Details for: CRP

Gene ID: 1401

Symbol: CRP

Ensembl ID: ENSG00000132693

Description: C-reactive protein

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 6.69
    Marker Score: 8,269
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.75
    Marker Score: 6,835
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 2.57
    Marker Score: 13,801
  • Cell Name: T cell (CL0000084)
    Fold Change: 1.91
    Marker Score: 3,288
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.89
    Marker Score: 2,107
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.82
    Marker Score: 7,847
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 1.68
    Marker Score: 520
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.54
    Marker Score: 2,919
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.45
    Marker Score: 1,556
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.41
    Marker Score: 9,058
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.22
    Marker Score: 1,160
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7,692
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.12
    Marker Score: 418
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.07
    Marker Score: 733
  • Cell Name: pericyte (CL0000669)
    Fold Change: 1.02
    Marker Score: 596
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,814
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,040
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.97
    Marker Score: 1,965
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 0.97
    Marker Score: 364
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.95
    Marker Score: 989
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5,353
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2,742
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,290
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 499
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.85
    Marker Score: 1,107
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.84
    Marker Score: 1,358
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 712
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 403
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.75
    Marker Score: 1,197
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.74
    Marker Score: 163
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.72
    Marker Score: 691
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.7
    Marker Score: 193
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.66
    Marker Score: 530
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.63
    Marker Score: 291
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.59
    Marker Score: 590
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.49
    Marker Score: 1,026
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.45
    Marker Score: 7,079
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.44
    Marker Score: 263
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.43
    Marker Score: 327
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.43
    Marker Score: 418
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.42
    Marker Score: 251
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.4
    Marker Score: 174
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.38
    Marker Score: 2,304
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.37
    Marker Score: 363
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.32
    Marker Score: 115
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.29
    Marker Score: 136
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.28
    Marker Score: 188
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.27
    Marker Score: 93
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.25
    Marker Score: 251
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.2
    Marker Score: 178
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.2
    Marker Score: 125
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.19
    Marker Score: 84
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.16
    Marker Score: 38
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 0.16
    Marker Score: 139
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.14
    Marker Score: 294
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.14
    Marker Score: 88
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.13
    Marker Score: 113
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.13
    Marker Score: 29
  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 0.12
    Marker Score: 794
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.12
    Marker Score: 32
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.12
    Marker Score: 39
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.12
    Marker Score: 37
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.12
    Marker Score: 30
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.11
    Marker Score: 34
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.11
    Marker Score: 168
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.1
    Marker Score: 37
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.09
    Marker Score: 954
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.09
    Marker Score: 38
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.09
    Marker Score: 107
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.09
    Marker Score: 41
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.09
    Marker Score: 38
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.09
    Marker Score: 44
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 0.09
    Marker Score: 34
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.08
    Marker Score: 32
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.07
    Marker Score: 82
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.07
    Marker Score: 63
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.07
    Marker Score: 37
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.07
    Marker Score: 35
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.07
    Marker Score: 35
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.06
    Marker Score: 44
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.06
    Marker Score: 28
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.06
    Marker Score: 62
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.05
    Marker Score: 36
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.05
    Marker Score: 37
  • Cell Name: intrahepatic cholangiocyte (CL0002538)
    Fold Change: 0.05
    Marker Score: 20
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.05
    Marker Score: 34
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.05
    Marker Score: 36
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.05
    Marker Score: 35
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.05
    Marker Score: 28
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.05
    Marker Score: 36
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.05
    Marker Score: 44
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.05
    Marker Score: 36
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.05
    Marker Score: 23
  • Cell Name: epithelial cell of exocrine pancreas (CL1001433)
    Fold Change: 0.05
    Marker Score: 26
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.04
    Marker Score: 26
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.04
    Marker Score: 73
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.04
    Marker Score: 26
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 0.04
    Marker Score: 38

