Details for: CRIP1

Gene ID: 1396

Symbol: CRIP1

Ensembl ID: ENSG00000213145

Description: cysteine rich protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 270.1626
    Cell Significance Index: -42.0200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 168.5043
    Cell Significance Index: -42.7400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 98.7975
    Cell Significance Index: -50.8200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 93.5774
    Cell Significance Index: -44.1800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 34.1131
    Cell Significance Index: -42.0600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 25.0573
    Cell Significance Index: -54.8400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.6385
    Cell Significance Index: -41.8900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.7855
    Cell Significance Index: -42.5600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 8.1755
    Cell Significance Index: 240.1100
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 4.4827
    Cell Significance Index: 38.5200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.3041
    Cell Significance Index: -11.5300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 4.0490
    Cell Significance Index: 116.6600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.8972
    Cell Significance Index: 371.4100
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 1.8473
    Cell Significance Index: 5.6300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.5863
    Cell Significance Index: 36.6500
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 1.5309
    Cell Significance Index: 26.3000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.2319
    Cell Significance Index: 14.0000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.1627
    Cell Significance Index: 33.3300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.1012
    Cell Significance Index: 119.7800
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.0104
    Cell Significance Index: 8.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.9530
    Cell Significance Index: 112.3900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.8010
    Cell Significance Index: 79.2400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.7924
    Cell Significance Index: 16.8800
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 0.7904
    Cell Significance Index: 2.2700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.6867
    Cell Significance Index: 24.1300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.6609
    Cell Significance Index: 45.7100
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.6298
    Cell Significance Index: 11.6400
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.5798
    Cell Significance Index: 2.8200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5691
    Cell Significance Index: 310.8200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5114
    Cell Significance Index: 11.0800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.4757
    Cell Significance Index: 7.3600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4457
    Cell Significance Index: 72.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3922
    Cell Significance Index: 74.6400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.3536
    Cell Significance Index: 2.9700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3087
    Cell Significance Index: 19.9200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2875
    Cell Significance Index: 21.4300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2517
    Cell Significance Index: 30.9500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1308
    Cell Significance Index: 3.2700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0273
    Cell Significance Index: 12.0600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0111
    Cell Significance Index: 8.4000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0100
    Cell Significance Index: -1.8000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0227
    Cell Significance Index: -42.7600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0275
    Cell Significance Index: -50.6500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0324
    Cell Significance Index: -49.8600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0384
    Cell Significance Index: -52.2400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0388
    Cell Significance Index: -5.3300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0442
    Cell Significance Index: -2.2300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0652
    Cell Significance Index: -48.2800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0661
    Cell Significance Index: -48.4300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0792
    Cell Significance Index: -50.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0869
    Cell Significance Index: -49.0000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0918
    Cell Significance Index: -2.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1112
    Cell Significance Index: -50.4500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1214
    Cell Significance Index: -43.5300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1470
    Cell Significance Index: -6.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1673
    Cell Significance Index: -19.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1731
    Cell Significance Index: -22.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.2016
    Cell Significance Index: -40.0000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2022
    Cell Significance Index: -3.0300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2140
    Cell Significance Index: -2.2200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.2190
    Cell Significance Index: -43.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2433
    Cell Significance Index: -51.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2467
    Cell Significance Index: -25.2000
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: -0.2964
    Cell Significance Index: -2.9400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2975
    Cell Significance Index: -50.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3017
    Cell Significance Index: -34.5600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3472
    Cell Significance Index: -50.4800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3660
    Cell Significance Index: -15.0000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4305
    Cell Significance Index: -33.0400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4371
