Details for: F2r

Gene ID: 14062

Symbol: F2r

Ensembl ID: ENSMUSG00000048376

Description: coagulation factor II thrombin receptor

Associated with

  • Class a/1 (rhodopsin-like receptors)
    (R-MMU-373076)
  • Common pathway of fibrin clot formation
    (R-MMU-140875)
  • Formation of fibrin clot (clotting cascade)
    (R-MMU-140877)
  • G alpha (q) signalling events
    (R-MMU-416476)
  • Gpcr downstream signalling
    (R-MMU-388396)
  • Gpcr ligand binding
    (R-MMU-500792)
  • Peptide ligand-binding receptors
    (R-MMU-375276)
  • Platelet activation, signaling and aggregation
    (R-MMU-76002)
  • Signaling by gpcr
    (R-MMU-372790)
  • Thrombin signalling through proteinase activated receptors (pars)
    (R-MMU-456926)
  • Activation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0006919)
  • Blood coagulation
    (GO:0007596)
  • Caveola
    (GO:0005901)
  • Cell-cell junction maintenance
    (GO:0045217)
  • Cell surface
    (GO:0009986)
  • Connective tissue replacement involved in inflammatory response wound healing
    (GO:0002248)
  • Dendritic cell homeostasis
    (GO:0036145)
  • Early endosome
    (GO:0005769)
  • Establishment of synaptic specificity at neuromuscular junction
    (GO:0007529)
  • G-protein alpha-subunit binding
    (GO:0001965)
  • G-protein beta-subunit binding
    (GO:0031681)
  • G protein-coupled receptor activity
    (GO:0004930)
  • G protein-coupled receptor signaling pathway
    (GO:0007186)
  • Hemostasis
    (GO:0007599)
  • Heterotrimeric g-protein binding
    (GO:0032795)
  • Homeostasis of number of cells within a tissue
    (GO:0048873)
  • Inflammatory response
    (GO:0006954)
  • Late endosome
    (GO:0005770)
  • Membrane
    (GO:0016020)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of glomerular filtration
    (GO:0003105)
  • Negative regulation of neuron apoptotic process
    (GO:0043524)
  • Negative regulation of renin secretion into blood stream
    (GO:1900134)
  • Neuromuscular junction
    (GO:0031594)
  • Phospholipase c-activating g protein-coupled receptor signaling pathway
    (GO:0007200)
  • Plasma membrane
    (GO:0005886)
  • Platelet activation
    (GO:0030168)
  • Platelet dense tubular network
    (GO:0031094)
  • Positive regulation of blood coagulation
    (GO:0030194)
  • Positive regulation of calcium ion transport
    (GO:0051928)
  • Positive regulation of cell migration
    (GO:0030335)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of collagen biosynthetic process
    (GO:0032967)
  • Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043280)
  • Positive regulation of cytosolic calcium ion concentration
    (GO:0007204)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of gtpase activity
    (GO:0043547)
  • Positive regulation of interleukin-6 production
    (GO:0032755)
  • Positive regulation of interleukin-8 production
    (GO:0032757)
  • Positive regulation of mapk cascade
    (GO:0043410)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of release of sequestered calcium ion into cytosol
    (GO:0051281)
  • Positive regulation of rho protein signal transduction
    (GO:0035025)
  • Positive regulation of smooth muscle contraction
    (GO:0045987)
  • Positive regulation of vasoconstriction
    (GO:0045907)
  • Postsynaptic membrane
    (GO:0045211)
  • Protein kinase c-activating g protein-coupled receptor signaling pathway
    (GO:0007205)
  • Regulation of blood coagulation
    (GO:0030193)
  • Regulation of interleukin-1 beta production
    (GO:0032651)
  • Release of sequestered calcium ion into cytosol
    (GO:0051209)
  • Response to lipopolysaccharide
    (GO:0032496)
  • Response to wounding
    (GO:0009611)
  • Signaling receptor binding
    (GO:0005102)
  • Signal transduction
    (GO:0007165)
  • Thrombin-activated receptor activity
    (GO:0015057)
  • Thrombin-activated receptor signaling pathway
    (GO:0070493)
  • Trans-synaptic signaling by endocannabinoid, modulating synaptic transmission
    (GO:0099553)

Other Information

Genular Protein ID: 2893539528

Symbol: PAR1_MOUSE

Name: Proteinase-activated receptor 1

UniProtKB Accession Codes:

P30558 P97507 Q3TVP3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DNASU 1 EMBL 8 EPD 1 Ensembl 1 GO 56 Gene3D 1 GeneTree 1 Genevisible 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MGI 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 4 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 8784787

Title: Conserved structure and adjacent location of the thrombin receptor and protease-activated receptor 2 genes define a protease-activated receptor gene cluster.

PubMed ID: 8784787

DOI: 10.1007/bf03401632

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8678993

Title: Structure and localization of the thrombin receptor gene on mouse chromosome 13.

PubMed ID: 8678993

DOI: 10.1007/s003359900189

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

Sequence Information:

  • Length: 430
  • Mass: 47790
  • Checksum: 395FD64FAE52C9BF
  • Sequence:
    • MGPRRLLIVA LGLSLCGPLL SSRVPMSQPE SERTDATVNP RSFFLRNPSE NTFELVPLGD 
EEEEEKNESV LLEGRAVYLN ISLPPHTPPP PFISEDASGY LTSPWLTLFM PSVYTIVFIV 
SLPLNVLAIA VFVLRMKVKK PAVVYMLHLA MADVLFVSVL PFKISYYFSG TDWQFGSGMC 
RFATAAFYGN MYASIMLMTV ISIDRFLAVV YPIQSLSWRT LGRANFTCVV IWVMAIMGVV 
PLLLKEQTTR VPGLNITTCH DVLSENLMQG FYSYYFSAFS AIFFLVPLIV STVCYTSIIR 
CLSSSAVANR SKKSRALFLS AAVFCIFIVC FGPTNVLLIV HYLFLSDSPG TEAAYFAYLL 
CVCVSSVSCC IDPLIYYYAS SECQRHLYSI LCCKESSDPN SCNSTGQLMP SKMDTCSSHL 
NNSIYKKLLA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.