CRK | ENSG00000167193 | NCBI 1398

Details for: CRK

Gene ID: 1398

Symbol: CRK

Ensembl ID: ENSG00000167193

Description: CRK proto-oncogene, adaptor protein

Associated with

Arms-mediated activation
(R-HSA-170984)
Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Downstream signal transduction
(R-HSA-186763)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Integrin signaling
(R-HSA-354192)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-HSA-512988)
Leishmania infection
(R-HSA-9658195)
Leishmania phagocytosis
(R-HSA-9664417)
Met activates rap1 and rac1
(R-HSA-8875555)
Met promotes cell motility
(R-HSA-8875878)
Met receptor recycling
(R-HSA-8875656)
P130cas linkage to mapk signaling for integrins
(R-HSA-372708)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet aggregation (plug formation)
(R-HSA-76009)
Prolonged erk activation events
(R-HSA-169893)
Ptk6 regulates rho gtpases, ras gtpase and map kinases
(R-HSA-8849471)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of signaling by cbl
(R-HSA-912631)
Signaling by interleukins
(R-HSA-449147)
Signaling by met
(R-HSA-6806834)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by pdgf
(R-HSA-186797)
Signaling by ptk6
(R-HSA-8848021)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by vegf
(R-HSA-194138)
Signalling to erks
(R-HSA-187687)
Signal transduction
(R-HSA-162582)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Actin cytoskeleton organization
(GO:0030036)
Cell chemotaxis
(GO:0060326)
Cell migration
(GO:0016477)
Cell population proliferation
(GO:0008283)
Cellular response to endothelin
(GO:1990859)
Cellular response to insulin-like growth factor stimulus
(GO:1990314)
Cellular response to nerve growth factor stimulus
(GO:1990090)
Cellular response to nitric oxide
(GO:0071732)
Cellular response to transforming growth factor beta stimulus
(GO:0071560)
Cerebellar neuron development
(GO:0098749)
Cerebral cortex development
(GO:0021987)
Cytoskeletal protein binding
(GO:0008092)
Dendrite development
(GO:0016358)
Enzyme-linked receptor protein signaling pathway
(GO:0007167)
Ephrin receptor binding
(GO:0046875)
Ephrin receptor signaling pathway
(GO:0048013)
Establishment of cell polarity
(GO:0030010)
Helper t cell diapedesis
(GO:0035685)
Hippocampus development
(GO:0021766)
Insulin-like growth factor receptor binding
(GO:0005159)
Kinase binding
(GO:0019900)
Lipid metabolic process
(GO:0006629)
Negative regulation of cell motility
(GO:2000146)
Negative regulation of natural killer cell mediated cytotoxicity
(GO:0045953)
Negative regulation of wound healing
(GO:0061045)
Neuron migration
(GO:0001764)
Phosphotyrosine residue binding
(GO:0001784)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of rac protein signal transduction
(GO:0035022)
Positive regulation of skeletal muscle acetylcholine-gated channel clustering
(GO:1904395)
Positive regulation of smooth muscle cell migration
(GO:0014911)
Positive regulation of substrate adhesion-dependent cell spreading
(GO:1900026)
Postsynaptic specialization assembly
(GO:0098698)
Protein binding
(GO:0005515)
Protein localization to membrane
(GO:0072657)
Protein phosphorylated amino acid binding
(GO:0045309)
Protein tyrosine kinase binding
(GO:1990782)
Receptor tyrosine kinase binding
(GO:0030971)
Reelin-mediated signaling pathway
(GO:0038026)
Regulation of actin cytoskeleton organization
(GO:0032956)
Regulation of cell adhesion mediated by integrin
(GO:0033628)
Regulation of cell motility
(GO:2000145)
Regulation of cell shape
(GO:0008360)
Regulation of dendrite development
(GO:0050773)
Regulation of gtpase activity
(GO:0043087)
Regulation of intracellular signal transduction
(GO:1902531)
Regulation of signal transduction
(GO:0009966)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Regulation of wound healing
(GO:0061041)
Response to cholecystokinin
(GO:0061847)
Response to hepatocyte growth factor
(GO:0035728)
Response to hydrogen peroxide
(GO:0042542)
Response to peptide
(GO:1901652)
Response to yeast
(GO:0001878)
Scaffold protein binding
(GO:0097110)
Sh2 domain binding
(GO:0042169)
Sh3 domain binding
(GO:0017124)
Signaling adaptor activity
(GO:0035591)
Signaling receptor complex adaptor activity
(GO:0030159)
Ubiquitin protein ligase binding
(GO:0031625)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 355.0093
Cell Significance Index: -55.2200
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 218.0029
Cell Significance Index: -55.3000
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 144.3630
Cell Significance Index: -59.4700
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 121.0279
Cell Significance Index: -57.1400
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 110.8165
Cell Significance Index: -45.0200
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 103.0745
Cell Significance Index: -53.0200
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 85.3362
Cell Significance Index: -57.2600
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 47.4369
Cell Significance Index: -45.2900
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 45.9465
Cell Significance Index: -56.6500
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 19.9600
Cell Significance Index: -53.4700
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 14.4271
Cell Significance Index: -56.9300
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 12.6748
Cell Significance Index: -27.7400
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 12.5771
Cell Significance Index: -38.6300
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 2.5308
Cell Significance Index: 34.5300
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 1.9340
Cell Significance Index: 51.6400
