Details for: HAPLN1

Gene ID: 1404

Symbol: HAPLN1

Ensembl ID: ENSG00000145681

Description: hyaluronan and proteoglycan link protein 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 20.7150
    Cell Significance Index: -9.7800
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 6.4523
    Cell Significance Index: 38.1000
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 5.7745
    Cell Significance Index: 95.1600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 4.2798
    Cell Significance Index: 92.7200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 4.0947
    Cell Significance Index: 251.0500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 2.1268
    Cell Significance Index: 32.0500
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 1.7479
    Cell Significance Index: 10.2600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.5934
    Cell Significance Index: 157.6200
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 1.5919
    Cell Significance Index: 7.3500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 1.2894
    Cell Significance Index: 245.3800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.1077
    Cell Significance Index: 23.5900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.0281
    Cell Significance Index: -2.2500
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.8727
    Cell Significance Index: 7.9200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7647
    Cell Significance Index: 690.4500
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.7636
    Cell Significance Index: 3.3800
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.6564
    Cell Significance Index: 3.1400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.6451
    Cell Significance Index: 9.9800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6400
    Cell Significance Index: 104.0900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4026
    Cell Significance Index: 24.1700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.3565
    Cell Significance Index: 8.6400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2771
    Cell Significance Index: 12.5600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2408
    Cell Significance Index: 16.6500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.2176
    Cell Significance Index: 150.4700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.1992
    Cell Significance Index: 4.1700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1834
    Cell Significance Index: 65.7700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1098
    Cell Significance Index: 6.7500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1003
    Cell Significance Index: 12.8600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0925
    Cell Significance Index: 2.3100
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0353
    Cell Significance Index: 0.7500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0269
    Cell Significance Index: 0.4500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0103
    Cell Significance Index: 0.3300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.0069
    Cell Significance Index: 0.1100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0004
    Cell Significance Index: 0.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0040
    Cell Significance Index: -7.5200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0042
    Cell Significance Index: -0.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0054
    Cell Significance Index: -9.9500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0065
    Cell Significance Index: -10.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0069
    Cell Significance Index: -3.1200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0078
    Cell Significance Index: -10.6700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0110
    Cell Significance Index: -0.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0111
    Cell Significance Index: -0.3900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0130
    Cell Significance Index: -2.6000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0134
    Cell Significance Index: -9.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0167
    Cell Significance Index: -10.5900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0173
    Cell Significance Index: -9.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0184
    Cell Significance Index: -10.3500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0185
    Cell Significance Index: -0.4000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0268
    Cell Significance Index: -5.3200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0324
    Cell Significance Index: -9.3200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0365
    Cell Significance Index: -0.8800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0420
    Cell Significance Index: -7.1800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0509
    Cell Significance Index: -10.7200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0558
    Cell Significance Index: -10.0700
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0593
    Cell Significance Index: -1.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0640
    Cell Significance Index: -8.7900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0654
    Cell Significance Index: -9.5100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0705
    Cell Significance Index: -8.2200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0719
    Cell Significance Index: -1.0300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0780
    Cell Significance Index: -2.1800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0815
    Cell Significance Index: -3.5400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0830
    Cell Significance Index: -9.5100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0832
    Cell Significance Index: -10.2300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0885
    Cell Significance Index: -11.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0956
    Cell Significance Index: -9.9500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0966
    Cell Significance Index: -9.8700
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0987
    Cell Significance Index: -1.2800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1238
    Cell Significance Index: -5.7700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1243
    Cell Significance Index: -9.5400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1258
    Cell Significance Index: -8.4600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1535
    Cell Significance Index: -11.4400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1615
    Cell Significance Index: -6.6200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1798
    Cell Significance Index: -10.0900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1965
    Cell Significance Index: -5.0500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1987
    Cell Significance Index: -8.7900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2037
    Cell Significance Index: -5.4400
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.2082
    Cell Significance Index: -2.9900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.2114
    Cell Significance Index: -3.1200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2196
    Cell Significance Index: -11.5300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2278
    Cell Significance Index: -5.9900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2324
    Cell Significance Index: -8.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.2340
    Cell Significance Index: -11.0000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2341
    Cell Significance Index: -2.6600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2465
    Cell Significance Index: -9.0500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.2465
    Cell Significance Index: -4.2500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2477
    Cell Significance Index: -5.1700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2605
    Cell Significance Index: -5.2300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.2672
    Cell Significance Index: -5.2600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2675
    Cell Significance Index: -9.3700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.2754
    Cell Significance Index: -13.9200
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2816
    Cell Significance Index: -9.2200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2819
    Cell Significance Index: -1.9100
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.2941
    Cell Significance Index: -2.9100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2973
    Cell Significance Index: -9.4700
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.3018
    Cell Significance Index: -5.8900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.3192
    Cell Significance Index: -9.1100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3217
    Cell Significance Index: -11.1800
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.3285
    Cell Significance Index: -3.1200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3368
    Cell Significance Index: -9.9200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3392
    Cell Significance Index: -9.0900
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3440
    Cell Significance Index: -10.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HAPLN1 is a 30-kDa protein that belongs to the hyaluronan-binding protein family. Its primary function is to bind hyaluronic acid (HA), a key component of the extracellular matrix (ECM), and proteoglycans, which are heavily glycosylated ECM molecules. This binding event facilitates the organization and remodeling of the ECM, which is crucial for tissue development, repair, and maintenance. HAPLN1's ability to interact with HA and proteoglycans also enables it to modulate cell adhesion, migration, and differentiation, making it a pivotal protein in various biological processes. **Pathways and Functions:** HAPLN1's involvement in multiple signaling pathways underscores its multifaceted role in cellular processes. Notably, it is implicated in: 1. **Cell adhesion:** HAPLN1's interaction with HA and proteoglycans regulates cell-cell and cell-ECM interactions, influencing cell migration, differentiation, and survival. 2. **Extracellular matrix organization:** HAPLN1's binding to HA and proteoglycans promotes ECM remodeling, which is essential for tissue development, repair, and maintenance. 3. **Glial cell differentiation:** HAPLN1's expression in glial cells, such as GABAergic cortical interneurons, suggests its involvement in the regulation of glial cell differentiation and function. 4. **Neuroblast proliferation:** HAPLN1's role in positive regulation of neuroblast proliferation highlights its potential as a therapeutic target for neurodevelopmental disorders. **Clinical Significance:** HAPLN1's involvement in various biological processes makes it an attractive candidate for therapeutic intervention in diseases characterized by altered ECM dynamics, immune dysfunction, or neurodevelopmental disorders. Some potential clinical applications of HAPLN1 include: 1. **Wound healing:** HAPLN1's role in ECM remodeling and tissue repair makes it a promising target for the development of novel wound-healing therapies. 2. **Cancer:** Altered HAPLN1 expression has been observed in various cancers, suggesting its potential as a therapeutic target for cancer treatment. 3. **Neurological disorders:** HAPLN1's involvement in glial cell differentiation and neuroblast proliferation makes it a potential therapeutic target for neurodevelopmental disorders, such as autism spectrum disorder or schizophrenia. In conclusion, HAPLN1's multifaceted role in cellular processes, ECM dynamics, and immune regulation underscores its significance as a potential therapeutic target for various diseases. Further research is necessary to fully elucidate the mechanisms underlying HAPLN1's functions and to explore its clinical applications.

