Details for: AAMP

Gene ID: 14

Symbol: AAMP

Ensembl ID: ENSG00000127837

Description: angio associated migratory cell protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    CSI Score: 13.2
  • Cell Name: conjunctival epithelial cell (CL1000432)
    CSI Score: 4.9
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    CSI Score: 4.5
  • Cell Name: stem cell (CL0000034)
    CSI Score: 4.2
  • Cell Name: pancreatic acinar cell (CL0002064)
    CSI Score: 4.1
  • Cell Name: pancreatic ductal cell (CL0002079)
    CSI Score: 4.0
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    CSI Score: 3.5
  • Cell Name: enterocyte (CL0000584)
    CSI Score: 3.4
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    CSI Score: 3.4
  • Cell Name: malignant cell (CL0001064)
    CSI Score: 3.2
  • Cell Name: myeloid leukocyte (CL0000766)
    CSI Score: 3.2
  • Cell Name: kidney epithelial cell (CL0002518)
    CSI Score: 2.9
  • Cell Name: transit amplifying cell of colon (CL0009011)
    CSI Score: 2.6
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    CSI Score: 2.6
  • Cell Name: peripheral nervous system neuron (CL2000032)
    CSI Score: 2.6
  • Cell Name: epithelial cell (CL0000066)
    CSI Score: 2.5
  • Cell Name: secretory cell (CL0000151)
    CSI Score: 2.5
  • Cell Name: mesenchymal cell (CL0008019)
    CSI Score: 2.4
  • Cell Name: transit amplifying cell (CL0009010)
    CSI Score: 2.4
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    CSI Score: 2.4
  • Cell Name: stratified epithelial cell (CL0000079)
    CSI Score: 2.3
  • Cell Name: hepatocyte (CL0000182)
    CSI Score: 2.3
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    CSI Score: 2.3
  • Cell Name: glioblast (CL0000030)
    CSI Score: 2.2
  • Cell Name: mesenchymal stem cell (CL0000134)
    CSI Score: 2.1
  • Cell Name: placental villous trophoblast (CL2000060)
    CSI Score: 2.0
  • Cell Name: muscle cell (CL0000187)
    CSI Score: 2.0
  • Cell Name: exhausted T cell (CL0011025)
    CSI Score: 2.0
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    CSI Score: 2.0
  • Cell Name: obsolete animal cell (CL0000548)
    CSI Score: 2.0
  • Cell Name: neuron (CL0000540)
    CSI Score: 1.9
  • Cell Name: colon epithelial cell (CL0011108)
    CSI Score: 1.9
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    CSI Score: 1.9
  • Cell Name: pancreatic A cell (CL0000171)
    CSI Score: 1.9
  • Cell Name: intestinal epithelial cell (CL0002563)
    CSI Score: 1.9
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    CSI Score: 1.8
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    CSI Score: 1.7
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    CSI Score: 1.7
  • Cell Name: Hofbauer cell (CL3000001)
    CSI Score: 1.7
  • Cell Name: glial cell (CL0000125)
    CSI Score: 1.7
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    CSI Score: 1.7
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    CSI Score: 1.6
  • Cell Name: mesodermal cell (CL0000222)
    CSI Score: 1.6
  • Cell Name: pulmonary alveolar type 2 cell (CL0002063)
    CSI Score: 1.6
  • Cell Name: ciliated epithelial cell (CL0000067)
    CSI Score: 1.6
  • Cell Name: goblet cell (CL0000160)
    CSI Score: 1.6
  • Cell Name: enteric smooth muscle cell (CL0002504)
    CSI Score: 1.6
  • Cell Name: myeloid cell (CL0000763)
    CSI Score: 1.5
  • Cell Name: ON-bipolar cell (CL0000749)
    CSI Score: 1.5
  • Cell Name: thymocyte (CL0000893)
    CSI Score: 1.4
  • Cell Name: corneal epithelial cell (CL0000575)
    CSI Score: 1.4
  • Cell Name: OFF-bipolar cell (CL0000750)
    CSI Score: 1.4
  • Cell Name: precursor B cell (CL0000817)
    CSI Score: 1.4
  • Cell Name: Mueller cell (CL0000636)
    CSI Score: 1.4
  • Cell Name: type I NK T cell (CL0000921)
    CSI Score: 1.4
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    CSI Score: 1.3
  • Cell Name: retinal rod cell (CL0000604)
    CSI Score: 1.3
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    CSI Score: 1.2
  • Cell Name: naive B cell (CL0000788)
    CSI Score: 1.2
  • Cell Name: keratinocyte (CL0000312)
    CSI Score: 1.2
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    CSI Score: 1.2
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    CSI Score: 1.2
  • Cell Name: classical monocyte (CL0000860)
    CSI Score: 1.2
  • Cell Name: glutamatergic neuron (CL0000679)
    CSI Score: 1.2
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    CSI Score: 1.2
  • Cell Name: ciliated cell (CL0000064)
    CSI Score: 1.2
  • Cell Name: neural progenitor cell (CL0011020)
    CSI Score: 1.1
  • Cell Name: oligodendrocyte (CL0000128)
    CSI Score: 1.1
  • Cell Name: squamous epithelial cell (CL0000076)
    CSI Score: 1.1
  • Cell Name: myofibroblast cell (CL0000186)
    CSI Score: 1.0
  • Cell Name: mononuclear phagocyte (CL0000113)
    CSI Score: 1.0
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    CSI Score: 1.0
  • Cell Name: tracheal goblet cell (CL1000329)
    CSI Score: 1.0
  • Cell Name: lung ciliated cell (CL1000271)
    CSI Score: 1.0
  • Cell Name: memory B cell (CL0000787)
    CSI Score: 1.0
  • Cell Name: CD14-positive monocyte (CL0001054)
    CSI Score: 1.0
  • Cell Name: melanocyte (CL0000148)
    CSI Score: 1.0
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    CSI Score: 1.0
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    CSI Score: 0.9
  • Cell Name: type B pancreatic cell (CL0000169)
    CSI Score: 0.9
  • Cell Name: forebrain radial glial cell (CL0013000)
    CSI Score: 0.9
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    CSI Score: 0.9
  • Cell Name: GABAergic neuron (CL0000617)
    CSI Score: 0.9
  • Cell Name: mature NK T cell (CL0000814)
    CSI Score: 0.9
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    CSI Score: 0.8
  • Cell Name: macrophage (CL0000235)
    CSI Score: 0.8
  • Cell Name: endothelial cell (CL0000115)
    CSI Score: 0.8
  • Cell Name: cardiac muscle cell (CL0000746)
    CSI Score: 0.8
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    CSI Score: 0.8
  • Cell Name: blood cell (CL0000081)
    CSI Score: 0.7
  • Cell Name: stromal cell (CL0000499)
    CSI Score: 0.7
  • Cell Name: alveolar macrophage (CL0000583)
    CSI Score: 0.6
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    CSI Score: 0.6
  • Cell Name: cardiac endothelial cell (CL0010008)
    CSI Score: 0.6
  • Cell Name: intestinal crypt stem cell (CL0002250)
    CSI Score: 0.6
  • Cell Name: naive T cell (CL0000898)
    CSI Score: 0.6
  • Cell Name: promonocyte (CL0000559)
    CSI Score: 0.6
  • Cell Name: extravillous trophoblast (CL0008036)
    CSI Score: 0.6
  • Cell Name: basal cell (CL0000646)
    CSI Score: 0.5
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    CSI Score: 0.5

