Details for: HAPLN1

Gene ID: 1404

Symbol: HAPLN1

Ensembl ID: ENSG00000145681

Description: hyaluronan and proteoglycan link protein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.15
    Marker Score: 3170.5
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.3
    Marker Score: 1299
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 170053
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.43
    Marker Score: 21437
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.39
    Marker Score: 2873
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 870
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.27
    Marker Score: 360
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 855
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.17
    Marker Score: 486
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4813
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.09
    Marker Score: 2073.5
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.07
    Marker Score: 4155
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.06
    Marker Score: 2163
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.04
    Marker Score: 796
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71822
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48047
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.98
    Marker Score: 526
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.95
    Marker Score: 428
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5315
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 373
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 325
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.9
    Marker Score: 540
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.82
    Marker Score: 374.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1261
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 707
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.74
    Marker Score: 4419
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 461
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.72
    Marker Score: 258
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.71
    Marker Score: 11106
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.64
    Marker Score: 23788
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.59
    Marker Score: 188
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.59
    Marker Score: 4542
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.58
    Marker Score: 303
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 445
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.47
    Marker Score: 506
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.46
    Marker Score: 205
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.45
    Marker Score: 216
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.43
    Marker Score: 363
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.4
    Marker Score: 390
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.39
    Marker Score: 372
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 371
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.36
    Marker Score: 1399
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.34
    Marker Score: 152
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.34
    Marker Score: 806
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.33
    Marker Score: 139
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.32
    Marker Score: 374
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.32
    Marker Score: 77
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.31
    Marker Score: 144
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.3
    Marker Score: 516.5
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.3
    Marker Score: 126
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.29
    Marker Score: 270
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.28
    Marker Score: 1156
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.28
    Marker Score: 100
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.28
    Marker Score: 96
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.27
    Marker Score: 206
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.27
    Marker Score: 533
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.27
    Marker Score: 111
  • Cell Name: mature NK T cell (CL0000814)
    Fold Change: 0.26
    Marker Score: 121
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.25
    Marker Score: 147
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.24
    Marker Score: 221
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.24
    Marker Score: 1003
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.24
    Marker Score: 174
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.23
    Marker Score: 136
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.23
    Marker Score: 73
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.22
    Marker Score: 878
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.22
    Marker Score: 181
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.22
    Marker Score: 100
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.22
    Marker Score: 68
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.21
    Marker Score: 466
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.21
    Marker Score: 261
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.21
    Marker Score: 139
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.2
    Marker Score: 53
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.2
    Marker Score: 118
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.19
    Marker Score: 7114
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.19
    Marker Score: 105
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.18
    Marker Score: 176
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.17
    Marker Score: 61
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.16
    Marker Score: 144
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.15
    Marker Score: 126
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 0.15
    Marker Score: 99
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.14
    Marker Score: 95
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.14
    Marker Score: 77
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.14
    Marker Score: 156
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.14
    Marker Score: 99
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.14
    Marker Score: 79
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.13
    Marker Score: 121
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.13
    Marker Score: 72

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Other Information

**Key characteristics** * Hapln1 is a transmembrane protein that is expressed in the extracellular matrix (ECM) of the CNS. * It is a large protein that is composed of two immunoglobulin heavy chains and two immunoglobulin light chains. * Hapln1 is a glycoprotein that is involved in cell adhesion, migration, and signaling. * It is a key component of the perineuronal net, a network of cell adhesion molecules that is important for the development and maintenance of the CNS. * Hapln1 is also involved in the regulation of neuroblast proliferation, skeletal system development, and synapse formation. **Pathways and functions** * Hapln1 is involved in cell adhesion by binding to a variety of ECM proteins, including fibronectin, collagen, and proteoglycans. * It is also involved in migration by binding to extracellular matrix proteins and guiding the cell's movement. * Hapln1 is a signaling molecule that is involved in a variety of cellular processes, including cell adhesion, migration, and differentiation. * It is also involved in the regulation of neuroblast proliferation, skeletal system development, and synapse formation. **Clinical significance** Mutations in the Hapln1 gene have been linked to a number of neurological disorders, including autism, schizophrenia, and Alzheimer's disease. These mutations can lead to changes in the composition and structure of the ECM, which can disrupt cell adhesion, migration, and signaling. This can lead to a variety of neurological symptoms, including seizures, behavioral problems, and cognitive impairment. **Additional information** * Hapln1 is a highly conserved protein that is found in mammals. * It is expressed in high levels in the brain, spinal cord, and eyes. * Hapln1 is a promising target for treatment of neurological disorders.

Genular Protein ID: 4171422888

Symbol: HPLN1_HUMAN

Name: Hyaluronan and proteoglycan link protein 1

UniProtKB Accession Codes:

P10915 B2R9A9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 5 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 4 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2320422

Title: The primary structure of human cartilage link protein.

PubMed ID: 2320422

DOI: 10.1093/nar/18.5.1292

PubMed ID: 2336413

Title:

PubMed ID: 2336413

DOI: 10.1093/nar/18.8.2214

PubMed ID: 2286376

Title: Complete amino acid sequence of human cartilage link protein (CRTL1) deduced from cDNA clones and chromosomal assignment of the gene.

PubMed ID: 2286376

DOI: 10.1016/0888-7543(90)90044-u

PubMed ID: 2030970

Title: Characterization of the promoter for the rat and human link protein gene.

PubMed ID: 2030970

DOI: 10.1093/nar/19.8.1933

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11027579

Title: The brain link protein-1 (BRAL1): cDNA cloning, genomic structure, and characterization as a novel link protein expressed in adult brain.

PubMed ID: 11027579

DOI: 10.1006/bbrc.2000.3583

PubMed ID: 12663660

Title: A hyaluronan binding link protein gene family whose members are physically linked adjacent to chondroitin sulfate proteoglycan core protein genes: the missing links.

PubMed ID: 12663660

DOI: 10.1074/jbc.m213100200

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 354
  • Mass: 40166
  • Checksum: 315C96EC3AC2626A
  • Sequence:
    • MKSLLLLVLI SICWADHLSD NYTLDHDRAI HIQAENGPHL LVEAEQAKVF SHRGGNVTLP 
CKFYRDPTAF GSGIHKIRIK WTKLTSDYLK EVDVFVSMGY HKKTYGGYQG RVFLKGGSDS 
DASLVITDLT LEDYGRYKCE VIEGLEDDTV VVALDLQGVV FPYFPRLGRY NLNFHEAQQA 
CLDQDAVIAS FDQLYDAWRG GLDWCNAGWL SDGSVQYPIT KPREPCGGQN TVPGVRNYGF 
WDKDKSRYDV FCFTSNFNGR FYYLIHPTKL TYDEAVQACL NDGAQIAKVG QIFAAWKILG 
YDRCDAGWLA DGSVRYPISR PRRRCSPTEA AVRFVGFPDK KHKLYGVYCF RAYN

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.