Details for: CRHBP

Gene ID: 1393

Symbol: CRHBP

Ensembl ID: ENSG00000145708

Description: corticotropin releasing hormone binding protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 29.2037
    Cell Significance Index: -4.5400
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 28.5568
    Cell Significance Index: 106.4300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 11.2860
    Cell Significance Index: -4.5900
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 6.3938
    Cell Significance Index: 60.7800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 4.7919
    Cell Significance Index: -4.5800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.6782
    Cell Significance Index: -4.5400
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.4912
    Cell Significance Index: 19.6700
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.5668
    Cell Significance Index: 11.4900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.1822
    Cell Significance Index: -4.6700
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.0215
    Cell Significance Index: 10.5800
  • Cell Name: sst chodl GABAergic cortical interneuron (CL4023121)
    Fold Change: 0.7159
    Cell Significance Index: 5.0200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.5793
    Cell Significance Index: 3.5000
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.5406
    Cell Significance Index: 6.9900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.1996
    Cell Significance Index: 3.3600
  • Cell Name: endothelial stalk cell (CL0002671)
    Fold Change: 0.1981
    Cell Significance Index: 2.2200
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.1957
    Cell Significance Index: 1.3600
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.1552
    Cell Significance Index: 0.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1544
    Cell Significance Index: 98.0400
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.1473
    Cell Significance Index: 1.9100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1155
    Cell Significance Index: 7.1000
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0884
    Cell Significance Index: 2.3700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0834
    Cell Significance Index: 2.2400
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.0800
    Cell Significance Index: 0.9900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0422
    Cell Significance Index: 0.7500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0379
    Cell Significance Index: 26.2000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0372
    Cell Significance Index: 0.7900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.0367
    Cell Significance Index: 0.8800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0137
    Cell Significance Index: 0.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0106
    Cell Significance Index: 2.1300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0042
    Cell Significance Index: 0.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0006
    Cell Significance Index: 1.1600
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0006
    Cell Significance Index: -0.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0012
    Cell Significance Index: -0.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0027
    Cell Significance Index: -4.9700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0032
    Cell Significance Index: -4.8700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0037
    Cell Significance Index: -5.0800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0063
    Cell Significance Index: -4.7700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0066
    Cell Significance Index: -4.9000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0069
    Cell Significance Index: -5.0600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0085
    Cell Significance Index: -5.3200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0088
    Cell Significance Index: -4.9800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0100
    Cell Significance Index: -4.5500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0124
    Cell Significance Index: -3.5800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0140
    Cell Significance Index: -2.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0143
    Cell Significance Index: -2.5800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0219
    Cell Significance Index: -3.1800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0219
    Cell Significance Index: -2.5800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0248
    Cell Significance Index: -5.2300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0262
    Cell Significance Index: -4.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0268
    Cell Significance Index: -3.4300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0315
    Cell Significance Index: -3.8800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0319
    Cell Significance Index: -3.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0358
    Cell Significance Index: -4.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0363
    Cell Significance Index: -4.6900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0378
    Cell Significance Index: -3.8600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0392
    Cell Significance Index: -4.5600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0425
    Cell Significance Index: -4.4300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0507
    Cell Significance Index: -3.8900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0518
    Cell Significance Index: -1.6500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0537
    Cell Significance Index: -4.2500
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0593
    Cell Significance Index: -0.8500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0598
    Cell Significance Index: -0.8600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0616
    Cell Significance Index: -4.1500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0629
    Cell Significance Index: -4.6900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0671
    Cell Significance Index: -4.3300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0704
    Cell Significance Index: -3.3100
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0719
    Cell Significance Index: -1.5000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0724
    Cell Significance Index: -1.2400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0740
    Cell Significance Index: -4.1600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0791
    Cell Significance Index: -4.1200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0798
    Cell Significance Index: -3.5300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0825
    Cell Significance Index: -3.1300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0842
    Cell Significance Index: -4.4200
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0852
    Cell Significance Index: -2.2400
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0911
    Cell Significance Index: -3.1900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0918
    Cell Significance Index: -2.2900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1006
    Cell Significance Index: -2.5700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1042
    Cell Significance Index: -3.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1203
    Cell Significance Index: -5.6100
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1287
    Cell Significance Index: -2.7800
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1339
    Cell Significance Index: -1.6900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1367
    Cell Significance Index: -2.6900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.1402
    Cell Significance Index: -2.1300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1403
    Cell Significance Index: -5.1500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1445
    Cell Significance Index: -5.0200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1446
    Cell Significance Index: -5.0800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1460
    Cell Significance Index: -4.3000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1486
    Cell Significance Index: -4.2400
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1503
    Cell Significance Index: -2.1900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1515
    Cell Significance Index: -3.7800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1565
    Cell Significance Index: -4.1800
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1567
    Cell Significance Index: -1.6800
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.1567
    Cell Significance Index: -4.9600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1577
    Cell Significance Index: -3.3700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1596
    Cell Significance Index: -2.7300
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.1607
    Cell Significance Index: -1.1900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1619
    Cell Significance Index: -1.5400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1619
    Cell Significance Index: -3.2500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1647
    Cell Significance Index: -4.7200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1669
    Cell Significance Index: -4.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Structure and Function**: CRHBP is a secretin family receptor that binds to CRH, regulating its activity and availability. It has been shown to have both agonist and antagonist properties, depending on the context. 2. **Expression Patterns**: CRHBP is expressed in various cell types, including neurons, endothelial cells, and hematopoietic stem cells. Its expression is regulated by multiple factors, including stress, hormones, and growth factors. 3. **Regulation of CRH Signaling**: CRHBP is involved in the regulation of CRH signaling pathways, including the corticotropin-releasing hormone receptor (CRHR) and the CRH receptor antagonist (CRHR2). 4. **Interactions with Other Molecules**: CRHBP interacts with other molecules, including CRH, CRHR, and CRHR2, to regulate its activity and availability. **Pathways and Functions** 1. **Stress Response**: CRHBP plays a crucial role in the stress response by regulating CRH levels and activity. Elevated CRHBP levels have been observed in response to stress, which can lead to an increase in CRH signaling and the release of stress hormones. 2. **Anxiety and Depression**: CRHBP has been implicated in the pathophysiology of anxiety and depression. Dysregulation of CRHBP and CRH signaling has been observed in individuals with anxiety and depression disorders. 3. **Neurodegenerative Diseases**: CRHBP has been implicated in the pathogenesis of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. Dysregulation of CRHBP and CRH signaling has been observed in these diseases. 4. **Metabolic Regulation**: CRHBP has been shown to regulate glucose and lipid metabolism. Elevated CRHBP levels have been observed in individuals with metabolic disorders, such as diabetes and obesity. **Clinical Significance** 1. **Anxiety and Depression Disorders**: CRHBP may serve as a potential therapeutic target for anxiety and depression disorders. Modulating CRHBP levels and activity may help to reduce symptoms of these disorders. 2. **Neurodegenerative Diseases**: CRHBP may play a role in the pathogenesis of neurodegenerative diseases. Understanding the role of CRHBP in these diseases may lead to the development of novel therapeutic strategies. 3. **Metabolic Regulation**: CRHBP may serve as a potential therapeutic target for metabolic disorders. Modulating CRHBP levels and activity may help to regulate glucose and lipid metabolism. 4. **Cancer**: CRHBP has been implicated in the pathogenesis of certain cancers, including breast and lung cancer. Dysregulation of CRHBP and CRH signaling has been observed in these cancers. In conclusion, CRHBP is a complex protein that plays a crucial role in regulating CRH signaling and activity. Its dysregulation has been implicated in various physiological and pathological processes, including stress response, anxiety, depression, and neurodegenerative diseases. Further research is needed to fully understand the role of CRHBP in these processes and to develop novel therapeutic strategies for the treatment of these disorders.

