Details for: AAMP

Gene ID: 14

Symbol: AAMP

Ensembl ID: ENSG00000127837

Description: angio associated migratory cell protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 220.1932
    Cell Significance Index: -34.2500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 122.6919
    Cell Significance Index: -31.1200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 86.3493
    Cell Significance Index: -35.0800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 84.9250
    Cell Significance Index: -40.1000
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 78.3362
    Cell Significance Index: -40.3000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 59.9794
    Cell Significance Index: -40.2500
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 37.0833
    Cell Significance Index: -35.4100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 31.1528
    Cell Significance Index: -38.4100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 10.3608
    Cell Significance Index: -27.7600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.1139
    Cell Significance Index: -39.9100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.8362
    Cell Significance Index: -27.1400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 6.0496
    Cell Significance Index: -13.2400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 2.0515
    Cell Significance Index: 223.1500
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.8511
    Cell Significance Index: 14.7800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.3155
    Cell Significance Index: 34.5900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.2449
    Cell Significance Index: 65.3600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.2402
    Cell Significance Index: 170.3100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2186
    Cell Significance Index: 33.1700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.1635
    Cell Significance Index: 14.9000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.1263
    Cell Significance Index: 83.9400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.1169
    Cell Significance Index: 10.2900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.1139
    Cell Significance Index: 12.1100
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.0959
    Cell Significance Index: 75.7900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0944
    Cell Significance Index: 56.8500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.0888
    Cell Significance Index: 22.7900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0578
    Cell Significance Index: 190.6900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.0307
    Cell Significance Index: 132.1300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.0050
    Cell Significance Index: 129.8500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9606
    Cell Significance Index: 118.1200
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.9313
    Cell Significance Index: 43.7700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9251
    Cell Significance Index: 91.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.8667
    Cell Significance Index: 40.4100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8030
    Cell Significance Index: 438.5500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7682
    Cell Significance Index: 34.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.7256
    Cell Significance Index: 143.9900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.7085
    Cell Significance Index: 20.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.6241
    Cell Significance Index: 73.6000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6127
    Cell Significance Index: 31.9200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.6050
    Cell Significance Index: 21.0300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.5973
    Cell Significance Index: 264.0900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5701
    Cell Significance Index: 12.3500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5634
    Cell Significance Index: 39.8500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5340
    Cell Significance Index: 15.3900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5269
    Cell Significance Index: 34.0000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.4816
    Cell Significance Index: 12.8600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.4004
    Cell Significance Index: 7.0800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3410
    Cell Significance Index: 5.1100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3130
    Cell Significance Index: 53.4500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2694
    Cell Significance Index: 3.0600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2605
    Cell Significance Index: 52.2500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2313
    Cell Significance Index: 14.5800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1861
    Cell Significance Index: 168.0800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1832
    Cell Significance Index: 34.8700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1481
    Cell Significance Index: 4.3500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1310
    Cell Significance Index: 3.6600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0925
    Cell Significance Index: 3.2500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0912
    Cell Significance Index: 2.9200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0627
    Cell Significance Index: 22.5000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0379
    Cell Significance Index: 6.1700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0353
    Cell Significance Index: 24.4500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0263
    Cell Significance Index: 19.8700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0137
    Cell Significance Index: 0.2300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0002
    Cell Significance Index: -0.3300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0005
    Cell Significance Index: -0.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0033
    Cell Significance Index: -2.3900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0065
    Cell Significance Index: -4.0400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0105
    Cell Significance Index: -19.4000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0128
    Cell Significance Index: -9.4500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0159
    Cell Significance Index: -24.5100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0203
    Cell Significance Index: -2.0700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0270
    Cell Significance Index: -36.7400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0277
    Cell Significance Index: -17.6200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0316
    Cell Significance Index: -0.8400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0441
    Cell Significance Index: -24.8800
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.0596
    Cell Significance Index: -0.3500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0659
    Cell Significance Index: -1.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0714
    Cell Significance Index: -32.4200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0793
    Cell Significance Index: -16.7000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0916
    Cell Significance Index: -10.5000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1057
    Cell Significance Index: -30.4200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1628
    Cell Significance Index: -4.1600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1804
    Cell Significance Index: -26.2200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1828
    Cell Significance Index: -21.3000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.2076
    Cell Significance Index: -5.1900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2621
    Cell Significance Index: -16.1100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.2639
    Cell Significance Index: -3.6000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2944
    Cell Significance Index: -33.6100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3381
    Cell Significance Index: -4.0300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3466
    Cell Significance Index: -5.9400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3494
    Cell Significance Index: -26.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3716
    Cell Significance Index: -38.7000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3835
    Cell Significance Index: -25.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3885
    Cell Significance Index: -30.7700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4229
    Cell Significance Index: -9.7700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.4349
    Cell Significance Index: -26.1100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.4409
    Cell Significance Index: -24.7400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.4456
    Cell Significance Index: -13.1300
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -0.4655
    Cell Significance Index: -6.5300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.5096
    Cell Significance Index: -5.2800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.5443
    Cell Significance Index: -10.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** AAMP is significantly expressed in various cell types, including placental villous trophoblast, decidual cells, mesodermal cells, epithelial cells of the esophagus, interstitial cells of the ovary, cortical thymic epithelial cells, kidney cells, epithelial cells of the nephron, and GABAergic amacrine cells. 2. **Protein Binding:** AAMP has been shown to interact with various proteins, including heparin-binding proteins, which suggests its role in cell-cell interactions and adhesion. 3. **Signal Transduction:** AAMP is involved in signaling pathways, including those mediated by receptor tyrosine kinases, epidermal growth factor receptors (EGFR), and vascular endothelial growth factor (VEGF). 4. **Cellular Migration:** AAMP plays a crucial role in cellular migration, a process essential for tissue development, repair, and immune responses. **Pathways and Functions:** 1. **Angiogenesis:** AAMP is involved in the regulation of angiogenesis, a process critical for tissue development, repair, and immune responses. It interacts with VEGF and other angiogenic factors to promote endothelial cell migration and proliferation. 2. **Immune Response:** AAMP plays a role in the innate immune response, particularly in the context of the NLRP3 inflammasome pathway. It is involved in the regulation of inflammatory responses and the production of pro-inflammatory cytokines. 3. **Cellular Migration:** AAMP is involved in the regulation of cellular migration, a process essential for tissue development, repair, and immune responses. It interacts with microtubule cytoskeleton proteins to regulate cell shape and movement. 4. **Signaling by Receptor Tyrosine Kinases:** AAMP is involved in signaling pathways mediated by receptor tyrosine kinases (RTKs), including EGFR and NLRP3. These pathways regulate various cellular processes, including cell growth, differentiation, and survival. **Clinical Significance:** 1. **Cancer:** AAMP's role in angiogenesis and cellular migration makes it a potential target for cancer therapy. Its expression is often upregulated in cancer cells, suggesting its involvement in tumor progression. 2. **Inflammatory Diseases:** AAMP's involvement in the innate immune response makes it a potential target for the treatment of inflammatory diseases, such as rheumatoid arthritis and atherosclerosis. 3. **Neurological Disorders:** AAMP's expression in GABAergic amacrine cells suggests its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Reproductive Health:** AAMP's expression in placental villous trophoblast and decidual cells makes it a potential biomarker for reproductive health and pregnancy complications. In conclusion, the AAMP gene is a fascinating molecule that plays a crucial role in various biological processes, including angiogenesis, immune response, and cellular migration. Its involvement in cancer, inflammatory diseases, neurological disorders, and reproductive health makes it a potential target for therapeutic interventions. Further research is needed to fully elucidate the mechanisms underlying AAMP's functions and its role in human disease.

