Details for: CRHR1

Gene ID: 1394

Symbol: CRHR1

Ensembl ID: ENSG00000120088

Description: corticotropin releasing hormone receptor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.5244
    Cell Significance Index: 19.7300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.4049
    Cell Significance Index: 34.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.3436
    Cell Significance Index: 43.0400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.2546
    Cell Significance Index: 17.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9538
    Cell Significance Index: 191.3300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.9145
    Cell Significance Index: 56.0700
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 0.7465
    Cell Significance Index: 7.1800
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.6086
    Cell Significance Index: 2.9600
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.4443
    Cell Significance Index: 3.3900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4295
    Cell Significance Index: 81.7300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.4194
    Cell Significance Index: 19.0100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.3055
    Cell Significance Index: 18.3400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3010
    Cell Significance Index: 6.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2109
    Cell Significance Index: 75.6400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1977
    Cell Significance Index: 19.5600
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.1974
    Cell Significance Index: 4.1200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1968
    Cell Significance Index: 21.4100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1723
    Cell Significance Index: 5.0600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1372
    Cell Significance Index: 123.8500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1138
    Cell Significance Index: 2.3600
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.1101
    Cell Significance Index: 0.9800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1014
    Cell Significance Index: 16.4900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0900
    Cell Significance Index: 3.9800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0761
    Cell Significance Index: 2.8800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0719
    Cell Significance Index: 4.9800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0146
    Cell Significance Index: 0.7400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0054
    Cell Significance Index: 0.3400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.0034
    Cell Significance Index: 0.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0010
    Cell Significance Index: 0.0300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0046
    Cell Significance Index: -0.1600
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0049
    Cell Significance Index: -0.0900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0063
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0093
    Cell Significance Index: -6.8800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0105
    Cell Significance Index: -0.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0154
    Cell Significance Index: -1.8000
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: -0.0155
    Cell Significance Index: -0.2200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0170
    Cell Significance Index: -0.7000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0204
    Cell Significance Index: -0.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0233
    Cell Significance Index: -2.3800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0245
    Cell Significance Index: -0.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0259
    Cell Significance Index: -4.6600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0289
    Cell Significance Index: -3.9700
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron (CL4030065)
    Fold Change: -0.0392
    Cell Significance Index: -0.4100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0418
    Cell Significance Index: -1.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0419
    Cell Significance Index: -5.1500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0455
    Cell Significance Index: -1.4900
  • Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
    Fold Change: -0.0467
    Cell Significance Index: -0.4800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0510
    Cell Significance Index: -0.6800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0589
    Cell Significance Index: -1.2500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0591
    Cell Significance Index: -6.7700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0611
    Cell Significance Index: -0.9200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0653
    Cell Significance Index: -1.3100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0671
    Cell Significance Index: -2.3500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0700
    Cell Significance Index: -2.2300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0700
    Cell Significance Index: -3.9300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0736
    Cell Significance Index: -1.5900
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0804
    Cell Significance Index: -1.5900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0830
    Cell Significance Index: -0.9900
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0833
    Cell Significance Index: -1.0100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.0881
    Cell Significance Index: -2.2000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0966
    Cell Significance Index: -2.4100
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.0989
    Cell Significance Index: -1.2400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1042
    Cell Significance Index: -5.4300
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.1055
    Cell Significance Index: -1.0700
  • Cell Name: lung resident memory CD8-positive, alpha-beta T cell (CL4033039)
    Fold Change: -0.1092
    Cell Significance Index: -0.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1097
