CRK | ENSG00000167193 | NCBI 1398

Details for: CRK

Gene ID: 1398

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: CRK

Ensembl ID: ENSG00000167193

Description: CRK proto-oncogene, adaptor protein

Cell Significance Landscape

Display Count:

Associated with

Arms-mediated activation
(R-HSA-170984)
Cytokine signaling in immune system
(R-HSA-1280215)
Disease
(R-HSA-1643685)
Downstream signal transduction
(R-HSA-186763)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-HSA-2029480)
Fcgr3a-mediated phagocytosis
(R-HSA-9664422)
Hemostasis
(R-HSA-109582)
Immune system
(R-HSA-168256)
Infectious disease
(R-HSA-5663205)
Innate immune system
(R-HSA-168249)
Integrin signaling
(R-HSA-354192)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-HSA-512988)
Leishmania infection
(R-HSA-9658195)
Leishmania phagocytosis
(R-HSA-9664417)
Met activates rap1 and rac1
(R-HSA-8875555)
Met promotes cell motility
(R-HSA-8875878)
Met receptor recycling
(R-HSA-8875656)
P130cas linkage to mapk signaling for integrins
(R-HSA-372708)
Parasite infection
(R-HSA-9664407)
Parasitic infection pathways
(R-HSA-9824443)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Platelet aggregation (plug formation)
(R-HSA-76009)
Prolonged erk activation events
(R-HSA-169893)
Ptk6 regulates rho gtpases, ras gtpase and map kinases
(R-HSA-8849471)
Regulation of actin dynamics for phagocytic cup formation
(R-HSA-2029482)
Regulation of signaling by cbl
(R-HSA-912631)
Signaling by interleukins
(R-HSA-449147)
Signaling by met
(R-HSA-6806834)
Signaling by non-receptor tyrosine kinases
(R-HSA-9006927)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by pdgf
(R-HSA-186797)
Signaling by ptk6
(R-HSA-8848021)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by vegf
(R-HSA-194138)
Signalling to erks
(R-HSA-187687)
Signal transduction
(R-HSA-162582)
Vegfa-vegfr2 pathway
(R-HSA-4420097)
Actin cytoskeleton
(GO:0015629)
Actin cytoskeleton organization
(GO:0030036)
Cell chemotaxis
(GO:0060326)
Cell migration
(GO:0016477)
Cell population proliferation
(GO:0008283)
Cellular response to endothelin
(GO:1990859)
Cellular response to insulin-like growth factor stimulus
(GO:1990314)
Cellular response to nerve growth factor stimulus
(GO:1990090)
Cellular response to nitric oxide
(GO:0071732)
Cellular response to transforming growth factor beta stimulus
(GO:0071560)
Cerebellar neuron development
(GO:0098749)
Cerebral cortex development
(GO:0021987)
Cytoplasm
(GO:0005737)
Cytoskeletal protein binding
(GO:0008092)
Cytosol
(GO:0005829)
Dendrite development
(GO:0016358)
Enzyme-linked receptor protein signaling pathway
(GO:0007167)
Ephrin receptor binding
(GO:0046875)
Ephrin receptor signaling pathway
(GO:0048013)
Establishment of cell polarity
(GO:0030010)
Extracellular exosome
(GO:0070062)
Helper t cell diapedesis
(GO:0035685)
Hippocampus development
(GO:0021766)
Insulin-like growth factor receptor binding
(GO:0005159)
Kinase binding
(GO:0019900)
Lipid metabolic process
(GO:0006629)
Membrane
(GO:0016020)
Negative regulation of cell motility
(GO:2000146)
Negative regulation of natural killer cell mediated cytotoxicity
(GO:0045953)
Negative regulation of wound healing
(GO:0061045)
Neuromuscular junction
(GO:0031594)
Neuron migration
(GO:0001764)
Nucleus
(GO:0005634)
Phosphotyrosine residue binding
(GO:0001784)
Plasma membrane
(GO:0005886)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of rac protein signal transduction
(GO:0035022)
Positive regulation of skeletal muscle acetylcholine-gated channel clustering
(GO:1904395)
Positive regulation of smooth muscle cell migration
(GO:0014911)
Positive regulation of substrate adhesion-dependent cell spreading
(GO:1900026)
Postsynaptic specialization assembly
(GO:0098698)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein localization to membrane
(GO:0072657)
Protein phosphorylated amino acid binding
(GO:0045309)
Protein tyrosine kinase binding
(GO:1990782)
Receptor tyrosine kinase binding
(GO:0030971)
Reelin-mediated signaling pathway
(GO:0038026)
Regulation of actin cytoskeleton organization
(GO:0032956)
Regulation of cell adhesion mediated by integrin
(GO:0033628)
Regulation of cell motility
(GO:2000145)
Regulation of cell shape
(GO:0008360)
Regulation of dendrite development
(GO:0050773)
Regulation of gtpase activity
(GO:0043087)
Regulation of intracellular signal transduction
(GO:1902531)
Regulation of signal transduction
(GO:0009966)
Regulation of t cell migration
(GO:2000404)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Regulation of wound healing
(GO:0061041)
Response to cholecystokinin
(GO:0061847)
Response to hepatocyte growth factor
(GO:0035728)
Response to hydrogen peroxide
(GO:0042542)
Response to peptide
(GO:1901652)
Response to yeast
(GO:0001878)
Scaffold protein binding
(GO:0097110)
Sh2 domain binding
(GO:0042169)
Sh3 domain binding
(GO:0017124)
Signaling adaptor activity
(GO:0035591)
Signaling receptor complex adaptor activity
(GO:0030159)
Ubiquitin protein ligase binding
(GO:0031625)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

