Details for: CRKL

Gene ID: 1399

Symbol: CRKL

Ensembl ID: ENSG00000099942

Description: CRK like proto-oncogene, adaptor protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 149.4099
    Cell Significance Index: -23.2400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 94.6605
    Cell Significance Index: -24.0100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 66.3798
    Cell Significance Index: -27.3500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 55.0281
    Cell Significance Index: -25.9800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 48.0185
    Cell Significance Index: -24.7000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 20.1751
    Cell Significance Index: -24.8800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 9.0468
    Cell Significance Index: -24.2400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 6.5604
    Cell Significance Index: -20.1500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 6.4596
    Cell Significance Index: -25.4900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 4.1625
    Cell Significance Index: -9.1100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 2.0632
    Cell Significance Index: 240.4400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.3754
    Cell Significance Index: 395.7300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3098
    Cell Significance Index: 17.8700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0715
    Cell Significance Index: 214.9500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0093
    Cell Significance Index: 109.7900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0000
    Cell Significance Index: 60.0400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9077
    Cell Significance Index: 147.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7071
    Cell Significance Index: 140.3200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6842
    Cell Significance Index: 18.2700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5118
    Cell Significance Index: 35.4000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5028
    Cell Significance Index: 453.9500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4401
    Cell Significance Index: 83.7500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.4163
    Cell Significance Index: 51.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4128
    Cell Significance Index: 74.4200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3807
    Cell Significance Index: 136.5600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3670
    Cell Significance Index: 10.5800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3623
    Cell Significance Index: 7.8500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3528
    Cell Significance Index: 15.9900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.2737
    Cell Significance Index: 15.3600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2699
    Cell Significance Index: 186.6600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.2572
    Cell Significance Index: 7.0000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2309
    Cell Significance Index: 102.0700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1933
    Cell Significance Index: 10.0400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1743
    Cell Significance Index: 20.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1567
    Cell Significance Index: 21.5200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1520
    Cell Significance Index: 15.0400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.1420
    Cell Significance Index: 3.8100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1375
    Cell Significance Index: 75.1000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1356
    Cell Significance Index: 3.7900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1088
    Cell Significance Index: 8.3500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0607
    Cell Significance Index: 10.3700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0394
    Cell Significance Index: 0.6600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0307
    Cell Significance Index: 1.0800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0223
    Cell Significance Index: 1.0400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0192
    Cell Significance Index: 1.3600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0126
    Cell Significance Index: 1.6100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0125
    Cell Significance Index: 23.5600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0095
    Cell Significance Index: 0.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0025
    Cell Significance Index: 3.7800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0013
    Cell Significance Index: -2.4100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0034
    Cell Significance Index: -4.6400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0058
    Cell Significance Index: -0.2000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0084
    Cell Significance Index: -0.9600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0085
    Cell Significance Index: -6.2900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0127
    Cell Significance Index: -8.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0182
    Cell Significance Index: -11.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0183
    Cell Significance Index: -13.8600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0190
    Cell Significance Index: -8.6300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0221
    Cell Significance Index: -16.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0225
    Cell Significance Index: -1.3800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0312
    Cell Significance Index: -17.5800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0426
    Cell Significance Index: -1.1200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0493
    Cell Significance Index: -2.3200
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0497
    Cell Significance Index: -1.0300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0568
    Cell Significance Index: -5.8000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0683
    Cell Significance Index: -4.5900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0690
    Cell Significance Index: -14.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0712
    Cell Significance Index: -10.3500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0871
    Cell Significance Index: -5.4900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0939
    Cell Significance Index: -1.6100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0981
    Cell Significance Index: -12.6700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1011
    Cell Significance Index: -2.6000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1120
    Cell Significance Index: -2.3800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.1151
    Cell Significance Index: -0.7200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1167
    Cell Significance Index: -2.5000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1295
    Cell Significance Index: -5.7300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1311
    Cell Significance Index: -9.7700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1352
    Cell Significance Index: -4.3300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1655
    Cell Significance Index: -18.8900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1901
    Cell Significance Index: -7.2000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2167
    Cell Significance Index: -4.7500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2251
    Cell Significance Index: -23.4400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2631
    Cell Significance Index: -20.8400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2823
    Cell Significance Index: -14.8200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3056
    Cell Significance Index: -8.7200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.3061
    Cell Significance Index: -18.7700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.3350
    Cell Significance Index: -3.6500
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.3602
    Cell Significance Index: -5.4700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3652
    Cell Significance Index: -10.4700
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.4120
    Cell Significance Index: -3.3600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4199
    Cell Significance Index: -10.0700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4566
    Cell Significance Index: -13.4100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4648
    Cell Significance Index: -9.7300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4738
    Cell Significance Index: -15.0900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -0.4762
    Cell Significance Index: -8.0100
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.4935
    Cell Significance Index: -6.6600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4963
    Cell Significance Index: -12.6800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5073
    Cell Significance Index: -12.6800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.5331
    Cell Significance Index: -18.6800
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.5372
    Cell Significance Index: -7.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Adaptor Function:** CRKL serves as a scaffold protein that facilitates the assembly of signaling complexes by binding to multiple protein partners, including receptors, kinases, and phosphatases. 2. **Tyrosine Phosphorylation:** CRKL is phosphorylated at tyrosine residues, which modulates its activity and interactions with other proteins. 3. **Cell-Type Specificity:** CRKL expression is highly restricted to specific cell types, including immune cells, neurons, and germ cells, suggesting its unique role in these contexts. 4. **Multiple Signaling Pathways:** CRKL is involved in various signaling pathways, including those mediated by receptor tyrosine kinases, growth factor receptors, and cytokine receptors. **Pathways and Functions:** 1. **Immune Cell Signaling:** CRKL is involved in signaling pathways that control immune cell function, including T cell receptor signaling, helper T cell diapedesis, and cytokine signaling in the immune system. 2. **Neurodevelopment:** CRKL plays a role in neuronal development, including dendrite development, neuron migration, and postsynaptic specialization assembly. 3. **Cell Migration:** CRKL is involved in regulating cell migration, including the regulation of cell adhesion mediated by integrin and the promotion of cell motility by the Met receptor. 4. **Germ Cell Development:** CRKL is expressed in germ cells and is involved in spermatogenesis and the regulation of single fertilization. **Clinical Significance:** 1. **Cancer:** Alterations in CRKL expression and function have been implicated in various cancers, including leukemia, lymphoma, and solid tumors. 2. **Neurological Disorders:** CRKL mutations have been associated with neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 3. **Immunological Disorders:** CRKL is involved in the regulation of immune cell function, and alterations in its expression or function may contribute to immunological disorders, such as autoimmune diseases. 4. **Therapeutic Targeting:** CRKL is a potential therapeutic target for cancer and neurological disorders, as small molecule inhibitors or RNA-based therapies targeting CRKL may offer novel therapeutic options. In conclusion, CRKL is a versatile adaptor protein that plays a critical role in immune cell signaling, development, and differentiation. Its unique expression pattern and involvement in multiple signaling pathways highlight its importance in distinct cellular contexts. Further research is needed to fully elucidate the mechanisms of CRKL and its clinical significance.