    Cell Significance Index: -5.1600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1149
    Cell Significance Index: -1.4500
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.1182
    Cell Significance Index: -1.9200
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.1194
    Cell Significance Index: -2.3500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1208
    Cell Significance Index: -1.7300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1221
    Cell Significance Index: -2.8200
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1297
    Cell Significance Index: -2.6400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1524
    Cell Significance Index: -4.0700
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.1556
    Cell Significance Index: -2.6600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.1556
    Cell Significance Index: -1.9400
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1560
    Cell Significance Index: -3.9800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1675
    Cell Significance Index: -3.3400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1713
    Cell Significance Index: -2.8700
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.1749
    Cell Significance Index: -3.4200
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.1785
    Cell Significance Index: -2.6700
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1791
    Cell Significance Index: -2.0900
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.1819
    Cell Significance Index: -2.0900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1833
    Cell Significance Index: -5.2600
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: -0.1885
    Cell Significance Index: -2.0400
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.1925
    Cell Significance Index: -2.1100
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.1926
    Cell Significance Index: -3.2400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.1965
    Cell Significance Index: -3.0400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1984
    Cell Significance Index: -5.4000
  • Cell Name: diffuse bipolar 1 cell (CL4033027)
    Fold Change: -0.2085
    Cell Significance Index: -2.5500
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.2111
    Cell Significance Index: -2.3000
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.2160
    Cell Significance Index: -3.2800
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2161
    Cell Significance Index: -3.1500
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.2182
    Cell Significance Index: -3.1000
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2226
    Cell Significance Index: -5.5500
  • Cell Name: invaginating midget bipolar cell (CL4033034)
    Fold Change: -0.2333
    Cell Significance Index: -2.8800
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.2357
    Cell Significance Index: -3.7900
  • Cell Name: secretory cell (CL0000151)
    Fold Change: -0.2451
    Cell Significance Index: -1.7000
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.2461
    Cell Significance Index: -3.3800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.2484
    Cell Significance Index: -2.0500
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.2490
    Cell Significance Index: -3.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **CRHR1 Structure:** CRHR1 is a G protein-coupled receptor (GPCR) that belongs to the secretin family of receptors. 2. **CRH Binding:** CRHR1 binds to corticotropin-releasing hormone (CRH), a neuropeptide hormone involved in stress response and immune regulation. 3. **Signaling Pathways:** CRHR1 activates adenylate cyclase activity, leading to the production of cyclic AMP (cAMP), a secondary messenger involved in various cellular processes, including gene expression and protein phosphorylation. 4. **Cellular Expression:** CRHR1 is highly expressed in classical monocytes, conventional dendritic cells, lymphocytes, and neurons, indicating its involvement in immune and nervous system functions. **Pathways and Functions:** 1. **Adenylate Cyclase Activity:** CRHR1 activates adenylate cyclase, leading to the production of cAMP, which regulates various cellular processes, including gene expression and protein phosphorylation. 2. **Corticotropin Secretion:** CRHR1 mediates the effects of CRH on the secretion of corticosterone, a glucocorticoid hormone involved in stress response and immune regulation. 3. **Immune Response:** CRHR1 is involved in the regulation of immune responses, including the activation of classical monocytes and dendritic cells, and the production of cytokines. 4. **Behavioral Response:** CRHR1 is also involved in the regulation of behavioral responses, including fear response and exploration behavior. 5. **Neurotransmission:** CRHR1 is expressed in neurons and is involved in the regulation of neurotransmission, including the release of neurotransmitters involved in stress response and anxiety. **Clinical Significance:** 1. **Stress Response:** CRHR1 plays a critical role in the regulation of stress response, including the secretion of corticosterone, which is involved in the response to physical and psychological stress. 2. **Immune Regulation:** CRHR1 is involved in the regulation of immune responses, including the activation of classical monocytes and dendritic cells, and the production of cytokines. 3. **Anxiety and Depression:** CRHR1 has been implicated in the pathophysiology of anxiety and depression, with altered expression and function of CRHR1 observed in individuals with these disorders. 4. **Neurological Disorders:** CRHR1 has also been implicated in the pathophysiology of various neurological disorders, including Alzheimer's disease, Parkinson's disease, and schizophrenia. 5. **Pharmacological Targeting:** CRHR1 has been identified as a potential therapeutic target for the treatment of various disorders, including anxiety, depression, and immune-related disorders. In conclusion, CRHR1 plays a critical role in the regulation of various physiological and pathological processes, including stress response, immune function, and behavior. Further research is needed to fully understand the mechanisms of CRHR1 and its clinical significance.

