CRK | ENSG00000167193 | NCBI 1398

Details for: CRK

Gene ID: 1398

Symbol: CRK

Ensembl ID: ENSG00000167193

Description: CRK proto-oncogene, adaptor protein

Associated with

Arms-mediated activation
(R-HSA-170984)
Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Downstream signal transduction
(R-HSA-186763)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Integrin signaling
(R-HSA-354192)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-HSA-512988)
Leishmania infection
(R-HSA-9658195)
Leishmania phagocytosis
(R-HSA-9664417)
Met activates rap1 and rac1
(R-HSA-8875555)
Met promotes cell motility
(R-HSA-8875878)
Met receptor recycling
(R-HSA-8875656)
P130cas linkage to mapk signaling for integrins
(R-HSA-372708)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet aggregation (plug formation)
(R-HSA-76009)
Prolonged erk activation events
(R-HSA-169893)
Ptk6 regulates rho gtpases, ras gtpase and map kinases
(R-HSA-8849471)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of signaling by cbl
(R-HSA-912631)
Signaling by interleukins
(R-HSA-449147)
Signaling by met
(R-HSA-6806834)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by pdgf
(R-HSA-186797)
Signaling by ptk6
(R-HSA-8848021)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by vegf
(R-HSA-194138)
Signalling to erks
(R-HSA-187687)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Actin cytoskeleton organization
(GO:0030036)
Cell chemotaxis
(GO:0060326)
Cell migration
(GO:0016477)
Cell population proliferation
(GO:0008283)
Cellular response to endothelin
(GO:1990859)
Cellular response to insulin-like growth factor stimulus
(GO:1990314)
Cellular response to nerve growth factor stimulus
(GO:1990090)
Cellular response to nitric oxide
(GO:0071732)
Cellular response to transforming growth factor beta stimulus
(GO:0071560)
Cerebellar neuron development
(GO:0098749)
Cerebral cortex development
(GO:0021987)
Cytoskeletal protein binding
(GO:0008092)
Dendrite development
(GO:0016358)
Ephrin receptor binding
(GO:0046875)
Ephrin receptor signaling pathway
(GO:0048013)
Establishment of cell polarity
(GO:0030010)
Helper t cell diapedesis
(GO:0035685)
Hippocampus development
(GO:0021766)
Insulin-like growth factor receptor binding
(GO:0005159)
Kinase binding
(GO:0019900)
Lipid metabolic process
(GO:0006629)
Negative regulation of cell motility
(GO:2000146)
Negative regulation of natural killer cell mediated cytotoxicity
(GO:0045953)
Negative regulation of wound healing
(GO:0061045)
Neuron migration
(GO:0001764)
Nucleus
(GO:0005634)
Phosphotyrosine residue binding
(GO:0001784)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of rac protein signal transduction
(GO:0035022)
Positive regulation of skeletal muscle acetylcholine-gated channel clustering
(GO:1904395)
Positive regulation of smooth muscle cell migration
(GO:0014911)
Positive regulation of substrate adhesion-dependent cell spreading
(GO:1900026)
Postsynaptic specialization assembly
(GO:0098698)
Protein binding
(GO:0005515)
Protein localization to membrane
(GO:0072657)
Protein phosphorylated amino acid binding
(GO:0045309)
Protein self-association
(GO:0043621)
Protein tyrosine kinase binding
(GO:1990782)
Receptor tyrosine kinase binding
(GO:0030971)
Reelin-mediated signaling pathway
(GO:0038026)
Regulation of actin cytoskeleton organization
(GO:0032956)
Regulation of cell adhesion mediated by integrin
(GO:0033628)
Regulation of cell shape
(GO:0008360)
Regulation of dendrite development
(GO:0050773)
Regulation of gtpase activity
(GO:0043087)
Regulation of intracellular signal transduction
(GO:1902531)
Regulation of protein binding
(GO:0043393)
Regulation of signal transduction
(GO:0009966)
Regulation of t cell migration
(GO:2000404)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to cholecystokinin
(GO:0061847)
Response to hepatocyte growth factor
(GO:0035728)
Response to hydrogen peroxide
(GO:0042542)
Response to yeast
(GO:0001878)
Scaffold protein binding
(GO:0097110)
Sh2 domain binding
(GO:0042169)
Sh3 domain binding
(GO:0017124)
Signaling adaptor activity
(GO:0035591)
Signaling receptor complex adaptor activity
(GO:0030159)
Signal transduction
(GO:0007165)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