transit amplifying cell of colon CL0009011

CSI 12.39

rCSI 14.55%

PRS 26.5
myoepithelial cell CL0000185

CSI 9.9

rCSI 25.04%

PRS 28.5
CD1c-positive myeloid dendritic cell CL0002399

CSI 8.04

rCSI 9.71%

PRS 28.09
choroid plexus epithelial cell CL0000706

CSI 7.35

rCSI 12.03%

PRS 17.75
alternatively activated macrophage CL0000890

CSI 6.74

rCSI 8.47%

PRS 35.31
endothelial cell of vascular tree CL0002139

CSI 6.35

rCSI 34.72%

PRS 34.29
myeloid dendritic cell CL0000782

CSI 5.97

rCSI 8.65%

PRS 35.17
hepatic stellate cell CL0000632

CSI 5.97

rCSI 22.36%

PRS 19.45
effector memory CD8-positive, alpha-beta T cell CL0000913

CSI 5.78

rCSI 5.26%

PRS 35.3
paneth cell CL0000510

CSI 5.73

rCSI 8.46%

PRS 35.94
regular atrial cardiac myocyte CL0002129

CSI 5.08

rCSI 16.35%

PRS 23.98
epithelial cell CL0000066

CSI 4.78

rCSI 7.34%

PRS 30.93
vein endothelial cell of respiratory system CL4033008

CSI 4.46

rCSI 30.62%

PRS 43.7
neuroblast (sensu Vertebrata) CL0000031

CSI 3.58

rCSI 4.59%

PRS 22.19
erythroblast CL0000765

CSI 3.58

rCSI 9.49%

PRS 35.59
podocyte CL0000653

CSI 3.54

rCSI 15.72%

PRS 22.57
endothelial cell of placenta CL0009092

CSI 3.47

rCSI 17.1%

PRS 31.24
common myeloid progenitor CL0000049

CSI 3.13

rCSI 2.53%

PRS 23.39
CD4-positive, alpha-beta thymocyte CL0000810

CSI 3.03

rCSI 2.43%

PRS 41.1
basal cell CL0000646

CSI 3

rCSI 4.01%

PRS 25.22
cardiac endothelial cell CL0010008

CSI 2.93

rCSI 11.81%

PRS 21.27
mesenchymal cell CL0008019

CSI 2.78

rCSI 7.06%

PRS 23.05
CD14-low, CD16-positive monocyte CL0002396

CSI 2.73

rCSI 2.11%

PRS 21.72
VIP GABAergic cortical interneuron CL4023016

CSI 2.69

rCSI 3.21%

PRS 13.61
secretory cell CL0000151

CSI 2.66

rCSI 2.77%

PRS 23.75
CD14-positive monocyte CL0001054

CSI 2.65

rCSI 3.3%

PRS 32.47
alveolar macrophage CL0000583

CSI 2.57

rCSI 4.24%

PRS 27.44
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 2.47

rCSI 1.66%

PRS 28.79
type B pancreatic cell CL0000169

CSI 2.47

rCSI 5.47%

PRS 21.38
interstitial cell of Cajal CL0002088

CSI 2.4

rCSI 3.05%

PRS 26.74
kidney interstitial alternatively activated macrophage CL1000695

CSI 2.39

rCSI 6.24%

PRS 21.66
alveolar type 1 fibroblast cell CL4028004

CSI 2.29

rCSI 2.51%

PRS 25.96
epicardial adipocyte CL1000309

CSI 2.26

rCSI 7.35%

PRS 27.87
keratinocyte CL0000312

CSI 2.22

rCSI 1.86%

PRS 27.42
renal beta-intercalated cell CL0002201

CSI 2.22

rCSI 5.28%

PRS 26.18
midzonal region hepatocyte CL0019028

CSI 2.2

rCSI 5.16%

PRS 32.79
placental villous trophoblast CL2000060

CSI 2.13

rCSI 3.3%

PRS 21.63
CD14-positive, CD16-positive monocyte CL0002397

CSI 2.11

rCSI 2.77%

PRS 33.11
megakaryocyte-erythroid progenitor cell CL0000050

CSI 2.08

rCSI 1.88%

PRS 21.07
inflammatory macrophage CL0000863

CSI 2

rCSI 3.42%

PRS 46.21
perivascular cell CL4033054

CSI 1.96

rCSI 2.68%

PRS 26.17
ciliated epithelial cell CL0000067

CSI 1.96

rCSI 1.72%

PRS 16.85
retinal ganglion cell CL0000740

CSI 1.95

rCSI 4.3%

PRS 16.51
radial glial cell CL0000681

CSI 1.95

rCSI 2.71%

PRS 23.43
melanocyte CL0000148

CSI 1.93

rCSI 1.43%

PRS 19.95
paneth cell of epithelium of small intestine CL1000343

CSI 1.89

rCSI 5.3%

PRS 35.68
intestinal crypt stem cell of small intestine CL0009017

CSI 1.88

rCSI 5.07%

PRS 30.01
epithelial cell of lung CL0000082

CSI 1.86

rCSI 1.54%

PRS 22
goblet cell CL0000160

CSI 1.85

rCSI 1.75%

PRS 24.3
brush cell of tracheobronchial tree CL0002075

CSI 1.85

rCSI 5.49%

PRS 32.2
sncg GABAergic cortical interneuron CL4023015

CSI 1.85

rCSI 2.97%

PRS 15.03
early lymphoid progenitor CL0000936

CSI 1.84

rCSI 1.62%

PRS 26.82
precursor B cell CL0000817

CSI 1.82

rCSI 1.59%

PRS 30.67
common dendritic progenitor CL0001029

CSI 1.76

rCSI 2.21%

PRS 30.13
interneuron CL0000099

CSI 1.76

rCSI 3.53%

PRS 17.08
mesodermal cell CL0000222

CSI 1.72

rCSI 2.06%

PRS 22.54
muscle cell CL0000187

CSI 1.7

rCSI 3.49%

PRS 47.34
promonocyte CL0000559

CSI 1.69

rCSI 2.9%

PRS 31.41
tracheobronchial serous cell CL0019001

CSI 1.67

rCSI 7.22%

PRS 41.24
mucous neck cell CL0000651

CSI 1.67

rCSI 2.4%

PRS 36.21
enteroendocrine cell CL0000164

CSI 1.66

rCSI 2.27%

PRS 25.73
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 1.66

rCSI 4.3%

PRS 21.46
renal alpha-intercalated cell CL0005011

CSI 1.66

rCSI 2.22%

PRS 29.74
