CRP | ENSG00000132693 | NCBI 1401

Details for: CRP

Gene ID: 1401

Symbol: CRP

Ensembl ID: ENSG00000132693

Description: C-reactive protein

Associated with

Classical antibody-mediated complement activation
(R-HSA-173623)
Complement cascade
(R-HSA-166658)
Creation of c4 and c2 activators
(R-HSA-166786)
Immune system
(R-HSA-168256)
Initial triggering of complement
(R-HSA-166663)
Innate immune system
(R-HSA-168249)
Acute-phase response
(GO:0006953)
Calcium ion binding
(GO:0005509)
Choline binding
(GO:0033265)
Complement component c1q complex binding
(GO:0001849)
Defense response to gram-positive bacterium
(GO:0050830)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Identical protein binding
(GO:0042802)
Inflammatory response
(GO:0006954)
Innate immune response
(GO:0045087)
Low-density lipoprotein particle binding
(GO:0030169)
Low-density lipoprotein particle receptor binding
(GO:0050750)
Negative regulation of lipid storage
(GO:0010888)
Negative regulation of macrophage derived foam cell differentiation
(GO:0010745)
Negative regulation of mononuclear cell proliferation
(GO:0032945)
Opsonization
(GO:0008228)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of superoxide anion generation
(GO:0032930)
Protein binding
(GO:0005515)
Regulation of interleukin-8 production
(GO:0032677)
Vasoconstriction
(GO:0042310)
Virion binding
(GO:0046790)

Other Information

Proteins

C-reactive protein

Genular Protein ID: 3311840252

Symbol: CRP_HUMAN

Name: C-reactive protein

UniProtKB Accession Codes:

P02741 A8K078 D3DVD9 D3DVE0 Q08AK3 Q8WW75

Database IDs:

Citations:

PubMed ID: 2997165

Title: Genomic DNA sequence for human C-reactive protein.

PubMed ID: 2997165

DOI: 10.1016/s0021-9258(17)38880-4

PubMed ID: 3840479

Title: Characterization of genomic and complementary DNA sequence of human C-reactive protein, and comparison with the complementary DNA sequence of serum amyloid P component.

PubMed ID: 3840479

DOI: 10.1016/s0021-9258(17)38881-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6685157

Title: Biosynthesis and postsynthetic processing of human C-reactive protein.

PubMed ID: 6685157

PubMed ID: 6857266

Title: Isolation of human C-reactive protein complementary DNA and localization of the gene to chromosome 1.

PubMed ID: 6857266

DOI: 10.1126/science.6857266

PubMed ID: 762075

Title: Primary structure of human C-reactive protein.

PubMed ID: 762075

DOI: 10.1016/s0021-9258(17)37943-7

PubMed ID: 403526

Title: Partial amino-acid sequences of human and rabbit C-reactive proteins: homology with immunoglobulins and histocompatibility antigens.

PubMed ID: 403526

DOI: 10.1073/pnas.74.3.1214

PubMed ID: 21037097

Title: Secreted M-ficolin anchors onto monocyte transmembrane G protein-coupled receptor 43 and cross talks with plasma C-reactive protein to mediate immune signaling and regulate host defense.

PubMed ID: 21037097

DOI: 10.4049/jimmunol.1001225

PubMed ID: 7881902

Title: Comparative analyses of pentraxins: implications for protomer assembly and ligand binding.

PubMed ID: 7881902

DOI: 10.1016/s0969-2126(94)00105-7

PubMed ID: 8599761

Title: Three dimensional structure of human C-reactive protein.

PubMed ID: 8599761

DOI: 10.1038/nsb0496-346

PubMed ID: 10368284

Title: The physiological structure of human C-reactive protein and its complex with phosphocholine.

PubMed ID: 10368284

DOI: 10.1016/s0969-2126(99)80023-9

Sequence Information:

Length: 224
Mass: 25039
Checksum: 669228636A8544F6
Sequence:

MEKLLCFLVL TSLSHAFGQT DMSRKAFVFP KESDTSYVSL KAPLTKPLKA FTVCLHFYTE 
LSSTRGYSIF SYATKRQDNE ILIFWSKDIG YSFTVGGSEI LFEVPEVTVA PVHICTSWES 
ASGIVEFWVD GKPRVRKSLK KGYTVGAEAS IILGQEQDSF GGNFEGSQSL VGDIGNVNMW 
DFVLSPDEIN TIYLGGPFSP NVLNWRALKY EVQGEVFTKP QLWP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: CRP

Associated with

Other Information

Genomic DNA sequence for human C-reactive protein. PubMed ID: 2997165

Characterization of genomic and complementary DNA sequence of human C-reactive protein, and comparison with the complementary DNA sequence of serum amyloid P component. PubMed ID: 3840479

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and biological annotation of human chromosome 1. PubMed ID: 16710414

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Biosynthesis and postsynthetic processing of human C-reactive protein. PubMed ID: 6685157

Isolation of human C-reactive protein complementary DNA and localization of the gene to chromosome 1. PubMed ID: 6857266

Primary structure of human C-reactive protein. PubMed ID: 762075

Partial amino-acid sequences of human and rabbit C-reactive proteins: homology with immunoglobulins and histocompatibility antigens. PubMed ID: 403526

Secreted M-ficolin anchors onto monocyte transmembrane G protein-coupled receptor 43 and cross talks with plasma C-reactive protein to mediate immune signaling and regulate host defense. PubMed ID: 21037097

Comparative analyses of pentraxins: implications for protomer assembly and ligand binding. PubMed ID: 7881902

Three dimensional structure of human C-reactive protein. PubMed ID: 8599761

The physiological structure of human C-reactive protein and its complex with phosphocholine. PubMed ID: 10368284