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 1.5570
Cell Significance Index: 42.3800
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.5472
Cell Significance Index: 80.5900
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.4185
Cell Significance Index: 85.1600
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.2674
Cell Significance Index: 137.8500
Cell Name: neoplastic cell (CL0001063)
Fold Change: 1.1445
Cell Significance Index: 227.1300
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 1.0813
Cell Significance Index: 216.9100
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.9526
Cell Significance Index: 117.1300
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.8830
Cell Significance Index: 159.1700
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.8741
Cell Significance Index: 25.1900
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.8391
Cell Significance Index: 115.2400
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.8328
Cell Significance Index: 37.7500
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.7809
Cell Significance Index: 59.9300
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.7648
Cell Significance Index: 274.3300
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.6243
Cell Significance Index: 340.9200
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.5092
Cell Significance Index: 17.7000
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.4809
Cell Significance Index: 22.6000
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.4803
Cell Significance Index: 24.9500
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.4496
Cell Significance Index: 198.7900
Cell Name: lactocyte (CL0002325)
Fold Change: 0.4492
Cell Significance Index: 58.0400
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.4314
Cell Significance Index: 32.1500
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4222
Cell Significance Index: 41.7600
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.3884
Cell Significance Index: 18.1100
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.3098
Cell Significance Index: 214.3000
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.2977
Cell Significance Index: 8.3200
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: 0.2774
Cell Significance Index: 7.1300
Cell Name: sebum secreting cell (CL0000317)
Fold Change: 0.2627
Cell Significance Index: 18.5800
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.2467
Cell Significance Index: 42.1200
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.2261
Cell Significance Index: 141.1800
Cell Name: odontoblast (CL0000060)
Fold Change: 0.2094
Cell Significance Index: 26.8500
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 0.1751
Cell Significance Index: 3.1000
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.1672
Cell Significance Index: 11.5700
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.1576
Cell Significance Index: 29.9900
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.1560
Cell Significance Index: 5.4800
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.0846
Cell Significance Index: 5.3300
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.0112
Cell Significance Index: 10.1100
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0097
Cell Significance Index: 18.2800
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: -0.0095
Cell Significance Index: -1.5500
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0142
Cell Significance Index: -19.2900
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0151
Cell Significance Index: -23.3200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0158
Cell Significance Index: -10.0200
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0163
Cell Significance Index: -11.9500
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0178
Cell Significance Index: -32.8100
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0179
Cell Significance Index: -13.2500
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0203
Cell Significance Index: -9.2300
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0309
Cell Significance Index: -23.4000
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.0448
Cell Significance Index: -2.3500
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0665
Cell Significance Index: -37.5200
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -0.0750
Cell Significance Index: -1.2600
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.0782
Cell Significance Index: -4.8100
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0801
Cell Significance Index: -11.6500
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0945
Cell Significance Index: -27.2000
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.1027
Cell Significance Index: -10.4900
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1148
Cell Significance Index: -6.4400
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.1314
Cell Significance Index: -2.7500
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1668
Cell Significance Index: -35.1300
Cell Name: Hofbauer cell (CL3000001)
Fold Change: -0.1680
Cell Significance Index: -1.3700
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.1798
Cell Significance Index: -20.6000
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.2480
Cell Significance Index: -28.3100
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: -0.2710
Cell Significance Index: -31.9600
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: -0.2731
Cell Significance Index: -4.6000
Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.2895
Cell Significance Index: -18.6800
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.2910