myeloid leukocyte CL0000766

CSI 1.65

rCSI 1.52%

PRS 24.25
lung pericyte CL0009089

CSI 1.63

rCSI 4.29%

PRS 27.69
CD4-positive helper T cell CL0000492

CSI 1.62

rCSI 1.23%

PRS 31.87
astrocyte of the cerebral cortex CL0002605

CSI 1.61

rCSI 3.61%

PRS 14.41
ionocyte CL0005006

CSI 1.61

rCSI 1.72%

PRS 21.34
retinal rod cell CL0000604

CSI 1.58

rCSI 2.79%

PRS 22.55
adipocyte CL0000136

CSI 1.58

rCSI 2.03%

PRS 22.38
blood vessel endothelial cell CL0000071

CSI 1.56

rCSI 3.23%

PRS 23.1
stem cell CL0000034

CSI 1.53

rCSI 1.47%

PRS 16.93
cerebellar granule cell CL0001031

CSI 1.52

rCSI 2.23%

PRS 21.32
basal cell of prostate epithelium CL0002341

CSI 1.51

rCSI 4.38%

PRS 46.5
epithelial cell of lower respiratory tract CL0002632

CSI 1.51

rCSI 1.17%

PRS 22.36
pulmonary ionocyte CL0017000

CSI 1.51

rCSI 1.83%

PRS 28.96
intestinal tuft cell CL0019032

CSI 1.49

rCSI 2.28%

PRS 26.41
M cell of gut CL0000682

CSI 1.49

rCSI 1.58%

PRS 38.86
retinal blood vessel endothelial cell CL0002585

CSI 1.49

rCSI 2.37%

PRS 25.39
fibroblast of lung CL0002553

CSI 1.49

rCSI 1.38%

PRS 23.21
granulocyte CL0000094

CSI 1.47

rCSI 2.25%

PRS 30.14
respiratory basal cell CL0002633

CSI 1.47

rCSI 1.52%

PRS 27.38
IgA plasma cell CL0000987

CSI 1.47

rCSI 1.5%

PRS 41.44
skin fibroblast CL0002620

CSI 1.47

rCSI 1.26%

PRS 35.03
pulmonary capillary endothelial cell CL4028001

CSI 1.45

rCSI 2.76%

PRS 36.22
Kupffer cell CL0000091

CSI 1.45

rCSI 3.31%

PRS 22.62
cerebral cortex GABAergic interneuron CL0010011

CSI 1.44

rCSI 4.24%

PRS 27.2
smooth muscle cell of prostate CL1000487

CSI 1.43

rCSI 8.43%

PRS 63.83
bronchus fibroblast of lung CL2000093

CSI 1.41

rCSI 1.15%

PRS 24.29
conjunctival epithelial cell CL1000432

CSI 1.41

rCSI 2.15%

PRS 23.36
BEST4+ enteroycte CL4030026

CSI 1.38

rCSI 1.72%

PRS 24.71
multi-ciliated epithelial cell CL0005012

CSI 1.38

rCSI 1.38%

PRS 19.83
lung secretory cell CL1000272

CSI 1.38

rCSI 3.4%

PRS 21.46
mucus secreting cell CL0000319

CSI 1.37

rCSI 2.18%

PRS 29.68
pvalb GABAergic cortical interneuron CL4023018

CSI 1.36

rCSI 1.7%

PRS 12.91
colonocyte CL1000347

CSI 1.36

rCSI 1.94%

PRS 30.94
cardiac neuron CL0010022

CSI 1.36

rCSI 4.34%

PRS 19.03
fibroblast of cardiac tissue CL0002548

CSI 1.35

rCSI 6.48%

PRS 18.99
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 1.35

rCSI 1.56%

PRS 20.06
neural crest cell CL0011012

CSI 1.34

rCSI 1.06%

PRS 15.9

stromal cell of ovary CL0002132

CSI 0.1

rCSI 0.2%

PRS 37.6%
acinar cell of salivary gland CL0002623

CSI 0.1

rCSI 3.3%

PRS 42.7%
indirect pathway medium spiny neuron CL4023029

CSI 0.2

rCSI 4.8%

PRS 13.3%
direct pathway medium spiny neuron CL4023026

CSI 0.2

rCSI 4.9%

PRS 12.4%
central nervous system neuron CL2000029

CSI 0.2

rCSI 1.7%

PRS 14.3%
paneth cell of colon CL0009009

CSI 0.3

rCSI 2.6%

PRS 54.7%
respiratory goblet cell CL0002370

CSI 0.3

rCSI 3.0%

PRS 43.3%
mesenchymal stem cell CL0000134

CSI 0.3

rCSI 3.2%

PRS 40.1%
pancreatic stellate cell CL0002410

CSI 0.3

rCSI 1.9%

PRS 34.0%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 0.3

rCSI 1.0%

PRS 15.8%
intestinal crypt stem cell of colon CL0009043

CSI 0.4

rCSI 2.6%

PRS 41.6%
colon macrophage CL0009038

CSI 0.4

rCSI 1.8%

PRS 46.5%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 0.4

rCSI 2.3%

PRS 14.5%
basal-myoepithelial cell of mammary gland CL0002324

CSI 0.4

rCSI 0.8%

PRS 47.4%
regular ventricular cardiac myocyte CL0002131

CSI 0.4

rCSI 2.5%

PRS 18.1%
amacrine cell CL0000561

CSI 0.4

rCSI 1.2%

PRS 17.9%
chondrocyte CL0000138

CSI 0.4

rCSI 0.7%

PRS 19.6%
tracheal goblet cell CL1000329

CSI 0.4

rCSI 0.9%

PRS 43.6%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 0.4

rCSI 1.6%

PRS 13.0%
deuterosomal cell CL4033044

CSI 0.5

rCSI 1.6%

PRS 36.0%
L6b glutamatergic cortical neuron CL4023038

CSI 0.5

rCSI 1.5%

PRS 14.7%
retinal cone cell CL0000573

CSI 0.5

rCSI 0.8%

PRS 17.7%
lamp5 GABAergic cortical interneuron CL4023011

CSI 0.5

rCSI 0.9%

PRS 13.8%
microcirculation associated smooth muscle cell CL0008035

CSI 0.5

rCSI 1.5%

PRS 26.1%
near-projecting glutamatergic cortical neuron CL4023012

CSI 0.5

rCSI 2.0%

PRS 14.3%
transit amplifying cell of small intestine CL0009012

CSI 0.5

rCSI 2.4%

PRS 41.8%
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 0.6

rCSI 1.7%

PRS 34.0%
