Details for: CRHBP

Gene ID: 1393

Symbol: CRHBP

Ensembl ID: ENSG00000145708

Description: corticotropin releasing hormone binding protein

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: amacrine cell (CL0000561)
    Fold Change: 3.33
    Marker Score: 10682
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.75
    Marker Score: 2943
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 2.22
    Marker Score: 18793
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 2.17
    Marker Score: 549.5
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.92
    Marker Score: 1389
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.77
    Marker Score: 429
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 1.7
    Marker Score: 395
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.34
    Marker Score: 294
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.24
    Marker Score: 342
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.14
    Marker Score: 7560
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71827
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48052
  • Cell Name: interneuron (CL0000099)
    Fold Change: 1
    Marker Score: 455
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: 0.99
    Marker Score: 952
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.98
    Marker Score: 2485
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.96
    Marker Score: 1954
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5347
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5291
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.83
    Marker Score: 30695
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.83
    Marker Score: 289
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.76
    Marker Score: 479
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.76
    Marker Score: 213
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.76
    Marker Score: 579
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.71
    Marker Score: 188
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.7
    Marker Score: 1332.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.66
    Marker Score: 350
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.65
    Marker Score: 12946
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.61
    Marker Score: 197
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 0.6
    Marker Score: 139
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.56
    Marker Score: 297
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 0.55
    Marker Score: 412
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.5
    Marker Score: 339
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.46
    Marker Score: 460
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.43
    Marker Score: 6776
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.41
    Marker Score: 119
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.4
    Marker Score: 242
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.4
    Marker Score: 144
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.39
    Marker Score: 122
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.36
    Marker Score: 3451
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.36
    Marker Score: 1480
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.34
    Marker Score: 111
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.34
    Marker Score: 143.5
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.34
    Marker Score: 139
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.33
    Marker Score: 293
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.33
    Marker Score: 91
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.31
    Marker Score: 74
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.3
    Marker Score: 83
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.3
    Marker Score: 73
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.27
    Marker Score: 1141
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.25
    Marker Score: 114
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.25
    Marker Score: 95
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.25
    Marker Score: 122
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.24
    Marker Score: 1470
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.24
    Marker Score: 70
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.24
    Marker Score: 114
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.23
    Marker Score: 415
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.23
    Marker Score: 204
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.22
    Marker Score: 530
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.19
    Marker Score: 116
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.19
    Marker Score: 337
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.19
    Marker Score: 51
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.19
    Marker Score: 65
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.19
    Marker Score: 449
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.18
    Marker Score: 1418
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.18
    Marker Score: 114
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.17
    Marker Score: 213
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.17
    Marker Score: 291
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.16
    Marker Score: 166
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.16
    Marker Score: 70
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.16
    Marker Score: 79
  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 0.16
    Marker Score: 127
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.16
    Marker Score: 41
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.15
    Marker Score: 104
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.15
    Marker Score: 46
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.14
    Marker Score: 222
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.14
    Marker Score: 52
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.14
    Marker Score: 61
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.14
    Marker Score: 386
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.13
    Marker Score: 146
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.13
    Marker Score: 40
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.13
    Marker Score: 64
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.13
    Marker Score: 157
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.12
    Marker Score: 84
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.12
    Marker Score: 84
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.12
    Marker Score: 346.5
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.12
    Marker Score: 372
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.12
    Marker Score: 44
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 0.12
    Marker Score: 513
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.12
    Marker Score: 474
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.11
    Marker Score: 602
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.11
    Marker Score: 64
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.11
    Marker Score: 109
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.11
    Marker Score: 21

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Other Information

**Key characteristics:** * CRHBP is a type I G protein-coupled receptor (GPCR). * It is expressed in high levels in the pituitary gland, where it is thought to regulate the release of CRH. * It is also expressed in low levels in the brain and other peripheral tissues. * It is a highly conserved protein, with a similar sequence in mammals and birds. **Pathways and functions:** * The CRHBP is a key component of the pituitary CRH signaling pathway. * It is activated by the binding of CRH to its receptor on the surface of pituitary cells. * This activation triggers a cascade of intracellular events that lead to the release of CRH from the pituitary cells. * CRH then binds to receptors on target cells, which can lead to a variety of cellular responses, including growth, differentiation, and migration. **Clinical significance:** * Mutations in the CRHBP gene have been linked to a number of human diseases, including pituitary tumors and diabetes. * The CRHBP is a potential therapeutic target for these diseases. * Inhibition of CRHBP has been shown to inhibit pituitary growth and tumor formation. **Additional information:** * The CRHBP is a relatively novel protein, with no known paralogs in mammals. * It is a type I GPCR, which is characterized by the presence of a single extracellular domain that is homologous to the extracellular domain of other GPCRs. * The CRHBP is a highly effective antagonist of CRH, which is a potent stimulator of pituitary growth.

Genular Protein ID: 3619718304

Symbol: CRHBP_HUMAN

Name: Corticotropin-releasing factor-binding protein

UniProtKB Accession Codes:

P24387 Q53F32 Q6FHT5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 36 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1846945

Title: Cloning and characterization of the cDNAs for human and rat corticotropin releasing factor-binding proteins.

PubMed ID: 1846945

DOI: 10.1038/349423a0

PubMed ID: 8307998

Title: Assignment of disulfide bonds in corticotropin-releasing factor-binding protein.

PubMed ID: 8307998

DOI: 10.1016/s0021-9258(17)41780-7

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8198617

Title: Cloning and structure of the human corticotrophin releasing factor-binding protein gene (CRHBP).

PubMed ID: 8198617

DOI: 10.1006/geno.1993.1141

Sequence Information:

  • Length: 322
  • Mass: 36144
  • Checksum: 771A894BE06039BD
  • Sequence:
    • MSPNFKLQCH FILIFLTALR GESRYLELRE AADYDPFLLF SANLKRELAG EQPYRRALRC 
LDMLSLQGQF TFTADRPQLH CAAFFISEPE EFITIHYDQV SIDCQGGDFL KVFDGWILKG 
EKFPSSQDHP LPSAERYIDF CESGLSRRSI RSSQNVAMIF FRVHEPGNGF TLTIKTDPNL 
FPCNVISQTP NGKFTLVVPH QHRNCSFSII YPVVIKISDL TLGHVNGLQL KKSSAGCEGI 
GDFVELLGGT GLDPSKMTPL ADLCYPFHGP AQMKVGCDNT VVRMVSSGKH VNRVTFEYRQ 
LEPYELENPN GNSIGEFCLS GL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.