Details for: CRP

Gene ID: 1401

Symbol: CRP

Ensembl ID: ENSG00000132693

Description: C-reactive protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 43.0524
    Cell Significance Index: 113.5700
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 3.1909
    Cell Significance Index: 53.7500
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 3.0348
    Cell Significance Index: 11.4300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.4050
    Cell Significance Index: 40.2500
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.6870
    Cell Significance Index: 9.7200
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.6773
    Cell Significance Index: 20.0000
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 1.4790
    Cell Significance Index: 19.0000
  • Cell Name: hepatic pit cell (CL2000054)
    Fold Change: 1.4110
    Cell Significance Index: 3.7800
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.3567
    Cell Significance Index: 4.7200
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.2031
    Cell Significance Index: 11.8700
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.9878
    Cell Significance Index: 7.5900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.7313
    Cell Significance Index: 12.3000
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.7263
    Cell Significance Index: 10.7200
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.1341
    Cell Significance Index: 1.1900
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.1247
    Cell Significance Index: 1.1900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0951
    Cell Significance Index: 59.3700
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.0950
    Cell Significance Index: 0.7500
  • Cell Name: pancreatic epsilon cell (CL0005019)
    Fold Change: 0.0642
    Cell Significance Index: 0.6000
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.0619
    Cell Significance Index: 0.7400
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.0590
    Cell Significance Index: 0.5400
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.0488
    Cell Significance Index: 0.3800
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.0438
    Cell Significance Index: 0.3900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0438
    Cell Significance Index: 8.6900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.0336
    Cell Significance Index: 3.8500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0267
    Cell Significance Index: 3.0500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0241
    Cell Significance Index: 0.3500
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.0222
    Cell Significance Index: 0.2900
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.0207
    Cell Significance Index: 0.2100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0105
    Cell Significance Index: 0.4900
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.0072
    Cell Significance Index: 0.1000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0070
    Cell Significance Index: 1.1900
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.0045
    Cell Significance Index: 0.0500
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: 0.0035
    Cell Significance Index: 0.0700
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 0.0010
    Cell Significance Index: 0.0100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.0005
    Cell Significance Index: 0.2600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.0005
    Cell Significance Index: 0.3800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: -0.0009
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0009
    Cell Significance Index: -0.1800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0018
    Cell Significance Index: -0.0700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0019
    Cell Significance Index: -0.1000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0037
    Cell Significance Index: -0.5100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0046
    Cell Significance Index: -0.9300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0057
    Cell Significance Index: -0.1500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0080
    Cell Significance Index: -1.0300
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.0087
    Cell Significance Index: -0.0900
  • Cell Name: brain vascular cell (CL4023072)
    Fold Change: -0.0091
    Cell Significance Index: -0.1000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0108
    Cell Significance Index: -0.2200
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0108
    Cell Significance Index: -0.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0113
    Cell Significance Index: -1.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0113
    Cell Significance Index: -0.7600
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: -0.0132
    Cell Significance Index: -0.1800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0154
    Cell Significance Index: -9.7600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0170
    Cell Significance Index: -0.4400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0173
    Cell Significance Index: -0.9700
  • Cell Name: microglial cell (CL0000129)
    Fold Change: -0.0196
    Cell Significance Index: -0.2300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0200
    Cell Significance Index: -1.0400
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: -0.0203
    Cell Significance Index: -0.2100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0215
    Cell Significance Index: -0.2400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0222
    Cell Significance Index: -1.0500
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: -0.0223
    Cell Significance Index: -0.1900
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.0235
    Cell Significance Index: -0.3800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0235
    Cell Significance Index: -0.6400
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0247
    Cell Significance Index: -0.3000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0270
    Cell Significance Index: -0.7700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0273
    Cell Significance Index: -0.7300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.0284
    Cell Significance Index: -0.4600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0287
    Cell Significance Index: -0.9400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0305