Genular Protein ID: 4063807469

Symbol: CRKL_HUMAN

Name: Crk-like protein

UniProtKB Accession Codes:

P46109 A8KA44 D3DX35

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 EvolutionaryTrace 1 GO 62 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRINTS 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 6 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8361759

Title: Isolation and chromosomal localization of CRKL, a human crk-like gene.

PubMed ID: 8361759

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9614078

Title: Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transduction.

PubMed ID: 9614078

DOI: 10.1074/jbc.273.24.14780

PubMed ID: 9020138

Title: Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells.

PubMed ID: 9020138

DOI: 10.1074/jbc.272.7.4230

PubMed ID: 10022120

Title: Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation.

PubMed ID: 10022120

DOI: 10.1038/sj.onc.1202411

PubMed ID: 12393632

Title: DOCK2 associates with CrkL and regulates Rac1 in human leukemia cell lines.

PubMed ID: 12393632

DOI: 10.1182/blood-2001-11-0032

PubMed ID: 11443118

Title: CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling.

PubMed ID: 11443118

DOI: 10.1074/jbc.m102924200

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19004829

Title: DOCK5 and DOCK1 regulate Caco-2 intestinal epithelial cell spreading and migration on collagen IV.

PubMed ID: 19004829

DOI: 10.1074/jbc.m808010200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 303
  • Mass: 33777
  • Checksum: 294CF1EE2CD44B81
  • Sequence:
    • MSSARFDSSD RSAWYMGPVS RQEAQTRLQG QRHGMFLVRD SSTCPGDYVL SVSENSRVSH 
YIINSLPNRR FKIGDQEFDH LPALLEFYKI HYLDTTTLIE PAPRYPSPPM GSVSAPNLPT 
AEDNLEYVRT LYDFPGNDAE DLPFKKGEIL VIIEKPEEQW WSARNKDGRV GMIPVPYVEK 
LVRSSPHGKH GNRNSNSYGI PEPAHAYAQP QTTTPLPAVS GSPGAAITPL PSTQNGPVFA 
KAIQKRVPCA YDKTALALEV GDIVKVTRMN INGQWEGEVN GRKGLFPFTH VKIFDPQNPD 
ENE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.