GABAergic neuron CL0000617

CSI 0.6

rCSI 1.9%

PRS 16.7%
lung microvascular endothelial cell CL2000016

CSI 0.6

rCSI 12.1%

PRS 57.5%
endothelial cell of uterus CL0009095

CSI 0.6

rCSI 4.6%

PRS 56.6%
pulmonary alveolar type 1 cell CL0002062

CSI 0.6

rCSI 3.7%

PRS 28.9%
pancreatic ductal cell CL0002079

CSI 0.7

rCSI 1.3%

PRS 23.8%
mammary gland epithelial cell CL0002327

CSI 0.7

rCSI 2.4%

PRS 39.5%
enterocyte of epithelium of small intestine CL1000334

CSI 0.7

rCSI 10.6%

PRS 53.0%
hepatocyte CL0000182

CSI 0.7

rCSI 1.3%

PRS 21.4%
megakaryocyte CL0000556

CSI 0.7

rCSI 3.1%

PRS 39.4%
mature B cell CL0000785

CSI 0.7

rCSI 0.6%

PRS 29.3%
colon goblet cell CL0009039

CSI 0.7

rCSI 1.8%

PRS 34.1%
lung macrophage CL1001603

CSI 0.8

rCSI 1.7%

PRS 27.3%
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 0.8

rCSI 1.9%

PRS 13.5%
retina horizontal cell CL0000745

CSI 0.8

rCSI 1.2%

PRS 21.4%
parietal epithelial cell CL1000452

CSI 0.8

rCSI 2.1%

PRS 19.2%
Hofbauer cell CL3000001

CSI 0.8

rCSI 1.5%

PRS 29.5%
extravillous trophoblast CL0008036

CSI 0.8

rCSI 1.0%

PRS 20.3%
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 0.8

rCSI 1.2%

PRS 21.4%
keratocyte CL0002363

CSI 0.8

rCSI 2.0%

PRS 33.6%
type EC enteroendocrine cell CL0000577

CSI 0.8

rCSI 2.9%

PRS 37.1%
kidney connecting tubule epithelial cell CL1000768

CSI 0.8

rCSI 2.1%

PRS 17.6%
small intestine goblet cell CL1000495

CSI 0.8

rCSI 1.8%

PRS 30.8%
endocardial cell CL0002350

CSI 0.9

rCSI 4.1%

PRS 28.1%
helper T cell CL0000912

CSI 0.9

rCSI 1.2%

PRS 32.4%
glutamatergic neuron CL0000679

CSI 0.9

rCSI 1.8%

PRS 22.5%
macroglial cell CL0000126

CSI 0.9

rCSI 2.3%

PRS 29.3%
corneal epithelial cell CL0000575

CSI 0.9

rCSI 2.5%

PRS 39.9%
late pro-B cell CL0002048

CSI 0.9

rCSI 2.2%

PRS 58.0%
endothelial cell of arteriole CL1000412

CSI 0.9

rCSI 5.2%

PRS 55.0%
duct epithelial cell CL0000068

CSI 1.0

rCSI 1.4%

PRS 24.6%
neural progenitor cell CL0011020

CSI 1.0

rCSI 4.2%

PRS 21.2%
pancreatic acinar cell CL0002064

CSI 1.0

rCSI 1.3%

PRS 25.4%
epithelial cell of proximal tubule CL0002306

CSI 1.0

rCSI 2.3%

PRS 22.5%
retinal pigment epithelial cell CL0002586

CSI 1.0

rCSI 1.9%

PRS 24.2%
nasal mucosa goblet cell CL0002480

CSI 1.0

rCSI 1.1%

PRS 33.2%
T-helper 17 cell CL0000899

CSI 1.0

rCSI 0.8%

PRS 41.1%
respiratory suprabasal cell CL4033048

CSI 1.0

rCSI 1.3%

PRS 26.8%
colon epithelial cell CL0011108

CSI 1.0

rCSI 1.1%

PRS 21.6%
granulocyte monocyte progenitor cell CL0000557

CSI 1.1

rCSI 0.9%

PRS 26.2%
club cell CL0000158

CSI 1.1

rCSI 1.6%

PRS 26.2%
type L enteroendocrine cell CL0002279

CSI 1.1

rCSI 2.0%

PRS 43.9%
enteroendocrine cell of small intestine CL0009006

CSI 1.1

rCSI 2.4%

PRS 34.8%
retinal bipolar neuron CL0000748

CSI 1.1

rCSI 2.1%

PRS 16.8%
acinar cell CL0000622

CSI 1.1

rCSI 1.6%

PRS 30.3%
lung neuroendocrine cell CL1000223

CSI 1.1

rCSI 1.6%

PRS 26.4%
enteric smooth muscle cell CL0002504

CSI 1.1

rCSI 1.6%

PRS 25.9%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 1.1

rCSI 2.0%

PRS 13.6%
vascular associated smooth muscle cell CL0000359

CSI 1.1

rCSI 3.6%

PRS 27.6%
luminal cell of prostate epithelium CL0002340

CSI 1.1

rCSI 6.1%

PRS 39.7%
alveolar adventitial fibroblast CL4028006

CSI 1.1

rCSI 1.8%

PRS 23.2%
intestinal epithelial cell CL0002563

CSI 1.2

rCSI 1.2%

PRS 24.1%
foveolar cell of stomach CL0002179

CSI 1.2

rCSI 2.5%

PRS 36.4%
tendon cell CL0000388

CSI 1.2

rCSI 3.0%

PRS 54.3%
cardiac muscle cell CL0000746

CSI 1.2

rCSI 1.7%

PRS 18.0%
intrahepatic cholangiocyte CL0002538

CSI 1.2

rCSI 2.9%

PRS 40.4%
periportal region hepatocyte CL0019026

CSI 1.2

rCSI 4.6%

PRS 31.4%
renal principal cell CL0005009

CSI 1.2

rCSI 3.1%

PRS 29.3%
peripheral nervous system neuron CL2000032

CSI 1.2

rCSI 1.6%

PRS 20.3%
glandular epithelial cell CL0000150

CSI 1.2

rCSI 3.2%

PRS 44.2%
mononuclear phagocyte CL0000113

CSI 1.2

rCSI 2.7%

PRS 26.6%
enterocyte of epithelium of large intestine CL0002071

CSI 1.2

rCSI 6.4%

PRS 38.7%
rod bipolar cell CL0000751

CSI 1.2

rCSI 2.2%

PRS 19.1%
glioblast CL0000030

CSI 1.2

rCSI 2.0%

PRS 19.7%
enterocyte CL0000584

CSI 1.2

rCSI 2.0%

PRS 34.6%
squamous epithelial cell CL0000076

CSI 1.3

rCSI 3.0%

PRS 28.6%
pancreatic A cell CL0000171

CSI 1.3

rCSI 1.3%

PRS 24.6%
lung ciliated cell CL1000271