Genular Protein ID: 4171422888

Symbol: HPLN1_HUMAN

Name: Hyaluronan and proteoglycan link protein 1

UniProtKB Accession Codes:

P10915 B2R9A9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 4 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2320422

Title: The primary structure of human cartilage link protein.

PubMed ID: 2320422

DOI: 10.1093/nar/18.5.1292

PubMed ID: 2336413

Title:

PubMed ID: 2336413

DOI: 10.1093/nar/18.8.2214

PubMed ID: 2286376

Title: Complete amino acid sequence of human cartilage link protein (CRTL1) deduced from cDNA clones and chromosomal assignment of the gene.

PubMed ID: 2286376

DOI: 10.1016/0888-7543(90)90044-u

PubMed ID: 2030970

Title: Characterization of the promoter for the rat and human link protein gene.

PubMed ID: 2030970

DOI: 10.1093/nar/19.8.1933

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11027579

Title: The brain link protein-1 (BRAL1): cDNA cloning, genomic structure, and characterization as a novel link protein expressed in adult brain.

PubMed ID: 11027579

DOI: 10.1006/bbrc.2000.3583

PubMed ID: 12663660

Title: A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links.

PubMed ID: 12663660

DOI: 10.1074/jbc.m213100200

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 354
  • Mass: 40166
  • Checksum: 315C96EC3AC2626A
  • Sequence:
    • MKSLLLLVLI SICWADHLSD NYTLDHDRAI HIQAENGPHL LVEAEQAKVF SHRGGNVTLP 
CKFYRDPTAF GSGIHKIRIK WTKLTSDYLK EVDVFVSMGY HKKTYGGYQG RVFLKGGSDS 
DASLVITDLT LEDYGRYKCE VIEGLEDDTV VVALDLQGVV FPYFPRLGRY NLNFHEAQQA 
CLDQDAVIAS FDQLYDAWRG GLDWCNAGWL SDGSVQYPIT KPREPCGGQN TVPGVRNYGF 
WDKDKSRYDV FCFTSNFNGR FYYLIHPTKL TYDEAVQACL NDGAQIAKVG QIFAAWKILG 
YDRCDAGWLA DGSVRYPISR PRRRCSPTEA AVRFVGFPDK KHKLYGVYCF RAYN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.