Adapter molecule crk
A0A0S2Z3K9_HUMAN

Genular Protein ID: 463348270

Symbol: CRK_HUMAN

Name: Adapter molecule crk

UniProtKB Accession Codes:

P46108 A8MWE8 B0LPE8 D3DTH6 Q96GA9 Q96HJ0

Database IDs:

Citations:

PubMed ID: 1630456

Title: Two species of human CRK cDNA encode proteins with distinct biological activities.

PubMed ID: 1630456

DOI: 10.1128/mcb.12.8.3482-3489.1992

PubMed ID: 8378094

Title: CRK proto-oncogene maps to human chromosome band 17p13.

PubMed ID: 8378094

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8657152

Title: DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane.

PubMed ID: 8657152

DOI: 10.1128/mcb.16.4.1770

PubMed ID: 8662907

Title: Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins.

PubMed ID: 8662907

DOI: 10.1074/jbc.271.24.14468

PubMed ID: 9614078

Title: Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction.

PubMed ID: 9614078

DOI: 10.1074/jbc.273.24.14780

PubMed ID: 10362357

Title: cbl-3: a new mammalian cbl family protein.

PubMed ID: 10362357

DOI: 10.1038/sj.onc.1202753

PubMed ID: 10733900

Title: Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined by its internal tyrosine phosphorylation.

PubMed ID: 10733900

DOI: 10.1006/bbrc.2000.2374

PubMed ID: 10964504

Title: NGF-dependent neurite outgrowth in PC12 cells overexpressing the Src homology 2-domain protein shb requires activation of the Rap1 pathway.

PubMed ID: 10964504

DOI: 10.1006/excr.2000.4984

PubMed ID: 11870224

Title: Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling.

PubMed ID: 11870224

DOI: 10.1242/jcs.115.5.1059

PubMed ID: 12432078

Title: Novel function of Chat in controlling cell adhesion via Cas-Crk-C3G-pathway-mediated Rap1 activation.

PubMed ID: 12432078

DOI: 10.1242/jcs.00207

PubMed ID: 12628187

Title: DOCK4, a GTPase activator, is disrupted during tumorigenesis.

PubMed ID: 12628187

DOI: 10.1016/s0092-8674(03)00155-7

PubMed ID: 12878163

Title: Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk.

PubMed ID: 12878163

DOI: 10.1016/s0014-4827(03)00206-4

PubMed ID: 16076871

Title: Direct recruitment of CRK and GRB2 to VEGFR-3 induces proliferation, migration, and survival of endothelial cells through the activation of ERK, AKT, and JNK pathways.

PubMed ID: 16076871

DOI: 10.1182/blood-2005-04-1388

PubMed ID: 16129412

Title: Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor.

PubMed ID: 16129412

DOI: 10.1016/j.bbrc.2005.08.055

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17038317

Title: Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas.

PubMed ID: 17038317

DOI: 10.1074/jbc.m604342200

PubMed ID: 18024423

Title: Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding.

PubMed ID: 18024423

DOI: 10.1074/jbc.m706361200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19807924

Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

PubMed ID: 19807924

DOI: 10.1186/1471-2172-10-53

PubMed ID: 19004829

Title: DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell spreading and migration on collagen IV.

PubMed ID: 19004829

DOI: 10.1074/jbc.m808010200

PubMed ID: 19381274

Title: Unc119 protects from Shigella infection by inhibiting the Abl family kinases.

PubMed ID: 19381274

DOI: 10.1371/journal.pone.0005211

PubMed ID: 20534451

Title: Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression.