Genular Protein ID: 706716539

Symbol: G3CIS4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 430
  • Mass: 49183
  • Checksum: 6228C8C515464E67
  • Sequence:
  • MGGHPQLRLV KALLLLGLNP VSASLQDQHC ESLSLASNIS GLQCNASVDL IGTCWPRSPA 
    GQLVVRPCPA FFYGVRYNTT NNGYRECLAN GSWAARVNYS ECQEILNEEK KSKVHYHVAV 
    IINYLGHCIS LVALLVAFVL FLRLRSIRCL RNDQADGALE VGAPWSGAPF QVRRSIRCLR 
    NIIHWNLISA FILRNATWFV VQLTMSPEVH QSNVGWCRLV TAAYNYFHVT NFFWMFGEGC 
    YLHTAIVLTY STDRLRKWMF ICIGWGVPFP IIVAWAIGKL YYDNEKCWFG KRPGVYTDYI 
    YQGPMILVLL INFIFLFNIV RILMTKLRAS TTSETIQYRK AVKATLVLLP LLGITYMLFF 
    VNPGEDEVSR VVFIYFNSFL ESFQVRSAIR KRWHRWQDKH SIRARVARAM SIPTSPTRVS 
    FHSIKQSTAV

Genular Protein ID: 3731143632

Symbol: K9J956_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 154
  • Mass: 16708
  • Checksum: 9A7535D093B61EF3
  • Sequence:
  • MGGHPQLRLV KALLLLGLNP VSASLQDQHC ESLSLASNIS EKKQGALPCR SHHQLPGPLY 
    LPGGPPGGLC PLSAAQEHPV PAKHHPLEPH LRLHPAQRHL VRGPANHEPR GPPEQRGLVQ 
    VGDSRLQLLP CDQLLLDVRR GLLPAHSHRA HLLH

Genular Protein ID: 465597102

Symbol: B3SXS2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 21123435

Title: Activation of Type 1 CRH receptor isoforms induces serotonin release from human carcinoid BON-1N cells: an enterochromaffin cell model.

PubMed ID: 21123435

DOI: 10.1210/en.2010-0997

Sequence Information:

  • Length: 194
  • Mass: 21048
  • Checksum: 97D90AF6EED3F732
  • Sequence:
  • MGGHPQLRLV KALLLLGLNP VSASLQDQHC ESLSLASNIS GLQCNASVDL IGTCWPRSPA 
    GQLVVRPCPA FFYGVRYNTT KKKQGALPCR SHHQLPGPLY LPGGPPGGLC PLSAAQEHPV 
    PAKHHPLEPH LRLHPAQRHL VRGPANHEPR GPPEQRGLVQ VGDSRLQLLP CDQLLLDVRR 
    GLLPAHSHRA HLLH

Genular Protein ID: 986111447

Symbol: B3TIK8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 21123435

Title: Activation of Type 1 CRH receptor isoforms induces serotonin release from human carcinoid BON-1N cells: an enterochromaffin cell model.

PubMed ID: 21123435

DOI: 10.1210/en.2010-0997

Sequence Information:

  • Length: 314
  • Mass: 36648
  • Checksum: 7A0B55F1C9F7A3E9
  • Sequence:
  • MVSATIPQKK SKVHYHVAVI INYLGHCISL VALLVAFVLF LRLRSIRCLR NIIHWNLISA 
    FILRNATWFV VQLTMSPEVH QSNVGWCRLV TAAYNYFHVT NFFWMFGEGC YLHTAIVLTY 
    STDRLRKWMF ICIGWGVPFP IIVAWAIGKL YYDNEKCWFG KRPGVYTDYI YQGPMILVLL 
    INFIFLFNIV RILMTKLRAS TTSETIQYRK AVKATLVLLP LLGITYMLFF VNPGEDEVSR 
    VVFIYFNSFL ESFQGFFVSV FYCFLNSEVR SAIRKRWHRW QDKHSIRARV ARAMSIPTSP 
    TRVSFHSIKQ STAV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.