CREM | ENSG00000095794 | NCBI 1390

Details for: CREM

Gene ID: 1390

Symbol: CREM

Ensembl ID: ENSG00000095794

Description: cAMP responsive element modulator

Associated with

Circadian clock
(R-HSA-400253)
Atf4-creb1 transcription factor complex
(GO:1990589)
Camp response element binding protein binding
(GO:0008140)
Cell differentiation
(GO:0030154)
Chromatin
(GO:0000785)
Cytoplasm
(GO:0005737)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Dna binding
(GO:0003677)
Glycosphingolipid metabolic process
(GO:0006687)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleus
(GO:0005634)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rhythmic process
(GO:0048511)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific double-stranded dna binding
(GO:1990837)
Signal transduction
(GO:0007165)
Spermatogenesis
(GO:0007283)

Other Information

Proteins

Inducible cAMP early repressor

Genular Protein ID: 3920522282

Symbol: CREM_HUMAN

Name: Inducible cAMP early repressor

UniProtKB Accession Codes:

Q03060 A8K014 A8K3J7 A8K6A1 A8MPQ2 B4DXC1 C9J785 C9JZ10 E9PAR4 E9PHM1 O75519 Q14501 Q14503 Q14504 Q14505 Q14506 Q15731 Q16114 Q16116 Q5T9H7 Q5W1A6 Q5W1A7 Q5W1A8 Q5W1A9 Q5W1B0 Q5W1B2 Q7Z2Q6 Q8IVD4 Q96AG7 Q9NZ98 Q9NZ99 Q9NZB9

Database IDs:

Citations:

PubMed ID: 7916662

Title: Human CREM gene: evolutionary conservation, chromosomal localization, and inducibility of the transcript.

PubMed ID: 7916662

PubMed ID: 8206879

Title: Novel isoforms of human cyclic AMP-responsive element modulator (hCREM) mRNA.

PubMed ID: 8206879

DOI: 10.1093/oxfordjournals.jbchem.a124332

PubMed ID: 8622971

Title: cAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytes.

PubMed ID: 8622971

DOI: 10.1073/pnas.93.8.3536

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12397208

Title: Novel leader exons of the cyclic adenosine 3',5'-monophosphate response element modulator (CREM) gene, transcribed from promoters P3 and P4, are highly testis-specific in primates.

PubMed ID: 12397208

DOI: 10.1093/molehr/8.11.965

PubMed ID: 1461747

Title: Cyclic AMP response element binding protein CREB and modulator protein CREM are products of distinct genes.

PubMed ID: 1461747

DOI: 10.1093/nar/20.22.6106

PubMed ID: 16143638

Title: Combinations of genetic changes in the human cAMP-responsive element modulator gene: a clue towards understanding some forms of male infertility?

PubMed ID: 16143638

DOI: 10.1093/molehr/gah209

PubMed ID: 10373550

Title: Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis.

PubMed ID: 10373550

DOI: 10.1128/mcb.19.7.5001

PubMed ID: 11044457

Title: CREM activator and repressor isoforms in human testis: sequence variations and inaccurate splicing during impaired spermatogenesis.

PubMed ID: 11044457

DOI: 10.1093/molehr/6.11.967

PubMed ID: 14511788

Title: Different CREM-isoform gene expression between equine and human normal and impaired spermatogenesis.

PubMed ID: 14511788

DOI: 10.1016/s0093-691x(03)00142-0

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

Sequence Information:

Length: 345
Mass: 37006
Checksum: 4DDEE62904CDD0E6
Sequence:

MTMETVESQH DGSITASLTE SKSAHVQTQT GQNSIPALAQ VSVAGSGTRR GSPAVTLVQL 
PSGQTIHVQG VIQTPQPWVI QSSEIHTVQV AAIAETDESA ESEGVIDSHK RREILSRRPS 
YRKILNELSS DVPGVPKIEE ERSEEEGTPP SIATMAVPTS IYQTSTGQYI AIAQGGTIQI 
SNPGSDGVQG LQALTMTNSG APPPGATIVQ YAAQSADGTQ QFFVPGSQVV VQDEETELAP 
SHMAAATGDM PTYQIRAPTA ALPQGVVMAA SPGSLHSPQQ LAEEATRKRE LRLMKNREAA 
KECRRRKKEY VKCLESRVAV LEVQNKKLIE ELETLKDICS PKTDY

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CREM

Associated with

Other Information

Human CREM gene: evolutionary conservation, chromosomal localization, and inducibility of the transcript. PubMed ID: 7916662

Novel isoforms of human cyclic AMP-responsive element modulator (hCREM) mRNA. PubMed ID: 8206879

cAMP inducibility of transcriptional repressor ICER in developing and mature human T lymphocytes. PubMed ID: 8622971

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 10. PubMed ID: 15164054

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Novel leader exons of the cyclic adenosine 3',5'-monophosphate response element modulator (CREM) gene, transcribed from promoters P3 and P4, are highly testis-specific in primates. PubMed ID: 12397208

Cyclic AMP response element binding protein CREB and modulator protein CREM are products of distinct genes. PubMed ID: 1461747

Combinations of genetic changes in the human cAMP-responsive element modulator gene: a clue towards understanding some forms of male infertility? PubMed ID: 16143638

Human Cdc34 and Rad6B ubiquitin-conjugating enzymes target repressors of cyclic AMP-induced transcription for proteolysis. PubMed ID: 10373550

CREM activator and repressor isoforms in human testis: sequence variations and inaccurate splicing during impaired spermatogenesis. PubMed ID: 11044457

Different CREM-isoform gene expression between equine and human normal and impaired spermatogenesis. PubMed ID: 14511788

Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis. PubMed ID: 18220336

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163