    Cell Significance Index: -1.1200
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: -0.0313
    Cell Significance Index: -0.3300
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.0332
    Cell Significance Index: -0.3800
  • Cell Name: plasmablast (CL0000980)
    Fold Change: -0.0345
    Cell Significance Index: -0.3200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.0362
    Cell Significance Index: -0.5200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0377
    Cell Significance Index: -1.0800
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: -0.0386
    Cell Significance Index: -0.4100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0392
    Cell Significance Index: -0.5400
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0396
    Cell Significance Index: -0.3700
  • Cell Name: monocyte (CL0000576)
    Fold Change: -0.0400
    Cell Significance Index: -0.4600
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.0401
    Cell Significance Index: -0.4300
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0404
    Cell Significance Index: -0.7900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0412
    Cell Significance Index: -1.0500
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0414
    Cell Significance Index: -0.5500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0430
    Cell Significance Index: -1.0500
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.0435
    Cell Significance Index: -0.4500
  • Cell Name: B cell (CL0000236)
    Fold Change: -0.0440
    Cell Significance Index: -0.5200
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: -0.0443
    Cell Significance Index: -0.4200
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.0444
    Cell Significance Index: -0.4600
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: -0.0462
    Cell Significance Index: -0.4300
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: -0.0473
    Cell Significance Index: -0.5300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0475
    Cell Significance Index: -0.8400
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0484
    Cell Significance Index: -0.6100
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: -0.0491
    Cell Significance Index: -0.4900
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: -0.0528
    Cell Significance Index: -0.4200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0536
    Cell Significance Index: -1.5800
  • Cell Name: mature B cell (CL0000785)
    Fold Change: -0.0538
    Cell Significance Index: -0.3500
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.0550
    Cell Significance Index: -0.9400
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0551
    Cell Significance Index: -0.7200
  • Cell Name: adipocyte (CL0000136)
    Fold Change: -0.0555
    Cell Significance Index: -0.7400
  • Cell Name: naive B cell (CL0000788)
    Fold Change: -0.0560
    Cell Significance Index: -0.5900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0561
    Cell Significance Index: -0.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CRP is a pentameric protein composed of five subunits, each consisting of two polypeptide chains (A and B). It is synthesized by the liver in response to pro-inflammatory cytokines, such as IL-6 and IL-1β, and is primarily produced by hepatocytes. CRP is characterized by its high affinity for negatively charged surfaces, including negatively charged lipids, nucleic acids, and proteins. This property allows it to bind to various molecules, including low-density lipoprotein (LDL) particles and the complement component C1q, modulating their activity and function. **Pathways and Functions** CRP is involved in several key pathways, including: 1. **Acute-phase response**: CRP is synthesized in response to pro-inflammatory cytokines, such as IL-6 and IL-1β, and is released into the bloodstream, where it plays a crucial role in the acute-phase response. 2. **Inflammatory response**: CRP binds to various proteins and cells, modulating their activity and function, thereby regulating inflammation and immune system activation. 3. **Complement cascade**: CRP binds to the complement component C1q, activating the complement cascade and modulating its activity. 4. **Immune system regulation**: CRP regulates immune system activation by binding to T cells and plasma cells, modulating their activity and function. 5. **Antibody-mediated complement activation**: CRP binds to classical antibodies, activating the complement cascade and modulating its activity. **Functions** CRP has several key functions, including: 1. **Opsonization**: CRP binds to pathogens, such as Gram-positive bacteria, marking them for destruction by phagocytic cells. 2. **Defense against Gram-positive bacteria**: CRP regulates the defense against Gram-positive bacteria by binding to their cell walls and modulating their activity. 3. **Regulation of lipid storage**: CRP regulates lipid storage by binding to LDL particles and modulating their activity. 4. **Negative regulation of macrophage-derived foam cell differentiation**: CRP regulates macrophage-derived foam cell differentiation by binding to LDL particles and modulating their activity. 5. **Regulation of interleukin-8 production**: CRP regulates interleukin-8 production by binding to T cells and plasma cells, modulating their activity and function. **Clinical Significance** CRP is a widely used biomarker for inflammation and immune system activation. Elevated levels of CRP are associated with various conditions, including: 1. **Inflammatory diseases**: CRP is elevated in inflammatory diseases, such as rheumatoid arthritis, lupus, and inflammatory bowel disease. 2. **Cardiovascular disease**: CRP is elevated in cardiovascular disease, including atherosclerosis and myocardial infarction. 3. **Infections**: CRP is elevated in infections, such as sepsis and pneumonia. 4. **Cancer**: CRP is elevated in some types of cancer, including colorectal and pancreatic cancer. In conclusion, CRP is a multifunctional protein that plays a crucial role in the innate immune response, particularly in the acute-phase response. Its key characteristics, pathways, and functions highlight its importance in regulating inflammation, immune system activation, and defense against pathogens. Its clinical significance is reflected in its use as a biomarker for various conditions, including inflammatory diseases, cardiovascular disease, infections, and cancer.