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** AAMP is significantly expressed in various cell types, including placental villous trophoblast, decidual cells, mesodermal cells, epithelial cells of the esophagus, interstitial cells of the ovary, cortical thymic epithelial cells, kidney cells, epithelial cells of the nephron, and GABAergic amacrine cells. 2. **Protein Binding:** AAMP has been shown to interact with various proteins, including heparin-binding proteins, which suggests its role in cell-cell interactions and adhesion. 3. **Signal Transduction:** AAMP is involved in signaling pathways, including those mediated by receptor tyrosine kinases, epidermal growth factor receptors (EGFR), and vascular endothelial growth factor (VEGF). 4. **Cellular Migration:** AAMP plays a crucial role in cellular migration, a process essential for tissue development, repair, and immune responses. **Pathways and Functions:** 1. **Angiogenesis:** AAMP is involved in the regulation of angiogenesis, a process critical for tissue development, repair, and immune responses. It interacts with VEGF and other angiogenic factors to promote endothelial cell migration and proliferation. 2. **Immune Response:** AAMP plays a role in the innate immune response, particularly in the context of the NLRP3 inflammasome pathway. It is involved in the regulation of inflammatory responses and the production of pro-inflammatory cytokines. 3. **Cellular Migration:** AAMP is involved in the regulation of cellular migration, a process essential for tissue development, repair, and immune responses. It interacts with microtubule cytoskeleton proteins to regulate cell shape and movement. 4. **Signaling by Receptor Tyrosine Kinases:** AAMP is involved in signaling pathways mediated by receptor tyrosine kinases (RTKs), including EGFR and NLRP3. These pathways regulate various cellular processes, including cell growth, differentiation, and survival. **Clinical Significance:** 1. **Cancer:** AAMP's role in angiogenesis and cellular migration makes it a potential target for cancer therapy. Its expression is often upregulated in cancer cells, suggesting its involvement in tumor progression. 2. **Inflammatory Diseases:** AAMP's involvement in the innate immune response makes it a potential target for the treatment of inflammatory diseases, such as rheumatoid arthritis and atherosclerosis. 3. **Neurological Disorders:** AAMP's expression in GABAergic amacrine cells suggests its potential role in neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Reproductive Health:** AAMP's expression in placental villous trophoblast and decidual cells makes it a potential biomarker for reproductive health and pregnancy complications. In conclusion, the AAMP gene is a fascinating molecule that plays a crucial role in various biological processes, including angiogenesis, immune response, and cellular migration. Its involvement in cancer, inflammatory diseases, neurological disorders, and reproductive health makes it a potential target for therapeutic interventions. Further research is needed to fully elucidate the mechanisms underlying AAMP's functions and its role in human disease.

