Genular: Defining Cellular Identity and Function

Details for: Esr2

Gene ID: 13983

Symbol: Esr2

Ensembl ID: ENSMUSG00000021055

Description: estrogen receptor 2 (beta)

Associated with

Esr-mediated signaling
(R-MMU-8939211)
Extra-nuclear estrogen signaling
(R-MMU-9009391)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Intracellular signaling by second messengers
(R-MMU-9006925)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Nuclear receptor transcription pathway
(R-MMU-383280)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-MMU-6811558)
Pip3 activates akt signaling
(R-MMU-1257604)
Rna polymerase ii transcription
(R-MMU-73857)
Signaling by nuclear receptors
(R-MMU-9006931)
Signal transduction
(R-MMU-162582)
Androgen receptor signaling pathway
(GO:0030521)
Behavioral fear response
(GO:0001662)
Brain development
(GO:0007420)
Cell population proliferation
(GO:0008283)
Cellular response to estradiol stimulus
(GO:0071392)
Cellular response to estrogen stimulus
(GO:0071391)
Cellular response to lipopolysaccharide
(GO:0071222)
Cytoplasm
(GO:0005737)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna binding
(GO:0003677)
Enzyme binding
(GO:0019899)
Epithelial cell maturation involved in prostate gland development
(GO:0060743)
Epithelial cell proliferation
(GO:0050673)
Estradiol binding
(GO:1903924)
Estrogen binding
(GO:0099130)
Estrogen response element binding
(GO:0034056)
Estrous cycle
(GO:0044849)
Heterocyclic compound binding
(GO:1901363)
Hormone-mediated apoptotic signaling pathway
(GO:0008628)
Hormone binding
(GO:0042562)
Intracellular estrogen receptor signaling pathway
(GO:0030520)
Intracellular membrane-bounded organelle
(GO:0043231)
Intracellular steroid hormone receptor signaling pathway
(GO:0030518)
Learning or memory
(GO:0007611)
Lipid binding
(GO:0008289)
Metal ion binding
(GO:0046872)
Mitochondrion
(GO:0005739)
Negative regulation of androgen receptor signaling pathway
(GO:0060766)
Negative regulation of behavior
(GO:0048521)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of epithelial cell proliferation
(GO:0050680)
Negative regulation of feeding behavior
(GO:2000252)
Negative regulation of neuron apoptotic process
(GO:0043524)
Negative regulation of reactive oxygen species metabolic process
(GO:2000378)
Negative regulation of smooth muscle cell proliferation
(GO:0048662)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neuronal cell body
(GO:0043025)
Neuron migration
(GO:0001764)
Nuclear estrogen receptor activity
(GO:0030284)
Nuclear receptor activity
(GO:0004879)
Nuclear steroid receptor activity
(GO:0003707)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Organic cyclic compound binding
(GO:0097159)
Ovarian follicle development
(GO:0001541)
Perikaryon
(GO:0043204)
Perinuclear region of cytoplasm
(GO:0048471)
Peroxisome proliferator activated receptor binding
(GO:0042975)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of dna-binding transcription factor activity
(GO:0051091)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of epidermal growth factor receptor signaling pathway
(GO:0045742)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Promoter-specific chromatin binding
(GO:1990841)
Prostate gland epithelium morphogenesis
(GO:0060740)
Protein-dna complex
(GO:0032993)
Protein binding
(GO:0005515)
Regulation of cell population proliferation
(GO:0042127)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to testosterone
(GO:0033574)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific dna binding
(GO:0043565)
Sertoli cell proliferation
(GO:0060011)
Steroid binding
(GO:0005496)
Steroid hormone binding
(GO:1990239)
Uterus development
(GO:0060065)
Vagina development
(GO:0060068)
Vasodilation
(GO:0042311)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Genular Protein ID: 739202816

Symbol: ESR2_MOUSE

Name: Estrogen receptor beta

UniProtKB Accession Codes:

O08537 B2RUC6 E9QKX7 O35635 O70519 Q8BG65 Q91Z86

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9058381

Title: Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta.

