Details for: ADORA3

Gene ID: 140

Symbol: ADORA3

Ensembl ID: ENSG00000282608

Description: adenosine A3 receptor

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 2.01
    Marker Score: 1999
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.86
    Marker Score: 1858
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1173
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.39
    Marker Score: 2830
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 859
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 490
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.16
    Marker Score: 2202
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4821
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.11
    Marker Score: 701
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 506
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251813
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 512
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 465
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 377
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5352
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.93
    Marker Score: 381
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 329
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.88
    Marker Score: 676
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5294
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.84
    Marker Score: 13130
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.71
    Marker Score: 181
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.68
    Marker Score: 236
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.66
    Marker Score: 433.5
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.62
    Marker Score: 399
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.6
    Marker Score: 690
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.59
    Marker Score: 473
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.59
    Marker Score: 353
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.56
    Marker Score: 176
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.51
    Marker Score: 135
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.5
    Marker Score: 209
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.45
    Marker Score: 215
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.44
    Marker Score: 2643
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.43
    Marker Score: 192
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.41
    Marker Score: 665
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.4
    Marker Score: 267
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.4
    Marker Score: 129
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.39
    Marker Score: 1022
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.33
    Marker Score: 331
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.28
    Marker Score: 312
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.27
    Marker Score: 554
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.24
    Marker Score: 267
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.23
    Marker Score: 131
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.21
    Marker Score: 122
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.19
    Marker Score: 108
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.18
    Marker Score: 101
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.18
    Marker Score: 50
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.18
    Marker Score: 178
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.16
    Marker Score: 1002.5
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.16
    Marker Score: 171
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.16
    Marker Score: 678
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.15
    Marker Score: 48
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.14
    Marker Score: 437
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.14
    Marker Score: 135.5
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.14
    Marker Score: 254
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.14
    Marker Score: 94
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.13
    Marker Score: 121
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.12
    Marker Score: 52
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.12
    Marker Score: 127
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.11
    Marker Score: 67
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.1
    Marker Score: 50
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.1
    Marker Score: 50
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.1
    Marker Score: 46
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.09
    Marker Score: 106
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.09
    Marker Score: 233
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.09
    Marker Score: 44
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.09
    Marker Score: 89
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.09
    Marker Score: 20
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.09
    Marker Score: 902
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.09
    Marker Score: 156
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.09
    Marker Score: 78
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.09
    Marker Score: 45
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.08
    Marker Score: 48
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.08
    Marker Score: 160
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.08
    Marker Score: 55
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.08
    Marker Score: 20
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.07
    Marker Score: 23
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.07
    Marker Score: 31
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.07
    Marker Score: 18
  • Cell Name: pre-conventional dendritic cell (CL0002010)
    Fold Change: 0.07
    Marker Score: 20
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.07
    Marker Score: 24
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 15
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.06
    Marker Score: 33
  • Cell Name: salivary gland cell (CL0009005)
    Fold Change: 0.06
    Marker Score: 19
  • Cell Name: promonocyte (CL0000559)
    Fold Change: 0.06
    Marker Score: 39
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.06
    Marker Score: 44
  • Cell Name: basophil mast progenitor cell (CL0002028)
    Fold Change: 0.06
    Marker Score: 18
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.06
    Marker Score: 75
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.05
    Marker Score: 22
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.05
    Marker Score: 19
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.05
    Marker Score: 53

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Other Information

**Key characteristics:** * ADORA3 is a member of the G protein-coupled receptor (GPCR) family. * It is expressed in high levels in epithelial cells of the large intestine, Kupffer cells, colon goblet cells, and immature innate lymphoid cells. * It is also expressed in cardiac endothelial cells, goblet cells, enterocytes of the small intestine, and granulocyte monocyte progenitor cells. **Pathways and functions:** * ADORA3 is a key regulator of inflammation. It is expressed in epithelial cells of the intestine and is activated by adenosine, a molecule that is released by immune cells. When ADORA3 is activated, it triggers a cascade of intracellular events that leads to the production of inflammatory cytokines. * ADORA3 is also involved in cell migration and proliferation. It is expressed in epithelial cells of the intestine and is important for the migration of enterocytes and other cells to the site of inflammation. * ADORA3 is also involved in cell survival. It is expressed in epithelial cells of the intestine and is important for the survival of enterocytes and other cells that are exposed to injury. **Clinical significance:** ADORA3 gene polymorphisms have been linked to a number of diseases, including inflammatory bowel disease (IBD), Crohn's disease, and ulcerative colitis. These diseases are characterized by inflammation and tissue damage in the digestive tract. ADORA3 is a potential target for new therapies for these diseases. **Additional information:** * ADORA3 is a highly conserved protein. It is found in mammals, birds, and fish. * It is a heterodimeric protein, meaning that it consists of two subunits that are held together by a linker peptide. * It is a member of the adenosine receptor superfamily, which is a large family of GPCRs that are involved in a variety of cellular processes, including inflammation, cell migration, and proliferation.

