Details for: CREBL2

Gene ID: 1389

Symbol: CREBL2

Ensembl ID: ENSG00000111269

Description: cAMP responsive element binding protein like 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.46
    Marker Score: 167934.5
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.16
    Marker Score: 1163
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.15
    Marker Score: 570
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.01
    Marker Score: 2291
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71696
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47919
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.99
    Marker Score: 2485
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30391
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2396
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.94
    Marker Score: 216
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.94
    Marker Score: 8035
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.93
    Marker Score: 16445
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 431
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2699
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.9
    Marker Score: 1829.5
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.9
    Marker Score: 447
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.89
    Marker Score: 8489
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.87
    Marker Score: 1445
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.87
    Marker Score: 2325
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.85
    Marker Score: 21841
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4828.5
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 304
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.83
    Marker Score: 1197.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.83
    Marker Score: 1282.5
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.83
    Marker Score: 1688
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.83
    Marker Score: 51073
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.83
    Marker Score: 861
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.83
    Marker Score: 1037
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.82
    Marker Score: 336
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.82
    Marker Score: 17521.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.82
    Marker Score: 1209
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.81
    Marker Score: 12681
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.81
    Marker Score: 922
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.8
    Marker Score: 848
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.8
    Marker Score: 8227
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.78
    Marker Score: 292
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.78
    Marker Score: 6753
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.78
    Marker Score: 2752
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 591
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.77
    Marker Score: 3215
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.76
    Marker Score: 7192
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 306
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.76
    Marker Score: 1386
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.76
    Marker Score: 219
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.75
    Marker Score: 14971
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.75
    Marker Score: 438
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.75
    Marker Score: 27683
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.74
    Marker Score: 254
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.73
    Marker Score: 2829
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.71
    Marker Score: 370
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.71
    Marker Score: 1711
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.7
    Marker Score: 226
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.69
    Marker Score: 780
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.69
    Marker Score: 26362.5
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.69
    Marker Score: 2374
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.69
    Marker Score: 413
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.69
    Marker Score: 4475
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.69
    Marker Score: 2878.5
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.68
    Marker Score: 1444
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.68
    Marker Score: 693
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.68
    Marker Score: 452
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.67
    Marker Score: 742
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.67
    Marker Score: 165
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.67
    Marker Score: 1300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.66
    Marker Score: 605
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.66
    Marker Score: 163
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.66
    Marker Score: 5053.5
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.65
    Marker Score: 227
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.65
    Marker Score: 921
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.65
    Marker Score: 357
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.65
    Marker Score: 1676
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.64
    Marker Score: 778
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.64
    Marker Score: 146.5
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.64
    Marker Score: 231
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.63
    Marker Score: 201
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.63
    Marker Score: 255
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.63
    Marker Score: 703
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.63
    Marker Score: 1111
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.62
    Marker Score: 570.5
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.62
    Marker Score: 425
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.62
    Marker Score: 664
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.61
    Marker Score: 2496
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.61
    Marker Score: 138
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.61
    Marker Score: 1161
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.6
    Marker Score: 743
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.6
    Marker Score: 519
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.59
    Marker Score: 392
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.59
    Marker Score: 141.5
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.59
    Marker Score: 141.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.59
    Marker Score: 618
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.59
    Marker Score: 203
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.58
    Marker Score: 302
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.58
    Marker Score: 8663
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.58
    Marker Score: 142.5
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.58
    Marker Score: 2393
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.58
    Marker Score: 556

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Other Information

**Key characteristics:** - It is a cAMP-responsive element binding protein. - It is expressed in a variety of cell types, including mural cells, Kupffer cells, central nervous system macrophages, acinar cells of the salivary gland, cerebral cortex GABAergic interneurons, forebrain radial glial cells, kidney collecting duct principal cells, absorptive cells, intestinal crypt stem cells of colon, and keratocytes. - It is a key regulator of the cell cycle and is involved in the regulation of cell differentiation. - It is also involved in the regulation of metabolism, including the control of fat cell differentiation, glucose import, and lipid biosynthetic processes. **Pathways and functions:** - CREBL2 is involved in the regulation of cell cycle by binding to DNA sequences in the promoters of cell cycle genes and regulating their expression. - It is also involved in the regulation of cell differentiation by binding to DNA sequences in the promoters of cell fate-determining genes and regulating their expression. - It is also involved in the regulation of metabolism by binding to DNA sequences in the promoters of genes involved in energy metabolism and regulating their expression. **Clinical significance:** - Mutations in CREBL2 have been linked to a number of human diseases, including cancer, cardiovascular disease, and diabetes. - Targeting CREBL2 has been investigated as a therapeutic strategy for these diseases.

Genular Protein ID: 694549730

Symbol: CRBL2_HUMAN

Name: cAMP-responsive element-binding protein-like 2

UniProtKB Accession Codes:

O60519 B5BUM5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 9693048

Title: CREBL2, a novel transcript from the chromosome 12 region flanked by ETV6 and CDKN1B.

PubMed ID: 9693048

DOI: 10.1006/geno.1998.5366

PubMed ID: 19054851

Title: Human protein factory for converting the transcriptome into an in vitro-expressed proteome.

PubMed ID: 19054851

DOI: 10.1038/nmeth.1273

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18063805

Title: AMP-activated protein kinase phosphorylates transcription factors of the CREB family.

PubMed ID: 18063805

DOI: 10.1152/japplphysiol.00900.2007

Sequence Information:

  • Length: 120
  • Mass: 13784
  • Checksum: E191B2D239EDA17B
  • Sequence:
    • MDDSKVVGGK VKKPGKRGRK PAKIDLKAKL ERSRQSAREC RARKKLRYQY LEELVSSRER 
AICALREELE MYKQWCMAMD QGKIPSEIKA LLTGEEQNKS QQNSSRHTKA GKTDANSNSW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.