Genular Protein ID: 3619718304

Symbol: CRHBP_HUMAN

Name: Corticotropin-releasing factor-binding protein

UniProtKB Accession Codes:

P24387 Q53F32 Q6FHT5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 36 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1846945

Title: Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins.

PubMed ID: 1846945

DOI: 10.1038/349423a0

PubMed ID: 8307998

Title: Assignment of disulfide bonds in corticotropin-releasing factor-binding protein.

PubMed ID: 8307998

DOI: 10.1016/s0021-9258(17)41780-7

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8198617

Title: Cloning and structure of the human corticotrophin releasing factor-binding protein gene (CRHBP).

PubMed ID: 8198617

DOI: 10.1006/geno.1993.1141

Sequence Information:

  • Length: 322
  • Mass: 36144
  • Checksum: 771A894BE06039BD
  • Sequence:
    • MSPNFKLQCH FILIFLTALR GESRYLELRE AADYDPFLLF SANLKRELAG EQPYRRALRC 
LDMLSLQGQF TFTADRPQLH CAAFFISEPE EFITIHYDQV SIDCQGGDFL KVFDGWILKG 
EKFPSSQDHP LPSAERYIDF CESGLSRRSI RSSQNVAMIF FRVHEPGNGF TLTIKTDPNL 
FPCNVISQTP NGKFTLVVPH QHRNCSFSII YPVVIKISDL TLGHVNGLQL KKSSAGCEGI 
GDFVELLGGT GLDPSKMTPL ADLCYPFHGP AQMKVGCDNT VVRMVSSGKH VNRVTFEYRQ 
LEPYELENPN GNSIGEFCLS GL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.