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CRP is a pentameric protein composed of five subunits, each consisting of two polypeptide chains (A and B). It is synthesized by the liver in response to pro-inflammatory cytokines, such as IL-6 and IL-1β, and is primarily produced by hepatocytes. CRP is characterized by its high affinity for negatively charged surfaces, including negatively charged lipids, nucleic acids, and proteins. This property allows it to bind to various molecules, including low-density lipoprotein (LDL) particles and the complement component C1q, modulating their activity and function. **Pathways and Functions** CRP is involved in several key pathways, including: 1. **Acute-phase response**: CRP is synthesized in response to pro-inflammatory cytokines, such as IL-6 and IL-1β, and is released into the bloodstream, where it plays a crucial role in the acute-phase response. 2. **Inflammatory response**: CRP binds to various proteins and cells, modulating their activity and function, thereby regulating inflammation and immune system activation. 3. **Complement cascade**: CRP binds to the complement component C1q, activating the complement cascade and modulating its activity. 4. **Immune system regulation**: CRP regulates immune system activation by binding to T cells and plasma cells, modulating their activity and function. 5. **Antibody-mediated complement activation**: CRP binds to classical antibodies, activating the complement cascade and modulating its activity. **Functions** CRP has several key functions, including: 1. **Opsonization**: CRP binds to pathogens, such as Gram-positive bacteria, marking them for destruction by phagocytic cells. 2. **Defense against Gram-positive bacteria**: CRP regulates the defense against Gram-positive bacteria by binding to their cell walls and modulating their activity. 3. **Regulation of lipid storage**: CRP regulates lipid storage by binding to LDL particles and modulating their activity. 4. **Negative regulation of macrophage-derived foam cell differentiation**: CRP regulates macrophage-derived foam cell differentiation by binding to LDL particles and modulating their activity. 5. **Regulation of interleukin-8 production**: CRP regulates interleukin-8 production by binding to T cells and plasma cells, modulating their activity and function. **Clinical Significance** CRP is a widely used biomarker for inflammation and immune system activation. Elevated levels of CRP are associated with various conditions, including: 1. **Inflammatory diseases**: CRP is elevated in inflammatory diseases, such as rheumatoid arthritis, lupus, and inflammatory bowel disease. 2. **Cardiovascular disease**: CRP is elevated in cardiovascular disease, including atherosclerosis and myocardial infarction. 3. **Infections**: CRP is elevated in infections, such as sepsis and pneumonia. 4. **Cancer**: CRP is elevated in some types of cancer, including colorectal and pancreatic cancer. In conclusion, CRP is a multifunctional protein that plays a crucial role in the innate immune response, particularly in the acute-phase response. Its key characteristics, pathways, and functions highlight its importance in regulating inflammation, immune system activation, and defense against pathogens. Its clinical significance is reflected in its use as a biomarker for various conditions, including inflammatory diseases, cardiovascular disease, infections, and cancer.

Genular Protein ID: 3311840252

Symbol: CRP_HUMAN

Name: C-reactive protein

UniProtKB Accession Codes:

P02741 A8K078 D3DVD9 D3DVE0 Q08AK3 Q8WW75

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 1 CPTC 1 CTD 1 ChEBI 9 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 2 EMBL 15 EMDB 7 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 19 PDBsum 14 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2997165

Title: Genomic DNA sequence for human C-reactive protein.

PubMed ID: 2997165

DOI: 10.1016/s0021-9258(17)38880-4

PubMed ID: 3840479

Title: Characterization of genomic and complementary DNA sequence of human C-reactive protein, and comparison with the complementary DNA sequence of serum amyloid P component.

PubMed ID: 3840479

DOI: 10.1016/s0021-9258(17)38881-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 6685157

Title: Biosynthesis and postsynthetic processing of human C-reactive protein.

PubMed ID: 6685157

PubMed ID: 6857266

Title: Isolation of human C-reactive protein complementary DNA and localization of the gene to chromosome 1.

PubMed ID: 6857266

DOI: 10.1126/science.6857266

PubMed ID: 762075

Title: Primary structure of human C-reactive protein.

PubMed ID: 762075

DOI: 10.1016/s0021-9258(17)37943-7

PubMed ID: 403526

Title: Partial amino-acid sequences of human and rabbit C-reactive proteins: homology with immunoglobulins and histocompatibility antigens.

PubMed ID: 403526

DOI: 10.1073/pnas.74.3.1214

PubMed ID: 21037097

Title: Secreted M-ficolin anchors onto monocyte transmembrane G protein-coupled receptor 43 and cross talks with plasma C-reactive protein to mediate immune signaling and regulate host defense.

PubMed ID: 21037097

DOI: 10.4049/jimmunol.1001225

PubMed ID: 7881902

Title: Comparative analyses of pentraxins: implications for protomer assembly and ligand binding.

PubMed ID: 7881902

DOI: 10.1016/s0969-2126(94)00105-7

PubMed ID: 8599761

Title: Three dimensional structure of human C-reactive protein.

PubMed ID: 8599761

DOI: 10.1038/nsb0496-346

PubMed ID: 10368284

Title: The physiological structure of human C-reactive protein and its complex with phosphocholine.

PubMed ID: 10368284

DOI: 10.1016/s0969-2126(99)80023-9

Sequence Information:

  • Length: 224
  • Mass: 25039
  • Checksum: 669228636A8544F6
  • Sequence:
    • MEKLLCFLVL TSLSHAFGQT DMSRKAFVFP KESDTSYVSL KAPLTKPLKA FTVCLHFYTE 
LSSTRGYSIF SYATKRQDNE ILIFWSKDIG YSFTVGGSEI LFEVPEVTVA PVHICTSWES 
ASGIVEFWVD GKPRVRKSLK KGYTVGAEAS IILGQEQDSF GGNFEGSQSL VGDIGNVNMW 
DFVLSPDEIN TIYLGGPFSP NVLNWRALKY EVQGEVFTKP QLWP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.