Genular: Defining Cellular Identity and Function

Details for: Esr1

Gene ID: 13982

Symbol: Esr1

Ensembl ID: ENSMUSG00000019768

Description: estrogen receptor 1 (alpha)

Associated with

Deubiquitination
(R-MMU-5688426)
Esr-mediated signaling
(R-MMU-8939211)
Estrogen-dependent gene expression
(R-MMU-9018519)
Extra-nuclear estrogen signaling
(R-MMU-9009391)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Intracellular signaling by second messengers
(R-MMU-9006925)
Metabolism of proteins
(R-MMU-392499)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Nuclear receptor transcription pathway
(R-MMU-383280)
Nuclear signaling by erbb4
(R-MMU-1251985)
Ovarian tumor domain proteases
(R-MMU-5689896)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-MMU-6811558)
Pip3 activates akt signaling
(R-MMU-1257604)
Post-translational protein modification
(R-MMU-597592)
Rna polymerase ii transcription
(R-MMU-73857)
Runx1 regulates estrogen receptor mediated transcription
(R-MMU-8931987)
Signaling by erbb4
(R-MMU-1236394)
Signaling by nuclear receptors
(R-MMU-9006931)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signal transduction
(R-MMU-162582)
Sumo e3 ligases sumoylate target proteins
(R-MMU-3108232)
Sumoylation
(R-MMU-2990846)
Sumoylation of intracellular receptors
(R-MMU-4090294)
Tfap2 (ap-2) family regulates transcription of growth factors and their receptors
(R-MMU-8866910)
Transcriptional regulation by runx1
(R-MMU-8878171)
Transcriptional regulation by the ap-2 (tfap2) family of transcription factors
(R-MMU-8864260)
14-3-3 protein binding
(GO:0071889)
Androgen metabolic process
(GO:0008209)
Antral ovarian follicle growth
(GO:0001547)
Atpase binding
(GO:0051117)
Beta-catenin binding
(GO:0008013)
Calmodulin binding
(GO:0005516)
Chromatin binding
(GO:0003682)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna binding
(GO:0003677)
Enzyme binding
(GO:0019899)
Epithelial cell development
(GO:0002064)
Estrogen response element binding
(GO:0034056)
Fibroblast proliferation
(GO:0048144)
G protein-coupled estrogen receptor activity
(GO:0038054)
Hormone binding
(GO:0042562)
Identical protein binding
(GO:0042802)
Intracellular estrogen receptor signaling pathway
(GO:0030520)
Intracellular steroid hormone receptor signaling pathway
(GO:0030518)
Lipid binding
(GO:0008289)
Male gonad development
(GO:0008584)
Metal ion binding
(GO:0046872)
Negative regulation of canonical nf-kappab signal transduction
(GO:0043124)
Negative regulation of dna-binding transcription factor activity
(GO:0043433)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of glucose import
(GO:0046325)
Negative regulation of mitotic nuclear division
(GO:0045839)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of smooth muscle cell proliferation
(GO:0048662)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nuclear estrogen receptor activity
(GO:0030284)
Nuclear estrogen receptor binding
(GO:0030331)
Nuclear receptor activity
(GO:0004879)
Nuclear steroid receptor activity
(GO:0003707)
Phosphatidylinositol 3-kinase regulatory subunit binding
(GO:0036312)
Phospholipase c-activating g protein-coupled receptor signaling pathway
(GO:0007200)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of epidermal growth factor receptor signaling pathway
(GO:0045742)
Positive regulation of epithelial cell proliferation
(GO:0050679)
Positive regulation of fibroblast proliferation
(GO:0048146)
Positive regulation of nitric-oxide synthase activity
(GO:0051000)
Positive regulation of nitric oxide biosynthetic process
(GO:0045429)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Promoter-specific chromatin binding
(GO:1990841)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of inflammatory response
(GO:0050727)
Regulation of toll-like receptor signaling pathway
(GO:0034121)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to estradiol
(GO:0032355)
Response to estrogen
(GO:0043627)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Stem cell differentiation
(GO:0048863)
Steroid binding
(GO:0005496)
Steroid hormone mediated signaling pathway
(GO:0043401)
Tbp-class protein binding
(GO:0017025)
Tfiib-class transcription factor binding
(GO:0001093)
Transcription by rna polymerase ii
(GO:0006366)
Transcription coactivator binding
(GO:0001223)
Transcription coregulator binding
(GO:0001221)
Transcription corepressor binding
(GO:0001222)
Transcription factor binding
(GO:0008134)
Type 1 metabotropic glutamate receptor binding
(GO:0031798)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Estrogen receptor

Genular Protein ID: 2435273636

Symbol: ESR1_MOUSE

Name: Estrogen receptor

UniProtKB Accession Codes:

P19785 Q9JJT5 Q9QY51 Q9QY52

Database IDs:

Citations:

PubMed ID: 2484714

Title: Structural organization and expression of the mouse estrogen receptor.

PubMed ID: 2484714

DOI: 10.1210/mend-1-10-735

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 10899303

Title: Tissue-specific expression of multiple mRNA variants of the mouse estrogen receptor alpha gene.

PubMed ID: 10899303

DOI: 10.1016/s0014-5793(00)01750-6

PubMed ID: 7641693

Title: Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor.

PubMed ID: 7641693

DOI: 10.1002/j.1460-2075.1995.tb00044.x

PubMed ID: 9448000

Title: POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element.

