    Cell Significance Index: -10.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0247
    Cell Significance Index: -11.1900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0274
    Cell Significance Index: -3.1400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0322
    Cell Significance Index: -4.6800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0324
    Cell Significance Index: -18.2800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0486
    Cell Significance Index: -1.0400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0519
    Cell Significance Index: -6.7100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0612
    Cell Significance Index: -12.8800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0679
    Cell Significance Index: -19.5400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0718
    Cell Significance Index: -2.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0743
    Cell Significance Index: -5.7000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1094
    Cell Significance Index: -12.7500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1099
    Cell Significance Index: -3.0700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1125
    Cell Significance Index: -7.9600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1152
    Cell Significance Index: -13.5900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1552
    Cell Significance Index: -3.0300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1631
    Cell Significance Index: -2.7300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.2012
    Cell Significance Index: -4.3600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2204
    Cell Significance Index: -22.9500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2271
    Cell Significance Index: -17.9900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2393
    Cell Significance Index: -6.8600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.2467
    Cell Significance Index: -7.9000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2774
    Cell Significance Index: -17.9000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3204
    Cell Significance Index: -16.6900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3246
    Cell Significance Index: -3.8700
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.3402
    Cell Significance Index: -8.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3799
    Cell Significance Index: -23.2900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3883
    Cell Significance Index: -9.9800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.4042
    Cell Significance Index: -20.4300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4273
    Cell Significance Index: -11.4300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4301
    Cell Significance Index: -11.3100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4568
    Cell Significance Index: -13.4200
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4696
    Cell Significance Index: -10.8500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4794
    Cell Significance Index: -16.6600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4960
    Cell Significance Index: -10.2900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5102
    Cell Significance Index: -14.5600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5110
    Cell Significance Index: -9.4500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.5132
    Cell Significance Index: -6.3700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.5429
    Cell Significance Index: -17.2900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.5496
    Cell Significance Index: -18.0000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5609
    Cell Significance Index: -19.6500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.5673
    Cell Significance Index: -9.0000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5827
    Cell Significance Index: -21.3900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6012
    Cell Significance Index: -12.7600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.6313
    Cell Significance Index: -10.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CREBL2 is a member of the CREB (cAMP-responsive element-binding protein) family, which is known for its ability to regulate gene expression in response to cAMP signaling. CREBL2 shares a high degree of sequence homology with CREB and exhibits similar DNA-binding properties. Its expression is widespread across various cell types, including mural cells, Kupffer cells, and GABAergic interneurons, suggesting a broad functional repertoire. **Pathways and Functions:** CREBL2 is involved in several key pathways, including: 1. **Cell Cycle Regulation:** CREBL2 modulates the cell cycle by regulating the expression of genes involved in cell proliferation and differentiation. 2. **Cell Differentiation:** CREBL2 plays a crucial role in the differentiation of various cell types, including fat cells, glucose-importing cells, and lipid-biosynthetic cells. 3. **Gene Expression Regulation:** CREBL2 acts as a transcriptional regulator, controlling the expression of genes involved in various cellular processes, including DNA-templated transcription, protein binding, and signal transduction. 4. **Signaling Pathways:** CREBL2 interacts with various signaling molecules, including cAMP, to regulate cellular responses to external stimuli. **Clinical Significance:** CREBL2's involvement in disease states has been increasingly recognized, with potential implications in various conditions, including: 1. **Metabolic Disorders:** Alterations in CREBL2 expression have been linked to metabolic disorders, such as obesity and diabetes, highlighting its role in glucose and lipid metabolism. 2. **Neurological Disorders:** CREBL2's expression in GABAergic interneurons suggests its potential involvement in neurological disorders, such as epilepsy and schizophrenia. 3. **Cancer:** CREBL2's ability to regulate cell cycle and differentiation pathways makes it a potential target for cancer therapy. In conclusion, CREBL2 is a multifunctional transcription factor that plays a critical role in various cellular processes, including cell cycle regulation, differentiation, and gene expression. Its involvement in disease states highlights the need for further research into its mechanisms of action and potential therapeutic applications. **Recommendations:** 1. Further studies are needed to elucidate the molecular mechanisms underlying CREBL2's functions in different cell types and disease states. 2. CREBL2's potential as a therapeutic target should be explored, particularly in the context of metabolic and neurological disorders. 3. The role of CREBL2 in cancer development and progression should be investigated, with a focus on its interactions with other signaling pathways. By continuing to unravel the complexities of CREBL2, we can gain a deeper understanding of its significance in human health and disease, ultimately leading to the development of novel therapeutic strategies.

Genular Protein ID: 694549730

Symbol: CRBL2_HUMAN

Name: cAMP-responsive element-binding protein-like 2

UniProtKB Accession Codes:

O60519 B5BUM5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 GO 15 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 9693048

Title: CREBL2, a novel transcript from the chromosome 12 region flanked by ETV6 and CDKN1B.

PubMed ID: 9693048

DOI: 10.1006/geno.1998.5366

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18063805

Title: AMP-activated protein kinase phosphorylates transcription factors of the CREB family.

PubMed ID: 18063805

DOI: 10.1152/japplphysiol.00900.2007

Sequence Information:

  • Length: 120
  • Mass: 13784
  • Checksum: E191B2D239EDA17B
  • Sequence:
    • MDDSKVVGGK VKKPGKRGRK PAKIDLKAKL ERSRQSAREC RARKKLRYQY LEELVSSRER 
AICALREELE MYKQWCMAMD QGKIPSEIKA LLTGEEQNKS QQNSSRHTKA GKTDANSNSW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.