Cell Significance Index: -19.5700
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: -0.2996
Cell Significance Index: -1.8100
Cell Name: granulosa cell (CL0000501)
Fold Change: -0.3079
Cell Significance Index: -8.1000
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.3088
Cell Significance Index: -35.9900
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.3277
Cell Significance Index: -7.1000
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.3987
Cell Significance Index: -11.4300
Cell Name: basal cell of epidermis (CL0002187)
Fold Change: -0.4286
Cell Significance Index: -6.5100
Cell Name: cerebellar granule cell (CL0001031)
Fold Change: -0.4750
Cell Significance Index: -8.1400
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: -0.4771
Cell Significance Index: -12.7900
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4953
Cell Significance Index: -51.5700
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.5043
Cell Significance Index: -39.9400
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.6168
Cell Significance Index: -5.6800
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: -0.6598
Cell Significance Index: -18.8300
Cell Name: preadipocyte (CL0002334)
Fold Change: -0.6717
Cell Significance Index: -13.1100
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.6825
Cell Significance Index: -30.1900
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.7452
Cell Significance Index: -15.8700
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.7529
Cell Significance Index: -46.1600
Cell Name: Purkinje cell (CL0000121)
Fold Change: -0.7609
Cell Significance Index: -16.6600
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.7821
Cell Significance Index: -25.0500
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: -0.7912
Cell Significance Index: -11.3800
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.8469
Cell Significance Index: -32.0700
Cell Name: type I muscle cell (CL0002211)
Fold Change: -0.8537
Cell Significance Index: -20.8300
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: -0.8738
Cell Significance Index: -12.9000
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.8842
Cell Significance Index: -13.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** CRK is a member of the C3 domain-containing protein family and shares structural homology with the Src homology 2 (SH2) andSrc homology 3 (SH3) domain-containing proteins. It contains two SH2 domains, which are essential for its interaction with tyrosine-phosphorylated proteins. CRK is also characterized by its ability to bind to phospholipase C gamma (PLC-γ) and phospholipase C gamma II (PLC-γII), which are involved in the regulation of cell signaling pathways. Additionally, CRK contains a proline-rich sequence, which is essential for its interaction with other proteins. **Pathways and Functions** CRK is involved in various signaling pathways, including: 1. **Met signaling pathway**: CRK is a key adaptor protein in the Met signaling pathway, which is involved in cell migration, proliferation, and survival. 2. **Ephrin receptor signaling pathway**: CRK is involved in the regulation of Ephrin receptor signaling, which is crucial for cell migration, adhesion, and morphogenesis. 3. **Integrin signaling pathway**: CRK is a key regulator of integrin signaling, which is essential for cell adhesion, migration, and proliferation. 4. **Cytokine signaling pathway**: CRK is involved in the regulation of cytokine signaling, which is crucial for immune responses and inflammation. 5. **Neurotrophin signaling pathway**: CRK is a key adaptor protein in the neurotrophin signaling pathway, which is involved in neuronal development, survival, and function. CRK's functions include: 1. **Cell migration**: CRK is involved in the regulation of cell migration, which is crucial for various physiological and pathological processes, including cancer metastasis and wound healing. 2. **Cell proliferation**: CRK is involved in the regulation of cell proliferation, which is essential for tissue development and homeostasis. 3. **Intracellular signaling**: CRK is a key regulator of intracellular signaling pathways, which are involved in various cellular processes, including cell survival, differentiation, and migration. 4. **Actin cytoskeleton organization**: CRK is involved in the regulation of actin cytoskeleton organization, which is crucial for cell shape, migration, and intracellular signaling. **Clinical Significance** Dysregulation of CRK has been implicated in various diseases, including: 1. **Cancer**: CRK is overexpressed in various cancers, including breast, lung, and colon cancer, and is involved in cancer progression and metastasis. 2. **Cardiovascular diseases**: CRK is involved in the regulation of cardiovascular diseases, including atherosclerosis and hypertension. 3. **Infectious diseases**: CRK is involved in the regulation of immune responses and is implicated in various infectious diseases, including HIV and tuberculosis. 4. **Neurological disorders**: CRK is involved in the regulation of neuronal development and function and is implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, CRK is a crucial adaptor protein involved in various cellular processes, including cell migration, proliferation, and signaling. Its dysregulation has been implicated in various diseases, including cancer, cardiovascular diseases, and infectious diseases. Further research is needed to fully understand the role of CRK in human disease and to develop therapeutic strategies targeting this protein.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Adapter molecule crk
A0A0S2Z3K9_HUMAN

