Details for: AAMP

Gene ID: 14

Symbol: AAMP

Ensembl ID: ENSG00000127837

Description: angio associated migratory cell protein

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.96
    Marker Score: 7695
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.9
    Marker Score: 8214
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.83
    Marker Score: 24092
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.71
    Marker Score: 14746
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.7
    Marker Score: 11046
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.68
    Marker Score: 6222
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.68
    Marker Score: 1121
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.66
    Marker Score: 3469.5
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.63
    Marker Score: 3306
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.59
    Marker Score: 1687
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.59
    Marker Score: 6140
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.58
    Marker Score: 1677
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.58
    Marker Score: 3743
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.57
    Marker Score: 2314
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.56
    Marker Score: 9955
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.55
    Marker Score: 2544
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.53
    Marker Score: 3469
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.53
    Marker Score: 4154
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.52
    Marker Score: 15344
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.52
    Marker Score: 3712.5
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.52
    Marker Score: 1196
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.52
    Marker Score: 51603
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.51
    Marker Score: 833
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.49
    Marker Score: 6110
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.45
    Marker Score: 1465
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.45
    Marker Score: 1567
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.45
    Marker Score: 1822
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.44
    Marker Score: 337
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.44
    Marker Score: 2442
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.42
    Marker Score: 4450
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.4
    Marker Score: 6739
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.38
    Marker Score: 10267
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.37
    Marker Score: 3235
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.37
    Marker Score: 756
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 1.37
    Marker Score: 6715
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.36
    Marker Score: 2170
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.36
    Marker Score: 506
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.34
    Marker Score: 1932
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.31
    Marker Score: 14776
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.31
    Marker Score: 1738
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.3
    Marker Score: 546
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.3
    Marker Score: 45092
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.29
    Marker Score: 2070
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.28
    Marker Score: 1069.5
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.28
    Marker Score: 14854
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.26
    Marker Score: 794
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.25
    Marker Score: 1508
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.24
    Marker Score: 839
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 1.24
    Marker Score: 7334
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.23
    Marker Score: 1161.5
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.22
    Marker Score: 2296
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.22
    Marker Score: 9526
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.21
    Marker Score: 3298
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.2
    Marker Score: 2342
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.2
    Marker Score: 1699
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.19
    Marker Score: 1121
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.19
    Marker Score: 1122
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.19
    Marker Score: 423
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.19
    Marker Score: 284
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.18
    Marker Score: 1328
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.18
    Marker Score: 785
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.18
    Marker Score: 300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.17
    Marker Score: 1212
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.16
    Marker Score: 1242
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.16
    Marker Score: 1355
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.15
    Marker Score: 1765.5
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.15
    Marker Score: 283
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.15
    Marker Score: 835
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.14
    Marker Score: 542
  • Cell Name: theca cell (CL0000503)
    Fold Change: 1.14
    Marker Score: 818
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.14
    Marker Score: 1015
  • Cell Name: club cell (CL0000158)
    Fold Change: 1.13
    Marker Score: 1325
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.13
    Marker Score: 321
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.13
    Marker Score: 222
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.12
    Marker Score: 706
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.12
    Marker Score: 3321
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.11
    Marker Score: 1346
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 1.11
    Marker Score: 507
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.1
    Marker Score: 1957
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.1
    Marker Score: 318
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.1
    Marker Score: 2957.5
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 1.1
    Marker Score: 981
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.1
    Marker Score: 1860.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.1
    Marker Score: 1113
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.1
    Marker Score: 266
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.1
    Marker Score: 1050
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.1
    Marker Score: 564
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.09
    Marker Score: 544
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.09
    Marker Score: 378
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.09
    Marker Score: 350
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.09
    Marker Score: 2485
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 1.09
    Marker Score: 444
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 1.09
    Marker Score: 345
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.08
    Marker Score: 571
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.08
    Marker Score: 2722
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.08
    Marker Score: 1389
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.08
    Marker Score: 1963
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.07
    Marker Score: 518
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 1.07
    Marker Score: 273
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.07
    Marker Score: 552