Genular Protein ID: 3311840252

Symbol: CRP_HUMAN

Name: C-reactive protein

UniProtKB Accession Codes:

P02741 A8K078 D3DVD9 D3DVE0 Q08AK3 Q8WW75

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 1 CPTC 1 CTD 1 ChEBI 9 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 15 EMDB 7 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 14 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2997165

Title: Genomic DNA sequence for human C-reactive protein.

PubMed ID: 2997165

DOI: 10.1016/s0021-9258(17)38880-4

PubMed ID: 3840479

Title: Characterization of genomic and complementary DNA sequence of human C-reactive protein, and comparison with the complementary DNA sequence of serum amyloid P component.

PubMed ID: 3840479

DOI: 10.1016/s0021-9258(17)38881-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6685157

Title: Biosynthesis and postsynthetic processing of human C-reactive protein.

PubMed ID: 6685157

PubMed ID: 6857266

Title: Isolation of human C-reactive protein complementary DNA and localization of the gene to chromosome 1.

PubMed ID: 6857266

DOI: 10.1126/science.6857266

PubMed ID: 762075

Title: Primary structure of human C-reactive protein.

PubMed ID: 762075

DOI: 10.1016/s0021-9258(17)37943-7

PubMed ID: 403526

Title: Partial amino-acid sequences of human and rabbit C-reactive proteins: homology with immunoglobulins and histocompatibility antigens.

PubMed ID: 403526

DOI: 10.1073/pnas.74.3.1214

PubMed ID: 21037097

Title: Secreted M-ficolin anchors onto monocyte transmembrane G protein-coupled receptor 43 and cross talks with plasma C-reactive protein to mediate immune signaling and regulate host defense.

PubMed ID: 21037097

DOI: 10.4049/jimmunol.1001225

PubMed ID: 7881902

Title: Comparative analyses of pentraxins: implications for protomer assembly and ligand binding.

PubMed ID: 7881902

DOI: 10.1016/s0969-2126(94)00105-7

PubMed ID: 8599761

Title: Three dimensional structure of human C-reactive protein.

PubMed ID: 8599761

DOI: 10.1038/nsb0496-346

PubMed ID: 10368284

Title: The physiological structure of human C-reactive protein and its complex with phosphocholine.

PubMed ID: 10368284

DOI: 10.1016/s0969-2126(99)80023-9

Sequence Information:

  • Length: 224
  • Mass: 25039
  • Checksum: 669228636A8544F6
  • Sequence:
    • MEKLLCFLVL TSLSHAFGQT DMSRKAFVFP KESDTSYVSL KAPLTKPLKA FTVCLHFYTE 
LSSTRGYSIF SYATKRQDNE ILIFWSKDIG YSFTVGGSEI LFEVPEVTVA PVHICTSWES 
ASGIVEFWVD GKPRVRKSLK KGYTVGAEAS IILGQEQDSF GGNFEGSQSL VGDIGNVNMW 
DFVLSPDEIN TIYLGGPFSP NVLNWRALKY EVQGEVFTKP QLWP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.