CSI 1.3

rCSI 1.5%

PRS 17.1%
renal interstitial pericyte CL1001318

CSI 1.3

rCSI 3.5%

PRS 21.5%
cerebral cortex endothelial cell CL1001602

CSI 1.3

rCSI 2.2%

PRS 17.7%
transit amplifying cell CL0009010

CSI 1.3

rCSI 1.9%

PRS 37.1%
Bergmann glial cell CL0000644

CSI 1.3

rCSI 1.7%

PRS 22.9%
lung endothelial cell CL1001567

CSI 1.3

rCSI 2.9%

PRS 51.2%
intermediate monocyte CL0002393

CSI 1.3

rCSI 1.9%

PRS 23.7%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary **[CRK](/details-gene/1398)** is a proto-oncogene that encodes a signaling adaptor protein crucial for intracellular signal transduction. Lacking intrinsic enzymatic activity, it functions as a molecular scaffold, utilizing its Src homology 2 (SH2) and 3 (SH3) domains to link phosphotyrosine-containing proteins with downstream effectors. This positions [CRK](/details-gene/1398) as a central hub in pathways that regulate cell adhesion, migration, and proliferation ([Link](https://doi.org/10.1128/mcb.12.8.3482-3489.1992)). Its significance is highlighted by its expression across a wide range of cell types, including highly proliferative epithelial cells like [transit amplifying cell of colon](/details-cell/CL0009011), contractile cells such as [myoepithelial cell](/details-cell/CL0000185), and key immune cells like [CD1c-positive myeloid dendritic cell](/details-cell/CL0002399), indicating its fundamental role in diverse physiological processes. ## Cellular Roles and Expression Landscape **Overall**, the expression profile of **[CRK](/details-gene/1398)** reveals its widespread importance as a signaling intermediary in numerous cell lineages, rather than as a marker for a single cell type. Its highest significance is observed in the [transit amplifying cell of colon](/details-cell/CL0009011) (CSI: 12.39), a rapidly dividing cell population, which is consistent with the gene's established role in promoting cell proliferation and growth. High CSI values are also seen in various mesenchymal and epithelial-like cells, including [myoepithelial cell](/details-cell/CL0000185) (CSI: 9.90), [choroid plexus epithelial cell](/details-cell/CL0000706) (CSI: 7.35), and [hepatic stellate cell](/details-cell/CL0000632) (CSI: 5.97), suggesting a key function in processes related to tissue structure, contractility, and response to growth factors. Furthermore, **[CRK](/details-gene/1398)** is a significant component of the immune system's signaling machinery. It is prominently expressed in antigen-presenting cells such as [CD1c-positive myeloid dendritic cell](/details-cell/CL0002399) (CSI: 8.04), [myeloid dendritic cell](/details-cell/CL0000782) (CSI: 5.97), and [alternatively activated macrophage](/details-cell/CL0000890) (CSI: 6.74), as well as in adaptive immune cells like the [effector memory CD8-positive, alpha-beta T cell](/details-cell/CL0000913) (CSI: 5.78). This pattern points to a role in immune cell activation, migration, and effector functions. The gene's importance extends to the vasculature, with significant expression in [endothelial cell of vascular tree](/details-cell/CL0002139) (CSI: 6.35), aligning with its involvement in signaling pathways that control angiogenesis and vascular integrity. ## Pathways and Molecular Function The function of **[CRK](/details-gene/1398)** is defined by its role as an adaptor protein, mediating signal transduction through protein-protein interactions. Its molecular function is dominated by `Signaling adaptor activity` ([GO:0035591](https://www.ebi.ac.uk/QuickGO/term/GO:0035591)), primarily through its capacity for `Phosphotyrosine residue binding` ([GO:0001784](https://www.ebi.ac.uk/QuickGO/term/GO:0001784)) via its SH2 domain and binding to proline-rich motifs via its SH3 domain ([SH3 domain binding](https://www.ebi.ac.uk/QuickGO/term/GO:0017124)) ([Link](https://doi.org/10.1074/jbc.271.24.14468)). These interactions allow it to bridge activated `Receptor tyrosine kinase binding` ([GO:0030971](https://www.ebi.ac.uk/QuickGO/term/GO:0030971)) to downstream signaling cascades. This scaffolding function translates into the regulation of critical biological processes. **[CRK](/details-gene/1398)** is integral to pathways controlling the cytoskeleton and cell movement, as evidenced by its annotation for `Actin cytoskeleton organization` ([GO:0030036](https://www.ebi.ac.uk/QuickGO/term/GO:0030036)) and `Cell migration` ([GO:0016477](https://www.ebi.ac.uk/QuickGO/term/GO:0016477)). This is consistent with its demonstrated interaction with DOCK180, a key regulator of the RAC1 GTPase involved in cell morphology ([Link](https://doi.org/10.1128/mcb.16.4.1770)). Reactome pathway analysis further specifies the contexts where **[CRK](/details-gene/1398)** operates. It is a key player in `Signaling by receptor tyrosine kinases` ([R-HSA-9006934](https://reactome.org/content/detail/R-HSA-9006934)), including specific pathways like `Signaling by pdgf` ([R-HSA-186797](https://reactome.org/content/detail/R-HSA-186797)) and the `Vegfa-vegfr2 pathway` ([R-HSA-4420097](https://reactome.org/content/detail/R-HSA-4420097)), which aligns with its expression in endothelial and mesenchymal cells. In the immune system, its importance is highlighted by its involvement in `Cytokine signaling in immune system` ([R-HSA-1280215](https://reactome.org/content/detail/R-HSA-1280215)) and `Fcgamma receptor (fcgr) dependent phagocytosis` ([R-HSA-2029480](https://reactome.org/content/detail/R-HSA-2029480)), providing a molecular basis for its high significance in myeloid cells. Additionally, its role in cell adhesion is underscored by its participation in `Integrin signaling` ([R-HSA-354192](https://reactome.org/content/detail/R-HSA-354192)). ## Research Directions The widespread role of **[CRK](/details-gene/1398)** in fundamental cellular processes, particularly cell proliferation and migration, combined with its status as a proto-oncogene ([OMIM: 164762](https://omim.org/entry/164762)), makes it a gene of significant interest in cancer biology and immunology. ### Proposed Hypotheses: 1. Given its proto-oncogenic nature and its highest CSI score in the highly proliferative [transit amplifying cell of colon](/details-cell/CL0009011), we hypothesize that overexpression or dysregulation of **[CRK](/details-gene/1398)** is a critical event in the development and progression of colorectal cancer, where it may amplify signals from growth factor receptors to drive uncontrolled cell division and metastasis. 2. Based on its high significance in [CD1c-positive myeloid dendritic cell](/details-cell/CL0002399) and its direct involvement in the `Fcgamma receptor (fcgr) dependent phagocytosis` pathway ([R-HSA-2029480](https://reactome.org/content/detail/R-HSA-2029480)), we propose that **[CRK](/details-gene/1398)** is essential for efficient antigen uptake by dendritic cells. It likely acts as a critical adaptor to recruit cytoskeletal machinery to the phagocytic cup, thereby influencing the efficacy of the adaptive immune response. ### Experimental Approach: To test the first hypothesis regarding the role of **[CRK](/details-gene/1398)** in colorectal cancer, a multifaceted approach could be employed. CRISPR-Cas9-mediated knockout of **[CRK](/details-gene/1398)** in a panel of colorectal cancer cell lines would be performed. The resulting knockout cells would be compared to isogenic controls in functional assays measuring proliferation (e.g., cell counting, colony formation), migration (e.g., transwell assays), and invasion (e.g., Matrigel invasion assays). Furthermore, using patient-derived organoid models, the effect of **[CRK](/details-gene/1398)** knockout on tumoroid growth and architecture could be assessed to provide a more physiologically relevant context. ### Therapeutic Potential: As a proto-oncogenic signaling node, **[CRK](/details-gene/1398)** represents a compelling target for therapeutic **inhibition**, particularly in cancers driven by aberrant receptor tyrosine kinase signaling. Because [CRK](/details-gene/1398) itself is not an enzyme, direct inhibition is challenging. However, developing small molecules or peptidomimetics that specifically disrupt the protein-protein interactions mediated by its SH2 or SH3 domains could be a viable strategy. Such an approach could uncouple hyperactive upstream receptors from the downstream pathways that drive malignant phenotypes. The broad expression of [CRK](/details-gene/1398) may pose a risk for on-target toxicity, necessitating careful therapeutic window assessment or the development of strategies to target its function specifically in cancer cells.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Adapter molecule crk
A0A0S2Z3K9_HUMAN

