Genular: Defining Cellular Identity and Function

Details for: F2

Gene ID: 14061

Symbol: F2

Ensembl ID: ENSMUSG00000027249

Description: coagulation factor II

Associated with

Cell surface interactions at the vascular wall
(R-MMU-202733)
Class a/1 (rhodopsin-like receptors)
(R-MMU-373076)
Common pathway of fibrin clot formation
(R-MMU-140875)
Complement cascade
(R-MMU-166658)
Formation of fibrin clot (clotting cascade)
(R-MMU-140877)
G alpha (q) signalling events
(R-MMU-416476)
Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
(R-MMU-159854)
Gamma-carboxylation of protein precursors
(R-MMU-159740)
Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
(R-MMU-163841)
Gpcr downstream signalling
(R-MMU-388396)
Gpcr ligand binding
(R-MMU-500792)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Intrinsic pathway of fibrin clot formation
(R-MMU-140837)
Metabolism of proteins
(R-MMU-392499)
Peptide ligand-binding receptors
(R-MMU-375276)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Platelet aggregation (plug formation)
(R-MMU-76009)
Post-translational protein modification
(R-MMU-597592)
Regulation of complement cascade
(R-MMU-977606)
Removal of aminoterminal propeptides from gamma-carboxylated proteins
(R-MMU-159782)
Signaling by gpcr
(R-MMU-372790)
Signal transduction
(R-MMU-162582)
Thrombin signalling through proteinase activated receptors (pars)
(R-MMU-456926)
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the golgi apparatus
(R-MMU-159763)
Acute-phase response
(GO:0006953)
Antimicrobial humoral immune response mediated by antimicrobial peptide
(GO:0061844)
Blood coagulation
(GO:0007596)
Calcium ion binding
(GO:0005509)
Cell surface receptor signaling pathway
(GO:0007166)
Collagen-containing extracellular matrix
(GO:0062023)
Cytolysis by host of symbiont cells
(GO:0051838)
Endopeptidase activity
(GO:0004175)
External side of plasma membrane
(GO:0009897)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fibrinolysis
(GO:0042730)
G protein-coupled receptor signaling pathway
(GO:0007186)
Hemostasis
(GO:0007599)
Heparin binding
(GO:0008201)
Hydrolase activity
(GO:0016787)
Ligand-gated ion channel signaling pathway
(GO:1990806)
Lipopolysaccharide binding
(GO:0001530)
Negative regulation of astrocyte differentiation
(GO:0048712)
Negative regulation of cytokine production involved in inflammatory response
(GO:1900016)
Negative regulation of proteolysis
(GO:0045861)
Neutrophil-mediated killing of gram-negative bacterium
(GO:0070945)
Peptidase activity
(GO:0008233)
Platelet activation
(GO:0030168)
Positive regulation of blood coagulation
(GO:0030194)
Positive regulation of cell growth
(GO:0030307)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of collagen biosynthetic process
(GO:0032967)
Positive regulation of insulin secretion
(GO:0032024)
Positive regulation of lipid kinase activity
(GO:0090218)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of phospholipase c-activating g protein-coupled receptor signaling pathway
(GO:1900738)
Positive regulation of protein localization to nucleus
(GO:1900182)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of reactive oxygen species metabolic process
(GO:2000379)
Positive regulation of release of sequestered calcium ion into cytosol
(GO:0051281)
Protein binding
(GO:0005515)
Proteolysis
(GO:0006508)
Regulation of cell shape
(GO:0008360)
Regulation of cytosolic calcium ion concentration
(GO:0051480)
Regulation of gene expression
(GO:0010468)
Response to wounding
(GO:0009611)
Serine-type endopeptidase activity
(GO:0004252)
Serine-type peptidase activity
(GO:0008236)
Signaling receptor binding
(GO:0005102)
Thrombin-activated receptor signaling pathway
(GO:0070493)
Thrombospondin receptor activity
(GO:0070053)

Other Information

Proteins

Prothrombin

Genular Protein ID: 2061501848

Symbol: THRB_MOUSE

Name: Prothrombin

UniProtKB Accession Codes:

P19221

Database IDs:

Citations:

PubMed ID: 2222810

Title: Characterization of the cDNA coding for mouse prothrombin and localization of the gene on mouse chromosome 2.

PubMed ID: 2222810

DOI: 10.1089/dna.1990.9.487

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1557383

Title: Partial characterization of vertebrate prothrombin cDNAs: amplification and sequence analysis of the B chain of thrombin from nine different species.

PubMed ID: 1557383

DOI: 10.1073/pnas.89.7.2779

PubMed ID: 17330941

Title: Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides.

PubMed ID: 17330941

DOI: 10.1021/pr0604559

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 17428793

Title: Structural basis of Na+ activation mimicry in murine thrombin.

PubMed ID: 17428793

DOI: 10.1074/jbc.m701323200

PubMed ID: 17606903

Title: Crystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4.

PubMed ID: 17606903

DOI: 10.1073/pnas.0704409104

Sequence Information:

Length: 618
Mass: 70269
Checksum: B89F719AAFD601E0
Sequence:

MSHVRGLGLP GCLALAALVS LVHSQHVFLA PQQALSLLQR VRRANSGFLE ELRKGNLERE 
CVEEQCSYEE AFEALESPQD TDVFWAKYTV CDSVRKPRET FMDCLEGRCA MDLGVNYLGT 
VNVTHTGIQC QLWRSRYPHK PEINSTTHPG ADLKENFCRN PDSSTTGPWC YTTDPTVRRE 
ECSVPVCGQE GRTTVVMTPR SGGSKDNLSP PLGQCLTERG RLYQGNLAVT TLGSPCLPWN 
SLPAKTLSKY QDFDPEVKLV ENFCRNPDWD EEGAWCYVAG QPGDFEYCNL NYCEEAVGEE 
NYDVDESIAG RTTDAEFHTF FNEKTFGLGE ADCGLRPLFE KKSLKDTTEK ELLDSYIDGR 
IVEGWDAEKG IAPWQVMLFR KSPQELLCGA SLISDRWVLT AAHCILYPPW DKNFTENDLL 
VRIGKHSRTR YERNVEKISM LEKIYVHPRY NWRENLDRDI ALLKLKKPVP FSDYIHPVCL 
PDKQTVTSLL RAGYKGRVTG WGNLRETWTT NINEIQPSVL QVVNLPIVER PVCKASTRIR 
ITDNMFCAGF KVNDTKRGDA CEGDSGGPFV MKSPFNNRWY QMGIVSWGEG CDRKGKYGFY 
THVFRLKRWI QKVIDQFG

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: F2

Associated with

Other Information

Characterization of the cDNA coding for mouse prothrombin and localization of the gene on mouse chromosome 2. PubMed ID: 2222810

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Partial characterization of vertebrate prothrombin cDNAs: amplification and sequence analysis of the B chain of thrombin from nine different species. PubMed ID: 1557383

Enhanced analysis of the mouse plasma proteome using cysteine-containing tryptic glycopeptides. PubMed ID: 17330941

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Structural basis of Na+ activation mimicry in murine thrombin. PubMed ID: 17428793

Crystal structures of murine thrombin in complex with the extracellular fragments of murine protease-activated receptors PAR3 and PAR4. PubMed ID: 17606903