PubMed ID: 9058381

DOI: 10.1210/mend.11.3.9902

PubMed ID: 9280064

Title: Mouse estrogen receptor beta forms estrogen response element-binding heterodimers with estrogen receptor alpha.

PubMed ID: 9280064

DOI: 10.1210/mend.11.10.9989

PubMed ID: 11878304

Title: Exposure of KS483 cells to estrogen enhances osteogenesis and inhibits adipogenesis.

PubMed ID: 11878304

DOI: 10.1359/jbmr.2002.17.3.394

PubMed ID: 9192892

Title: The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function.

PubMed ID: 9192892

DOI: 10.1038/42652

PubMed ID: 9607809

Title: Transcription and translation of estrogen receptor-beta in the male reproductive tract of estrogen receptor-alpha knock-out and wild-type mice.

PubMed ID: 9607809

DOI: 10.1210/endo.139.6.6028

PubMed ID: 9685228

Title: Estrogen receptor-beta mRNA variants in human and murine tissues.

PubMed ID: 9685228

DOI: 10.1016/s0303-7207(98)00050-1

PubMed ID: 10230404

Title: Ligand-independent recruitment of SRC-1 to estrogen receptor beta through phosphorylation of activation function AF-1.

PubMed ID: 10230404

DOI: 10.1016/s1097-2765(00)80479-7

PubMed ID: 10995228

Title: Alternative O-glycosylation/O-phosphorylation of the murine estrogen receptor beta.

PubMed ID: 10995228

DOI: 10.1021/bi000755i

PubMed ID: 10788465

Title: Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR.

PubMed ID: 10788465

DOI: 10.1074/jbc.275.18.13510

PubMed ID: 11704680

Title: Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors.

PubMed ID: 11704680

DOI: 10.1074/jbc.m110417200

Sequence Information:

Length: 530
Mass: 59070
Checksum: BEFA25F62650A8D4
Sequence:

MEIKNSPSSL TSPASYNCSQ SILPLEHGPI YIPSSYVESR HEYSAMTFYS PAVMNYSVPS 
STGNLEGGPV RQTASPNVLW PTSGHLSPLA THCQSSLLYA EPQKSPWCEA RSLEHTLPVN 
RETLKRKLGG SGCASPVTSP SAKRDAHFCA VCSDYASGYH YGVWSCEGCK AFFKRSIQGH 
NDYICPATNQ CTIDKNRRKS CQACRLRKCY EVGMVKCGSR RERCGYRIVR RQRSASEQVH 
CLNKAKRTSG HTPRVKELLL NSLSPEQLVL TLLEAEPPNV LVSRPSMPFT EASMMMSLTK 
LADKELVHMI GWAKKIPGFV ELSLLDQVRL LESCWMEVLM VGLMWRSIDH PGKLIFAPDL 
VLDRDEGKCV EGILEIFDML LATTARFREL KLQHKEYLCV KAMILLNSSM YPLATASQEA 
ESSRKLTHLL NAVTDALVWV ISKSGISSQQ QSVRLANLLM LLSHVRHISN KGMEHLLSMK 
CKNVVPVYDL LLEMLNAHTL RGYKSSISGS ECCSTEDSKS KEGSQNLQSQ

Genular Protein ID: 643518792

Symbol: A0A0R4J0Y6_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A0R4J0Y6

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 549
Mass: 61204
Checksum: 5EDD161F17C67CCB
Sequence:

MSICASSHKD FSQLRPTQDM EIKNSPSSLT SPASYNCSQS ILPLEHGPIY IPSSYVESRH 
EYSAMTFYSP AVMNYSVPSS TGNLEGGPVR QTASPNVLWP TSGHLSPLAT HCQSSLLYAE 
PQKSPWCEAR SLEHTLPVNR ETLKRKLGGS GCASPVTSPS AKRDAHFCAV CSDYASGYHY 
GVWSCEGCKA FFKRSIQGHN DYICPATNQC TIDKNRRKSC QACRLRKCYE VGMVKCGSRR 
ERCGYRIVRR QRSASEQVHC LNKAKRTSGH TPRVKELLLN SLSPEQLVLT LLEAEPPNVL 
VSRPSMPFTE ASMMMSLTKL ADKELVHMIG WAKKIPGFVE LSLLDQVRLL ESCWMEVLMV 
GLMWRSIDHP GKLIFAPDLV LDRDEGKCVE GILEIFDMLL ATTARFRELK LQHKEYLCVK 
AMILLNSSMY PLATASQEAE SSRKLTHLLN AVTDALVWVI SKSGISSQQQ SVRLANLLML 
LSHVRHISNK GMEHLLSMKC KNVVPVYDLL LEMLNAHTLR GYKSSISGSE CCSTEDSKSK 
EGSQNLQSQ

Genular Protein ID: 4057679935

Symbol: A0A1W2P736_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A1W2P736

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

Sequence Information:

Length: 567
Mass: 63218
Checksum: BFB388C189FABE78
Sequence:

MSICASSHKD FSQLRPTQDM EIKNSPSSLT SPASYNCSQS ILPLEHGPIY IPSSYVESRH 
EYSAMTFYSP AVMNYSVPSS TGNLEGGPVR QTASPNVLWP TSGHLSPLAT HCQSSLLYAE 
PQKSPWCEAR SLEHTLPVNR ETLKRKLGGS GCASPVTSPS AKRDAHFCAV CSDYASGYHY 
GVWSCEGCKA FFKRSIQGHN DYICPATNQC TIDKNRRKSC QACRLRKCYE VGMVKCGSRR 
ERCGYRIVRR QRSASEQVHC LNKAKRTSGH TPRVKELLLN SLSPEQLVLT LLEAEPPNVL 
VSRPSMPFTE ASMMMSLTKL ADKELVHMIG WAKKIPGFVE LSLLDQVRLL ESCWMEVLMV 
GLMWRSIDHP GKLIFAPDLV LDRSSEDPHW HVAQTKSAVP RDEGKCVEGI LEIFDMLLAT 
TARFRELKLQ HKEYLCVKAM ILLNSSMYPL ATASQEAESS RKLTHLLNAV TDALVWVISK 
SGISSQQQSV RLANLLMLLS HVRHISNKGM EHLLSMKCKN VVPVYDLLLE MLNAHTLRGY 
KSSISGSECC STEDSKSKEG SQNLQSQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Esr2

Associated with

Other Information

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cloning, chromosomal localization, and functional analysis of the murine estrogen receptor beta. PubMed ID: 9058381

Mouse estrogen receptor beta forms estrogen response element-binding heterodimers with estrogen receptor alpha. PubMed ID: 9280064

Exposure of KS483 cells to estrogen enhances osteogenesis and inhibits adipogenesis. PubMed ID: 11878304

The transcriptional co-activator p/CIP binds CBP and mediates nuclear-receptor function. PubMed ID: 9192892

Transcription and translation of estrogen receptor-beta in the male reproductive tract of estrogen receptor-alpha knock-out and wild-type mice. PubMed ID: 9607809

Estrogen receptor-beta mRNA variants in human and murine tissues. PubMed ID: 9685228

Ligand-independent recruitment of SRC-1 to estrogen receptor beta through phosphorylation of activation function AF-1. PubMed ID: 10230404

Alternative O-glycosylation/O-phosphorylation of the murine estrogen receptor beta. PubMed ID: 10995228

Isolation and characterization of peroxisome proliferator-activated receptor (PPAR) interacting protein (PRIP) as a coactivator for PPAR. PubMed ID: 10788465

Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors. PubMed ID: 11704680

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Database document:

PubMed ID: 16141072

PubMed ID: 19468303

PubMed ID: 15489334

PubMed ID: 9058381

PubMed ID: 9280064

PubMed ID: 11878304

PubMed ID: 9192892

PubMed ID: 9607809

PubMed ID: 9685228

PubMed ID: 10230404

PubMed ID: 10995228

PubMed ID: 10788465

PubMed ID: 11704680

PubMed ID: 19468303

PubMed ID: 19468303