Genular Protein ID: 463348270

Symbol: CRK_HUMAN

Name: Adapter molecule crk

UniProtKB Accession Codes:

P46108 A8MWE8 B0LPE8 D3DTH6 Q96GA9 Q96HJ0

Database IDs:

Citations:

PubMed ID: 1630456

Title: Two species of human CRK cDNA encode proteins with distinct biological activities.

PubMed ID: 1630456

DOI: 10.1128/mcb.12.8.3482-3489.1992

PubMed ID: 8378094

Title: CRK proto-oncogene maps to human chromosome band 17p13.

PubMed ID: 8378094

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8657152

Title: DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane.

PubMed ID: 8657152

DOI: 10.1128/mcb.16.4.1770

PubMed ID: 8662907

Title: Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins.

PubMed ID: 8662907

DOI: 10.1074/jbc.271.24.14468

PubMed ID: 9614078

Title: Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction.

PubMed ID: 9614078

DOI: 10.1074/jbc.273.24.14780

PubMed ID: 10362357

Title: cbl-3: a new mammalian cbl family protein.

PubMed ID: 10362357

DOI: 10.1038/sj.onc.1202753

PubMed ID: 10733900

Title: Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined by its internal tyrosine phosphorylation.

PubMed ID: 10733900

DOI: 10.1006/bbrc.2000.2374

PubMed ID: 10964504

Title: NGF-dependent neurite outgrowth in PC12 cells overexpressing the Src homology 2-domain protein shb requires activation of the Rap1 pathway.

PubMed ID: 10964504

DOI: 10.1006/excr.2000.4984

PubMed ID: 11870224

Title: Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling.

PubMed ID: 11870224

DOI: 10.1242/jcs.115.5.1059

PubMed ID: 12432078

Title: Novel function of Chat in controlling cell adhesion via Cas-Crk-C3G-pathway-mediated Rap1 activation.

PubMed ID: 12432078

DOI: 10.1242/jcs.00207

PubMed ID: 12628187

Title: DOCK4, a GTPase activator, is disrupted during tumorigenesis.

PubMed ID: 12628187

DOI: 10.1016/s0092-8674(03)00155-7

PubMed ID: 12878163

Title: Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk.

PubMed ID: 12878163

DOI: 10.1016/s0014-4827(03)00206-4

PubMed ID: 16076871

Title: Direct recruitment of CRK and GRB2 to VEGFR-3 induces proliferation, migration, and survival of endothelial cells through the activation of ERK, AKT, and JNK pathways.

PubMed ID: 16076871

DOI: 10.1182/blood-2005-04-1388

PubMed ID: 16129412

Title: Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor.

PubMed ID: 16129412

DOI: 10.1016/j.bbrc.2005.08.055

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17038317

Title: Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas.

PubMed ID: 17038317

DOI: 10.1074/jbc.m604342200

PubMed ID: 18024423

Title: Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding.

PubMed ID: 18024423

DOI: 10.1074/jbc.m706361200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19807924

Title: Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening.