PubMed ID: 20534451

DOI: 10.1073/pnas.0914776107

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 31311869

Title: PEAK3/C19orf35 pseudokinase, a new NFK3 kinase family member, inhibits CrkII through dimerization.

PubMed ID: 31311869

DOI: 10.1073/pnas.1906360116

PubMed ID: 12384576

Title: Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide.

PubMed ID: 12384576

DOI: 10.1073/pnas.212518799

PubMed ID: 17515907

Title: Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK.

PubMed ID: 17515907

DOI: 10.1038/nsmb1241

Sequence Information:

Length: 304
Mass: 33831
Checksum: 4CFBFB65BFC2E265
Sequence:

MAGNFDSEER SSWYWGRLSR QEAVALLQGQ RHGVFLVRDS STSPGDYVLS VSENSRVSHY 
IINSSGPRPP VPPSPAQPPP GVSPSRLRIG DQEFDSLPAL LEFYKIHYLD TTTLIEPVSR 
SRQGSGVILR QEEAEYVRAL FDFNGNDEED LPFKKGDILR IRDKPEEQWW NAEDSEGKRG 
MIPVPYVEKY RPASASVSAL IGGNQEGSHP QPLGGPEPGP YAQPSVNTPL PNLQNGPIYA 
RVIQKRVPNA YDKTALALEV GELVKVTKIN VSGQWEGECN GKRGHFPFTH VRLLDQQNPD 
EDFS

Genular Protein ID: 3163442072

Symbol: A0A0S2Z3K9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z3K9

Database IDs:

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

Length: 204
Mass: 22906
Checksum: B4C5BF23887B6B80
Sequence:

MAGNFDSEER SSWYWGRLSR QEAVALLQGQ RHGVFLVRDS STSPGDYVLS VSENSRVSHY 
IINSSGPRPP VPPSPAQPPP GVSPSRLRIG DQEFDSLPAL LEFYKIHYLD TTTLIEPVSR 
SRQGSGVILR QEEAEYVRAL FDFNGNDEED LPFKKGDILR IRDKPEEQWW NAEDSEGKRG 
MIPVPYVEKY RPASASVSAL IGGR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CRK

Associated with

Other Information

Two species of human CRK cDNA encode proteins with distinct biological activities. PubMed ID: 1630456

CRK proto-oncogene maps to human chromosome band 17p13. PubMed ID: 8378094

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane. PubMed ID: 8657152

Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins. PubMed ID: 8662907

Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction. PubMed ID: 9614078

cbl-3: a new mammalian cbl family protein. PubMed ID: 10362357

Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined by its internal tyrosine phosphorylation. PubMed ID: 10733900

NGF-dependent neurite outgrowth in PC12 cells overexpressing the Src homology 2-domain protein shb requires activation of the Rap1 pathway. PubMed ID: 10964504

Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling. PubMed ID: 11870224

Novel function of Chat in controlling cell adhesion via Cas-Crk-C3G-pathway-mediated Rap1 activation. PubMed ID: 12432078

DOCK4, a GTPase activator, is disrupted during tumorigenesis. PubMed ID: 12628187

Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk. PubMed ID: 12878163

Direct recruitment of CRK and GRB2 to VEGFR-3 induces proliferation, migration, and survival of endothelial cells through the activation of ERK, AKT, and JNK pathways. PubMed ID: 16076871

Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor. PubMed ID: 16129412

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas. PubMed ID: 17038317

Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding. PubMed ID: 18024423

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. PubMed ID: 19807924

DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell spreading and migration on collagen IV. PubMed ID: 19004829

Unc119 protects from Shigella infection by inhibiting the Abl family kinases. PubMed ID: 19381274

Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression. PubMed ID: 20534451

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

PEAK3/C19orf35 pseudokinase, a new NFK3 kinase family member, inhibits CrkII through dimerization. PubMed ID: 31311869

Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide. PubMed ID: 12384576

Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK. PubMed ID: 17515907

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. PubMed ID: 26871637