Details for: CRIP2

Gene ID: 1397

Symbol: CRIP2

Ensembl ID: ENSG00000182809

Description: cysteine rich protein 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 310.3599
    Cell Significance Index: -48.2800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 191.3710
    Cell Significance Index: -48.5400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 107.6289
    Cell Significance Index: -43.7300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 103.7654
    Cell Significance Index: -48.9900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 45.5253
    Cell Significance Index: -43.4700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 39.1458
    Cell Significance Index: -48.2700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 12.2629
    Cell Significance Index: -48.3900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.8739
    Cell Significance Index: -36.4700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 7.9315
    Cell Significance Index: 140.1600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.7778
    Cell Significance Index: 196.7800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 3.4338
    Cell Significance Index: 39.0100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.8263
    Cell Significance Index: 49.7100
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.7039
    Cell Significance Index: 10.0600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.6998
    Cell Significance Index: 928.2900
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.6372
    Cell Significance Index: 37.8300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.5955
    Cell Significance Index: 185.9400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.4267
    Cell Significance Index: 630.7900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.3557
    Cell Significance Index: 175.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.2170
    Cell Significance Index: 56.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1704
    Cell Significance Index: 143.9100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.1240
    Cell Significance Index: 83.7700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.0219
    Cell Significance Index: 35.5100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.9305
    Cell Significance Index: 167.7400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.9043
    Cell Significance Index: 13.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6081
    Cell Significance Index: 121.9900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.6021
    Cell Significance Index: 5.5500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.5717
    Cell Significance Index: 43.8800
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.5063
    Cell Significance Index: 3.1700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.4401
    Cell Significance Index: 31.1300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3163
    Cell Significance Index: 16.4300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3060
    Cell Significance Index: 276.3200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3043
    Cell Significance Index: 57.9100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1998
    Cell Significance Index: 9.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1570
    Cell Significance Index: 17.9800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1437
    Cell Significance Index: 19.7300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1325
    Cell Significance Index: 16.9900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1069
    Cell Significance Index: 10.5800
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.0885
    Cell Significance Index: 0.3300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0848
    Cell Significance Index: 1.2200
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.0678
    Cell Significance Index: 0.4500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.0479
    Cell Significance Index: 3.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0347
    Cell Significance Index: 12.4500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0248
    Cell Significance Index: 0.1500
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0206
    Cell Significance Index: 15.1300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0050
    Cell Significance Index: 0.8200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0064
    Cell Significance Index: -9.9100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0123
    Cell Significance Index: -7.7100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0149
    Cell Significance Index: -28.1400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0154
    Cell Significance Index: -11.4000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0186
    Cell Significance Index: -25.3000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0205
    Cell Significance Index: -37.8900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0251
    Cell Significance Index: -18.9800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0400
    Cell Significance Index: -2.4500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0430
    Cell Significance Index: -1.5100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0461
    Cell Significance Index: -25.9800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0471
    Cell Significance Index: -29.9200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0546
    Cell Significance Index: -37.7800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0694
    Cell Significance Index: -13.7800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1086
    Cell Significance Index: -49.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1268
    Cell Significance Index: -12.9500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1387
    Cell Significance Index: -29.2200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.1488
    Cell Significance Index: -1.2500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1704
    Cell Significance Index: -4.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1766
    Cell Significance Index: -50.8100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1827
    Cell Significance Index: -31.2000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1840
    Cell Significance Index: -3.0800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2032
    Cell Significance Index: -5.0800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.2121
    Cell Significance Index: -23.0700
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: -0.2169
    Cell Significance Index: -1.0600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2547
    Cell Significance Index: -11.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3422
    Cell Significance Index: -49.7400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3833
    Cell Significance Index: -23.5600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3907
    Cell Significance Index: -44.6000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4141
    Cell Significance Index: -48.8400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4247
    Cell Significance Index: -33.6400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.4582
    Cell Significance Index: -31.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4771
    Cell Significance Index: -49.6800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5531
    Cell Significance Index: -16.2900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.5781
    Cell Significance Index: -30.3500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.5950
    Cell Significance Index: -16.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6030
    Cell Significance Index: -33.8400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6032
    Cell Significance Index: -38.9200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.6446
    Cell Significance Index: -38.7000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.7054
    Cell Significance Index: -31.2000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.7477
    Cell Significance Index: -5.9700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.8833
    Cell Significance Index: -33.4500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.9105
    Cell Significance Index: -57.3900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.9172
    Cell Significance Index: -19.8700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.9390
    Cell Significance Index: -24.6900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.9771
    Cell Significance Index: -35.8700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.0024
    Cell Significance Index: -32.1100
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -1.0314
    Cell Significance Index: -6.7100
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: -1.0434
    Cell Significance Index: -3.6300
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -1.0663
    Cell Significance Index: -4.9300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -1.1023
    Cell Significance Index: -30.8100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.1796
    Cell Significance Index: -25.8300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.1898
    Cell Significance Index: -41.6800
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: -1.2075
    Cell Significance Index: -15.5500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.2194
    Cell Significance Index: -38.8400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.2279
    Cell Significance Index: -40.2000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Cysteine-rich structure:** CRIP2 contains multiple cysteine residues, which are essential for the formation of disulfide bonds that stabilize the protein's structure. 2. **Endothelial cell specificity:** CRIP2 is predominantly expressed in endothelial cells, which line blood vessels and play a critical role in maintaining vascular homeostasis. 3. **Cell proliferation regulation:** CRIP2 is involved in the regulation of cell population proliferation, suggesting its potential role in tissue development and repair. 4. **Positive regulation of cell signaling:** CRIP2 is also involved in the positive regulation of cell signaling pathways, which could contribute to its role in maintaining cellular homeostasis. **Pathways and Functions:** 1. **Cell cortex organization:** CRIP2 is involved in the organization of the cell cortex, which is essential for maintaining cellular shape and structure. 2. **Hemopoiesis:** CRIP2 is expressed in hematopoietic cells and is involved in the regulation of cell population proliferation, suggesting its potential role in blood cell development. 3. **Protein binding:** CRIP2 interacts with various proteins, including cytoskeletal proteins and signaling molecules, to regulate cellular processes. 4. **Zinc ion binding:** CRIP2 contains zinc-binding motifs, which are essential for the regulation of protein function and cellular processes. **Clinical Significance:** 1. **Cardiovascular diseases:** CRIP2 expression is altered in various cardiovascular diseases, including heart failure and atherosclerosis, suggesting its potential role as a biomarker or therapeutic target. 2. **Cancer:** CRIP2 is overexpressed in certain types of cancer, including lung and breast cancer, and may contribute to tumor progression and metastasis. 3. **Endothelial dysfunction:** CRIP2 is involved in the regulation of endothelial cell function, and its dysregulation may contribute to endothelial dysfunction and related diseases. 4. **Regenerative medicine:** CRIP2 may play a role in tissue repair and regeneration, particularly in the context of cardiovascular and muscular diseases. In conclusion, CRIP2 is a multifunctional protein that plays a critical role in maintaining endothelial cell function, regulating cell population proliferation, and positive regulation of cell signaling pathways. Its dysregulation may contribute to various diseases, including cardiovascular, cancer, and endothelial dysfunction. Further research is needed to fully elucidate the role of CRIP2 in human health and disease.