Genular Protein ID: 463348270

Symbol: CRK_HUMAN

Name: Adapter molecule crk

UniProtKB Accession Codes:

P46108 A8MWE8 B0LPE8 D3DTH6 Q96GA9 Q96HJ0

Database IDs:

Citations:

PubMed ID: 1630456

Title: Two species of human CRK cDNA encode proteins with distinct biological activities.

PubMed ID: 1630456

DOI: 10.1128/mcb.12.8.3482-3489.1992

PubMed ID: 8378094

Title: CRK proto-oncogene maps to human chromosome band 17p13.

PubMed ID: 8378094

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8657152

Title: DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane.

PubMed ID: 8657152

DOI: 10.1128/mcb.16.4.1770

PubMed ID: 8662907

Title: Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins.

PubMed ID: 8662907

DOI: 10.1074/jbc.271.24.14468

PubMed ID: 9614078

Title: Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction.

PubMed ID: 9614078

DOI: 10.1074/jbc.273.24.14780

PubMed ID: 10362357

Title: cbl-3: a new mammalian cbl family protein.

PubMed ID: 10362357

DOI: 10.1038/sj.onc.1202753

PubMed ID: 10733900

Title: Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined by its internal tyrosine phosphorylation.

PubMed ID: 10733900

DOI: 10.1006/bbrc.2000.2374

PubMed ID: 10964504

Title: NGF-dependent neurite outgrowth in PC12 cells overexpressing the Src homology 2-domain protein shb requires activation of the Rap1 pathway.

PubMed ID: 10964504

DOI: 10.1006/excr.2000.4984

PubMed ID: 11870224

Title: Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling.

PubMed ID: 11870224

DOI: 10.1242/jcs.115.5.1059

PubMed ID: 12432078

Title: Novel function of Chat in controlling cell adhesion via Cas-Crk-C3G-pathway-mediated Rap1 activation.

PubMed ID: 12432078

DOI: 10.1242/jcs.00207

PubMed ID: 12628187

Title: DOCK4, a GTPase activator, is disrupted during tumorigenesis.

PubMed ID: 12628187

DOI: 10.1016/s0092-8674(03)00155-7

PubMed ID: 12878163

Title: Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk.

PubMed ID: 12878163

DOI: 10.1016/s0014-4827(03)00206-4

PubMed ID: 16076871

Title: Direct recruitment of CRK and GRB2 to VEGFR-3 induces proliferation, migration, and survival of endothelial cells through the activation of ERK, AKT, and JNK pathways.

PubMed ID: 16076871

DOI: 10.1182/blood-2005-04-1388

PubMed ID: 16129412

Title: Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor.

PubMed ID: 16129412

DOI: 10.1016/j.bbrc.2005.08.055

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17038317

Title: Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas.

PubMed ID: 17038317

DOI: 10.1074/jbc.m604342200

PubMed ID: 18024423

Title: Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding.

PubMed ID: 18024423

DOI: 10.1074/jbc.m706361200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19807924

Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

PubMed ID: 19807924

DOI: 10.1186/1471-2172-10-53

PubMed ID: 19004829

Title: DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell spreading and migration on collagen IV.

PubMed ID: 19004829

DOI: 10.1074/jbc.m808010200

PubMed ID: 19381274

Title: Unc119 protects from Shigella infection by inhibiting the Abl family kinases.