Genular Protein ID: 2650843394

Symbol: AAMP_HUMAN

Name: Angio-associated migratory cell protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7743515

Title: Identification of a new immunoglobulin superfamily protein expressed in blood vessels with a heparin-binding consensus sequence.

PubMed ID: 7743515

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10329261

Title: Angio-associated migratory cell protein is expressed as an extracellular protein by blood-vessel-associated mesenchymal cells.

PubMed ID: 10329261

DOI: 10.1006/mvre.1999.2144

PubMed ID: 18634987

Title: Blockade of angio-associated migratory cell protein inhibits smooth muscle cell migration and neointima formation in accelerated atherosclerosis.

PubMed ID: 18634987

DOI: 10.1016/j.jacc.2008.03.055

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 434
  • Mass: 46751
  • Checksum: A7B8314442EBAF15
  • Sequence:
  • MESESESGAA ADTPPLETLS FHGDEEIIEV VELDPGPPDP DDLAQEMEDV DFEEEEEEEG 
    NEEGWVLEPQ EGVVGSMEGP DDSEVTFALH SASVFCVSLD PKTNTLAVTG GEDDKAFVWR 
    LSDGELLFEC AGHKDSVTCA GFSHDSTLVA TGDMSGLLKV WQVDTKEEVW SFEAGDLEWM 
    EWHPRAPVLL AGTADGNTWM WKVPNGDCKT FQGPNCPATC GRVLPDGKRA VVGYEDGTIR 
    IWDLKQGSPI HVLKGTEGHQ GPLTCVAANQ DGSLILTGSV DCQAKLVSAT TGKVVGVFRP 
    ETVASQPSLG EGEESESNSV ESLGFCSVMP LAAVGYLDGT LAIYDLATQT LRHQCQHQSG 
    IVQLLWEAGT AVVYTCSLDG IVRLWDARTG RLLTDYRGHT AEILDFALSK DASLVVTTSG 
    DHKAKVFCVQ RPDR

Genular Protein ID: 4243246574

Symbol: C9JEH3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 435
  • Mass: 46822
  • Checksum: 14AF7FE6E2B51880
  • Sequence:
  • MESESESGAA ADTPPLETLS FHGDEEIIEV VELDPGPPDP ADDLAQEMED VDFEEEEEEE 
    GNEEGWVLEP QEGVVGSMEG PDDSEVTFAL HSASVFCVSL DPKTNTLAVT GGEDDKAFVW 
    RLSDGELLFE CAGHKDSVTC AGFSHDSTLV ATGDMSGLLK VWQVDTKEEV WSFEAGDLEW 
    MEWHPRAPVL LAGTADGNTW MWKVPNGDCK TFQGPNCPAT CGRVLPDGKR AVVGYEDGTI 
    RIWDLKQGSP IHVLKGTEGH QGPLTCVAAN QDGSLILTGS VDCQAKLVSA TTGKVVGVFR 
    PETVASQPSL GEGEESESNS VESLGFCSVM PLAAVGYLDG TLAIYDLATQ TLRHQCQHQS 
    GIVQLLWEAG TAVVYTCSLD GIVRLWDART GRLLTDYRGH TAEILDFALS KDASLVVTTS 
    GDHKAKVFCV QRPDR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.