PubMed ID: 9448000

DOI: 10.1128/mcb.18.2.1029

PubMed ID: 10207113

Title: Molecular determinants of the estrogen receptor-coactivator interface.

PubMed ID: 10207113

DOI: 10.1128/mcb.19.5.3895

PubMed ID: 10840033

Title: Mutations in the estrogen receptor ligand binding domain discriminate between hormone-dependent transactivation and transrepression.

PubMed ID: 10840033

DOI: 10.1074/jbc.m002497200

PubMed ID: 17595322

Title: Constitutive coactivator of peroxisome proliferator-activated receptor (PPARgamma), a novel coactivator of PPARgamma that promotes adipogenesis.

PubMed ID: 17595322

DOI: 10.1210/me.2006-0520

PubMed ID: 8999954

Title: A subpopulation of estrogen receptors are modified by O-linked N-acetylglucosamine.

PubMed ID: 8999954

DOI: 10.1074/jbc.272.4.2421

PubMed ID: 11226831

Title: Glycosylation of the murine estrogen receptor-alpha.

PubMed ID: 11226831

DOI: 10.1016/s0960-0760(00)00167-9

PubMed ID: 9192892

Title: The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function.

PubMed ID: 9192892

DOI: 10.1038/42652

PubMed ID: 10788465

Title: Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR.

PubMed ID: 10788465

DOI: 10.1074/jbc.275.18.13510

PubMed ID: 11704680

Title: Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors.

PubMed ID: 11704680

DOI: 10.1074/jbc.m110417200

PubMed ID: 15140878

Title: Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases.

PubMed ID: 15140878

DOI: 10.1074/jbc.m312300200

PubMed ID: 15988012

Title: GAC63, a GRIP1-dependent nuclear receptor coactivator.

PubMed ID: 15988012

DOI: 10.1128/mcb.25.14.5965-5972.2005

PubMed ID: 20005806

Title: Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation.

PubMed ID: 20005806

DOI: 10.1016/j.cell.2009.11.021

PubMed ID: 22031296

Title: DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors.

PubMed ID: 22031296

DOI: 10.1091/mbc.e11-07-0638

Sequence Information:

Length: 599
Mass: 66955
Checksum: 05F5E2FC21CC0A8B
Sequence:

MTMTLHTKAS GMALLHQIQG NELEPLNRPQ LKMPMERALG EVYVDNSKPT VFNYPEGAAY 
EFNAAAAAAA AASAPVYGQS GIAYGPGSEA AAFSANSLGA FPQLNSVSPS PLMLLHPPPQ 
LSPFLHPHGQ QVPYYLENEP SAYAVRDTGP PAFYRSNSDN RRQNGRERLS SSNEKGNMIM 
ESAKETRYCA VCNDYASGYH YGVWSCEGCK AFFKRSIQGH NDYMCPATNQ CTIDKNRRKS 
CQACRLRKCY EVGMMKGGIR KDRRGGRMLK HKRQRDDLEG RNEMGASGDM RAANLWPSPL 
VIKHTKKNSP ALSLTADQMV SALLDAEPPM IYSEYDPSRP FSEASMMGLL TNLADRELVH 
MINWAKRVPG FGDLNLHDQV HLLECAWLEI LMIGLVWRSM EHPGKLLFAP NLLLDRNQGK 
CVEGMVEIFD MLLATSSRFR MMNLQGEEFV CLKSIILLNS GVYTFLSSTL KSLEEKDHIH 
RVLDKITDTL IHLMAKAGLT LQQQHRRLAQ LLLILSHIRH MSNKGMEHLY NMKCKNVVPL 
YDLLLEMLDA HRLHAPASRM GVPPEEPSQT QLATTSSTSA HSLQTYYIPP EAEGFPNTI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Esr1

Associated with

Other Information

Structural organization and expression of the mouse estrogen receptor. PubMed ID: 2484714

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Tissue-specific expression of multiple mRNA variants of the mouse estrogen receptor alpha gene. PubMed ID: 10899303

Nuclear factor RIP140 modulates transcriptional activation by the estrogen receptor. PubMed ID: 7641693

POU transcription factors Brn-3a and Brn-3b interact with the estrogen receptor and differentially regulate transcriptional activity via an estrogen response element. PubMed ID: 9448000

Molecular determinants of the estrogen receptor-coactivator interface. PubMed ID: 10207113

Mutations in the estrogen receptor ligand binding domain discriminate between hormone-dependent transactivation and transrepression. PubMed ID: 10840033

Constitutive coactivator of peroxisome proliferator-activated receptor (PPARgamma), a novel coactivator of PPARgamma that promotes adipogenesis. PubMed ID: 17595322

A subpopulation of estrogen receptors are modified by O-linked N-acetylglucosamine. PubMed ID: 8999954

Glycosylation of the murine estrogen receptor-alpha. PubMed ID: 11226831

The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. PubMed ID: 9192892

Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR. PubMed ID: 10788465

Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors. PubMed ID: 11704680

Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases. PubMed ID: 15140878

GAC63, a GRIP1-dependent nuclear receptor coactivator. PubMed ID: 15988012

Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation. PubMed ID: 20005806

DHHC-7 and -21 are palmitoylacyltransferases for sex steroid receptors. PubMed ID: 22031296