Genular Protein ID: 2357870480

Symbol: AA3R_HUMAN

Name: Adenosine receptor A3

UniProtKB Accession Codes:

P0DMS8 A2A3P4 P33765 Q6UWU0 Q9BYZ1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEMBL 1 DNASU 1 DisGeNET 1 DrugBank 6 DrugCentral 1 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 Pfam 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 UniProtKB 1 VEuPathDB 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8399349

Title: cDNA cloning and sequence analysis of the human A3 adenosine receptor.

PubMed ID: 8399349

DOI: 10.1016/0167-4889(93)90077-3

PubMed ID: 8234299

Title: Molecular cloning and characterization of the human A3 adenosine receptor.

PubMed ID: 8234299

DOI: 10.1073/pnas.90.21.10365

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11214319

Title: Molecular phylogenetics and the origins of placental mammals.

PubMed ID: 11214319

DOI: 10.1038/35054550

PubMed ID: 27886186

Title: Genome-wide RNAi screening identifies TMIGD3 isoform1 as a suppressor of NF-kappaB and osteosarcoma progression.

PubMed ID: 27886186

DOI: 10.1038/ncomms13561

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 318
  • Mass: 36185
  • Checksum: 690E67986130FC28
  • Sequence:
    • MPNNSTALSL ANVTYITMEI FIGLCAIVGN VLVICVVKLN PSLQTTTFYF IVSLALADIA 
VGVLVMPLAI VVSLGITIHF YSCLFMTCLL LIFTHASIMS LLAIAVDRYL RVKLTVRYKR 
VTTHRRIWLA LGLCWLVSFL VGLTPMFGWN MKLTSEYHRN VTFLSCQFVS VMRMDYMVYF 
SFLTWIFIPL VVMCAIYLDI FYIIRNKLSL NLSNSKETGA FYGREFKTAK SLFLVLFLFA 
LSWLPLSIIN CIIYFNGEVP QLVLYMGILL SHANSMMNPI VYAYKIKKFK ETYLLILKAC 
VVCHPSDSLD TSIEKNSE

Genular Protein ID: 333592506

Symbol: H6VQ59_HUMAN

Name: N/A

UniProtKB Accession Codes:

H6VQ59

Database IDs:

ARBA 13 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 3 PROSITE 3 Pfam 1 RefSeq 2 RuleBase 1 SMART 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 317
  • Mass: 36053
  • Checksum: 716EE66158D21E11
  • Sequence:
    • PNNSTALSLA NVTYITMEIF IGLCAIVGNV LVICVVKLNP SLQTTTFYFI VSLALADIAV 
GVLVMPLAIV VSLGITIHFY SCLFMTCLLL IFTHASIMSL LAIAVDRYLR VKLTVRYKRV 
TTHRRIWLAL GLCWLVSFLV GLTPMFGWNM KLTSEYHRNV TFLSCQFVSV MRMDYMVYFS 
FLTWIFIPLV VMCAIYLDIF YIIRNKLSLN LSNSKETGAF YGREFKTAKS LFLVLFLFAL 
SWLPLSIINC IIYFNGEVPQ LVLYMGILLS HANSMMNPIV YAYKIKKFKE TYLLILKACV 
VCHPSDSLDT SIEKNSE

Genular Protein ID: 986028626

Symbol: A0A0J9YWR0_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A0J9YWR0

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 2 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 2 PROSITE 3 Pfam 1 Proteomes 2 RefSeq 1 RuleBase 1 SAM 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 123
  • Mass: 13255
  • Checksum: 9D7A47447562C05C
  • Sequence:
    • MPNNSTALSL ANVTYITMEI FIGLCAIVGN VLVICVVKLN PSLQTTTFYF IVSLALADIA 
VGVLVMPLAI VVSLGITIHF YSCLFMTCLL LIFTHASIMS LLAIAVDRYL RVKLTVSSIS 
PTL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.