PubMed ID: 19807924

DOI: 10.1186/1471-2172-10-53

PubMed ID: 19004829

Title: DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell spreading and migration on collagen IV.

PubMed ID: 19004829

DOI: 10.1074/jbc.m808010200

PubMed ID: 19381274

Title: Unc119 protects from Shigella infection by inhibiting the Abl family kinases.

PubMed ID: 19381274

DOI: 10.1371/journal.pone.0005211

PubMed ID: 20534451

Title: Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression.

PubMed ID: 20534451

DOI: 10.1073/pnas.0914776107

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 31311869

Title: PEAK3/C19orf35 pseudokinase, a new NFK3 kinase family member, inhibits CrkII through dimerization.

PubMed ID: 31311869

DOI: 10.1073/pnas.1906360116

PubMed ID: 12384576

Title: Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide.

PubMed ID: 12384576

DOI: 10.1073/pnas.212518799

PubMed ID: 17515907

Title: Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK.

PubMed ID: 17515907

DOI: 10.1038/nsmb1241

Sequence Information:

Length: 304
Mass: 33831
Checksum: 4CFBFB65BFC2E265
Sequence:

MAGNFDSEER SSWYWGRLSR QEAVALLQGQ RHGVFLVRDS STSPGDYVLS VSENSRVSHY 
IINSSGPRPP VPPSPAQPPP GVSPSRLRIG DQEFDSLPAL LEFYKIHYLD TTTLIEPVSR 
SRQGSGVILR QEEAEYVRAL FDFNGNDEED LPFKKGDILR IRDKPEEQWW NAEDSEGKRG 
MIPVPYVEKY RPASASVSAL IGGNQEGSHP QPLGGPEPGP YAQPSVNTPL PNLQNGPIYA 
RVIQKRVPNA YDKTALALEV GELVKVTKIN VSGQWEGECN GKRGHFPFTH VRLLDQQNPD 
EDFS

Genular Protein ID: 3163442072

Symbol: A0A0S2Z3K9_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0S2Z3K9

Database IDs:

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

Length: 204
Mass: 22906
Checksum: B4C5BF23887B6B80
Sequence:

MAGNFDSEER SSWYWGRLSR QEAVALLQGQ RHGVFLVRDS STSPGDYVLS VSENSRVSHY 
IINSSGPRPP VPPSPAQPPP GVSPSRLRIG DQEFDSLPAL LEFYKIHYLD TTTLIEPVSR 
SRQGSGVILR QEEAEYVRAL FDFNGNDEED LPFKKGDILR IRDKPEEQWW NAEDSEGKRG 
MIPVPYVEKY RPASASVSAL IGGR

Details for: CRK

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Two species of human CRK cDNA encode proteins with distinct biological activities. PubMed ID: 1630456

CRK proto-oncogene maps to human chromosome band 17p13. PubMed ID: 8378094

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membrane. PubMed ID: 8657152

Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins. PubMed ID: 8662907

Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction. PubMed ID: 9614078

cbl-3: a new mammalian cbl family protein. PubMed ID: 10362357

Differential interaction of CrkII adaptor protein with platelet-derived growth factor alpha- and beta-receptors is determined by its internal tyrosine phosphorylation. PubMed ID: 10733900

NGF-dependent neurite outgrowth in PC12 cells overexpressing the Src homology 2-domain protein shb requires activation of the Rap1 pathway. PubMed ID: 10964504

Ephrin-A5 induces rounding, blebbing and de-adhesion of EphA3-expressing 293T and melanoma cells by CrkII and Rho-mediated signalling. PubMed ID: 11870224

Novel function of Chat in controlling cell adhesion via Cas-Crk-C3G-pathway-mediated Rap1 activation. PubMed ID: 12432078

DOCK4, a GTPase activator, is disrupted during tumorigenesis. PubMed ID: 12628187

Identification of Tyr900 in the kinase domain of c-Kit as a Src-dependent phosphorylation site mediating interaction with c-Crk. PubMed ID: 12878163

Direct recruitment of CRK and GRB2 to VEGFR-3 induces proliferation, migration, and survival of endothelial cells through the activation of ERK, AKT, and JNK pathways. PubMed ID: 16076871

Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor. PubMed ID: 16129412

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

Ack1 mediates Cdc42-dependent cell migration and signaling to p130Cas. PubMed ID: 17038317

Regulation of 3-phosphoinositide-dependent protein kinase-1 (PDK1) by Src involves tyrosine phosphorylation of PDK1 and Src homology 2 domain binding. PubMed ID: 18024423

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening. PubMed ID: 19807924

DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell spreading and migration on collagen IV. PubMed ID: 19004829

Unc119 protects from Shigella infection by inhibiting the Abl family kinases. PubMed ID: 19381274

Pseudopodium-enriched atypical kinase 1 regulates the cytoskeleton and cancer progression. PubMed ID: 20534451

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features. PubMed ID: 22223895

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

PEAK3/C19orf35 pseudokinase, a new NFK3 kinase family member, inhibits CrkII through dimerization. PubMed ID: 31311869

Structure of a regulatory complex involving the Abl SH3 domain, the Crk SH2 domain, and a Crk-derived phosphopeptide. PubMed ID: 12384576

Structural basis for the transforming activity of human cancer-related signaling adaptor protein CRK. PubMed ID: 17515907

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. PubMed ID: 26871637