    Cell Significance Index: -8.5300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5549
    Cell Significance Index: -9.5100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.5666
    Cell Significance Index: -40.0700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.6351
    Cell Significance Index: -50.3000
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.6387
    Cell Significance Index: -11.0100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.6588
    Cell Significance Index: -44.3000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.6907
    Cell Significance Index: -12.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7343
    Cell Significance Index: -45.0200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.7521
    Cell Significance Index: -39.0700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.7689
    Cell Significance Index: -47.2600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.8004
    Cell Significance Index: -36.2800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.8012
    Cell Significance Index: -44.9600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.8920
    Cell Significance Index: -41.5900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9786
    Cell Significance Index: -61.6800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.0815
    Cell Significance Index: -28.9300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.1336
    Cell Significance Index: -50.1400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.1967
    Cell Significance Index: -43.9300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.1985
    Cell Significance Index: -35.3000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.2116
    Cell Significance Index: -42.4500
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: -1.2441
    Cell Significance Index: -12.5500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.3259
    Cell Significance Index: -50.2100
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -1.3523
    Cell Significance Index: -26.4400
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -1.3591
    Cell Significance Index: -32.9200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.4096
    Cell Significance Index: -46.1500
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -1.4173
    Cell Significance Index: -61.6300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.4229
    Cell Significance Index: -38.7300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.4394
    Cell Significance Index: -30.1300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.4746
    Cell Significance Index: -46.9700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.4760
    Cell Significance Index: -51.2900
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: -1.5040
    Cell Significance Index: -15.0800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.5581
    Cell Significance Index: -40.9700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** CRIP1 is a cysteine-rich protein, characterized by its unique sequence and structure. The protein's name is derived from its high content of cysteine residues, which are essential for its function. CRIP1 exhibits a high degree of variability in its expression among different cell types, with significant expression in myeloid dendritic cells, T cells, and B cells. This suggests that CRIP1 may play a crucial role in the regulation of immune responses, particularly in the context of antigen presentation and T cell activation. **Pathways and Functions:** CRIP1 is involved in several signaling pathways, including: 1. **Cellular response to antibiotic**: CRIP1 has been shown to regulate the expression of genes involved in the response to antibiotics, suggesting its role in the defense against bacterial infections. 2. **Immune response**: CRIP1 is expressed in myeloid dendritic cells and plays a crucial role in the presentation of antigens to T cells, thereby regulating the immune response. 3. **Intrinsic apoptotic signaling pathway**: CRIP1 has been implicated in the regulation of apoptosis in response to DNA damage, suggesting its role in maintaining cellular homeostasis. 4. **Prostate gland stromal morphogenesis**: CRIP1 is expressed in glandular epithelial cells, where it may regulate the development and morphogenesis of the prostate gland. **Clinical Significance:** CRIP1 has been implicated in several human diseases, including: 1. **Autoimmune disorders**: CRIP1 has been shown to regulate the expression of genes involved in autoimmune responses, suggesting its potential role in the pathogenesis of autoimmune diseases, such as rheumatoid arthritis and lupus. 2. **Cancer**: CRIP1 has been implicated in the regulation of apoptosis and cell cycle progression, suggesting its potential role in cancer development and progression. 3. **Infectious diseases**: CRIP1 has been shown to regulate the expression of genes involved in the response to antibiotics, suggesting its potential role in the treatment of antibiotic-resistant infections. In conclusion, CRIP1 is a multifunctional protein that plays a crucial role in the regulation of immune responses and development. Further research is needed to fully elucidate the mechanisms by which CRIP1 regulates cellular processes and its clinical significance in human diseases. **Recommendations:** 1. **Further research**: Investigate the role of CRIP1 in specific disease contexts, such as autoimmune disorders, cancer, and infectious diseases. 2. **Functional studies**: Conduct in vitro and in vivo studies to elucidate the mechanisms by which CRIP1 regulates cellular processes. 3. **Therapeutic applications**: Explore the potential therapeutic applications of CRIP1, such as its use as a target for immunotherapies or cancer treatments.

Genular Protein ID: 3283192818

Symbol: CRIP1_HUMAN

Name: Cysteine-rich protein 1

UniProtKB Accession Codes:

P50238 H3BPI2 Q13628 Q53XY7 Q96J34

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 3 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7999070

Title: Isolation and characterization of a cDNA that codes for a LIM-containing protein which is developmentally regulated in heart.

PubMed ID: 7999070

DOI: 10.1006/bbrc.1994.2693

PubMed ID: 9126610

Title: Human cysteine-rich intestinal protein: cDNA cloning and expression of recombinant protein and identification in human peripheral blood mononuclear cells.

PubMed ID: 9126610

DOI: 10.1006/prep.1996.0709

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

Sequence Information:

  • Length: 77
  • Mass: 8533
  • Checksum: B342436418DBC021
  • Sequence:
    • MPKCPKCNKE VYFAERVTSL GKDWHRPCLK CEKCGKTLTS GGHAEHEGKP YCNHPCYAAM 
FGPKGFGRGG AESHTFK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.