Details for: CRKL

Gene ID: 1399

Symbol: CRKL

Ensembl ID: ENSG00000099942

Description: CRK like proto-oncogene, adaptor protein

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.29
    Marker Score: 79514
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.21
    Marker Score: 972
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.13
    Marker Score: 10782.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.13
    Marker Score: 1738
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.1
    Marker Score: 1914
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1
    Marker Score: 9427
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1
    Marker Score: 8608
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71710
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47934
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30394
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.96
    Marker Score: 885
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.96
    Marker Score: 2252
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.96
    Marker Score: 14951
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2398
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476.5
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.92
    Marker Score: 9515
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 433
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2706
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.88
    Marker Score: 3603
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.88
    Marker Score: 3402
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.88
    Marker Score: 32453
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.86
    Marker Score: 32600
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.85
    Marker Score: 4858
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.85
    Marker Score: 577
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 304
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.84
    Marker Score: 12535
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.83
    Marker Score: 878
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.82
    Marker Score: 16219
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.81
    Marker Score: 3345
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.8
    Marker Score: 857
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.78
    Marker Score: 5961
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.77
    Marker Score: 587
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.76
    Marker Score: 2814
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 304
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.75
    Marker Score: 301
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.73
    Marker Score: 782
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.73
    Marker Score: 842
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.73
    Marker Score: 7314
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.72
    Marker Score: 488
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 371
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.71
    Marker Score: 2737
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.69
    Marker Score: 723
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2860
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.67
    Marker Score: 216
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.67
    Marker Score: 608
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.67
    Marker Score: 232
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 170
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.66
    Marker Score: 222
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.65
    Marker Score: 205
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.65
    Marker Score: 3839.5
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.64
    Marker Score: 1734
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.62
    Marker Score: 307
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.62
    Marker Score: 373
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.62
    Marker Score: 906
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.61
    Marker Score: 1507
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.61
    Marker Score: 13080
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.61
    Marker Score: 3986
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.6
    Marker Score: 2521
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.6
    Marker Score: 375
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.6
    Marker Score: 3594
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6
    Marker Score: 382
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.6
    Marker Score: 394
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.6
    Marker Score: 147
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.59
    Marker Score: 595
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.59
    Marker Score: 2315
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.59
    Marker Score: 402
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.59
    Marker Score: 629
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.59
    Marker Score: 389
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.58
    Marker Score: 322
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.58
    Marker Score: 700
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.57
    Marker Score: 534
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.57
    Marker Score: 412
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.56
    Marker Score: 2590
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.56
    Marker Score: 319
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.56
    Marker Score: 588
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.55
    Marker Score: 537
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.54
    Marker Score: 700
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.54
    Marker Score: 479
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.53
    Marker Score: 425
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.53
    Marker Score: 131
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.53
    Marker Score: 141
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.53
    Marker Score: 259
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.53
    Marker Score: 126
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.53
    Marker Score: 1313
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.53
    Marker Score: 3427
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.52
    Marker Score: 350
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.52
    Marker Score: 3888
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.52
    Marker Score: 331
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.52
    Marker Score: 390
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.52
    Marker Score: 267
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.52
    Marker Score: 1403
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.51
    Marker Score: 209
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.51
    Marker Score: 1520
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.51
    Marker Score: 117
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.51
    Marker Score: 135
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.51
    Marker Score: 638.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.51
    Marker Score: 596
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.51
    Marker Score: 115

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Other Information

**Key characteristics:** - CRKL is a protein of the immunoglobulin superfamily. - It is a key adaptor protein in the regulation of the immune system. - It is expressed in a variety of immune cells, including dendritic cells, macrophages, and lymphocytes. - It is a key regulator of cytokine signaling in the immune system. **Pathways and functions:** - CRKL is involved in the regulation of the immune system through a variety of pathways, including the cytokine signaling pathway, the downstream signal transduction pathway, and the erythropoietin-mediated pathway. - In the cytokine signaling pathway, CRKL is a key regulator of the production of cytokines by dendritic cells. - In the downstream signal transduction pathway, CRKL is involved in the regulation of inflammation and cell migration. - In the erythropoietin-mediated pathway, CRKL is a key regulator of the production of erythropoietin, a protein that is essential for the production of red blood cells. **Clinical significance:** CRKL is a potential tumor suppressor gene. Mutations in the CRKL gene have been linked to the development of a variety of cancers, including breast cancer, lung cancer, and leukemia.

Genular Protein ID: 4063807469

Symbol: CRKL_HUMAN

Name: Crk-like protein

UniProtKB Accession Codes:

P46109 A8KA44 D3DX35

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EPD 1 Ensembl 2 EvolutionaryTrace 1 GO 61 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 6 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PROSITE-ProRule 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 6 RefSeq 1 SAM 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8361759

Title: Isolation and chromosomal localization of CRKL, a human crk-like gene.

PubMed ID: 8361759

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9614078

Title: Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction.

PubMed ID: 9614078

DOI: 10.1074/jbc.273.24.14780

PubMed ID: 9020138

Title: Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells.

PubMed ID: 9020138

DOI: 10.1074/jbc.272.7.4230

PubMed ID: 10022120

Title: Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation.

PubMed ID: 10022120

DOI: 10.1038/sj.onc.1202411

PubMed ID: 12393632

Title: DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines.

PubMed ID: 12393632

DOI: 10.1182/blood-2001-11-0032

PubMed ID: 11443118

Title: CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling.

PubMed ID: 11443118

DOI: 10.1074/jbc.m102924200

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19004829

Title: DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell spreading and migration on collagen IV.

PubMed ID: 19004829

DOI: 10.1074/jbc.m808010200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 303
  • Mass: 33777
  • Checksum: 294CF1EE2CD44B81
  • Sequence:
    • MSSARFDSSD RSAWYMGPVS RQEAQTRLQG QRHGMFLVRD SSTCPGDYVL SVSENSRVSH 
YIINSLPNRR FKIGDQEFDH LPALLEFYKI HYLDTTTLIE PAPRYPSPPM GSVSAPNLPT 
AEDNLEYVRT LYDFPGNDAE DLPFKKGEIL VIIEKPEEQW WSARNKDGRV GMIPVPYVEK 
LVRSSPHGKH GNRNSNSYGI PEPAHAYAQP QTTTPLPAVS GSPGAAITPL PSTQNGPVFA 
KAIQKRVPCA YDKTALALEV GDIVKVTRMN INGQWEGEVN GRKGLFPFTH VKIFDPQNPD 
ENE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.