CRKL | ENSG00000099942 | NCBI 1399

Details for: CRKL

Gene ID: 1399

Symbol: CRKL

Ensembl ID: ENSG00000099942

Description: CRK like proto-oncogene, adaptor protein

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Downstream signal transduction
(R-HSA-186763)
Erythropoietin activates ras
(R-HSA-9027284)
Frs2-mediated activation
(R-HSA-170968)
Immune system
(R-HSA-168256)
Interleukin-3, interleukin-5 and gm-csf signaling
(R-HSA-512988)
Met activates rap1 and rac1
(R-HSA-8875555)
Met promotes cell motility
(R-HSA-8875878)
Met receptor recycling
(R-HSA-8875656)
Prolonged erk activation events
(R-HSA-169893)
Regulation of signaling by cbl
(R-HSA-912631)
Signaling by erythropoietin
(R-HSA-9006335)
Signaling by interleukins
(R-HSA-449147)
Signaling by met
(R-HSA-6806834)
Signaling by ntrk1 (trka)
(R-HSA-187037)
Signaling by ntrks
(R-HSA-166520)
Signaling by pdgf
(R-HSA-186797)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signalling to erks
(R-HSA-187687)
Acetylcholine receptor signaling pathway
(GO:0095500)
Anterior/posterior pattern specification
(GO:0009952)
B cell apoptotic process
(GO:0001783)
Blood vessel development
(GO:0001568)
Cadherin binding
(GO:0045296)
Cell chemotaxis
(GO:0060326)
Cell migration
(GO:0016477)
Cellular response to interleukin-7
(GO:0098761)
Cellular response to transforming growth factor beta stimulus
(GO:0071560)
Cellular response to xenobiotic stimulus
(GO:0071466)
Cerebellar neuron development
(GO:0098749)
Cerebral cortex development
(GO:0021987)
Chordate pharynx development
(GO:0160093)
Cranial skeletal system development
(GO:1904888)
Cytosol
(GO:0005829)
Dendrite development
(GO:0016358)
Endothelin receptor signaling pathway
(GO:0086100)
Establishment of cell polarity
(GO:0030010)
Extrinsic component of postsynaptic membrane
(GO:0098890)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Helper t cell diapedesis
(GO:0035685)
Hippocampus development
(GO:0021766)
Identical protein binding
(GO:0042802)
Intracellular signal transduction
(GO:0035556)
Jnk cascade
(GO:0007254)
Lipid metabolic process
(GO:0006629)
Male gonad development
(GO:0008584)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of protein phosphorylation
(GO:0001933)
Neuromuscular junction
(GO:0031594)
Neuron migration
(GO:0001764)
Nucleoplasm
(GO:0005654)
Outflow tract morphogenesis
(GO:0003151)
Parathyroid gland development
(GO:0060017)
Phosphotyrosine residue binding
(GO:0001784)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of glial cell migration
(GO:1903977)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of rac protein signal transduction
(GO:0035022)
Positive regulation of skeletal muscle acetylcholine-gated channel clustering
(GO:1904395)
Positive regulation of substrate adhesion-dependent cell spreading
(GO:1900026)
Postsynaptic specialization assembly
(GO:0098698)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Ras protein signal transduction
(GO:0007265)
Receptor tyrosine kinase binding
(GO:0030971)
Reelin-mediated signaling pathway
(GO:0038026)
Regulation of cell adhesion mediated by integrin
(GO:0033628)
Regulation of cell growth
(GO:0001558)
Regulation of dendrite development
(GO:0050773)
Regulation of t cell migration
(GO:2000404)
Retinoic acid receptor signaling pathway
(GO:0048384)
Rna binding
(GO:0003723)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Signaling adaptor activity
(GO:0035591)
Signal transduction
(GO:0007165)
Single fertilization
(GO:0007338)
Spermatogenesis
(GO:0007283)
T cell receptor signaling pathway
(GO:0050852)
Thymus development
(GO:0048538)
Urogenital system development
(GO:0001655)

Other Information

Proteins

Crk-like protein

Genular Protein ID: 4063807469

Symbol: CRKL_HUMAN

Name: Crk-like protein

UniProtKB Accession Codes:

P46109 A8KA44 D3DX35

Database IDs:

Citations:

PubMed ID: 8361759

Title: Isolation and chromosomal localization of CRKL, a human crk-like gene.

PubMed ID: 8361759

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9614078

Title: Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction.

PubMed ID: 9614078

DOI: 10.1074/jbc.273.24.14780

PubMed ID: 9020138

Title: Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells.

PubMed ID: 9020138

DOI: 10.1074/jbc.272.7.4230

PubMed ID: 10022120

Title: Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation.

PubMed ID: 10022120

DOI: 10.1038/sj.onc.1202411

PubMed ID: 12393632

Title: DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines.

PubMed ID: 12393632

DOI: 10.1182/blood-2001-11-0032

PubMed ID: 11443118

Title: CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling.

PubMed ID: 11443118

DOI: 10.1074/jbc.m102924200

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19004829

Title: DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell spreading and migration on collagen IV.

PubMed ID: 19004829

DOI: 10.1074/jbc.m808010200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

Length: 303
Mass: 33777
Checksum: 294CF1EE2CD44B81
Sequence:

MSSARFDSSD RSAWYMGPVS RQEAQTRLQG QRHGMFLVRD SSTCPGDYVL SVSENSRVSH 
YIINSLPNRR FKIGDQEFDH LPALLEFYKI HYLDTTTLIE PAPRYPSPPM GSVSAPNLPT 
AEDNLEYVRT LYDFPGNDAE DLPFKKGEIL VIIEKPEEQW WSARNKDGRV GMIPVPYVEK 
LVRSSPHGKH GNRNSNSYGI PEPAHAYAQP QTTTPLPAVS GSPGAAITPL PSTQNGPVFA 
KAIQKRVPCA YDKTALALEV GDIVKVTRMN INGQWEGEVN GRKGLFPFTH VKIFDPQNPD 
ENE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CRKL

Associated with

Other Information

Isolation and chromosomal localization of CRKL, a human crk-like gene. PubMed ID: 8361759

A genome annotation-driven approach to cloning the human ORFeome. PubMed ID: 15461802

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction. PubMed ID: 9614078

Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells. PubMed ID: 9020138

Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation. PubMed ID: 10022120

DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines. PubMed ID: 12393632

CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling. PubMed ID: 11443118

Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. PubMed ID: 15592455

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell spreading and migration on collagen IV. PubMed ID: 19004829

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569