Genular Protein ID: 2361838455

Symbol: CRIP2_HUMAN

Name: Cysteine-rich protein 2

UniProtKB Accession Codes:

P52943 A1A4U1 B7Z6C0 E9PD13

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 4 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8824798

Title: Human ESP1/CRP2, a member of the LIM domain protein family: characterization of the cDNA and assignment of the gene locus to chromosome 14q32.3.

PubMed ID: 8824798

DOI: 10.1006/geno.1996.0028

PubMed ID: 8843343

Title: A novel cDNA encoding for a LIM domain protein located at human chromosome 14q32 as a candidate for leukemic translocation.

PubMed ID: 8843343

DOI: 10.1080/15216549600201831

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12508121

Title: The DNA sequence and analysis of human chromosome 14.

PubMed ID: 12508121

DOI: 10.1038/nature01348

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 208
  • Mass: 22493
  • Checksum: D32B99F98D51D3B0
  • Sequence:
    • MASKCPKCDK TVYFAEKVSS LGKDWHKFCL KCERCSKTLT PGGHAEHDGK PFCHKPCYAT 
LFGPKGVNIG GAGSYIYEKP LAEGPQVTGP IEVPAARAEE RKASGPPKGP SRASSVTTFT 
GEPNTCPRCS KKVYFAEKVT SLGKDWHRPC LRCERCGKTL TPGGHAEHDG QPYCHKPCYG 
ILFGPKGVNT GAVGSYIYDR DPEGKVQP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.