Genular Protein ID: 2650843394

Symbol: AAMP_HUMAN

Name: Angio-associated migratory cell protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7743515

Title: Identification of a new immunoglobulin superfamily protein expressed in blood vessels with a heparin-binding consensus sequence.

PubMed ID: 7743515

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10329261

Title: Angio-associated migratory cell protein is expressed as an extracellular protein by blood-vessel-associated mesenchymal cells.

PubMed ID: 10329261

DOI: 10.1006/mvre.1999.2144

PubMed ID: 18634987

Title: Blockade of angio-associated migratory cell protein inhibits smooth muscle cell migration and neointima formation in accelerated atherosclerosis.

PubMed ID: 18634987

DOI: 10.1016/j.jacc.2008.03.055

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 434
  • Mass: 46751
  • Checksum: A7B8314442EBAF15
  • Sequence:
  • MESESESGAA ADTPPLETLS FHGDEEIIEV VELDPGPPDP DDLAQEMEDV DFEEEEEEEG 
    NEEGWVLEPQ EGVVGSMEGP DDSEVTFALH SASVFCVSLD PKTNTLAVTG GEDDKAFVWR 
    LSDGELLFEC AGHKDSVTCA GFSHDSTLVA TGDMSGLLKV WQVDTKEEVW SFEAGDLEWM 
    EWHPRAPVLL AGTADGNTWM WKVPNGDCKT FQGPNCPATC GRVLPDGKRA VVGYEDGTIR 
    IWDLKQGSPI HVLKGTEGHQ GPLTCVAANQ DGSLILTGSV DCQAKLVSAT TGKVVGVFRP 
    ETVASQPSLG EGEESESNSV ESLGFCSVMP LAAVGYLDGT LAIYDLATQT LRHQCQHQSG 
    IVQLLWEAGT AVVYTCSLDG IVRLWDARTG RLLTDYRGHT AEILDFALSK DASLVVTTSG 
    DHKAKVFCVQ RPDR

Genular Protein ID: 4243246574

Symbol: C9JEH3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 435
  • Mass: 46822
  • Checksum: 14AF7FE6E2B51880
  • Sequence:
  • MESESESGAA ADTPPLETLS FHGDEEIIEV VELDPGPPDP ADDLAQEMED VDFEEEEEEE 
    GNEEGWVLEP QEGVVGSMEG PDDSEVTFAL HSASVFCVSL DPKTNTLAVT GGEDDKAFVW 
    RLSDGELLFE CAGHKDSVTC AGFSHDSTLV ATGDMSGLLK VWQVDTKEEV WSFEAGDLEW 
    MEWHPRAPVL LAGTADGNTW MWKVPNGDCK TFQGPNCPAT CGRVLPDGKR AVVGYEDGTI 
    RIWDLKQGSP IHVLKGTEGH QGPLTCVAAN QDGSLILTGS VDCQAKLVSA TTGKVVGVFR 
    PETVASQPSL GEGEESESNS VESLGFCSVM PLAAVGYLDG TLAIYDLATQ TLRHQCQHQS 
    GIVQLLWEAG TAVVYTCSLD GIVRLWDART GRLLTDYRGH TAEILDFALS KDASLVVTTS 
    GDHKAKVFCV QRPDR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.