PubMed ID: 19381274

DOI: 10.1371/journal.pone.0005211

PubMed ID: 20534451

Title: Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression.

PubMed ID: 20534451

DOI: 10.1073/pnas.0914776107

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 31311869

Title: PEAK3/C19orf35 pseudokinase, a new NFK3 kinase family member, inhibits CrkII through dimerization.

PubMed ID: 31311869

DOI: 10.1073/pnas.1906360116

PubMed ID: 12384576

Title: Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide.

PubMed ID: 12384576

DOI: 10.1073/pnas.212518799

PubMed ID: 17515907

Title: Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK.

PubMed ID: 17515907

DOI: 10.1038/nsmb1241

Sequence Information:

Length: 304
Mass: 33831
Checksum: 4CFBFB65BFC2E265
Sequence:

MAGNFDSEER SSWYWGRLSR QEAVALLQGQ RHGVFLVRDS STSPGDYVLS VSENSRVSHY 
IINSSGPRPP VPPSPAQPPP GVSPSRLRIG DQEFDSLPAL LEFYKIHYLD TTTLIEPVSR 
SRQGSGVILR QEEAEYVRAL FDFNGNDEED LPFKKGDILR IRDKPEEQWW NAEDSEGKRG 
MIPVPYVEKY RPASASVSAL IGGNQEGSHP QPLGGPEPGP YAQPSVNTPL PNLQNGPIYA 
RVIQKRVPNA YDKTALALEV GELVKVTKIN VSGQWEGECN GKRGHFPFTH VRLLDQQNPD 
EDFS

Genular Protein ID: 3163442072

Symbol: A0A0S2Z3K9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z3K9

Database IDs:

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

Length: 204
Mass: 22906
Checksum: B4C5BF23887B6B80
Sequence:

MAGNFDSEER SSWYWGRLSR QEAVALLQGQ RHGVFLVRDS STSPGDYVLS VSENSRVSHY 
IINSSGPRPP VPPSPAQPPP GVSPSRLRIG DQEFDSLPAL LEFYKIHYLD TTTLIEPVSR 
SRQGSGVILR QEEAEYVRAL FDFNGNDEED LPFKKGDILR IRDKPEEQWW NAEDSEGKRG 
MIPVPYVEKY RPASASVSAL IGGR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CRK

Associated with

Cells (max top 100)

Other Information

Two species of human CRK cDNA encode proteins with distinct biological activities. PubMed ID: 1630456

CRK proto-oncogene maps to human chromosome band 17p13. PubMed ID: 8378094

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane. PubMed ID: 8657152

Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins. PubMed ID: 8662907

Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction. PubMed ID: 9614078

cbl-3: a new mammalian cbl family protein. PubMed ID: 10362357

Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined by its internal tyrosine phosphorylation. PubMed ID: 10733900

NGF-dependent neurite outgrowth in PC12 cells overexpressing the Src homology 2-domain protein shb requires activation of the Rap1 pathway. PubMed ID: 10964504

Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling. PubMed ID: 11870224

Novel function of Chat in controlling cell adhesion via Cas-Crk-C3G-pathway-mediated Rap1 activation. PubMed ID: 12432078

DOCK4, a GTPase activator, is disrupted during tumorigenesis. PubMed ID: 12628187

Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk. PubMed ID: 12878163

Direct recruitment of CRK and GRB2 to VEGFR-3 induces proliferation, migration, and survival of endothelial cells through the activation of ERK, AKT, and JNK pathways. PubMed ID: 16076871

Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor. PubMed ID: 16129412

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas. PubMed ID: 17038317

Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding. PubMed ID: 18024423

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. PubMed ID: 19807924

DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell spreading and migration on collagen IV. PubMed ID: 19004829

Unc119 protects from Shigella infection by inhibiting the Abl family kinases. PubMed ID: 19381274

Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression. PubMed ID: 20534451

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

PEAK3/C19orf35 pseudokinase, a new NFK3 kinase family member, inhibits CrkII through dimerization. PubMed ID: 31311869

Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide. PubMed ID: 12384576

Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK. PubMed ID: 17515907

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. PubMed ID: 26871637