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Other Information

**Key characteristics:** * AAMP is a transmembrane protein that is expressed in a variety of cell types. * It is a member of the Angiogenesis factor family of proteins. * AAMP is a key regulator of angiogenesis, the process by which new blood vessels form. * It is also involved in cell differentiation, cytosol, and hemostasis. **Pathways and functions:** * AAMP is involved in the regulation of vascularization by binding to the VEGFR-2 receptor and promoting its activation. * It also binds to the EGF receptor and promotes its activation, which is important for the migration of endothelial cells. * AAMP is involved in the regulation of cell differentiation by promoting the expression of endothelial cell markers. * It is also involved in the regulation of apoptosis by binding to the Apaf-1 receptor and promoting its degradation. **Clinical significance:** * Mutations in the AAMP gene have been linked to a number of human diseases, including placental abruption, miscarriage, and preeclampsia. * AAMP is a promising target for the treatment of these diseases. **Additional information:** * AAMP is a protein that is highly conserved across species. * It is a secreted protein that is produced by endothelial cells. * It is a potent angiogenic factor that can induce the migration of endothelial cells in vitro.

Genular Protein ID: 2650843394

Symbol: AAMP_HUMAN

Name: Angio-associated migratory cell protein

UniProtKB Accession Codes:

Q13685 Q8WUJ9 Q96H92

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7743515

Title: Identification of a new immunoglobulin superfamily protein expressed in blood vessels with a heparin-binding consensus sequence.

PubMed ID: 7743515

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10329261

Title: Angio-associated migratory cell protein is expressed as an extracellular protein by blood-vessel-associated mesenchymal cells.

PubMed ID: 10329261

DOI: 10.1006/mvre.1999.2144

PubMed ID: 18634987

Title: Blockade of angio-associated migratory cell protein inhibits smooth muscle cell migration and neointima formation in accelerated atherosclerosis.

PubMed ID: 18634987

DOI: 10.1016/j.jacc.2008.03.055

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 434
  • Mass: 46751
  • Checksum: A7B8314442EBAF15
  • Sequence:
    • MESESESGAA ADTPPLETLS FHGDEEIIEV VELDPGPPDP DDLAQEMEDV DFEEEEEEEG 
NEEGWVLEPQ EGVVGSMEGP DDSEVTFALH SASVFCVSLD PKTNTLAVTG GEDDKAFVWR 
LSDGELLFEC AGHKDSVTCA GFSHDSTLVA TGDMSGLLKV WQVDTKEEVW SFEAGDLEWM 
EWHPRAPVLL AGTADGNTWM WKVPNGDCKT FQGPNCPATC GRVLPDGKRA VVGYEDGTIR 
IWDLKQGSPI HVLKGTEGHQ GPLTCVAANQ DGSLILTGSV DCQAKLVSAT TGKVVGVFRP 
ETVASQPSLG EGEESESNSV ESLGFCSVMP LAAVGYLDGT LAIYDLATQT LRHQCQHQSG 
IVQLLWEAGT AVVYTCSLDG IVRLWDARTG RLLTDYRGHT AEILDFALSK DASLVVTTSG 
DHKAKVFCVQ RPDR

Genular Protein ID: 4243246574

Symbol: C9JEH3_HUMAN

Name: N/A

UniProtKB Accession Codes:

C9JEH3

Database IDs:

ARBA 2 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 3 EPD 1 Ensembl 2 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 4 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 3 PROSITE-ProRule 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 435
  • Mass: 46822
  • Checksum: 14AF7FE6E2B51880
  • Sequence:
    • MESESESGAA ADTPPLETLS FHGDEEIIEV VELDPGPPDP ADDLAQEMED VDFEEEEEEE 
GNEEGWVLEP QEGVVGSMEG PDDSEVTFAL HSASVFCVSL DPKTNTLAVT GGEDDKAFVW 
RLSDGELLFE CAGHKDSVTC AGFSHDSTLV ATGDMSGLLK VWQVDTKEEV WSFEAGDLEW 
MEWHPRAPVL LAGTADGNTW MWKVPNGDCK TFQGPNCPAT CGRVLPDGKR AVVGYEDGTI 
RIWDLKQGSP IHVLKGTEGH QGPLTCVAAN QDGSLILTGS VDCQAKLVSA TTGKVVGVFR 
PETVASQPSL GEGEESESNS VESLGFCSVM PLAAVGYLDG TLAIYDLATQ TLRHQCQHQS 
GIVQLLWEAG TAVVYTCSLD GIVRLWDART GRLLTDYRGH TAEILDFALS KDASLVVTTS 
GDHKAKVFCV QRPDR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.